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  1. Article: Gender inequality in the global mental health research workforce: a research authorship scoping review and qualitative study in Nepal.

    Gurung, Dristy / Sangraula, Manaswi / Subba, Prasansa / Poudyal, Anubhuti / Mishra, Shelly / Kohrt, Brandon A

    BMJ global health

    2024  Volume 6, Issue 12

    Abstract: Introduction: Although women's health is prioritised in global research, few studies have identified structural barriers and strategies to promote female leadership and gender equality in the global health research workforce, especially in low-income ... ...

    Abstract Introduction: Although women's health is prioritised in global research, few studies have identified structural barriers and strategies to promote female leadership and gender equality in the global health research workforce, especially in low-income and middle-income countries.
    Methods: We conducted a mixed-methods study to evaluate gender equality in the mental health research workforce in Nepal. The scoping review assessed gender disparities in authorship of journal publications for Nepal mental health research, using databases (PsycINFO, PubMed, Web of Science, NepJol, NepMed) for 5 years. Qualitative interviews were conducted with 22 Nepali researchers to identify structural barriers limiting women's leadership.
    Results: Of 337 articles identified, 61% were by Nepali first authors. Among Nepali first authors, 38.3% were women. Nepali women had half the odds of being first authors compared with men, when referenced against non-Nepali authors (OR 0.50, 95% CI 1.30 to 3.16). When limiting publications to those based on funded research, the odds were worse for first authorship among Nepali women (OR 0.37, 95% CI 0.19 to 0.71). The qualitative analysis supported the scoping review and identified a lack of gender-friendly organisational policies, difficulties in communication and mobility, and limited opportunities for networking as barriers to women's leadership in global health research.
    Conclusion: Efforts are needed for greater representation of Nepali women in global mental health research, which will require transformative organisational policies to foster female leadership. Those in leadership need to recognise gender inequalities and take necessary steps to address them. Funding agencies should prioritise supporting organisations with gender equality task forces, policies and indicators.
    MeSH term(s) Authorship ; Female ; Health Personnel ; Humans ; Male ; Mental Health ; Nepal ; Workforce
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2021-006146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Polydipsia and Polyuria in a 12-year-old Girl.

    Mishra, Shelly / McCormick, Erika T / Marks, Brynn E

    Pediatrics in review

    2022  Volume 43, Issue 2, Page(s) 104–107

    MeSH term(s) Child ; Female ; Humans ; Polydipsia/diagnosis ; Polydipsia/etiology ; Polyuria/etiology
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2020-003202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Examining the Influence of COVID-19 Infection and Pandemic Restrictions on the Risk of Corneal Transplant Rejection or Failure: A Multicenter Study.

    Raiker, Rahul / Akosman, Sinan / Foos, William / Pakhchanian, Haig / Mishra, Shelly / Geist, Craig / Belyea, David A

    Seminars in ophthalmology

    2023  Volume 38, Issue 8, Page(s) 777–783

    Abstract: Purpose: The purpose of this study was to evaluate two aims. The first was whether patients with a history of keratoplasty who developed COVID-19 were at a higher risk of corneal graft rejection or failure. The second was examining whether patients who ... ...

    Abstract Purpose: The purpose of this study was to evaluate two aims. The first was whether patients with a history of keratoplasty who developed COVID-19 were at a higher risk of corneal graft rejection or failure. The second was examining whether patients who underwent a new keratoplasty during the first 2 years of the pandemic from 2020-2022 were at a higher risk of the same outcomes compared to those undergoing keratoplasty from 2017-2019 before the pandemic.
    Methods: A multicenter research network, TriNetX, was used to query for keratoplasty patients with or without a COVID-19 between January 2020 and July 2022. Additionally, the database was also queried to identify new keratoplasties performed from January 2020-July 2022 and compare it to keratoplasties performed during a similar pre-pandemic interval between 2017-2019. 1:1 Propensity Score Matching was utilized to adjust for confounders. Graft complication of either a rejection or failure was assessed within 120 day follow-up using the Cox proportional hazard model and survival analysis.
    Results: A total of 21,991 patients with any keratoplasty history were identified from January 2020-July 2022, of which 8.8% were diagnosed with COVID-19. Matching revealed two balanced cohorts of 1,927 patients where no significant difference in risk of corneal graft rejection or failure among groups ((aHR [95% CI] = 0.76 [0.43,1.34];
    Conclusions: This study found no significant increase in the risk of graft rejection or failure in patients with a prior keratoplasty history following COVID-19 diagnosis nor in any patients who had a new keratoplasty done during 2020-2022 when compared to a similar pre-pandemic interval.
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 632820-9
    ISSN 1744-5205 ; 0882-0538
    ISSN (online) 1744-5205
    ISSN 0882-0538
    DOI 10.1080/08820538.2023.2234495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Assessment of chest CT at CTDI

    Padole, Atul / Digumarthy, Subba / Flores, Efren / Madan, Rachna / Mishra, Shelly / Sharma, Amita / Kalra, Mannudeep K

    The British journal of radiology

    2017  Volume 90, Issue 1071, Page(s) 20160625

    Abstract: Objective: To assess the image quality of chest CT reconstructed with image-based iterative reconstruction (SafeCT; MedicVision: Methods: In an institutional review board-approved study, 25 patients gave written informed consent for acquisition of ... ...

    Abstract Objective: To assess the image quality of chest CT reconstructed with image-based iterative reconstruction (SafeCT; MedicVision
    Methods: In an institutional review board-approved study, 25 patients gave written informed consent for acquisition of three reduced dose (0.25-, 0.4- and 0.8-mGy) chest CT after standard of care CT (8 mGy) on a 64-channel multidetector CT (MDCT) and reconstructed with SafeCT, ASIR and MBIR. Two board-certified thoracic radiologists evaluated images from the lowest to the highest dose of the reduced dose CT series and subsequently for standard of care CT.
    Results: Out of the 182 detected lesions, the missed lesions were 35 at 0.25, 24 at 0.4 and 9 at 0.8 mGy with SafeCT, ASIR and MBIR, respectively. The most missed lesions were non-calcified lung nodules (NCLNs) 25/112 (<5 mm) at 0.25, 18/112 (<5 mm) at 0.4 and 3/112 (<4 mm) at 0.8 mGy. There were 78%, 84% and 97% lung nodules detected at 0.25, 0.4 and 0.8 mGy, respectively regardless of iterative reconstruction techniques (IRTs), Most mediastinum structures were not sufficiently seen at 0.25-0.8 mGy.
    Conclusion: NCLNs can be missed in chest CT at CTDI
    MeSH term(s) Female ; Humans ; Lung/diagnostic imaging ; Lung Neoplasms/diagnostic imaging ; Male ; Middle Aged ; Multidetector Computed Tomography/methods ; Radiographic Image Interpretation, Computer-Assisted/methods ; Radiography, Thoracic/methods
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20160625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Risk Factors, Imaging Findings, and Sex Differences in Spontaneous Coronary Artery Dissection.

    Sharma, Shilpa / Kaadan, M Ihsan / Duran, Jessica M / Ponzini, Francesca / Mishra, Shelly / Tsiaras, Sarah V / Scott, Nandita S / Weinberg, Ido / Ghoshhajra, Brian / Lindsay, Mark / Gibson, C Michael / Chi, Gerald / Michalak, Nate / Wood, Malissa J

    The American journal of cardiology

    2019  Volume 123, Issue 11, Page(s) 1783–1787

    Abstract: Spontaneous coronary artery dissection (SCAD) is increasingly being recognized. However, data supporting diagnosis and management are scarce. We analyze a contemporary and comprehensive SCAD registry to advance the understanding of SCAD risk factors, ... ...

    Abstract Spontaneous coronary artery dissection (SCAD) is increasingly being recognized. However, data supporting diagnosis and management are scarce. We analyze a contemporary and comprehensive SCAD registry to advance the understanding of SCAD risk factors, angiographic appearance, and gender differences. This is a retrospective analysis of a prospectively populated database of SCAD patients seen at the Massachusetts General Hospital (MGH) between June 2013 and October 2017. Core laboratory analysis of both coronary angiograms and computerized tomographic (CT) angiography of the extracoronary vessels was performed. Of the 113 patients, 87% were female and mean age was 47 ± 10 years. Traditional cardiovascular risk factors including hypertension, hyperlipidemia, and smoking were present in 27%, 14%, and 22% of patients. Among females, 14%, 8%, and 9% had a history of gestational hypertension, pre-eclampsia, and gestational diabetes, respectively. Fifteen percent had used fertility treatment and 47% of postmenopausal women had used hormone replacement therapy. Angiography showed multivessel SCAD in 42%, severe coronary artery tortuosity in 59%, and extracoronary vascular abnormalities in 100% of patients with complete CT angiographic imaging. Gender differences revealed a self-reported depression and anxiety prevalence of 20% and 32%, respectively, in women compared with 0% in men. Type 1 SCAD was more commonly diagnosed in men than women (71% vs 29%, p <0.01). In conclusion, we highlight under-recognized features of SCAD including (1) relation with pregnancy complications and exposure to hormonal therapy; (2) diffuse, multivessel process in tortuous coronaries on a background of extracoronary arterial abnormalities; and (3) gender differences highlighting the role of mental health as well as potential underdiagnoses in men.
    MeSH term(s) Adult ; Coronary Angiography ; Coronary Vessel Anomalies/diagnostic imaging ; Coronary Vessel Anomalies/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Sex Distribution ; Sex Factors ; Vascular Diseases/congenital ; Vascular Diseases/diagnostic imaging ; Vascular Diseases/epidemiology
    Language English
    Publishing date 2019-03-08
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2019.02.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Quantification of interstitial fluid on whole body CT: comparison with whole body autopsy.

    Lo Gullo, Roberto / Mishra, Shelly / Lira, Diego A / Padole, Atul / Otrakji, Alexi / Khawaja, Ranish Deedar Ali / Pourjabbar, Sarvenaz / Singh, Sarabjeet / Shepard, Jo-Anne O / Digumarthy, Subba R / Kalra, Mannudeep K / Stone, James R

    Forensic science, medicine, and pathology

    2015  Volume 11, Issue 4, Page(s) 488–496

    Abstract: Purpose: Interstitial fluid accumulation can occur in pleural, pericardial, and peritoneal spaces, and subcutaneous tissue planes. The purpose of the study was to assess if whole body CT examination in a postmortem setting could help determine the ... ...

    Abstract Purpose: Interstitial fluid accumulation can occur in pleural, pericardial, and peritoneal spaces, and subcutaneous tissue planes. The purpose of the study was to assess if whole body CT examination in a postmortem setting could help determine the presence and severity of third space fluid accumulation in the body.
    Materials and methods: Our study included 41 human cadavers (mean age 61 years, 25 males and 16 females) who had whole-body postmortem CT prior to autopsy. All bodies were maintained in the morgue in the time interval between death and autopsy. Two radiologists reviewed the whole-body CT examinations independently to grade third space fluid in the pleura, pericardium, peritoneum, and subcutaneous space using a 5-point grading system. Qualitative CT grading for third space fluid was correlated with the amount of fluid found on autopsy and the quantitative CT fluid volume, estimated using a dedicated software program (Volume, Syngo Explorer, Siemens Healthcare).
    Results: Moderate and severe peripheral edema was seen in 16/41 and 7/41 cadavers respectively. It is not possible to quantify anasarca at autopsy. Correlation between imaging data for third space fluid and the quantity of fluid found during autopsy was 0.83 for pleural effusion, 0.4 for pericardial effusion and 0.9 for ascites. The degree of anasarca was significantly correlated with the severity of ascites (p < 0.0001) but not with pleural or pericardial effusion. There was strong correlation between volumetric estimation and qualitative grading for anasarca (p < 0.0001) and pleural effusion (p < 0.0001).
    Conclusion: Postmortem CT can help in accurate detection and quantification of third space fluid accumulation. The quantity of ascitic fluid on postmortem CT can predict the extent of anasarca.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Ascites/diagnostic imaging ; Ascites/pathology ; Autopsy ; Bilirubin/analysis ; Cadaver ; Edema/diagnostic imaging ; Edema/pathology ; Extracellular Fluid/metabolism ; Female ; Forensic Pathology ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Pericardium/diagnostic imaging ; Pericardium/metabolism ; Pericardium/pathology ; Peritoneum/diagnostic imaging ; Peritoneum/metabolism ; Peritoneum/pathology ; Pleura/diagnostic imaging ; Pleura/metabolism ; Pleura/pathology ; Pleural Effusion/diagnostic imaging ; Pleural Effusion/pathology ; Serum Albumin/analysis ; Severity of Illness Index ; Subcutaneous Tissue/diagnostic imaging ; Subcutaneous Tissue/metabolism ; Subcutaneous Tissue/pathology ; Whole Body Imaging
    Chemical Substances Serum Albumin ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2195904-3
    ISSN 1556-2891 ; 1547-769X
    ISSN (online) 1556-2891
    ISSN 1547-769X
    DOI 10.1007/s12024-015-9728-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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