LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Mishra, Tanushree"
  2. AU=Chemes H E
  3. AU="Wang, Yuguang"
  4. AU="Wu, Sheng-Hua"
  5. AU="Irwin, Brian"
  6. AU="Vizcaíno-Velázquez, Pilar"
  7. AU="Cairncross, J Gregory"
  8. AU=Small Eusebius
  9. AU="Poppelaars, Marlou"
  10. AU="Hou, Yinmeng"
  11. AU="Tapias, Carlos"
  12. AU=Kojima Shihoko
  13. AU="Alcahut-Rodríguez, Cristian"
  14. AU="Whiteside, Theresa L"
  15. AU="Pappalettere, Carmine"
  16. AU="Bolla, Eleana"
  17. AU="Bajkowski, Jared"
  18. AU="Calleros Basilio, Laura"
  19. AU="Mohamad, Okbah"
  20. AU="Holy, Jon"
  21. AU="Farber, Mark O"
  22. AU="Gal, Adiv"
  23. AU="Badenhorst, Marelise"
  24. AU="Pachner, Andrew R"
  25. AU="Colón-Ramos, Daniel A" AU="Colón-Ramos, Daniel A"
  26. AU="Modzelewska, Dominika"
  27. AU="Boethig, Dietmar"
  28. AU="Jurinović, Luka"
  29. AU="Yashila Patel"
  30. AU="Zheng, Lei" AU="Zheng, Lei"
  31. AU="Seah, Penelope M Y"
  32. AU="Marianna Milano"
  33. AU="London, Kevin"
  34. AU=Pain Debkumar
  35. AU="Snider, Elizabeth"
  36. AU="Klein, J R"
  37. AU="Deslandes, K."
  38. AU="Xie, Dandan"
  39. AU=Ward Helen
  40. AU="Grace Deukmedjian"
  41. AU="Lindeman, Neal"
  42. AU="Okoli, Mary"
  43. AU="Mathew, Philip"
  44. AU=Staros Eric B

Suchergebnis

Treffer 1 - 8 von insgesamt 8

Suchoptionen

  1. Artikel ; Online: Bis-arylidene oxindoles for colorectal cancer nanotherapy.

    Bhattacharyya, Tithi / Mishra, Tanushree / Das, Debojyoti / Adhikari, Susanta S / Banerjee, Rajkumar

    Bioorganic chemistry

    2024  Band 146, Seite(n) 107294

    Abstract: Oxindoles are potent anti-cancer agents and are also used against microbial and fungal infections and for treating neurodegenerative diseases. These oxindoles are earlier established as estrogen receptor (ER)-targeted agents for killing ER (+) cancer ... ...

    Abstract Oxindoles are potent anti-cancer agents and are also used against microbial and fungal infections and for treating neurodegenerative diseases. These oxindoles are earlier established as estrogen receptor (ER)-targeted agents for killing ER (+) cancer cells. Our previously developed bis-arylidene oxindole, Oxifen (OXF) exhibits effective targeting towards ER (+) cancer cells which has a structural resemblance with tamoxifen. Herein, we have designed and synthesized few structural analogues of OXF such as BPYOX, ACPOX and ACPOXF to examine its cytotoxicity in different cancer as well as non-cancer cell lines and its potential to form self- aggregates in aqueous solution. Among these series of molecules, ACPOXF showed maximum toxicity in colorectal cancer cell line which are ER (-) but it also kills non-cancer cell line HEK-293, thereby reducing its cancer cell selectivity. Incidentally, ACPOXF exhibits self-aggregation, without the help of a co-lipid with nanometric size in aqueous solution. ACPOXF self-aggregate was co-formulated with glucocorticoid receptor (GR) synthetic ligand, dexamethasone (Dex) (called, ACPOXF-Dex aggregate) which could selectively kill ER (-) colorectal cancer cells and also could increase survivability of colon-tumour bearing mice. ACPOXF-Dex induced ROS up-regulation followed by apoptosis through expression of caspase-3. Further, we observed upregulation of antiproliferative factor, p53 and epithelial-to-mesenchymal (EMT) reversal marker E-cadherin in tumour mass. In conclusion, a typical structural modification in ER-targeting Oxifen moiety resulted in its self-aggregation that enabled it to carry a GR-ligand, thus broadening its selective antitumor property especially as colon cancer therapeutics.
    Mesh-Begriff(e) Mice ; Humans ; Animals ; Ligands ; HEK293 Cells ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Apoptosis ; Receptors, Estrogen/metabolism ; Oxindoles/chemistry ; Colorectal Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Proliferation
    Chemische Substanzen Ligands ; Antineoplastic Agents ; Receptors, Estrogen ; Oxindoles
    Sprache Englisch
    Erscheinungsdatum 2024-03-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2024.107294
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4207: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Cationic lipid-conjugated bis-arylidene oxindole derivatives as broad-spectrum breast cancer-selective therapeutics.

    Yousuf, Md / Sridharan, Kathyayani / Mishra, Tanushree / Mahadik, Namita S / Banerjee, Rajkumar / Adhikari, Susanta S

    Bioorganic chemistry

    2023  Band 133, Seite(n) 106395

    Abstract: Breast cancer is a heterogeneous malignancy with wide-ranging variations in therapeutic responses, overall survival etc. Major challenges for available chemotherapeutic agents in achieving clinical success are in maintaining systemic bio-distribution and ...

    Abstract Breast cancer is a heterogeneous malignancy with wide-ranging variations in therapeutic responses, overall survival etc. Major challenges for available chemotherapeutic agents in achieving clinical success are in maintaining systemic bio-distribution and avoiding non-specific adverse effects. Bis-arylidene oxindoles are estrogen receptor (ER)-selective bioactive molecules with moderate potency. In here, we have designed, synthesized and evaluated a series of twin aliphatic chain cationic lipid-conjugated bis-arylidene oxindole molecules with variations in nature of linker, lengths of carbon spacer and hydrophobic twin chains. We observed that among the various structural analogues, C8 twin-chain containing molecules, PGC8, S2C8 and S3C8 showed effective cancer cell-selective cytotoxicity in different cancer cell lines with an IC
    Mesh-Begriff(e) Humans ; Female ; Oxindoles/pharmacology ; Oxindoles/chemistry ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Cell Line ; Cell Cycle Checkpoints ; Lipids/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Apoptosis ; Cell Line, Tumor
    Chemische Substanzen Oxindoles ; Lipids ; Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2023-01-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106395
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4207: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel: A Prospective Cohort Study Analyzing Radiation-Induced Xerostomia and Quality of Life of Head and Neck Cancer Patients Treated With Intensity-Modulated Radiotherapy and 3D Conformal Radiotherapy Techniques at a Tertiary Cancer Center in Eastern India.

    Sahoo, Bijayalaxmi / Padhi, Sanjukta / Patra, Abinash C / Mahapatra, Bikash R / Mishra, Tanushree / Mishra, Saumya Ranjan / Patro, Kanhu Charan

    Cureus

    2023  Band 15, Heft 3, Seite(n) e36442

    Abstract: Introduction Cancer of the head and neck is one of the most common cancers in India. Radiotherapy (RT) plays a vital role in the management of head and neck cancer both as a curative and adjuvant modality. Xerostomia is the most common acute and late ... ...

    Abstract Introduction Cancer of the head and neck is one of the most common cancers in India. Radiotherapy (RT) plays a vital role in the management of head and neck cancer both as a curative and adjuvant modality. Xerostomia is the most common acute and late toxicity. Therefore, this study aimed to analyze radiation-induced xerostomia and the quality of life of patients treated with intensity-modulated radiotherapy (IMRT) and three-dimensional (3D) conformal radiotherapy (3DCRT). Objectives We aim to evaluate radiation-induced acute xerostomia both subjectively and objectively at three-month and one-year post-radiotherapy follow-up period in patients who received radiotherapy in conformal technique (IMRT) to the head and neck region and compare it with those who received the 3DCRT technique. We also aim to assess the recovery of salivary flow in the third month post-radiotherapy by measuring the parotid scintigraphy excretion fraction. Materials and methods Forty patients with head and neck squamous cell carcinoma (SCC) were randomly assigned to the IMRT and 3DCRT arms. Xerostomia during radiation and at three-month and one-year post-radiotherapy follow-up was assessed subjectively using the xerostomia-related quality of life (XeQOL) questionnaire and objectively by measuring the salivary flow rate and parotid scintigraphy. Results The result is analyzed using an independent t-test, Mann-Whitney U test, and Fisher's exact test. The analysis showed that patients treated with radiation by IMRT showed better XeQOL scores (43.40±2.326 in IMRT and 52.10±2.573 in 3DCRT, p<0.001) and Eating Assessment Tool-10 (EAT-10) score (27.65±2.796 in IMRT and 33.80±1.936 in 3DCRT, p<0.001) compared to those treated with 3DCRT. Analysis of the excretion fraction (EF%) of parotid scintigraphy depicted improvement in EF% for both right and left parotids in the IMRT arm with statistical significance (for right parotid, 25.22±12.98 in IMRT and 19.60±10.17 in 3DCRT, p=0.136, and for left parotid, 28.03±12.51 in IMRT and 15.35±11.49 in 3DCRT, p=0.0019). The mean rate of flow (ROF) of saliva showed a declining trend during the end of radiotherapy treatment compared to baseline, but the mean ROF of saliva was better in IMRT compared to 3DCRT, and the difference was statistically significant. The ROF of saliva starts improving during the one-year post-radiotherapy follow-up period. Pearson's chi-square test was used to analyze the correlation between mean parotid dose with EF% of parotid scintigraphy, and it showed a negative correlation, which is statistically significant for both 3DCRT and IMRT arms. Conclusion Xerostomia can be reduced by precision radiotherapies such as the parotid-sparing IMRT technique in head and neck cancer patients, hence improving the quality of life.
    Sprache Englisch
    Erscheinungsdatum 2023-03-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36442
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel: Comparison of Acute Gastrointestinal Toxicity of Intensity-Modulated Radiotherapy Versus Three-Dimensional Conformal Radiotherapy in Patients of Carcinoma Cervix.

    Padhi, Sanjukta / Mahapatra, Bikash Ranjan / Pati, Kartik Chandra / Sahoo, Bijayalaxmi / Kanungo, Satyabrata / Mishra, Tanushree / Muraleedharan, Anupam

    Cureus

    2023  Band 15, Heft 11, Seite(n) e48876

    Abstract: Introduction Cervical cancer is the most common gynaecological malignancy worldwide, with a higher prevalence in middle- and low-income countries. Chemoradiotherapy, followed by intracavitary brachytherapy, is the treatment of choice in locally advanced ... ...

    Abstract Introduction Cervical cancer is the most common gynaecological malignancy worldwide, with a higher prevalence in middle- and low-income countries. Chemoradiotherapy, followed by intracavitary brachytherapy, is the treatment of choice in locally advanced cervical cancer. The most common acute side effect of external beam radiotherapy (EBRT) is bowel toxicity in the form of diarrhoea and abdominal cramps. The treatment techniques of EBRT were revolutionised with the advent of intensity modulation. This study aims to prospectively analyse whether the dosimetric advantage of intensity-modulated radiotherapy (IMRT) over three-dimensional conformal radiotherapy (3DCRT) is translated clinically into a decrease in acute toxicity. Method Twenty-four patients were randomised into two groups: the 3DCRT and the IMRT. Acute gastrointestinal (GI) toxicity was assessed during treatment using radiation therapy oncology group grading. The factors under consideration were age, stage of the disease, treatment technique, chemotherapy, and the intention of therapy (radical or adjuvant). The mean bowel bag dose of the two techniques was analysed. Result Among the factors under consideration, it was found that the treatment technique was the only factor that had a significant association with acute bowel toxicity in both univariate (p = 0.036) and multivariate analyses (p = 0.028). The mean V25 (the volume receiving 25 Gy), V45, and V50 of the bowel bag in the IMRT arm were significantly less than the 3DCRT arm. Grades 2 and 3 acute bowel toxicities were also higher in the 3DCRT arm. Conclusion The treatment technique is essential to determining acute GI toxicity during pelvic radiotherapy. With IMRT, the dose to the bowel bag and, in turn, the acute bowel toxicity can be reduced.
    Sprache Englisch
    Erscheinungsdatum 2023-11-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48876
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: Small-Molecule Probe for Sensing Serum Albumin with Consequential Self-Assembly as a Fluorescent Organic Nanoparticle for Bioimaging and Drug-Delivery Applications.

    Guria, Subhajit / Ghosh, Avijit / Upadhyay, Priyanka / Das, Manas Kumar / Mishra, Tanushree / Adhikary, Arghya / Adhikari, Susanta

    ACS applied bio materials

    2020  Band 3, Heft 5, Seite(n) 3099–3113

    Abstract: The recognition of a specific protein in blood serum amidst similar proteins is a challenging and vital endeavor in clinical diagnostics. Herein, we have described a small-molecule probe (DFPAC-OH) that can induce self-assembly of human serum albumin ( ... ...

    Abstract The recognition of a specific protein in blood serum amidst similar proteins is a challenging and vital endeavor in clinical diagnostics. Herein, we have described a small-molecule probe (DFPAC-OH) that can induce self-assembly of human serum albumin (HSA) and bovine serum albumin (BSA) to generate a highly sustainable fluorescent organic nanoparticle (NP), useful for imaging and in vitro drug-delivery applications. In the midst of similar proteins, DFPAC-OH selectively binds in a noncovalent manner to serum albumin. The specific binding tailors the fluorescence properties of DFPAC-OH. The lowest detection limit for BSA is 47 nM with a binding constant of 1.03 × 10
    Sprache Englisch
    Erscheinungsdatum 2020-04-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.0c00146
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Artikel: Deciphering the associated risk on soil microbes upon use of biopesticides in rice ecosystem

    Mishra, Tanushree / Adak, Totan / Gadratagi, Basana Gowda / Govindharaj, Guru-Pirasanna-Pandi / Jena, Mayabini / Mukherjee, Arup Kumar / Munda, Sushmita / Patil, Naveenkumar B / Yadav, Manoj Kumar

    Environmental monitoring and assessment. 2019 Nov., v. 191, no. 11

    2019  

    Abstract: Plant species, viz Cleistanthus collinus, Lantana camara, and Strychnos nux-vomica are being traditionally used for pest management in rice. However, limited investigation has been carried out to understand the toxic effect of these materials on soil ... ...

    Abstract Plant species, viz Cleistanthus collinus, Lantana camara, and Strychnos nux-vomica are being traditionally used for pest management in rice. However, limited investigation has been carried out to understand the toxic effect of these materials on soil microbes. Hot water extracts of these plants were evaluated for their effects on soil microbial population and enzyme activities along with neem oil and chlorpyrifos as check. Soil microbial population, viz bacteria, fungi, phosphate-solubilizing bacteria (PSB), and asymbiotic nitrogen fixers were unchanged after application of plant extracts. Maximum population of bacteria including PSB and asymbiotic nitrogen fixers were observed in control, whereas, S. nux-vomica, and C. collinus–treated soil had higher number of actinomycetes and fungal population, respectively. Soil microbial biomass did not vary differently among the plant extracts. Application of plant extracts did not alter dehydrogenase, β-glycosidase, acid phosphatase, alkaline phosphatase, and urease content in soil. Secondary metabolites present in these plant extracts may be responsible for variable effects on soil microbes. Chlorpyrifos had a fleeting negative effect on soil microbes and enzymes in comparison to plant extracts. All the three plants did not have any negative effect on soil microbes and enzymes and can be safely recommended in rice pest management.
    Schlagwörter acid phosphatase ; Actinobacteria ; alkaline phosphatase ; bacteria ; biopesticides ; chlorpyrifos ; Cleistanthus collinus ; ecosystems ; enzyme activity ; fungi ; glycosidases ; Lantana camara ; microbial biomass ; neem oil ; nitrogen ; plant extracts ; rice ; risk ; secondary metabolites ; soil ; soil microorganisms ; Strychnos nux-vomica ; toxicity ; urease
    Sprache Englisch
    Erscheinungsverlauf 2019-11
    Umfang p. 654.
    Erscheinungsort Springer International Publishing
    Dokumenttyp Artikel
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-019-7823-3
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 5186: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  7. Artikel ; Online: Deciphering the associated risk on soil microbes upon use of biopesticides in rice ecosystem.

    Mishra, Tanushree / Govindharaj, Guru-Pirasanna-Pandi / Gadratagi, Basana Gowda / Patil, Naveenkumar B / Yadav, Manoj Kumar / Munda, Sushmita / Mukherjee, Arup Kumar / Jena, Mayabini / Adak, Totan

    Environmental monitoring and assessment

    2019  Band 191, Heft 11, Seite(n) 654

    Abstract: Plant species, viz Cleistanthus collinus, Lantana camara, and Strychnos nux-vomica are being traditionally used for pest management in rice. However, limited investigation has been carried out to understand the toxic effect of these materials on soil ... ...

    Abstract Plant species, viz Cleistanthus collinus, Lantana camara, and Strychnos nux-vomica are being traditionally used for pest management in rice. However, limited investigation has been carried out to understand the toxic effect of these materials on soil microbes. Hot water extracts of these plants were evaluated for their effects on soil microbial population and enzyme activities along with neem oil and chlorpyrifos as check. Soil microbial population, viz bacteria, fungi, phosphate-solubilizing bacteria (PSB), and asymbiotic nitrogen fixers were unchanged after application of plant extracts. Maximum population of bacteria including PSB and asymbiotic nitrogen fixers were observed in control, whereas, S. nux-vomica, and C. collinus-treated soil had higher number of actinomycetes and fungal population, respectively. Soil microbial biomass did not vary differently among the plant extracts. Application of plant extracts did not alter dehydrogenase, β-glycosidase, acid phosphatase, alkaline phosphatase, and urease content in soil. Secondary metabolites present in these plant extracts may be responsible for variable effects on soil microbes. Chlorpyrifos had a fleeting negative effect on soil microbes and enzymes in comparison to plant extracts. All the three plants did not have any negative effect on soil microbes and enzymes and can be safely recommended in rice pest management.
    Mesh-Begriff(e) Bacteria/drug effects ; Biological Control Agents/analysis ; Biological Control Agents/toxicity ; Biomass ; Ecosystem ; Environmental Monitoring/methods ; Fungi/drug effects ; Oryza/growth & development ; Soil/chemistry ; Soil Microbiology/standards ; Soil Pollutants/analysis ; Soil Pollutants/toxicity
    Chemische Substanzen Biological Control Agents ; Soil ; Soil Pollutants
    Sprache Englisch
    Erscheinungsdatum 2019-10-19
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-019-7823-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 5186: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel ; Online: Targeting the Trypanothione Reductase of Tissue-Residing

    Mukherjee, Debarati / Yousuf, Md / Dey, Somaditya / Chakraborty, Sondipon / Chaudhuri, Ankur / Kumar, Vinay / Sarkar, Biswajyoti / Nath, Supriya / Hussain, Aabid / Dutta, Aritri / Mishra, Tanushree / Roy, Biswajit Gopal / Singh, Sushma / Chakraborty, Sibani / Adhikari, Susanta / Pal, Chiranjib

    Journal of medicinal chemistry

    2020  Band 63, Heft 24, Seite(n) 15621–15638

    Abstract: Since inception, the magic bullets developed against leishmaniasis traveled a certain path and then dropped down due to either toxicity or the emergence of resistance. The route of administration is also an important concern. We developed a series of ... ...

    Abstract Since inception, the magic bullets developed against leishmaniasis traveled a certain path and then dropped down due to either toxicity or the emergence of resistance. The route of administration is also an important concern. We developed a series of water-soluble ferrocenylquinoline derivatives, targeting
    Mesh-Begriff(e) Administration, Oral ; Animals ; Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/metabolism ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/therapeutic use ; Binding Sites ; Disease Models, Animal ; Drug Design ; Drug Resistance/drug effects ; Ferrous Compounds/chemistry ; Half-Life ; Leishmania donovani/drug effects ; Leishmania donovani/enzymology ; Leishmaniasis, Visceral/drug therapy ; Metallocenes/chemistry ; Mice ; Molecular Docking Simulation ; Mononuclear Phagocyte System/metabolism ; Mononuclear Phagocyte System/parasitology ; NADH, NADPH Oxidoreductases/antagonists & inhibitors ; NADH, NADPH Oxidoreductases/metabolism ; Protozoan Proteins/antagonists & inhibitors ; Protozoan Proteins/metabolism ; Quinolines/chemistry ; Quinolines/metabolism ; Quinolines/pharmacology ; Quinolines/therapeutic use ; Reactive Oxygen Species/metabolism ; Solubility ; Structure-Activity Relationship
    Chemische Substanzen Antiprotozoal Agents ; Ferrous Compounds ; Metallocenes ; Protozoan Proteins ; Quinolines ; Reactive Oxygen Species ; NADH, NADPH Oxidoreductases (EC 1.6.-) ; trypanothione reductase (EC 1.8.1.12) ; ferrocene (U96PKG90JQ)
    Sprache Englisch
    Erscheinungsdatum 2020-12-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.0c00690
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 151: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang