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Article ; Online: Association between demographic features and perceived social support in the mental adjustment to breast cancer.

Mishra, Veena Shukla / Saranath, Dhananjaya

2019 Volume 28, Issue 3, Page(s) 629–634

Abstract: Objective: The mental adjustment to a breast cancer diagnosis is traumatic and stressful, with wide-ranging differences in the responses observed in Indian women. We investigated the association between demographic features and perceived social support ... ...

Abstract	Objective: The mental adjustment to a breast cancer diagnosis is traumatic and stressful, with wide-ranging differences in the responses observed in Indian women. We investigated the association between demographic features and perceived social support during the adjustment of patients to breast cancer. Methods: A total of 393 patients with breast cancer were included in the study. The patients were evaluated for mental adjustment to cancer and perceived social support on the Mental Adjustment to Cancer Scale and Multidimensional Scale of perceived social support. Regression analysis and bivariate correlation were performed to discern significant demographic features and social support in association with the adjustment to having breast cancer. Results: Multiple regression analysis revealed that mental adjustment factors accounted for 43% of the variance in fighting spirit and 41% of the variance in helplessness/hopelessness. The results of the multiple regression analysis suggested that age (t = -10.27, P < 0.000) and marital status (t = 3.03, P < 0.000) were predictive of patients' fighting spirit. Age was inversely (t = 9.81, P < 0.01) associated with fighting spirit, whereas family income (t = -3.82, P < 0.000) was inversely predictive of helplessness/hopelessness. Social support from significant others was predictive of a patient's fighting spirit and fatalism mental adjustment, while support from friends was predictive of helplessness/hopelessness. Conclusion: Demographic factors such as young age and high education are associated with good mental adjustment to breast cancer. Perceived support from significant others may fulfill the need for the socioemotional aspects of patient support that lead to the adjustment to a breast cancer diagnosis in patients.
MeSH term(s)	Adaptation, Psychological ; Adult ; Affect ; Aged ; Breast Neoplasms/psychology ; Female ; Friends ; Humans ; India ; Marital Status ; Middle Aged ; Social Perception ; Social Support
Language	English
Publishing date	2019-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1118536-3
ISSN	1099-1611 ; 1057-9249
ISSN (online)	1099-1611
ISSN	1057-9249
DOI	10.1002/pon.5001
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Article ; Online: Serological and molecular detection of Toxoplasma gondii and Neospora caninum in free-ranging rats from Nagpur, India.

Mishra, Veena / Mitra, Pallabi / Barbuddhe, Shruti / Thorat, Yogesh / Chavan, Kailas / Shinde, Shilpshri / Chaudhari, Sandeep / Khan, Waqar / Deshmukh, Abhijit S

Parasitology research

2023 Volume 123, Issue 1, Page(s) 63

Abstract: Toxoplasma gondii and Neospora caninum are cyst-forming coccidian parasites that infect both wild and domestic non-felids as intermediate hosts, with rodents serving as important reservoir hosts during their life cycles. This study was aimed at ... ...

Abstract	Toxoplasma gondii and Neospora caninum are cyst-forming coccidian parasites that infect both wild and domestic non-felids as intermediate hosts, with rodents serving as important reservoir hosts during their life cycles. This study was aimed at investigating T. gondii and N. caninum infections and identifying factors favouring T. gondii infection in free-ranging rats from India. A total of 181 rodents were trap-captured, and blood and brain samples were subsequently collected for serological and molecular examination of T. gondii and N. caninum. Antibodies against T. gondii and N. caninum were detected by MAT/NAT and IFAT in 13.8% (25/181) and 1.65% (3/181) of rodents, respectively. All three N. caninum samples positive by NAT/IFAT were also positive for ELISA, while for T. gondii, 19 of 25 MAT/IFAT positive samples were also positive for ELISA. The antibody titers (MAT/NAT/IFAT) of rodents seropositive for T. gondii ranged from 25 to 400, while those of rats seropositive for N. caninum ranged from 25 to 100. Also, using PCR, DNA from T. gondii (B1 gene) and N. caninum (NC5 gene) was found in 2.76% (5/181) of brain samples and 0.55% (1/181) of brain samples. All PCR positive samples were also seropositive. No mixed infections were observed in the serological and molecular detections. A Chi-square analysis revealed that older rats and rats living in urban areas are significantly associated with T. gondii infection; however, rodent species, gender, location, habitat types, and seasonality were statistically nonsignificant. Overall, this study demonstrated that T. gondii was widely distributed while N. caninum was less prevalent among free-ranging rats in the studied area.
MeSH term(s)	Animals ; Rats ; Neospora ; Toxoplasma/genetics ; Antibodies, Protozoan ; Coccidiosis/epidemiology ; Coccidiosis/veterinary ; Toxoplasmosis, Animal/diagnosis ; Toxoplasmosis, Animal/epidemiology ; Seroepidemiologic Studies ; Rodentia ; India/epidemiology
Chemical Substances	Antibodies, Protozoan
Language	English
Publishing date	2023-12-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-023-08095-9
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Article ; Online: Serological and Molecular Detection of

Roy, Megha / Mishra, Veena / Mitra, Pallabi / Umbardand, Yeshwant / Sapate, Vaishnavi / Khan, Waqar / Deshmukh, Abhijit S

Foodborne pathogens and disease

2023 Volume 21, Issue 2, Page(s) 99–108

Abstract: Toxoplasma ... ...

Abstract	Toxoplasma gondii
MeSH term(s)	Animals ; Swine ; Humans ; Sus scrofa ; Toxoplasma/genetics ; Seroepidemiologic Studies ; Farmers ; Antibodies, Protozoan ; Toxoplasmosis, Animal/epidemiology ; Swine Diseases/epidemiology ; India/epidemiology ; Immunoglobulin G ; DNA
Chemical Substances	Antibodies, Protozoan ; Immunoglobulin G ; DNA (9007-49-2)
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2148479-X
ISSN	1556-7125 ; 1535-3141
ISSN (online)	1556-7125
ISSN	1535-3141
DOI	10.1089/fpd.2023.0073
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Article ; Online: Desulfovibrio DA2_CueO is a novel multicopper oxidase with cuprous, ferrous and phenol oxidase activity.

Mancini, Stefano / Kumar, Ranjeet / Mishra, Veena / Solioz, Marc

Microbiology (Reading, England)

2017 Volume 163, Issue 8, Page(s) 1229–1236

Abstract: Desulfovibrio sp. A2 is a novel Gram-negative sulfate-reducing bacterium that was isolated from sediments of the Norilsk mining/smelting area in Russia. The organism possesses a monocistronic operon encoding a 71 kDa periplasmic multicopperoxidase, which ...

Abstract	Desulfovibrio sp. A2 is a novel Gram-negative sulfate-reducing bacterium that was isolated from sediments of the Norilsk mining/smelting area in Russia. The organism possesses a monocistronic operon encoding a 71 kDa periplasmic multicopperoxidase, which we call DA2_CueO. Histidine-tagged DA2_CueO expressed from a plasmid in Escherichia coli and purified by Ni-NTA affinity chromatography oxidizes Cu+ and Fe2+, and exhibits phenol oxidase activity with 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid), 2,3-dihydroxybenzoic acid and 2,6-dimethoxyphenol as substrates, using O2 as the oxidant. When expressed in an E. coli cueO knock-out strain, DA2_CueO exhibits phenol oxidase activity in vivo and enhances the copper tolerance of the strain. These findings indicate that the DA2_CueO gene of Desulfovibrio sp. A2 encodes a multicopperoxidase with a role in metal ion resistance. The enzyme displays some novel structural features, which are discussed.
MeSH term(s)	Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; Bacterial Proteins/metabolism ; Copper/metabolism ; Desulfovibrio/chemistry ; Desulfovibrio/enzymology ; Desulfovibrio/genetics ; Desulfovibrio/isolation & purification ; Ferrous Compounds/metabolism ; Geologic Sediments/microbiology ; Oxidoreductases/chemistry ; Oxidoreductases/genetics ; Oxidoreductases/isolation & purification ; Oxidoreductases/metabolism ; Phenol/metabolism
Chemical Substances	Bacterial Proteins ; Ferrous Compounds ; Phenol (339NCG44TV) ; Copper (789U1901C5) ; Oxidoreductases (EC 1.-)
Language	English
Publishing date	2017-07-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180712-x
ISSN	1465-2080 ; 1350-0872
ISSN (online)	1465-2080
ISSN	1350-0872
DOI	10.1099/mic.0.000509
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Article ; Online: Alexithymia in children with cancer and their siblings.

Mishra, Veena Shukla / Maudgal, Shubha / Theunissen, Stephanie C P M / Rieffe, Carolien

Journal of psychosomatic research

2012 Volume 72, Issue 4, Page(s) 266–268

Abstract: Objective: The purpose of this study was to examine the levels of alexithymia in children with cancer, in siblings of children with cancer, and in healthy controls.: Method: In order to compare the groups the Alexithymia Questionnaire for Children ... ...

Abstract	Objective: The purpose of this study was to examine the levels of alexithymia in children with cancer, in siblings of children with cancer, and in healthy controls. Method: In order to compare the groups the Alexithymia Questionnaire for Children was used. The study group consisted of 97 children with cancer, 95 siblings, and 151 healthy controls. Results: The highest level of alexithymia was reported by children diagnosed with cancer, followed by their siblings. Healthy controls reported the lowest level of alexithymia. No gender differences were observed. The intensity of cancer was a significant predictor of the alexithymia score, with patients with the most severe cancers reporting the highest levels of alexithymia. No differences were found between the patients with moderately severe and least severe cancers. Conclusions: Not only children with cancer, but also their siblings show significantly more alexithymia than their healthy counterparts. Professionals should aim at preventing or reducing the psychological problems in both patients and their siblings.
MeSH term(s)	Adolescent ; Affective Symptoms/diagnosis ; Affective Symptoms/psychology ; Child ; Cross-Cultural Comparison ; Emotions ; Female ; Humans ; India ; Internal-External Control ; Male ; Neoplasms/psychology ; Personality Inventory/statistics & numerical data ; Psychometrics/statistics & numerical data ; Reference Values ; Reproducibility of Results ; Sex Factors ; Siblings/psychology
Language	English
Publishing date	2012-04
Publishing country	England
Document type	Journal Article ; Validation Studies
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2011.12.007
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Article: Genome-wide gene expression analysis for target genes to differentiate patients with intestinal tuberculosis and Crohn's disease and discriminative value of FOXP3 mRNA expression.

Ahuja, Vineet / Subodh, Swati / Tuteja, Amit / Mishra, Veena / Garg, Sushil Kumar / Gupta, Neha / Makharia, Govind / Acharya, S K

Gastroenterology report

2015 Volume 4, Issue 1, Page(s) 59–67

Abstract: Background and aims: Crohn's disease (CD) and intestinal tuberculosis (ITB) are both chronic granulomatous conditions with similar phenotypic presentations. Hence, there is need for a biomarker to differentiate between both these two diseases. This ... ...

Abstract	Background and aims: Crohn's disease (CD) and intestinal tuberculosis (ITB) are both chronic granulomatous conditions with similar phenotypic presentations. Hence, there is need for a biomarker to differentiate between both these two diseases. This study aimed at genome-wide gene expression analysis of colonic biopsies from confirmed cases of ITB and CD in comparison with controls. To evaluate the role of T regulatory cells, forkhead box P3 (FOXP3) mRNA expression was quantified in serum as well as in colonic biopsies from patients with ITB and with the controls. Methods: Paired samples, including serum and colonic biopsies, were taken from 33 study subjects (CD, ITB and controls), and total RNA was extracted. Human whole genome gene expression microarray analysis was performed using the Illumina HumanWG-6 BeadChip Kit with six total RNA samples of the three groups in duplicates. Real-time PCR for FOXP3 mRNA expression was analyzed in serum samples and colonic biopsy samples (4-CD, 5-ITB, 4-controls). Results: In CD and ITB there was 1.5-fold upregulation of 92 and 382 genes and 1.5-fold downregulation of 91 and 256 genes, respectively. Peroxisome proliferators via the PPARγ pathway were most significantly downregulated (P < 0.005) in CD. Additionally, the IL4/5/6 signaling pathways and Toll-like receptor signaling pathway were identified as significantly differentially regulated (P < 0.005) at > 2-fold change. In ITB, the complement activation pathway, specifically the classical pathway, was the most significantly upregulated. FOXP3 mRNA expression was significantly elevated in colonic biopsies obtained from ITB patients as compared with CD cases (4.70 ± 2.21 vs 1.48 ± 0.31, P = 0.016). Conclusions: FOXP3 mRNA expression in colonic mucosa could be a discriminatory marker between ITB and CD. Upregulation of the complement activation pathway in ITB suggests that pathogenetic mechanisms for ITB are similar to those of pulmonary tuberculosis. In CD, downregulation of PPARγ was seen in colonic tissue, suggesting that restoration of PPARγ-dependent anti-microbial barrier function may be a therapeutic target.
Language	English
Publishing date	2015-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2710871-5
ISSN	2052-0034
ISSN	2052-0034
DOI	10.1093/gastro/gov015
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Article: VSL#3 induces and maintains short-term clinical response in patients with active microscopic colitis: a two-phase randomised clinical trial.

Rohatgi, Sarika / Ahuja, Vineet / Makharia, Govind K / Rai, Tarun / Das, Prasenjit / Dattagupta, Siddharth / Mishra, Veena / Garg, Sushil Kumar

BMJ open gastroenterology

2015 Volume 2, Issue 1, Page(s) e000018

Abstract: Background: The probiotic mixture VSL#3 has proven efficacious in inflammatory bowel diseases and irritable bowel syndrome; however, its efficacy in microscopic colitis (MC) is being investigated.: Objective: To evaluate the safety and efficacy of a ... ...

Abstract	Background: The probiotic mixture VSL#3 has proven efficacious in inflammatory bowel diseases and irritable bowel syndrome; however, its efficacy in microscopic colitis (MC) is being investigated. Objective: To evaluate the safety and efficacy of a multistrain probiotic, VSL#3, in inducing clinical remission and achieving clinical response, as compared with mesalamine, in patients with active MC. Methods: A randomised, open labelled study comparing the efficacy of 900 billion colony-forming units/day of VSL#3 (group (Gp) A) or 1.6 g of mesalamine/day (Gp B) for 8 weeks in 30 patients with MC was conducted. After a washout period of 2 weeks, Gp B received 8 weeks of VSL#3 and Gp A was off medication for the next 8 weeks. The primary end points were clinical remission and clinical response at 8 weeks. Results: Of 30 patients, 15 were randomised in each arm. 11 patients in Gp A and 13 patients in Gp B completed 8 weeks of treatment. 5 (46%) of 11 patients in Gp A and 1 (8%) of 13 patients in Gp B attained clinical remission (p=0.022). Clinical response was seen in Gp A, as evidenced by a lower stool weight (377.6±104.5 g) as compared with Gp B (507±168.2 g; p=0.03). VSL#3 was effective in maintaining clinical response up to 10 weeks, even after discontinuation of therapy. Secondary end points like stool parameters, histology and well-being improved in both treatment groups. Conclusions: The probiotic VSL#3 was found to offer the benefit of inducing as well as maintaining short-term clinical response in patients with active MC. Trial registration number: The clinical trial is registered with CLINICAL TRIAL REGISTRY INDIA; http://ctri.nic.in, CTRI No. "CTRI/2008/091/000086" (registered on: 23/06/2008).
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article
ISSN	2054-4774
ISSN	2054-4774
DOI	10.1136/bmjgast-2014-000018
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Book: Transactions costs and the effects of inflation on the relative price of durable goods

Mishra, Veena

(Discussion paper : Indira Gandhi Institute of Development Research ; 82)

1992

Author's details	Veena Mishra
Series title	Discussion paper : Indira Gandhi Institute of Development Research ; 82
Keywords	Transaktionskosten ; Konsumgüter ; Preis ; Inflation ; Theorie ; 152535*45
Language	English
Size	36 S
Document type	Book
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Article: Exchange rates, pass through and economic exposure

Sundaram, Anant K / Mishra, Veena

Journal of foreign exchange and international finance : JFEIF 6 ,1, S. 38-52

a review

1992

Author's details	Anant K. Sundaram and Veena Mishra
Keywords	Wechselkurs ; Hysterese ; Preiskonvergenz ; Theorie
Language	English
Publishing place	Pune
Document type	Article
ZDB-ID	1131146-0
ISSN	0970-3632
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Book: Exchange rates, pass through and economic exposure

Sundaram, Anant K / Mishra, Veena

a review

(Discussion paper : Indira Gandhi Institute of Development Research ; 30)

1990

Author's details	Anant K. Sundaram ; Veena Mishra
Series title	Discussion paper : Indira Gandhi Institute of Development Research ; 30
Keywords	24;34;60;59
Language	English
Size	31 S
Document type	Book
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