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Article ; Online: Prescription patterns of analgesics for oral conditions in india - Analysis of large medical audit data of outpatients in India's private healthcare sector.

Sayeed, Saif / Mathur, Manu Raj / Mishra, Vijay Kumar / Nagrath, Deepti / Watt, Richard G

Indian journal of dental research : official publication of Indian Society for Dental Research

2024 Volume 34, Issue 3, Page(s) 278–283

Abstract: Background: Analgesic use needs to be regulated due to its adverse effects. This study aimed to analyse the change in prescription rates and patterns of the analgesics prescribed for various oral conditions and to analyse their trends across different ... ...

Abstract	Background: Analgesic use needs to be regulated due to its adverse effects. This study aimed to analyse the change in prescription rates and patterns of the analgesics prescribed for various oral conditions and to analyse their trends across different age groups and gender to promote rational prescription of drugs and eventually influence regulatory policies. Methods: Secondary analysis was conducted on medical audit data collected from the private health sector in India. The prescription rate per 1000 persons per year was calculated from May 2013 to April 2016 using the mean projected population (PP) of India. Cross-tabulations were conducted to analyse the prescription rate and their changes across different age groups, gender and oral conditions. Findings: The mean analgesic prescription rate was highest among the 20-40 age group, and the highest increase was noted in 'non-steroidal anti-inflammatory drug (NSAID) combinations' (3.56 per 1000 persons per year) from May 2013 to April 2016. The 'NSAID combinations' group was also the most prescribed medication across all the oral conditions, with 'diseases of hard tissues' having the highest prescription rate (41.4 and 45.6 per 1000 persons per year, respectively, for 2013-14 and 2015-16). Interpretation: The results indicate an overall increase in the analgesic prescription rate, especially 'NSAID combinations' for each dental disease and age group, a finding that is hard to explain. Due to the lack of prescription guidelines in India, it is difficult to assess whether these analgesics were prescribed rationally or not.
MeSH term(s)	Humans ; Outpatients ; Health Care Sector ; Analgesics/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; India ; Medical Audit ; Prescriptions
Chemical Substances	Analgesics ; Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2024-01-10
Publishing country	India
Document type	Journal Article
ZDB-ID	1354886-4
ISSN	1998-3603 ; 0970-9290
ISSN (online)	1998-3603
ISSN	0970-9290
DOI	10.4103/ijdr.ijdr_104_23
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Article: Androgenic haploid plant development via embryogenesis with simultaneous determination of bioactive metabolites in Cambod tea (Camellia assamica ssp. lasiocalyx)

Mishra, Vijay Kumar / Bajpai, Ruchira / Chaturvedi, Rakhi

Plant cell, tissue, and organ culture. 2022 Mar., v. 148, no. 3

2022

Abstract: This pioneering work reports successful androgenic plant development via embryogenesis from microspore calluses in anther cultures and estimation of bioactive metabolites in in vitro regenerants and parent plant (control) of Cambod tea, Camellia assamica ...

Abstract	This pioneering work reports successful androgenic plant development via embryogenesis from microspore calluses in anther cultures and estimation of bioactive metabolites in in vitro regenerants and parent plant (control) of Cambod tea, Camellia assamica ssp. lasiocalyx (Planch MS) cultivar TV19. Anthers bearing microspores at early-to-late uni-nucleate stage were selected to initiate androgenesis. A pre-treatment of 5 °C for 5 days in the dark was most effective to initiate profusely growing white callusing from microspores within 10 weeks of culture on MS medium (6% sucrose) supplemented with high cytokinin/auxin ratio maintained by 6-benzylaminopurine (BAP) and 2,4-dichlorophenxoyacetic acid. Nodular structures on the callus surface differentiated into embryos. Further developement of the embryos occurred on embryogenesis medium but, with ten times reduced concentration of growth regulators and additives. Germination of embryos into complete plantlets was achieved when major salts in medium were reduced to half MS (½ MS) and augmented with BAP, GA₃ and IBA along with glutamine and serine. Cytological examination of the root-tip cells revealed that regenerated plantlets were haploids (2n = x = 15), which was further confirmed through flow cytometry. The hot-water extracts from in vitro haploid calluses, embryos and field-grown donor plant were utilized for quantification of (+)-catechin, (−)-epicatechin, (−)-epigallocatechin gallate, caffeine and theophylline. Our findings revealed that the metabolite profile of in vitro regenerated haploid cultures is comparable to that of the mother plant, thereby presenting them as potential source for genome duplication and development of genetically stable homozygous pure breeding lines.
Keywords	Camellia sinensis var. assamica ; androgenesis ; benzyladenine ; caffeine ; callus ; cultivars ; cytokinins ; flow cytometry ; genome ; germination ; glutamine ; haploidy ; homozygosity ; metabolites ; organ culture ; plant development ; plantlets ; root tips ; serine ; sucrose ; tea ; theophylline
Language	English
Dates of publication	2022-03
Size	p. 515-531.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	406394-6
ISSN	1573-5044 ; 0167-6857
ISSN (online)	1573-5044
ISSN	0167-6857
DOI	10.1007/s11240-021-02203-2
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Article: Studies on biological attributes and food utilization efficiency measures of Papilio demoleus on different host plants

Chauhan, Deepika / Srivastava, Poonam / Mishra, Vijay Kumar

Journal of entomological research. 2021 Dec., v. 45, no. suppl

2021

Abstract: During the study period, C. limon was the most suitable among the four hosts viz., Lemon, Citrus limon (L.), Bael, Aegle marmelos (L.), Kinnow, Citrus reticulata Blanco and Kari patta, Murraya koenigii (L.) for this butterfly. The shortest larval ... ...

Abstract	During the study period, C. limon was the most suitable among the four hosts viz., Lemon, Citrus limon (L.), Bael, Aegle marmelos (L.), Kinnow, Citrus reticulata Blanco and Kari patta, Murraya koenigii (L.) for this butterfly. The shortest larval development period (13.65 d) was observed on C. limon and significantly, longest period was recorded on M. koenigii (16.62 d) whereas the biggest pupae and adults occurred on C. limon. Murraya koenigii was the least preferred. Rest of the host plants viz., A. marmelos and C. reticulata recorded 15.63 and 14.19 d respectively. During study period approximate digestibility (AD) was higher on C. reticulata (92.08 ± 0.16), (75.0 ± 0.5), (63.38 ± 0.005) during first, third and fourth instar respectively however during second and fifth instar period it was observed higher on C. limon (89.01 ± 0.057) and A. marmelos (66.0 ± 0.5) respectively. Arranged in decreasing order of preference, the four hosts are C. limon, C.reticulata, A. marmelos and M. koenigii. As a general conclusion, both citrus species were suitable hosts for P. demoleus whereby M. koenigii was the least preferred among the four hosts examined.
Keywords	Aegle marmelos ; Bergera koenigii ; Citrus limon ; Citrus reticulata ; Papilio demoleus ; butterflies ; digestibility ; instars ; larval development ; mandarins ; research
Language	English
Dates of publication	2021-12
Size	p. 913-923.
Publishing place	Malhotra Publishing House
Document type	Article
ZDB-ID	446197-6
ISSN	0974-4576 ; 0378-9519
ISSN (online)	0974-4576
ISSN	0378-9519
DOI	10.5958/0974-4576.2021.00142.0
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Article: Field evaluation of different IPM modules against mustard aphid, Lipaphis erysimi (Kalt.) in Bundelkhand region

Mishra, Vijay Kumar / Usha / Devi, M. Soniya / Chaturvedi, S. K.

Journal of entomological research

2023 Volume 47, Issue 1, Page(s) 151

Document type	Article
ZDB-ID	446197-6
ISSN	0378-9519
Database	Current Contents Nutrition, Environment, Agriculture

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Article: Real-time water quality monitoring of River Ganga (India) using internet of things

Singh, Surya / Rai, Sarvesh / Singh, Prashant / Mishra, Vijay Kumar

Ecological informatics. 2022 Nov., v. 71

2022

Abstract: Achieving and maintaining suitable water quality is one of the important parameters to ensure health and well-being of the human as well as ecosystems. Among the various aquatic ecosystems, riverine ecosystems are more prone to pollution and therefore ... ...

Abstract	Achieving and maintaining suitable water quality is one of the important parameters to ensure health and well-being of the human as well as ecosystems. Among the various aquatic ecosystems, riverine ecosystems are more prone to pollution and therefore needs to be monitored frequently and on regular time intervals. In this context, real-time water quality monitoring system offers excellent opportunity to keep track of the water quality on a continuous basis; which not only helps to identify the affected location and pollution source, but also creates alert enabling the authorities to take immediate action. One such real-time water quality monitoring system was installed in the River Ganga (India), considering the fragility and significance of the Gangetic ecosystem. In this paper, we have presented the details of the real-time water quality monitoring system installed in River Ganga and results obtained through it for various parameters. The results have also been compared with the standard values. Additionally, based on this preliminary investigation, limitations and recommendations have also been presented to further enhance the utility of the system.
Keywords	Internet ; humans ; pollution ; riparian areas ; rivers ; water quality ; India
Language	English
Dates of publication	2022-11
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2212016-6
ISSN	1878-0512 ; 1574-9541
ISSN (online)	1878-0512
ISSN	1574-9541
DOI	10.1016/j.ecoinf.2022.101770
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Validation and minimally important difference of the Child-OIDP in a socioeconomically diverse sample of Indian adolescents.

Mathur, Manu Raj / Nagrath, Deepti / Yusuf, Huda / Mishra, Vijay Kumar / Tsakos, Georgios

Health and quality of life outcomes

2022 Volume 20, Issue 1, Page(s) 70

Abstract: Introduction: While different measures have been validated and used to assess the oral health related quality of life (OHRQoL) of children and adolescents, no previous study has tested the psychometric performance of OHRQoL amongst the most marginalized ...

Abstract	Introduction: While different measures have been validated and used to assess the oral health related quality of life (OHRQoL) of children and adolescents, no previous study has tested the psychometric performance of OHRQoL amongst the most marginalized adolescents, living in extremely deprived neighbourhoods like urban slums and resettlement areas in modern cities. Our study assessed the internal consistency reliability, construct validity and Minimally Important Difference (MID) of the Child-OIDP in a sample of adolescents aged 12-15 years reporting oral health problems that lived in three different types (including two extremely vulnerable) of neighbourhoods (urban slums, resettlement colonies, and middle and upper middle-class neighbourhoods) in the National Capital Territory of Delhi. Methods: We conducted data analysis on a cross-sectional study, comprising of 840 adolescents. The Child-OIDP was used as a measure of OHRQoL. Internal consistency reliability was tested using the standardized Cronbach's Alpha Coefficient. The Child-OIDP was also tested for content and construct validity (the latter through the median test), while a distribution-based approach was used to identify the MID. Results: The Indian Child-OIDP showed good internal consistency, as the Cronbach's alpha coefficient was 0.77. Inter-item correlation coefficients among the items ranged from 0.13 to 0.50, with the mean inter-item correlation being 0.30. The corrected item-total correlations ranged from 0.30 (social contact) to 0.54 (speaking). For construct validity, the Child-OIDP extent was significantly associated with three subjective oral and general health variables in the expected direction. The calculated effect sizes for these differences indicated that they were moderate (0.50-0.79). We also calculated the standard error of measurement (SEM) of Child-OIDP extent as 0.75. Conclusion: This study demonstrated that the Indian Child-OIDP is a reliable and valid measure for the assessment of the oral health related quality of life among Indian adolescents especially from marginalised and socioeconomically vulnerable groups. This is an essential step towards assessing oral health and evaluating oral health promotion interventions in those populations and settings.
MeSH term(s)	Adolescent ; Cross-Sectional Studies ; Humans ; Oral Health ; Psychometrics ; Quality of Life ; Reproducibility of Results
Language	English
Publishing date	2022-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2098765-1
ISSN	1477-7525 ; 1477-7525
ISSN (online)	1477-7525
ISSN	1477-7525
DOI	10.1186/s12955-022-01949-3
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Article ; Online: Socio-biomedical predictors of child nutrition in India: an ecological analysis from a nationally representative Demographic and Health Survey, 2015-2016.

Prusty, Ranjan Kumar / Bairwa, Mohan / Anwar, Fahmina / Mishra, Vijay Kumar / Patel, Kamalesh Kumar / Mangal, Daya Krishan

Journal of health, population, and nutrition

2022 Volume 41, Issue 1, Page(s) 1

Abstract: Background: Despite significant economic growth and development, undernutrition among children remains a major public health challenge for low- and middle-income countries in the twenty-first century. In Millennium Development Goals, India committed ... ...

Abstract	Background: Despite significant economic growth and development, undernutrition among children remains a major public health challenge for low- and middle-income countries in the twenty-first century. In Millennium Development Goals, India committed halving the prevalence of underweight children by 2015. This study aimed to explain the geographical variation in child malnutrition level and understand the socio-biomedical predictors of child nutrition in India. Methods: We used the data from India's National Family Health Survey 2015-2016. The survey provided estimates of stunting, wasting, and underweight at the national, state, and district level to measure nutritional status of under-five children. Level of stunting, wasting and underweight at the district level are considered as outcome variables. We have used variance inflation factor to check the multicollinearity between potential predictors of nutrition. In this study, we performed spatial analysis using ArcGIS and multiple linear regression analysis using Stata version 15. Results: Five states (Uttar Pradesh, Bihar, Madhya Pradesh, Jharkhand and Meghalaya) had very high prevalence of stunting (40% and above). High prevalence of wasting was documented in Jharkhand, Madhya Pradesh, Chhattisgarh, and Karnataka (23 to 29%). Jharkhand, Madhya Pradesh, Maharashtra, and Chhattisgarh had the highest proportion of underweight children in the country. We found that electricity and clean fuel use in the household, use of iodized salt, and level of exclusive breastfeeding had significantly negative influence on the stunting level in the districts. The use of iodized salt has similar effect on the wasting status of under-five children in the districts (b: - 0.27, p < 0.10). Further, underweight level had a negative association with clean fuel use for cooking (b: - 0.17, p < 0.01), use of iodized salt (b: - 0.36, p < 0.10), breastfeeding within one hour (b: - 0.18, p < 0.10), semisolid/solid food within 6-8 months (b: - 0.11, p < 0.05) and Gross Domestic Product of the districts (b: - 0.53, p < 0.10). Conclusion: In the study, a variety of factors including electricity and clean fuel use in the household, use of iodized salt, level of exclusive breastfeeding, breastfeeding within one hour, semisolid/solid food within 6-8 months and Gross Domestic Product of the districts have a significant association with nutritional status of children.
MeSH term(s)	Child ; Child Nutrition Disorders/epidemiology ; Child Nutritional Physiological Phenomena ; Female ; Growth Disorders/epidemiology ; Growth Disorders/etiology ; Humans ; India/epidemiology ; Infant ; Malnutrition/epidemiology ; Nutritional Status ; Prevalence ; Thinness/epidemiology
Language	English
Publishing date	2022-01-03
Publishing country	Bangladesh
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2025045-9
ISSN	2072-1315 ; 1606-0997
ISSN (online)	2072-1315
ISSN	1606-0997
DOI	10.1186/s41043-021-00273-8
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Article ; Online: Antibiotic prescriptions for oral diseases in India: evidence from national prescription data.

Mathur, Manu Raj / Nagrath, Deepti / Mishra, Vijay Kumar / Harris, Rebecca / Saeed, Syed Saif / Selvaraj, Sakthivel / Mehta, Aashna / Farooqui, Habib Hasan

BMC oral health

2023 Volume 23, Issue 1, Page(s) 170

Abstract: Introduction: The key objective of this research was to describe the prescription rate of various antibiotics for dental problems in India and to study the relevance of the prescriptions by analysing antibiotic types associated with different dental ... ...

Abstract	Introduction: The key objective of this research was to describe the prescription rate of various antibiotics for dental problems in India and to study the relevance of the prescriptions by analysing antibiotic types associated with different dental diagnoses, using a large-scale nationally representative dataset. Methods: We used a 12-month period (May 2015 to April 2016) medical audit dataset from IQVIA (formerly IMS Health). We coded the dental diagnosis provided in the medical audit data to the International Statistical Classification of Diseases and Related Health Problems (ICD-11) and the prescribed antibiotics for the diagnosis to the Anatomic Therapeutic Chemical (ATC) -2020 classification of the World Health Organization. The primary outcome measure was the medicine prescription rate per 1,000 persons per year (PRPY Results: Our main findings were-403 prescriptions per 1,000 persons per year in the year 2015 -2016 for all dental ailments. Across all ATC level 1 classification, 'Diseases of hard tissues' made up the majority of the prescriptions. 'Beta-lactam', 'Penicillin,' and 'Cephalosporins' were the most commonly prescribed antibiotics for dental diagnoses followed by 'Macrolides' and 'Quinolones'. 'Dental caries', 'Discoloration of tooth', and 'Toothache' were the most common reasons for 'Beta-Lactams' and 'Penicillin' prescriptions. Conclusion: To conclude our study reports first ever country (India) level estimates of antibiotic prescription by antibiotic classes, age groups, and ICD-11 classification for dental ailments.
MeSH term(s)	Humans ; Anti-Bacterial Agents/therapeutic use ; Drug Prescriptions ; Cephalosporins ; Penicillins ; India/epidemiology
Chemical Substances	Anti-Bacterial Agents ; Cephalosporins ; Penicillins
Language	English
Publishing date	2023-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-02889-0
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Article ; Online: Effect of an educational intervention on diet and physical activity among school-aged adolescents in Delhi -The i-PROMISe (PROMoting health literacy in Schools) Plus Study.

Rawal, Tina / Muris, Jean W M / Mishra, Vijay Kumar / Arora, Monika / Tandon, Nikhil / van Schayck, Onno C P

Dialogues in health

2023 Volume 2, Page(s) 100123

Abstract: Purpose: Emerging lifestyle changes due to rapid urbanization have led to an epidemiological transition and the rising prevalence of obesity is responsible for major non-communicable diseases (NCDs) which have further aggravated due to the COVID-19 ... ...

Abstract	Purpose: Emerging lifestyle changes due to rapid urbanization have led to an epidemiological transition and the rising prevalence of obesity is responsible for major non-communicable diseases (NCDs) which have further aggravated due to the COVID-19 pandemic. This study aims to assess the effectiveness of a comprehensive school-based intervention on diet and physical activity-related behavior of adolescents. Methods: In 2019, a cluster-randomized controlled trial was conducted in randomly selected ( Results: The difference in changes in diet and physical-activity-related behaviors of the students between the intervention and control schools were not significant in the intention to treat analysis probably due to the large drop-out due to COVID-19 measures: 304 students were available for follow-up in the intervention group and 122 in the control group (391 cases were excluded to make data comparable with baseline survey). The intake of vegetables (once a day) [β = 0.35, OR = 1.42, 95% CI (1.03, 1.95)] in the per-protocol analysis has increased among adolescents in the intervention group as compared to the control group. Conclusion: The findings of this study indicated a positive effect of the intervention on diet and physical-activity-related changes in the expected direction and highlights the importance of addressing such behavior to prevent obesity among adolescents and thus NCDs in the later stage of life.
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ISSN	2772-6533
ISSN (online)	2772-6533
DOI	10.1016/j.dialog.2023.100123
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Article: Studies on biological attributes and food utilization efficiency measures of Papilio demoleus on different host plants

Chauhan, Deepika / Srivastava, Poonam / Mishra, Vijay Kumar

Journal of entomological research

2021 Volume 45, Issue Suppl., Page(s) 913

Document type	Article
ZDB-ID	446197-6
ISSN	0378-9519
Database	Current Contents Nutrition, Environment, Agriculture

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