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Article ; Online: Menstrual Hygiene Management

Mishra Yachana

BIO Web of Conferences, Vol 86, p

An Overview of Global Awareness

2024 Volume 01022

Abstract: In developing nations, menstrual hygiene management (MHM) is a problem that is frequently disregarded. Women and girls who are menstruating are compelled to live in seclusion, are subject to mobility limitations and dietary restrictions, and may be ... ...

Abstract	In developing nations, menstrual hygiene management (MHM) is a problem that is frequently disregarded. Women and girls who are menstruating are compelled to live in seclusion, are subject to mobility limitations and dietary restrictions, and may be barred from engaging in daily activities. Due to its relationship with social and cultural components of a natural process that is sometimes shrouded in ingrained shame and taboos, menstrual hygiene waste management has not gotten enough attention and, as a result, has not been adequately researched. As a result, information on the amounts and whole lifespan of the created trash is either lacking or fraught with uncertainty. However, this work raises important and pertinent issues that may impact on the environment as well as the health, equality, and dignity of women. The present review also identifies the knowledge gaps that still need to be filled and offers potential solutions for the near future. Menstrual hygiene requires immediate consideration in the context of a pandemic, as does understanding the potential role that waste produced, for instance, in refugee camps, may have in spreading SARS-CoV-2. The current analysis suggests potential intervention tactics intended to remedy this ignorance. In order to achieve Sustainable Development Goals (SDG) 3.7 and 6.2, which address women's healthcare and hygiene requirements, there looked to be room for interventions through a coordinated national effort to promote awareness of MHM among women utilizing a variety of media outlets.
Keywords	Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
Subject code	360
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Current update on anticancer effects of icariin: A journey of the last ten years.

Gupta, Mukta / Mishra, Yachana / Mishra, Vijay / Tambuwala, Murtaza M

EXCLI journal

2022 Volume 21, Page(s) 680–686

Language	English
Publishing date	2022-04-06
Publishing country	Germany
Document type	Journal Article
ISSN	1611-2156
ISSN	1611-2156
DOI	10.17179/excli2022-4848
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Article ; Online: Precision epidemiology at the nexus of mathematics and nanotechnology: Unraveling the dance of viral dynamics.

Aljabali, Alaa A A / Obeid, Mohammad A / El-Tanani, Mohamed / Mishra, Vijay / Mishra, Yachana / Tambuwala, Murtaza M

Gene

2024 Volume 905, Page(s) 148174

Abstract: The intersection of mathematical modeling, nanotechnology, and epidemiology marks a paradigm shift in our battle against infectious diseases, aligning with the focus of the journal on the regulation, expression, function, and evolution of genes in ... ...

Abstract	The intersection of mathematical modeling, nanotechnology, and epidemiology marks a paradigm shift in our battle against infectious diseases, aligning with the focus of the journal on the regulation, expression, function, and evolution of genes in diverse biological contexts. This exploration navigates the intricate dance of viral transmission dynamics, highlighting mathematical models as dual tools of insight and precision instruments, a theme relevant to the diverse sections of Gene. In the context of virology, ethical considerations loom large, necessitating robust frameworks to protect individual rights, an aspect essential in infectious disease research. Global collaboration emerges as a critical pillar in our response to emerging infectious diseases, fortified by the predictive prowess of mathematical models enriched by nanotechnology. The synergy of interdisciplinary collaboration, training the next generation to bridge mathematical rigor, biology, and epidemiology, promises accelerated discoveries and robust models that account for real-world complexities, fostering innovation and exploration in the field. In this intricate review, mathematical modeling in viral transmission dynamics and epidemiology serves as a guiding beacon, illuminating the path toward precision interventions, global preparedness, and the collective endeavor to safeguard human health, resonating with the aim of advancing knowledge in gene regulation and expression.
MeSH term(s)	Humans ; Communicable Diseases/epidemiology ; Models, Theoretical ; Mathematics
Language	English
Publishing date	2024-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2024.148174
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Zs.A 1357: Show issues

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Article ; Online: Pathophysiology, diagnosis, and herbal medicine-based therapeutic implication of rheumatoid arthritis: an overview.

Kaur, Charanjit / Mishra, Yachana / Kumar, Rajesh / Singh, Gurvinder / Singh, Sukhraj / Mishra, Vijay / Tambuwala, Murtaza M

Inflammopharmacology

2024

Abstract: Rheumatoid arthritis (RA) stands as an autoimmune disorder characterized by chronic joint inflammation, resulting in profound physiological alterations within the body. Affecting approximately 0.4-1.3% of the global population, this condition poses ... ...

Abstract	Rheumatoid arthritis (RA) stands as an autoimmune disorder characterized by chronic joint inflammation, resulting in profound physiological alterations within the body. Affecting approximately 0.4-1.3% of the global population, this condition poses significant challenges as current therapeutic approaches primarily offer symptomatic relief, with the prospect of complete recovery remaining elusive. This review delves into the contemporary advancements in understanding the pathophysiology, diagnosis, and the therapeutic potential of herbal medicine in managing RA. Notably, early diagnosis during the initial stages emerges as the pivotal determinant for successful recovery post-treatment. Utilizing tools such as Magnetic Resonance Imaging (MRI), anti-citrullinated peptide antibody markers, and radiography proves crucial in pinpointing the diagnosis of RA with precision. Unveiling the intricate pathophysiological mechanisms of RA has paved the way for innovative therapeutic interventions, incorporating plant extracts and isolated phytoconstituents. In the realm of pharmacological therapy for RA, specific disease-modifying antirheumatic drugs have showcased commendable efficacy. However, this conventional approach is not without its drawbacks, as it is often associated with various side effects. The integration of methodological strategies, encompassing both pharmacological and plant-based herbal therapies, presents a promising avenue for achieving substantive recovery. This integrated approach not only addresses the symptoms but also strives to tackle the underlying causes of RA, fostering a more comprehensive and sustainable path towards healing.
Language	English
Publishing date	2024-03-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-024-01445-8
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Zs.A 3274: Show issues

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Article: Aptamers Versus Vascular Endothelial Growth Factor (VEGF): A New Battle against Ovarian Cancer.

Mishra, Yachana / Chattaraj, Aditi / Mishra, Vijay / Ranjan, Abhigyan / Tambuwala, Murtaza M

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 6

Abstract: Cancer is one of the diseases that causes a high mortality as it involves unregulated and abnormal cell growth proliferation that can manifest in any body region. One of the typical ovarian cancer symptoms is damage to the female reproductive system. The ...

Abstract	Cancer is one of the diseases that causes a high mortality as it involves unregulated and abnormal cell growth proliferation that can manifest in any body region. One of the typical ovarian cancer symptoms is damage to the female reproductive system. The death rate can be reduced through early detection of the ovarian cancer. Promising probes that can detect ovarian cancer are suitable aptamers. Aptamers, i.e., so-called chemical antibodies, have a strong affinity for the target biomarker and can typically be identified starting from a random library of oligonucleotides. Compared with other probes, ovarian cancer targeting using aptamers has demonstrated superior detection effectiveness. Various aptamers have been selected to detect the ovarian tumor biomarker, vascular endothelial growth factor (VEGF). The present review highlights the development of particular aptamers that target VEGF and detect ovarian cancer at its earliest stages. The therapeutic efficacy of aptamers in ovarian cancer treatment is also discussed.
Language	English
Publishing date	2023-06-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16060849
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Article ; Online: Carbon Nanotubes in Breast Cancer Treatment: An Insight into Properties, Functionalization, and Toxicity.

Srivastava, Neha / Mishra, Yachana / Mishra, Vijay / Ranjan, Abhigyan / Tambuwala, Murtaza M

Anti-cancer agents in medicinal chemistry

2023 Volume 23, Issue 14, Page(s) 1606–1617

Abstract: Breast cancer is the most common cancer among women worldwide. It is the main reason why women die from cancer. Early diagnosis due to increased public awareness and better screening helps to tackle the disease through surgical resection and curative ... ...

Abstract	Breast cancer is the most common cancer among women worldwide. It is the main reason why women die from cancer. Early diagnosis due to increased public awareness and better screening helps to tackle the disease through surgical resection and curative therapies. Chemotherapies are frequently used for cancer treatment, but these have severe adverse effects due to a lack of target specificity. Formulation development scientists and clinicians are now particularly concerned with developing safe and efficient drug delivery systems for breast cancer treatment. Potentially relevant literature to get the latest developments and updated information related to properties, functionalization, toxicity and application of carbon nanotubes in breast cancer treatment has been obtained from Web of Science, Scopus, and PubMed portals. Nanomedicine has emerged as a novel tool for target-specific delivery systems and other biomedical applications. Carbon nanotubes (CNTs) are gaining popularity due to their unique mechanical and physiochemical properties for the diagnosis and treatment of cancer. It is a promising carrier that can deliver micro and macromolecules to the cancer cell. CNTs can be functionalized at the surface with different functional groups, which helps in targeting the drugs to target cancer cells. The present review has elaborated on different functionalization approaches and toxicity aspects of CNTs.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Nanotubes, Carbon/adverse effects ; Nanotubes, Carbon/chemistry ; Nanomedicine ; Drug Delivery Systems
Chemical Substances	Nanotubes, Carbon
Language	English
Publishing date	2023-05-10
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/1871520623666230510094850
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Zs.A 5583: Show issues

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Article ; Online: Dendrimers based cancer nanotheranostics: An overview.

Saluja, Vikrant / Mishra, Yachana / Mishra, Vijay / Giri, Namita / Nayak, Pallavi

International journal of pharmaceutics

2021 Volume 600, Page(s) 120485

Abstract: Cancer is a known deadliest disease that requires a judicious diagnostic, targeting, and treatment strategy for an early prognosis and selective therapy. The major pitfalls of the conventional approach are non-specificity in targeting, failure to ... ...

Abstract	Cancer is a known deadliest disease that requires a judicious diagnostic, targeting, and treatment strategy for an early prognosis and selective therapy. The major pitfalls of the conventional approach are non-specificity in targeting, failure to precisely monitor therapy outcome, and cancer progression leading to malignancies. The unique physicochemical properties offered by nanotechnology derived nanocarriers have the potential to radically change the landscape of cancer diagnosis and therapeutic management. An integrative approach of utilizing both diagnostic and therapeutic functionality using a nanocarrier is termed as nanotheranostic. The nanotheranostics platform is designed in such a way that overcomes various biological barriers, efficiently targets the payload to the desired locus, and simultaneously supports planning, monitoring, and verification of treatment delivery to demonstrate an enhanced therapeutic efficacy. Thus, a nanotheranostic platform could potentially assist in drug targeting, image-guided focal therapy, drug release and distribution monitoring, predictionof treatment response, and patient stratification. A class of highly branched nanocarriers known as dendrimers is recognized as an advanced nanotheranostic platform that has the potential to revolutionize the oncology arena by its unique and exciting features. A dendrimer is a well-defined three-dimensional globular chemical architecture with a high level of monodispersity, amenability of precise size control, and surface functionalization. All the dendrimer properties exhibit a reproducible pharmacokinetic behavior that could ensure the desired biodistribution and efficacy. Dendrimers are thus being exploited as a nanotheranostic platform embodying a diverse class of therapeutic, imaging, and targeting moieties for cancer diagnosis and treatment.
MeSH term(s)	Dendrimers ; Drug Delivery Systems ; Humans ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Theranostic Nanomedicine ; Tissue Distribution
Chemical Substances	Dendrimers
Language	English
Publishing date	2021-03-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2021.120485
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Zs.A 1409: Show issues

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Article ; Online: Toxicological Profile of Polyethylene Terephthalate (PET) Microplastic in Ingested

Kauts, Simran / Mishra, Yachana / Yousuf, Sumaira / Bhardwaj, Rima / Singh, Sandeep K / Alshabrmi, Fahad M / Abdurahman, Mahmoud / Vamanu, Emanuel / Singh, Mahendra P

Toxics

2023 Volume 11, Issue 9

Abstract: Microplastics are readily available in the natural environment. Due to the pervasiveness of microplastic pollution, its effects on living organisms necessitate further investigation. The size, time of exposure, and amount of microplastic particles appear ...

Abstract	Microplastics are readily available in the natural environment. Due to the pervasiveness of microplastic pollution, its effects on living organisms necessitate further investigation. The size, time of exposure, and amount of microplastic particles appear to be the most essential factor in determining their toxicological effects, either organismal or sub-organismal. For our research work, we preferred to work on a terrestrial model organism
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11090782
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Article ; Online: Development and evaluation of a protease inhibitor antiretroviral drug-loaded carbon nanotube delivery system for enhanced efficacy in HIV treatment.

Srivastava, Neha / Mishra, Vijay / Mishra, Yachana / Ranjan, Abhigyan / Aljabali, Alaa A A / El-Tanani, Mohamed / Alfagih, Iman M / Tambuwala, Murtaza M

International journal of pharmaceutics

2023 Volume 650, Page(s) 123678

Abstract: The primary objective of this study was to enhance the effectiveness of the protease inhibitor antiretroviral drug by designing a novel delivery system using carboxylated multiwalled carbon nanotubes (COOH-MWCNTs). To achieve this, Fosamprenavir calcium ( ...

Abstract	The primary objective of this study was to enhance the effectiveness of the protease inhibitor antiretroviral drug by designing a novel delivery system using carboxylated multiwalled carbon nanotubes (COOH-MWCNTs). To achieve this, Fosamprenavir calcium (FPV), a prodrug of amprenavir known for inhibiting the proteolytic cleavage of immature virions, was selected as the protease inhibitor antiretroviral drug, and loaded onto COOH-MWCNTs using a direct loading method. The structural specificity of the drug-loaded MWCNTs, the percent entrapment efficiency, and in vitro drug release were rigorously evaluated for the developed formulation, referred to as FPV-MWCNT. Fourier transform infrared (FTIR) spectroscopy, Field emission scanning electron microscopy (FE-SEM), Raman spectroscopy, and atomic force microscopy (AFM) techniques were employed to confirm the structural integrity and specificity of the FPV-MWCNT formulation. The results demonstrated a remarkable entrapment efficiency of 79.57 ± 0.4 %, indicating the successful loading of FPV onto COOH-MWCNTs. FE-SEM and AFM analyses further confirmed the well-dispersed and elongated structure of the FPV-MWCNT formulation, without any signs of fracture, ensuring the stability and integrity of the drug delivery system. Moreover, particle size analysis revealed an average size of 290.1 nm, firmly establishing the nanoscale range of the formulation, with a zeta potential of 0.230 mV, signifying the system's colloidal stability. In vitro drug release studies conducted in methanolic phosphate buffer saline (PBS) at pH 7.4 and methanolic acetate buffer at pH 5 demonstrated sustained drug release from the FPV-MWCNT formulation. Over a period of 96 h, the formulation exhibited a cumulative drug release of 91.43 ± 2.3 %, showcasing the controlled and sustained release profile. Furthermore, hemolysis studies indicated a notable reduction in the toxicity of both FPV and MWCNT upon conjugation, although the percent hemolysis increased with higher concentrations, suggesting the need for careful consideration of dosage levels. In conclusion, the findings from this study underscore the potential of the FPV-MWCNT formulation as an effective and promising drug-conjugated system for delivering antiretroviral drugs. The successful encapsulation, sustained drug release, and reduced toxicity make FPV-MWCNT a compelling candidate for enhancing the therapeutic efficacy of protease inhibitor antiretroviral drugs in the treatment of HIV. The developed delivery system holds great promise for future advancements in HIV treatment and paves the way for further research and development in the field of drug delivery utilizing carbon nanotube-based systems.
MeSH term(s)	Humans ; Nanotubes, Carbon/chemistry ; Protease Inhibitors ; Hemolysis ; Drug Delivery Systems ; Enzyme Inhibitors ; Antiviral Agents ; Anti-Infective Agents ; HIV Infections
Chemical Substances	Nanotubes, Carbon ; Protease Inhibitors ; Enzyme Inhibitors ; Antiviral Agents ; Anti-Infective Agents
Language	English
Publishing date	2023-12-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.123678
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Article ; Online: Ran GTPase and Its Importance in Cellular Signaling and Malignant Phenotype.

El-Tanani, Mohamed / Nsairat, Hamdi / Mishra, Vijay / Mishra, Yachana / Aljabali, Alaa A A / Serrano-Aroca, Ángel / Tambuwala, Murtaza M

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Ran is a member of the Ras superfamily of proteins, which primarily regulates nucleocytoplasmic trafficking and mediates mitosis by regulating spindle formation and nuclear envelope (NE) reassembly. Therefore, Ran is an integral cell fate determinant. It ...

Abstract	Ran is a member of the Ras superfamily of proteins, which primarily regulates nucleocytoplasmic trafficking and mediates mitosis by regulating spindle formation and nuclear envelope (NE) reassembly. Therefore, Ran is an integral cell fate determinant. It has been demonstrated that aberrant Ran expression in cancer is a result of upstream dysregulation of the expression of various factors, such as osteopontin (OPN), and aberrant activation of various signaling pathways, including the extracellular-regulated kinase/mitogen-activated protein kinase (ERK/MEK) and phosphatidylinositol 3-kinase/Protein kinase B (PI3K/Akt) pathways. In vitro, Ran overexpression has severe effects on the cell phenotype, altering proliferation, adhesion, colony density, and invasion. Therefore, Ran overexpression has been identified in numerous types of cancer and has been shown to correlate with tumor grade and the degree of metastasis present in various cancers. The increased malignancy and invasiveness have been attributed to multiple mechanisms. Increased dependence on Ran for spindle formation and mitosis is a consequence of the upregulation of these pathways and the ensuing overexpression of Ran, which increases cellular dependence on Ran for survival. This increases the sensitivity of cells to changes in Ran concentration, with ablation being associated with aneuploidy, cell cycle arrest, and ultimately, cell death. It has also been demonstrated that Ran dysregulation influences nucleocytoplasmic transport, leading to transcription factor misallocation. Consequently, patients with tumors that overexpress Ran have been shown to have a higher malignancy rate and a shorter survival time compared to their counterparts.
MeSH term(s)	Humans ; GTP Phosphohydrolases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; ran GTP-Binding Protein/genetics ; Neoplasms/pathology ; Phenotype
Chemical Substances	GTP Phosphohydrolases (EC 3.6.1.-) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; ran GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2023-02-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043065
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