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  1. AU="Misran, Misni"
  2. AU="Hoebeke, P"
  3. AU="Mahajan, Raman"
  4. AU=Dutta Venkatesh
  5. AU="Rivera, Alexis"
  6. AU="Shaghayegh Tarani"
  7. AU="Miener, T"
  8. AU="Barker, Jenny C"
  9. AU="Lorimer, D. R."
  10. AU="Peh, Kelvin S-H"
  11. AU="Hossein Safarpour"
  12. AU="Hall, Frances"
  13. AU="Weckmann, U."
  14. AU="Martínez-Sáez, O"
  15. AU="dos Santos, Alejandra Filippo Gonzalez Neves"
  16. AU="Beverly Castillo Herrera"
  17. AU="Fatin Izzati Abdul Hadi"
  18. AU="Musinguzi, Nicholas"
  19. AU=Lee Edward Y
  20. AU="Raval, Urdhva"
  21. AU="Senn, L Kirsten"
  22. AU="Matsutani, Noriyuki"
  23. AU="Bernstein, Herbert J"
  24. AU="Elisa Impresari"
  25. AU="Feldman, Noa"
  26. AU="Dhingra, Mandeep Singh"

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  1. Artikel ; Online: Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan.

    Marlina, Anita / Misran, Misni

    ACS omega

    2023  Band 8, Heft 43, Seite(n) 40494–40507

    Abstract: Stearoyl chitosan (SC), derived from the acylation of chitosan, contributes to the efficiency of drug delivery systems because of its structure, which accommodates the drug in a particle. Nonetheless, its role in chemotherapy has been largely unexplored. ...

    Abstract Stearoyl chitosan (SC), derived from the acylation of chitosan, contributes to the efficiency of drug delivery systems because of its structure, which accommodates the drug in a particle. Nonetheless, its role in chemotherapy has been largely unexplored. The present study involves the synthesis of stearoyl chitosan through the reaction of depolymerized chitosan with stearoyl chloride under mild reaction conditions. The resulting compound was subjected to structural analysis utilizing Fourier-transform infrared (FTIR) spectroscopy,
    Sprache Englisch
    Erscheinungsdatum 2023-10-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05108
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  2. Artikel ; Online: Development of Nanostructured Lipid Carrier-Loaded Flavonoid-Enriched

    Shazwani, Sharifah Sarah / Marlina, Anita / Misran, Misni

    ACS omega

    2024  Band 9, Heft 15, Seite(n) 17379–17388

    Abstract: Flavonoids, which are bioactive molecules found ... ...

    Abstract Flavonoids, which are bioactive molecules found in
    Sprache Englisch
    Erscheinungsdatum 2024-04-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.4c00091
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  3. Artikel ; Online: Cholesterol-linoleic acid liposomes induced extracellular vesicles secretion from immortalized adipose-derived mesenchymal stem cells for

    Chen, Jzit Weii / Liew, Fong Fong / Tan, Hsiao Wei / Misran, Misni / Chung, Ivy

    Artificial cells, nanomedicine, and biotechnology

    2023  Band 51, Heft 1, Seite(n) 346–360

    Abstract: Extracellular vesicles (EVs) are small vesicles that are naturally released by cells and play a crucial role in cell-to-cell communication, tissue repair and regeneration. As naturally secreted EVs are limited, liposomes with different physicochemical ... ...

    Abstract Extracellular vesicles (EVs) are small vesicles that are naturally released by cells and play a crucial role in cell-to-cell communication, tissue repair and regeneration. As naturally secreted EVs are limited, liposomes with different physicochemical properties, such as 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and linoleic acid (LA) with modifications have been formulated to improve EVs secretion for
    Mesh-Begriff(e) Humans ; Liposomes/metabolism ; Linoleic Acid/analysis ; Linoleic Acid/metabolism ; Extracellular Vesicles/metabolism ; Mesenchymal Stem Cells/metabolism ; Cell Movement ; Cholesterol
    Chemische Substanzen Liposomes ; Linoleic Acid (9KJL21T0QJ) ; Cholesterol (97C5T2UQ7J)
    Sprache Englisch
    Erscheinungsdatum 2023-07-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2723095-8
    ISSN 2169-141X ; 2169-1401
    ISSN (online) 2169-141X
    ISSN 2169-1401
    DOI 10.1080/21691401.2023.2237534
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  4. Artikel ; Online: Mixed Oleic Acid-Erucic Acid Liposomes as a Carrier for Anticancer Drugs.

    Eh Suk, Vicit Rizal / Chung, Ivy / Misran, Misni

    Current drug delivery

    2020  Band 17, Heft 4, Seite(n) 292–302

    Abstract: Background: Liposomes are mostly known to be prepared from phospholipids and lipids and have a remarkable capacity to encapsulate both lipophobic and lipophilic molecules. However, there is little research on developing fatty acid liposomes for ... ...

    Abstract Background: Liposomes are mostly known to be prepared from phospholipids and lipids and have a remarkable capacity to encapsulate both lipophobic and lipophilic molecules. However, there is little research on developing fatty acid liposomes for chemotherapy.
    Objective: We have successfully prepared mixed fatty acid liposomes from two monounsaturated fatty acids, namely oleic acid and erucic acid, which stabilised by DOPEPEG2000. The Critical Vesicular Concentration (CVC) of liposomes was found to be within 0.09 to 0.21 mmol dm
    Methods: Encapsulation of various anticancer drugs such as folinic acid, methotrexate, doxorubicin, or irinotecan resulted in Encapsulation Efficiency (%EE) of up to 90%. Using a 3-(4, 5-dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the median Inhibitory Concentration (IC
    Results: The results suggest that mixed oleic acid-erucic acid liposomes are a potential new approach to further develop as an alternative vehicle of various drugs for cancer treatment.
    Mesh-Begriff(e) A549 Cells ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Carriers/chemistry ; Drug Screening Assays, Antitumor ; Erucic Acids/chemistry ; Humans ; Irinotecan/chemistry ; Irinotecan/pharmacology ; Leucovorin/chemistry ; Leucovorin/pharmacology ; Liposomes/chemistry ; Methotrexate/chemistry ; Methotrexate/pharmacology ; Oleic Acid/chemistry ; Particle Size ; Surface Properties
    Chemische Substanzen Antineoplastic Agents ; Drug Carriers ; Erucic Acids ; Liposomes ; erucic acid (075441GMF2) ; Oleic Acid (2UMI9U37CP) ; Irinotecan (7673326042) ; Doxorubicin (80168379AG) ; Leucovorin (Q573I9DVLP) ; Methotrexate (YL5FZ2Y5U1)
    Sprache Englisch
    Erscheinungsdatum 2020-02-06
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article
    ZDB-ID 2185284-4
    ISSN 1875-5704 ; 1567-2018
    ISSN (online) 1875-5704
    ISSN 1567-2018
    DOI 10.2174/1567201817666200210122933
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Interaction between C18 fatty acids and DOPE PEG2000 in Langmuir monolayers: effect of degree of unsaturation.

    Gew, Lai Ti / Misran, Misni

    Journal of biological physics

    2017  Band 43, Heft 3, Seite(n) 397–414

    Abstract: In this study, we address the effect of the cis-double bond in 1,2-dioleoyl-sn-glycero-3-phosphoethanolamide-N-[methoxy(polyethylene glycol)-2000, DOPE PEG2000 (DP), on the Langmuir monolayer of C18 fatty acids-namely, stearic acid (SA), oleic acid (L1), ...

    Abstract In this study, we address the effect of the cis-double bond in 1,2-dioleoyl-sn-glycero-3-phosphoethanolamide-N-[methoxy(polyethylene glycol)-2000, DOPE PEG2000 (DP), on the Langmuir monolayer of C18 fatty acids-namely, stearic acid (SA), oleic acid (L1), linoleic acid (L2), and linolenic acid (L3)-with the same head group but different degrees of saturation on their hydrocarbon chains. Negative values of Gibbs free energy of mixing (ΔG
    Mesh-Begriff(e) Fatty Acids/chemistry ; Phosphatidylethanolamines/chemistry ; Polyethylene Glycols/chemistry ; Thermodynamics
    Chemische Substanzen Fatty Acids ; Phosphatidylethanolamines ; dioleoyl phosphatidylethanolamine (2462-63-7) ; Polyethylene Glycols (30IQX730WE) ; polyethylene glycol 2000 (HAF0412YIT)
    Sprache Englisch
    Erscheinungsdatum 2017-07-27
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2016734-9
    ISSN 1573-0689 ; 0092-0606
    ISSN (online) 1573-0689
    ISSN 0092-0606
    DOI 10.1007/s10867-017-9459-2
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  6. Artikel ; Online: Bispecific antibodies for targeted delivery of anti-cancer therapeutic agents: A review

    Beishenaliev, Adilet / Loke, Yean Leng / Goh, Sook Jing / Geo, Hui Nee / Mugila, Malar / Misran, Misni / Chung, Lip Yong / Kiew, Lik Voon / Roffler, Steve / Teo, Yin Yin

    Journal of Controlled Release. 2023 July, v. 359 p.268-286

    2023  

    Abstract: Monospecific antibodies have been utilised increasingly for anti-cancer drug targeting owing to their ability to minimise off-target toxicity by binding specifically to a tumour epitope, hence selectively delivering drugs to the tumour cells. ... ...

    Abstract Monospecific antibodies have been utilised increasingly for anti-cancer drug targeting owing to their ability to minimise off-target toxicity by binding specifically to a tumour epitope, hence selectively delivering drugs to the tumour cells. Nevertheless, the monospecific antibodies only engage a single cell surface epitope to deliver their drug payload. Hence, their performance is often unsatisfactory in cancers where multiple epitopes need to be engaged for optimal cellular internalisation. In this context, bispecific antibodies (bsAbs) that simultaneously target two distinct antigens or two distinct epitopes of the same antigen offer a promising alternative in antibody-based drug delivery. This review describes the recent advances in developing bsAb-based drug delivery strategies, encompassing the direct conjugation of drug to bsAbs to form bispecific antibody-drug conjugates (bsADCs) and the surface functionalisation of nanoconstructs with bsAbs to form bsAb-coupled nanoconstructs. The article first details the roles of bsAbs in enhancing the internalisation and intracellular trafficking of bsADCs with subsequent release of chemotherapeutic drugs for an augmented therapeutic efficacy, particularly among heterogeneous tumour cell populations. Then, the article discusses the roles of bsAbs in facilitating the delivery of drug-encapsulating nanoconstructs, including organic/inorganic nanoparticles and large bacteria-derived minicells, that provide a larger drug loading capacity and better stability in blood circulation than bsADCs. The limitations of each type of bsAb-based drug delivery strategy and the future prospects of more versatile strategies (e.g., trispecific antibodies, autonomous drug delivery systems, theranostics) are also elaborated.
    Schlagwörter antineoplastic agents ; blood circulation ; cancer therapy ; drug therapy ; epitopes ; nanoparticles ; neoplasm cells ; neoplasms ; precision medicine ; toxicity ; Monospecific antibodies ; bispecific antibodies ; antibody-drug conjugate ; drug delivery ; active targeting ; nanoconstructs
    Sprache Englisch
    Erscheinungsverlauf 2023-07
    Umfang p. 268-286.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2023.05.032
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel: Development of nanostructured lipid carrier (NLC) assisted with polysorbate nonionic surfactants as a carrier for L-ascorbic acid and Gold Tri.E 30

    Eh Suk, Vicit Rizal / Mohd. Latif, Farhanim / Teo, Yin Yin / Misran, Misni

    Journal of food science and technology. 2020 Sept., v. 57, no. 9

    2020  

    Abstract: Lipid nanocarrier displays the advantages over conventional drug carriers as they are formulated with biodegradable and non-irritant lipids. However, the main drawbacks are the agglomeration of lipid particles, instability over storage, low drug loading, ...

    Abstract Lipid nanocarrier displays the advantages over conventional drug carriers as they are formulated with biodegradable and non-irritant lipids. However, the main drawbacks are the agglomeration of lipid particles, instability over storage, low drug loading, and the burst release of active ingredients. In this study, we investigated the effects of various polysorbate nonionic surfactants namely Tween 20, 40, 60, or 80 on the nanostructured lipid carrier (NLC). NLC incorporated with polysorbate nonionic surfactant was prepared by using high-pressure homogenization technique. The average size was reduced to 139.9 ± 15.8 nm in the presence of Tween 80 and remained stable in nano-size even incubated for 28 days. Encapsulation of L-ascorbic acid or Gold Tri.E 30 showed a high encapsulation efficiency of more than 75%, where the highest was Gold Tri.E in the presence of Tween 60 at 99.7%. In vitro release study showed that the release of both L-ascorbic acid and Gold Tri.E was significantly reduced in NLC with Tween as compared to bare active ingredients and NLC without Tween. In conclusion, the incorporation of Tween successfully produced a lipid nanocarrier that has the potential to be developed as a carrier of various active ingredients such as nutrients, extracts, and drugs.
    Schlagwörter ascorbic acid ; biodegradability ; drugs ; encapsulation ; food science ; homogenization ; lipids ; nanocarriers ; nonionic surfactants ; polysorbates
    Sprache Englisch
    Erscheinungsverlauf 2020-09
    Umfang p. 3259-3266.
    Erscheinungsort Springer India
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 242498-8
    ISSN 0975-8402 ; 0022-1155
    ISSN (online) 0975-8402
    ISSN 0022-1155
    DOI 10.1007/s13197-020-04357-x
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  8. Artikel: Albumin-fatty acid interactions at monolayer interface.

    Gew, Lai Ti / Misran, Misni

    Nanoscale research letters

    2014  Band 9, Heft 1, Seite(n) 218

    Abstract: The fluid mosaic model of Singer and Nicolson in 1972 shows how proteins are embedded in membranes. To elucidate the interactions between proteins and the surrounding lipids, stearic acid (SA) and bovine serum albumin (BSA) were used as lipid-protein ... ...

    Abstract The fluid mosaic model of Singer and Nicolson in 1972 shows how proteins are embedded in membranes. To elucidate the interactions between proteins and the surrounding lipids, stearic acid (SA) and bovine serum albumin (BSA) were used as lipid-protein components to mimic the normal membrane bilayer environment using the Langmuir-Blodgett technique. Surface pressure (π)-molecular area (A) isotherms were recorded for the SA monolayer in the presence of BSA on water. The mixed monolayer was successfully transferred onto an oxidized silicon wafer and imaged by tapping mode atomic force microscopy (AFM). Miscibility, compressibility and thermodynamic stability of the mixed system were examined. A large negative deviation of A ex, together with the minimum value of ΔG ex, was observed when the mole fraction of BSA (X BSA) was 0.8, indicating this to be the most stable mixture. In a compressibility analysis, X BSA was observed at below 50 mN m(-1), denoting a liquid-expanded phase and showing the occurrence of a strong interaction of SA with BSA molecules in this phase. AFM observations supported the quantitative data indicating that BSA was strongly attracted onto the membrane surface as predicted.
    Sprache Englisch
    Erscheinungsdatum 2014-05-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2253244-4
    ISSN 1556-276X ; 1931-7573
    ISSN (online) 1556-276X
    ISSN 1931-7573
    DOI 10.1186/1556-276X-9-218
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  9. Artikel: Development of nanostructured lipid carrier (NLC) assisted with polysorbate nonionic surfactants as a carrier for l-ascorbic acid and Gold Tri.E 30.

    Eh Suk, Vicit Rizal / Mohd Latif, Farhanim / Teo, Yin Yin / Misran, Misni

    Journal of food science and technology

    2020  Band 57, Heft 9, Seite(n) 3259–3266

    Abstract: Lipid nanocarrier displays the advantages over conventional drug carriers as they are formulated with biodegradable and non-irritant lipids. However, the main drawbacks are the agglomeration of lipid particles, instability over storage, low drug loading, ...

    Abstract Lipid nanocarrier displays the advantages over conventional drug carriers as they are formulated with biodegradable and non-irritant lipids. However, the main drawbacks are the agglomeration of lipid particles, instability over storage, low drug loading, and the burst release of active ingredients. In this study, we investigated the effects of various polysorbate nonionic surfactants namely Tween 20, 40, 60, or 80 on the nanostructured lipid carrier (NLC). NLC incorporated with polysorbate nonionic surfactant was prepared by using high-pressure homogenization technique. The average size was reduced to 139.9 ± 15.8 nm in the presence of Tween 80 and remained stable in nano-size even incubated for 28 days. Encapsulation of l-ascorbic acid or Gold Tri.E 30 showed a high encapsulation efficiency of more than 75%, where the highest was Gold Tri.E in the presence of Tween 60 at 99.7%. In vitro release study showed that the release of both l-ascorbic acid and Gold Tri.E was significantly reduced in NLC with Tween as compared to bare active ingredients and NLC without Tween. In conclusion, the incorporation of Tween successfully produced a lipid nanocarrier that has the potential to be developed as a carrier of various active ingredients such as nutrients, extracts, and drugs.
    Sprache Englisch
    Erscheinungsdatum 2020-03-23
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 242498-8
    ISSN 0975-8402 ; 0022-1155
    ISSN (online) 0975-8402
    ISSN 0022-1155
    DOI 10.1007/s13197-020-04357-x
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  10. Artikel ; Online: Bispecific antibodies for targeted delivery of anti-cancer therapeutic agents: A review.

    Beishenaliev, Adilet / Loke, Yean Leng / Goh, Sook Jing / Geo, Hui Nee / Mugila, Malar / Misran, Misni / Chung, Lip Yong / Kiew, Lik Voon / Roffler, Steve / Teo, Yin Yin

    Journal of controlled release : official journal of the Controlled Release Society

    2023  Band 359, Seite(n) 268–286

    Abstract: Monospecific antibodies have been utilised increasingly for anti-cancer drug targeting owing to their ability to minimise off-target toxicity by binding specifically to a tumour epitope, hence selectively delivering drugs to the tumour cells. ... ...

    Abstract Monospecific antibodies have been utilised increasingly for anti-cancer drug targeting owing to their ability to minimise off-target toxicity by binding specifically to a tumour epitope, hence selectively delivering drugs to the tumour cells. Nevertheless, the monospecific antibodies only engage a single cell surface epitope to deliver their drug payload. Hence, their performance is often unsatisfactory in cancers where multiple epitopes need to be engaged for optimal cellular internalisation. In this context, bispecific antibodies (bsAbs) that simultaneously target two distinct antigens or two distinct epitopes of the same antigen offer a promising alternative in antibody-based drug delivery. This review describes the recent advances in developing bsAb-based drug delivery strategies, encompassing the direct conjugation of drug to bsAbs to form bispecific antibody-drug conjugates (bsADCs) and the surface functionalisation of nanoconstructs with bsAbs to form bsAb-coupled nanoconstructs. The article first details the roles of bsAbs in enhancing the internalisation and intracellular trafficking of bsADCs with subsequent release of chemotherapeutic drugs for an augmented therapeutic efficacy, particularly among heterogeneous tumour cell populations. Then, the article discusses the roles of bsAbs in facilitating the delivery of drug-encapsulating nanoconstructs, including organic/inorganic nanoparticles and large bacteria-derived minicells, that provide a larger drug loading capacity and better stability in blood circulation than bsADCs. The limitations of each type of bsAb-based drug delivery strategy and the future prospects of more versatile strategies (e.g., trispecific antibodies, autonomous drug delivery systems, theranostics) are also elaborated.
    Mesh-Begriff(e) Humans ; Antibodies, Bispecific/therapeutic use ; Antineoplastic Agents/therapeutic use ; Neoplasms/therapy ; Antigens ; Immunoconjugates/therapeutic use ; Epitopes
    Chemische Substanzen Antibodies, Bispecific ; Antineoplastic Agents ; Antigens ; Immunoconjugates ; Epitopes
    Sprache Englisch
    Erscheinungsdatum 2023-06-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2023.05.032
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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