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  1. Article ; Online: Convergence of location, direction, and theta in the rat anteroventral thalamic nucleus.

    Lomi, Eleonora / Jeffery, Kate J / Mitchell, Anna S

    iScience

    2023  Volume 26, Issue 7, Page(s) 106993

    Abstract: The thalamus and cortex are anatomically interconnected, with the thalamus providing integral information for cortical functions. The anteroventral thalamic nucleus (AV) is reciprocally connected to retrosplenial cortex (RSC). Two distinct AV subfields, ... ...

    Abstract The thalamus and cortex are anatomically interconnected, with the thalamus providing integral information for cortical functions. The anteroventral thalamic nucleus (AV) is reciprocally connected to retrosplenial cortex (RSC). Two distinct AV subfields, dorsomedial (AVDM) and ventrolateral (AVVL), project differentially to granular vs. dysgranular RSC, respectively. To probe if functional responses of AV neurons differ, we recorded single neurons and local field potentials from AVDM and AVVL in rats during foraging. We observed place cells (neurons modulated by spatial location) in both AVDM and AVVL. Additionally, we characterized neurons modulated by theta oscillations, heading direction, and a conjunction of these. Place cells and conjunctive Theta-by-Head direction cells were more prevalent in AVVL; more non-conjunctive theta and directional neurons were prevalent in AVDM. These findings add further evidence that there are two thalamocortical circuits connecting AV and RSC, and reveal that the signaling involves place information in addition to direction and theta.
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106993
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  2. Article: The Effect of Vancomycin and Piperacillin-Tazobactam on Incidence of Acute Kidney Injury in Patients With Obesity.

    Wuerger, Angela / Bowden, Jarred / Mitchell, Anna / Marler, Jacob

    Hospital pharmacy

    2023  Volume 58, Issue 6, Page(s) 605–613

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1177/00185787231172388
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  3. Article: Structural Connectivity Changes After Fornix Transection in Macaques Using Probabilistic Diffusion Tractography.

    Pelekanos, Vassilis / Premereur, Elsie / Mitchell, Anna S

    Advances in experimental medicine and biology

    2023  Volume 1423, Page(s) 11–20

    Abstract: The fornix, the limbic system's white matter tract connecting the extended hippocampal system to subcortical structures of the medial diencephalon, is strongly associated with learning and memory in humans and nonhuman primates (NHPs). Here, we sought to ...

    Abstract The fornix, the limbic system's white matter tract connecting the extended hippocampal system to subcortical structures of the medial diencephalon, is strongly associated with learning and memory in humans and nonhuman primates (NHPs). Here, we sought to investigate alterations in structural connectivity across key cortical and subcortical regions after fornix transection in NHPs. We collected diffusion-weighted MRI (dMRI) data from three macaque monkeys that underwent bilateral fornix transection during neurosurgery and from four age- and cohort-matched control macaques that underwent surgery to implant a head-post but remained neurologically intact. dMRI data were collected from both groups at two time points, before and after the surgeries, and scans took place at around the same time for the two groups. We used probabilistic tractography and employed the number of tracking streamlines to quantify connectivity across our regions of interest (ROIs), in all dMRI sessions. In the neurologically intact monkeys, we observed high connectivity across certain ROIs, including the CA3 hippocampal subfield with the retrosplenial cortex (RSC), the anterior thalamus with the RSC, and the RSC with the anterior cingulate cortex (ACC). However, we found that, compared to the control group, the fornix-transected monkeys showed marked, significant, connectivity changes including increases between the anterior thalamus and the ACC and between the CA3 and the ACC, as well as decreases between the CA3 and the RSC. Our results highlight cortical and subcortical network changes after fornix transection and identify candidate indirect connectivity routes that may support memory functions after damage and/or neurodegeneration.
    MeSH term(s) Animals ; Humans ; Diffusion Tensor Imaging ; Fornix, Brain/diagnostic imaging ; Fornix, Brain/surgery ; Hippocampus/diagnostic imaging ; Hippocampus/surgery ; Gyrus Cinguli ; Macaca mulatta ; Neural Pathways/diagnostic imaging
    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-31978-5_2
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    Einzelsignatur: Show issues

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  4. Article ; Online: Risk of suboptimal hormone replacement therapy for young hypogonadal women and transgender women in the wake of the Joint BMS FSRH RCGP RCOG SfE and RCN Women's Health Forum safety alert.

    Mamoojee, Yaasir / Mitchell, Anna L / Quinton, Richard

    Clinical endocrinology

    2023  Volume 99, Issue 3, Page(s) 326–327

    MeSH term(s) Female ; Humans ; Transgender Persons ; Women's Health ; Hormone Replacement Therapy/adverse effects ; Estrogen Replacement Therapy
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Letter
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14937
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    Zs.A 814: Show issues Location:
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  5. Article: Hypertonie mit multiplen Komorbiditäten.

    Mitchell, Anna

    MMW Fortschritte der Medizin

    2016  Volume 157, Issue 19, Page(s) 47–48

    Title translation Arterial hypertension with multiple comorbidities.
    MeSH term(s) Biopsy ; Combined Modality Therapy ; Comorbidity ; Cooperative Behavior ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/pathology ; Diabetic Nephropathies/complications ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/pathology ; Drug Therapy, Combination ; Female ; Guideline Adherence ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Interdisciplinary Communication ; Kidney/pathology ; Life Style ; Middle Aged ; Patient Compliance ; Weight Loss
    Language German
    Publishing date 2016-02-18
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1478211-x
    ISSN 1438-3276
    ISSN 1438-3276
    DOI 10.1007/s15006-015-3730-x
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  6. Book ; Thesis: Die Wirkung von L-Threitol-1,4-Dimethansulfonat (Treosulfan) auf zwei menschliche neuroektodermale Tumorzellinien in vitro bei physiologischen Temperaturen und bei Hyperthermie

    Mitchell, Anna

    2001  

    Author's details vorgelegt von Anna Mitchell
    Language German
    Size 72 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Essen, Univ., Diss., 2002
    HBZ-ID HT013410085
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 E 3938 order for loan Magazin

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  7. Article ; Online: Cortico-thalamocortical interactions for learning, memory and decision-making.

    Perry, Brook A L / Mendez, Juan Carlos / Mitchell, Anna S

    The Journal of physiology

    2022  Volume 601, Issue 1, Page(s) 25–35

    Abstract: The thalamus and cortex are interconnected both functionally and anatomically and share a common developmental trajectory. Interactions between the mediodorsal thalamus (MD) and different parts of the prefrontal cortex are essential in cognitive ... ...

    Abstract The thalamus and cortex are interconnected both functionally and anatomically and share a common developmental trajectory. Interactions between the mediodorsal thalamus (MD) and different parts of the prefrontal cortex are essential in cognitive processes, such as learning and adaptive decision-making. Cortico-thalamocortical interactions involving other dorsal thalamic nuclei, including the anterior thalamus and pulvinar, also influence these cognitive processes. Our work, and that of others, indicates a crucial influence of these interdependent cortico-thalamocortical neural networks that contributes actively to the processing of information within the cortex. Each of these thalamic nuclei also receives potent subcortical inputs that are likely to provide additional influences on their regulation of cortical activity. Here, we highlight our current neuroscientific research aimed at establishing when cortico-MD thalamocortical neural network communication is vital within the context of a rapid learning and memory discrimination task. We are collecting evidence of MD-prefrontal cortex neural network communication in awake, behaving male rhesus macaques. Given the prevailing evidence, further studies are needed to identify both broad and specific mechanisms that govern how the MD, anterior thalamus and pulvinar cortico-thalamocortical interactions support learning, memory and decision-making. Current evidence shows that the MD (and the anterior thalamus) are crucial for frontotemporal communication, and the pulvinar is crucial for frontoparietal communication. Such work is crucial to advance our understanding of the neuroanatomical and physiological bases of these brain functions in humans. In turn, this might offer avenues to develop effective treatment strategies to improve the cognitive deficits often observed in many debilitating neurological disorders and diseases and in neurodegeneration.
    MeSH term(s) Animals ; Male ; Humans ; Macaca mulatta ; Learning/physiology ; Thalamus/physiology ; Prefrontal Cortex/physiology ; Neural Pathways/physiology
    Language English
    Publishing date 2022-08-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP282626
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  8. Article ; Online: Cervical screening in women with classic congenital adrenal hyperplasia: uptake and barriers.

    Devine, Kerri / Mitchell, Anna L

    BMJ sexual & reproductive health

    2020  Volume 47, Issue 2, Page(s) 153–154

    MeSH term(s) Adrenal Hyperplasia, Congenital/complications ; Adrenal Hyperplasia, Congenital/psychology ; Adult ; Early Detection of Cancer/methods ; Early Detection of Cancer/psychology ; Female ; Humans ; Mass Screening/methods ; Mass Screening/psychology ; Mass Screening/statistics & numerical data ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/prevention & control ; Uterine Cervical Neoplasms/psychology
    Language English
    Publishing date 2020-11-23
    Publishing country England
    Document type Letter
    ISSN 2515-2009
    ISSN (online) 2515-2009
    DOI 10.1136/bmjsrh-2020-200868
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  9. Article ; Online: Introduction to the special issue on "Genetic Screening and Testing".

    Mitchell, Anna L / Watanabe, Michiko

    Birth defects research

    2020  Volume 112, Issue 4, Page(s) 289–292

    MeSH term(s) Genetic Testing
    Language English
    Publishing date 2020-02-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 2104792-3
    ISSN 2472-1727
    ISSN (online) 2472-1727
    DOI 10.1002/bdr2.1637
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    Zs.A 749: Show issues Location:
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  10. Article ; Online: Variable cardiac responses in rhesus macaque monkeys after discrete mediodorsal thalamus manipulations.

    Méndez, Juan Carlos / Perry, Brook A L / Premereur, Elsie / Pelekanos, Vassilis / Ramadan, Tamara / Mitchell, Anna S

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 16913

    Abstract: The control of some physiological parameters, such as the heart rate, is known to have a role in cognitive and emotional processes. Cardiac changes are also linked to mental health issues and neurodegeneration. Thus, it is not surprising that many of the ...

    Abstract The control of some physiological parameters, such as the heart rate, is known to have a role in cognitive and emotional processes. Cardiac changes are also linked to mental health issues and neurodegeneration. Thus, it is not surprising that many of the brain structures typically associated with cognition and emotion also comprise a circuit-the central automatic network-responsible for the modulation of cardiovascular output. The mediodorsal thalamus (MD) is involved in higher cognitive processes and is also known to be connected to some of the key neural structures that regulate cardiovascular function. However, it is unclear whether the MD has any role in this circuitry. Here, we show that discrete manipulations (microstimulation during anaesthetized functional neuroimaging or localized cytotoxin infusions) to either the magnocellular or the parvocellular MD subdivisions led to observable and variable changes in the heart rate of female and male rhesus macaque monkeys. Considering the central positions that these two MD subdivisions have in frontal cortico-thalamocortical circuits, our findings suggest that MD contributions to autonomic regulation may interact with its identified role in higher cognitive processes, representing an important physiological link between cognition and emotion.
    MeSH term(s) Animals ; Male ; Female ; Macaca mulatta ; Thalamus ; Cognition/physiology ; Brain ; Neural Pathways/physiology
    Language English
    Publishing date 2023-10-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42752-4
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