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  1. AU="Mitra, Kalyan"
  2. AU="Sanjay Desai"
  3. AU=Cox David J AU=Cox David J
  4. AU="Grebenok, Robert J."
  5. AU="Blackburne, Brittney"
  6. AU="Bortoleti, Bruna Taciane da Silva"
  7. AU="Ehrbar, Martin"
  8. AU="Lepre, Davide"
  9. AU="Olszewska, Zuzanna"
  10. AU="Vojta, Leslie"
  11. AU=Wickstrom Eric AU=Wickstrom Eric
  12. AU="Gangavarapu, Sridevi"
  13. AU="Hussein, Hazem Abdelwaheb"
  14. AU=Cai Yixin AU=Cai Yixin
  15. AU="Hüls, Anke"
  16. AU="Poondru, Srinivasu"
  17. AU="Coca, Daniel"
  18. AU="Lebeau, Paul"
  19. AU="Dehghani, Sedigheh"
  20. AU="Ishibashi, Kenji"
  21. AU="Xu, Yanhua"
  22. AU="Matera, Katarzyna"
  23. AU="Ait-Ouarab, Slimane"
  24. AU="Nicola, Coppede"
  25. AU="Dewitt, John M"
  26. AU="Sorin M. Dudea"
  27. AU="Tanusha D. Ramdin"
  28. AU="Hao, Zehui"
  29. AU="Chauhan, Aman"

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  1. Artikel ; Online: Buparvaquone Induces Ultrastructural and Physiological Alterations Leading to Mitochondrial Dysfunction and Caspase-Independent Apoptotic Cell Death in Leishmania donovani.

    Majhi, Swetapadma / Awasthi, Bhanu Priya / Sharma, Rakesh Kumar / Mitra, Kalyan

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2024  

    Abstract: Leishmaniasis is a neglected tropical disease (endemic in 99 countries) caused by parasitic protozoa of the genus Leishmania. As treatment options are limited, there is an unmet need for new drugs. The hydroxynaphthoquinone class of compounds ... ...

    Abstract Leishmaniasis is a neglected tropical disease (endemic in 99 countries) caused by parasitic protozoa of the genus Leishmania. As treatment options are limited, there is an unmet need for new drugs. The hydroxynaphthoquinone class of compounds demonstrates broad-spectrum activity against protozoan parasites. Buparvaquone (BPQ), a member of this class, is the only drug licensed for the treatment of theileriosis. BPQ has shown promising antileishmanial activity but its mode of action is largely unknown. The aim of this study was to evaluate the ultrastructural and physiological effects of BPQ for elucidating the mechanisms underlying the in vitro antiproliferative activity in Leishmania donovani. Transmission and scanning electron microscopy analyses of BPQ-treated parasites revealed ultrastructural effects characteristic of apoptosis-like cell death, which include alterations in the nucleus, mitochondrion, kinetoplast, flagella, and the flagellar pocket. Using flow cytometry, laser scanning confocal microscopy, and fluorometry, we found that BPQ induced caspase-independent apoptosis-like cell death by losing plasma membrane phospholipid asymmetry and cell cycle arrest at sub-G0/G1 phase. Depolarization of the mitochondrial membrane leads to the generation of oxidative stress and impaired ATP synthesis followed by disruption of intracellular calcium homeostasis. Collectively, these findings provide valuable mechanistic insights and demonstrate BPQ's potential for development as an antileishmanial agent.
    Sprache Englisch
    Erscheinungsdatum 2024-05-06
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/mam/ozae034
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  2. Artikel ; Online: Plasmodium falciparum

    Shrivastava, Deepti / Jha, Akanksha / Kabrambam, Rajlakshmi / Vishwakarma, Jyoti / Mitra, Kalyan / Ramachandran, Ravishankar / Habib, Saman

    ACS infectious diseases

    2024  Band 10, Heft 1, Seite(n) 155–169

    Abstract: Replication of the malarial parasite in human erythrocytes requires massive zinc fluxes, necessitating the action of zinc transporters across the parasite plasma and organellar membranes. Although genetic knockout studies have been conducted on a few " ... ...

    Abstract Replication of the malarial parasite in human erythrocytes requires massive zinc fluxes, necessitating the action of zinc transporters across the parasite plasma and organellar membranes. Although genetic knockout studies have been conducted on a few "orphan" zinc transporters in
    Mesh-Begriff(e) Animals ; Humans ; Plasmodium falciparum/metabolism ; Apicoplasts/metabolism ; Parasites ; Cell Membrane ; Erythrocytes/parasitology
    Sprache Englisch
    Erscheinungsdatum 2024-01-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00426
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: HAS (Hajibandeh Index, American Society of Anesthesiologists Status, and Sarcopenia) Model Versus NELA (National Emergency Laparotomy Audit) Score in Predicting the Risk of Mortality After Emergency Laparotomy: A Retrospective Cohort Study.

    Linganathan, Saranya / Hughes, Ioan / Puthiyakunnel Saji, Alwin / Mitra, Kalyan / Hajibandeh, Shahin / Hajibandeh, Shahab

    Cureus

    2023  Band 15, Heft 12, Seite(n) e50180

    Abstract: Background The National Emergency Laparotomy Audit (NELA) mortality risk score is currently used in the UK to estimate mortality risk after emergency laparotomy. The HAS (Hajibandeh Index, American Society of Anesthesiologists status, and sarcopenia) is ... ...

    Abstract Background The National Emergency Laparotomy Audit (NELA) mortality risk score is currently used in the UK to estimate mortality risk after emergency laparotomy. The HAS (Hajibandeh Index, American Society of Anesthesiologists status, and sarcopenia) is a novel model with excellent accuracy in predicting the risk of mortality after emergency laparotomy. This study aimed to compare the predictive performance of the HAS model and NELA score in estimating mortality risk following emergency laparotomy. Methodology A retrospective cohort study was conducted including consecutive adult patients who underwent emergency laparotomy between January 2019 and January 2022. Thirty-day mortality was the primary outcome. In-hospital mortality and 90-day mortality were the secondary outcomes. The predictive tools were compared in terms of discrimination via receiver operating characteristic curve analysis, calibration via the Hosmer-Lemeshow test, and classification via classification table. Results Analysis of 818 patients showed that the area under the curve of HAS was superior to NELA for 30-day mortality (0.97 vs. 0.86, p < 0.0001), in-hospital mortality (0.90 vs. 0.83, p = 0.0004), and 90-day mortality (0.90 vs. 0.83, p = 0.0004). HAS demonstrated good calibration for 30-day mortality (p = 0.286), in-hospital mortality (p = 0.48), and 90-day mortality (p = 0.48) while NELA score showed poor calibration for 30-day mortality (p = 0.001), in-hospital mortality (p = 0.001), and 90-day mortality (p = 0.001). Conclusions The HAS model was superior to the NELA score in predicting mortality after emergency laparotomy. The HAS model may be worth paying attention to for external validation.
    Sprache Englisch
    Erscheinungsdatum 2023-12-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50180
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  4. Artikel ; Online: In vitro leishmanicidal effects of the anti-fungal drug natamycin are mediated through disruption of calcium homeostasis and mitochondrial dysfunction.

    Awasthi, Bhanu Priya / Mitra, Kalyan

    Apoptosis : an international journal on programmed cell death

    2018  Band 23, Heft 7-8, Seite(n) 420–435

    Abstract: Natamycin, a Food and Drug Administration approved anti-fungal drug, and also used as a food additive was evaluated for anti-leishmanial activity since it is known to specifically bind to ergosterol, which is essential to these parasites but absent in ... ...

    Abstract Natamycin, a Food and Drug Administration approved anti-fungal drug, and also used as a food additive was evaluated for anti-leishmanial activity since it is known to specifically bind to ergosterol, which is essential to these parasites but absent in mammals. Promising anti-proliferative activity was observed in both promastigote and amastigote forms of the parasite with IC
    Mesh-Begriff(e) Animals ; Apoptosis/drug effects ; Calcium/metabolism ; Cytosol/metabolism ; Homeostasis/drug effects ; Leishmania donovani/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Natamycin/pharmacology ; Reactive Oxygen Species/metabolism
    Chemische Substanzen Reactive Oxygen Species ; Natamycin (8O0C852CPO) ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2018-07-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452360-7
    ISSN 1573-675X ; 1360-8185
    ISSN (online) 1573-675X
    ISSN 1360-8185
    DOI 10.1007/s10495-018-1468-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Fully inkjet-printed flexible organic voltage inverters as a basic component in digital NOT gates.

    Luczak, Adam / Mitra, Kalyan Y / Baumann, Reinhard R / Zichner, Ralf / Luszczynska, Beata / Jung, Jaroslaw

    Scientific reports

    2022  Band 12, Heft 1, Seite(n) 10887

    Abstract: In relation to conventional vacuum-based processing techniques inkjet printing enables upscaling fabrication of basic electronic elements, such as transistors and diodes. We present the fully inkjet printed flexible electronic circuits, including organic ...

    Abstract In relation to conventional vacuum-based processing techniques inkjet printing enables upscaling fabrication of basic electronic elements, such as transistors and diodes. We present the fully inkjet printed flexible electronic circuits, including organic voltage inverter which can work as a NOT logic gate. For this purpose the special ink compositions were formulated to preparation of gate dielectric layer containing poly (4-vinylphenol) and of the semiconductor layer poly[2,5-(2-octyldodecyl)-3,6-diketopyrrolopyrrole-alt-5,5-(2,5-di(thien-2-yl)thieno [3,2-b]thiophene)]. A printed photoxidized poly (3-hexyltiophene) semiconductor was used as the active layer of the resistors. The operation of the printed inverters and NOT logic gates was analyzed based on the DC current-voltage characteristics of the devices. The resistance of the devices to atmospheric air was also tested. Not encapsulated samples stored for three years under ambient conditions. Followed by annealing to remove moisture showed unchanged electrical parameters in comparison to freshly printed samples.
    Sprache Englisch
    Erscheinungsdatum 2022-06-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-14797-4
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  6. Artikel: Downregulation of gamma subunit of TCP1 chaperonin of Leishmania donovani modulates extracellular vesicles-mediated macrophage microbicidal function

    Yadav, Shailendra / Anand, Apeksha / Chandra Balodi, Deep / Ramalingam, Karthik / Mitra, Kalyan / Maras, Jaswinder Singh / Goyal, Neena

    Microbial pathogenesis. 2022 Aug., v. 169

    2022  

    Abstract: T-complex protein-1 (TCP1) is a group II chaperonin, known to fold various proteins like actin and tubulin. In Leishmania donovani only one subunit that is gamma subunit (LdTCP1γ) has been functionally characterized as a homo-oligomeric complex that ... ...

    Abstract T-complex protein-1 (TCP1) is a group II chaperonin, known to fold various proteins like actin and tubulin. In Leishmania donovani only one subunit that is gamma subunit (LdTCP1γ) has been functionally characterized as a homo-oligomeric complex that exhibits ATP-dependent protein folding. The gene is essential for the survival and infectivity of the parasite. Leishmania parasite releases extracellular vesicles (EVs) containing numerous virulence factors, which play an essential role in parasite pathogenesis and modulate host immune cell signaling. The present study demonstrates that LdTCP1γ is secreted in the EVs and modulates host macrophage functions. EVs isolated from LdTCP1γ single-allele-replacement mutants significantly upregulate the microbicidal function of LPS-induced macrophage as evident by increased levels of proinflammatory cytokines (TNF-α, IL-6), iNOS and NO production. Further, the comparative proteomics of wild-type and single-allele-replacement mutant EVs showed that out of 876 identified proteins, 207 were significantly modulated. Among them, the top 50 modulated and abundantly secreted proteins constitute ∼40% of the total identified protein intensity and include virulence factors such as GP63, peroxiredoxin, enolase, HSP70, elongation factor 2, amastin, eukaryotic translation initiation factor and α-tubulin. The comparative proteomic analysis revealed that the proteome enrichment of the EVs from LdTCP1γ single-allele replacement mutants significantly differs from wild-type EVs, which may be responsible for the altered host microbicidal responses. Thus, our data provide new insight into the role of LdTCP1γ in EVs-mediated host-parasite interactions.
    Schlagwörter Leishmania donovani ; actin ; chaperonins ; genes ; interleukin-6 ; macrophages ; mutants ; parasites ; pathogenesis ; peptide elongation factors ; peroxiredoxin ; phosphopyruvate hydratase ; proteome ; proteomics ; tubulin ; virulence
    Sprache Englisch
    Erscheinungsverlauf 2022-08
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2022.105616
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Characterization of a Myeloid Differentiation Factor 2-Derived Peptide that Facilitates THP-1 Macrophage-Mediated Phagocytosis of Gram-Negative Bacteria.

    Tandon, Anshika / Harioudh, Munesh Kumar / Verma, Neeraj Kumar / Saroj, Jyotshana / Gupta, Arvind / Pant, Garima / Tripathi, Jitendra Kumar / Kumar, Amit / Kumari, Tripti / Tripathi, Amit Kumar / Mitra, Kalyan / Ghosh, Jimut Kanti

    ACS infectious diseases

    2024  Band 10, Heft 3, Seite(n) 845–857

    Abstract: Myeloid differentiation factor 2 (MD2), the TLR4 coreceptor, has been shown to possess opsonic activity and has been implicated in phagocytosis and intracellular killing of Gram-negative bacteria. However, any MD2 protein segment involved in phagocytosis ...

    Abstract Myeloid differentiation factor 2 (MD2), the TLR4 coreceptor, has been shown to possess opsonic activity and has been implicated in phagocytosis and intracellular killing of Gram-negative bacteria. However, any MD2 protein segment involved in phagocytosis of Gram-negative bacteria is not yet known. A short synthetic MD2 segment, MD54 (amino acid regions 54 to 69), was shown to interact with a Gram-negative bacterial outer membrane component, LPS, earlier. Furthermore, the MD54 peptide induced aggregation of LPS and facilitated its internalization in THP-1 cells. Currently, it has been investigated if MD2-derived MD54 possesses any opsonic property and role in phagocytosis of Gram-negative bacteria. Remarkably, we observed that MD54 facilitated agglutination of Gram-negative bacteria,
    Mesh-Begriff(e) Animals ; Mice ; Lipopolysaccharides/metabolism ; Escherichia coli/metabolism ; Phagocytosis ; Macrophages/metabolism ; Gram-Negative Bacteria/metabolism
    Chemische Substanzen Lipopolysaccharides
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00274
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  8. Artikel ; Online: Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma.

    Ishteyaque, Sharmeen / Singh, Gurvinder / Yadav, Karan Singh / Verma, Smriti / Sharma, Rakesh Kumar / Sen, Sumati / Srivastava, Anurag Kumar / Mitra, Kalyan / Lahiri, Amit / Bawankule, Dnyaneshwar U / Rath, Srikanta Kumar / Kumar, Dinesh / Mugale, Madhav Nilakanth

    Metabolism: clinical and experimental

    2024  Band 152, Seite(n) 155771

    Abstract: Background: Hepatocellular carcinoma (HCC) continues to pose a significant health challenge and is often diagnosed at advanced stages. Metabolic reprogramming is a hallmark of many cancer types, including HCC and it involves alterations in various ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) continues to pose a significant health challenge and is often diagnosed at advanced stages. Metabolic reprogramming is a hallmark of many cancer types, including HCC and it involves alterations in various metabolic or nutrient-sensing pathways within liver cells to facilitate the rapid growth and progression of tumours. However, the role of STAT3-NFκB in metabolic reprogramming is still not clear.
    Approach and results: Diethylnitrosamine (DEN) administered animals showed decreased body weight and elevated level of serum enzymes. Also, Transmission electron microscopy (TEM) analysis revealed ultrastructural alterations. Increased phosphorylated signal transducer and activator of transcription-3 (p-STAT3), phosphorylated nuclear factor kappa B (p-NFκβ), dynamin related protein 1 (Drp-1) and alpha-fetoprotein (AFP) expression enhance the carcinogenicity as revealed in immunohistochemistry (IHC). The enzyme-linked immunosorbent assay (ELISA) concentration of IL-6 was found to be elevated in time dependent manner both in blood serum and liver tissue. Moreover, immunoblot analysis showed increased level of p-STAT3, p-NFκβ and IL-6 stimulated the upregulation of mitophagy proteins such as Drp-1, Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK-1). Meanwhile, downregulation of Poly [ADP-ribose] polymerase 1 (PARP-1) and cleaved caspase 3 suppresses apoptosis and enhanced expression of AFP supports tumorigenesis. The mRNA level of STAT3 and Drp-1 was also found to be significantly increased. Furthermore, we performed high-field 800 MHz Nuclear Magnetic Resonance (NMR) based tissue and serum metabolomics analysis to identify metabolic signatures associated with the progression of liver cancer. The metabolomics findings revealed aberrant metabolic alterations in liver tissue and serum of 75th and 105th days of intervention groups in comparison to control, 15th and 45th days of intervention groups. Tissue metabolomics analysis revealed the accumulation of succinate in the liver tissue samples, whereas, serum metabolomics analysis revealed significantly decreased circulatory levels of ketone bodies (such as 3-hydroxybutyrate, acetate, acetone, etc.) and membrane metabolites suggesting activated ketolysis in advanced stages of liver cancer.
    Conclusion: STAT3-NFκβ signaling axis has a significant role in mitochondrial dysfunction and metabolic alterations in the development of HCC.
    Mesh-Begriff(e) Animals ; alpha-Fetoproteins/metabolism ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Interleukin-6/metabolism ; Liver Neoplasms/complications ; Liver Neoplasms/metabolism ; Mitochondrial Diseases/etiology ; Mitochondrial Diseases/metabolism ; NF-kappa B/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction
    Chemische Substanzen alpha-Fetoproteins ; Interleukin-6 ; NF-kappa B ; STAT3 Transcription Factor
    Sprache Englisch
    Erscheinungsdatum 2024-01-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2023.155771
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Sarcopenia versus clinical frailty scale in predicting the risk of postoperative mortality after emergency laparotomy: a retrospective cohort study.

    Hajibandeh, Shahab / Hajibandeh, Shahin / Brown, Christopher / Harper, Elizabeth Ryan / Saji, Alwin Puthiyakunnel / Hughes, Ioan / Mitra, Kalyan / Rashwany, Hind / Clayton, Amy / Patel, Neil / Abdelrahman, Tarig / Foliaki, Antonio / Kumar, Nagappan

    Langenbeck's archives of surgery

    2024  Band 409, Heft 1, Seite(n) 59

    Abstract: Objectives: To compare predictive significance of sarcopenia and clinical frailty scale (CFS) in terms of postoperative mortality in patients undergoing emergency laparotomy METHODS: In compliance with STROCSS statement standards, a retrospective cohort ...

    Abstract Objectives: To compare predictive significance of sarcopenia and clinical frailty scale (CFS) in terms of postoperative mortality in patients undergoing emergency laparotomy METHODS: In compliance with STROCSS statement standards, a retrospective cohort study with prospective data collection approach was conducted. The study period was between January 2017 and January 2022. All adult patients with non-traumatic acute abdominal pathology who underwent emergency laparotomy in our centre were included. The primary outcome was 30-day mortality and secondary outcomes were in-hospital mortality and 90-day mortality. The predictive value of sarcopenia and CFS were compared using the receiver operating characteristic (ROC) curve analysis and multivariable binary logistic regression analysis.
    Results: A total of 1043 eligible patients were included. The risk of 30-day mortality, in-hospital mortality, and 90-day mortality were 8%, 10%, and 11%, respectively. ROC curve analysis suggested that sarcopenia is a significantly stronger predictor of 30-day mortality (AUC: 0.87 vs. 0.70, P<0.0001), in-hospital mortality (AUC: 0.79 vs. 0.67, P=0.0011), and 90-day mortality (AUC: 0.79 vs. 0.67, P=0.0009) compared with CFS. Moreover, multivariable binary logistic regression analysis identified sarcopenia as an independent predictor of mortality [coefficient: 4.333, OR: 76.16 (95% CI 37.06-156.52), P<0.0001] but not the CFS [coefficient: 0.096, OR: 1.10 (95% CI 0.88-1.38), P=0.4047].
    Conclusions: Sarcopenia is a stronger predictor of postoperative mortality compared with CFS in patients undergoing emergency laparotomy. It cancels out the predictive value of clinical frailty scale in multivariable analyses; hence among the two variables, sarcopenia deserves to be included in preoperative predictive tools.
    Mesh-Begriff(e) Adult ; Humans ; Risk Factors ; Frailty/complications ; Frailty/diagnosis ; Sarcopenia/complications ; Laparotomy/adverse effects ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2024-02-14
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03252-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Quantification of Arbortristoside-A isolated from Nyctanthes arbor-tristis using HPLC: Method development and pharmaceutical applications.

    Gupta, Deepak / Singh, Sanjay / Tiwari, Amrendra K / Yadav, Pavan K / Sharma, Deepak / Mishra, Anjali / Kumar, Akhilesh / Bhatta, Rabi Sankar / Kanojiya, Sanjeev / Mitra, Kalyan / Narender, Tadigoppula / Patil, Umesh K / Jain, Sanjay K / Chourasia, Manish K

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2024  Band 1233, Seite(n) 123985

    Abstract: Arbortristoside-A (Arbor-A) is a naturally occurring iridoid glycoside and herbal-based lead molecule with proven medicinal potential. Aiming at the development of an efficient analytical tool for the quantification of Arbor-A in pharmaceutical dosage ... ...

    Abstract Arbortristoside-A (Arbor-A) is a naturally occurring iridoid glycoside and herbal-based lead molecule with proven medicinal potential. Aiming at the development of an efficient analytical tool for the quantification of Arbor-A in pharmaceutical dosage forms, in the presented work, we developed an economical, fast, and sensitive RP-HPLC-UV method and validated the procedure as per the ICH guidelines, Q2(R1). The chromatographic separation was accomplished under the optimised experimental conditions using an HPLC system with an LC-2010 autosampler, a PDA detector, and a Phenomenex C18 column with the mobile phase composed of a 70:30 (v/v) water-acetonitrile mixture eluting isocratically at a flow rate of 1 mL/min at ambient temperature, and UV detection at 310 nm. Arbor-A showed a sharp peak at the retention time of 5.60 min and exhibited linearity (R
    Mesh-Begriff(e) Chromatography, High Pressure Liquid/methods ; Limit of Detection ; Drug Stability ; Reproducibility of Results ; Pharmaceutical Preparations ; Iridoid Glucosides
    Chemische Substanzen arbortristoside A ; Pharmaceutical Preparations ; Iridoid Glucosides
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2023.123985
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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