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Article ; Online: Retraction Note: Barbaloin: an amazing chemical from the 'wonder plant' with multidimensional pharmacological attributes.

Mitra, Shreya Sikdar / Ghorai, Mimosa / Nandy, Samapika / Mukherjee, Nobendu / Kumar, Manoj / Radha / Ghosh, Arabinda / Jha, Niraj Kumar / Proćków, Jarosław / Dey, Abhijit

Naunyn-Schmiedeberg's archives of pharmacology

2024

Language	English
Publishing date	2024-04-13
Publishing country	Germany
Document type	Retraction of Publication
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-024-03064-0
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Article: Corrigendum: Phytotherapy for attention deficit hyperactivity disorder (ADHD): a systematic review and meta-analysis.

Dutta, Tusheema / Anand, Uttpal / Mitra, Shreya Sikdar / Ghorai, Mimosa / Jha, Niraj Kumar / Shaikh, Nusratbanu K / Shekhawat, Mahipal S / Pandey, Devendra Kumar / Proćków, Jarosław / Dey, Abhijit

Frontiers in pharmacology

2024 Volume 15, Page(s) 1365806

Abstract: This corrects the article DOI: 10.3389/fphar.2022.827411.]. ...

Abstract	[This corrects the article DOI: 10.3389/fphar.2022.827411.].
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1365806
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Article ; Online: Barbaloin: an amazing chemical from the 'wonder plant' with multidimensional pharmacological attributes.

Mitra, Shreya Sikdar / Ghorai, Mimosa / Nandy, Samapika / Mukherjee, Nobendu / Kumar, Manoj / Radha / Ghosh, Arabinda / Jha, Niraj Kumar / Proćków, Jarosław / Dey, Abhijit

publication RETRACTED

Naunyn-Schmiedeberg's archives of pharmacology

2022 Volume 395, Issue 12, Page(s) 1525–1536

Abstract: Aloe vera (L.) Burm.f. is nicknamed the 'Miracle plant' or sometimes as the 'Wonder plant'. It is a plant that has been used since ancient times for the innumerable health benefits associated with it. It is one of the important plants that has its use in ...

Abstract	Aloe vera (L.) Burm.f. is nicknamed the 'Miracle plant' or sometimes as the 'Wonder plant'. It is a plant that has been used since ancient times for the innumerable health benefits associated with it. It is one of the important plants that has its use in conventional medicinal treatments. It is a perennial succulent, drought-tolerant member of the family Asphodelaceae. There are scores of properties associated with the plant that help in curing various forms of human ailments. Extracts and gels obtained from plants have been shown to be wonderful healers of different conditions, mainly various skin problems. Also, this plant is popular in the cosmetics industry. The underlying properties of the plant are now mainly associated with the natural phytochemicals present in the plant. Diverse groups of phytoingredients are found in the plant, including various phenolics, amino acids, sugars, vitamins, and different other organic compounds, too. One of the primary ingredients found in the plant is the aloin molecule. It is an anthraquinone derivative and exists as an isomer of Aloin A and Aloin B. Barbaloin belonging to the first group is a glucoside of the aloe-emodin anthrone molecule. Various types of pharmacological properties exhibited by the plant can be attributed to this chemical. Few significant ones are antioxidant, anti-inflammatory, anti-diabetic, anti-cancer, anti-microbial, and anti-viral, along with their different immunity-boosting actions. Recently, molecular coupling studies have also found the role of these molecules as a potential cure against the ongoing COVID-19 disease. This study comprehensively focuses on the numerous pharmacological actions of the primary compound barbaloin obtained from the Aloe vera plant along with the mechanism of action and the potent application of these natural molecules under various conditions.
MeSH term(s)	Humans ; COVID-19 ; Aloe/chemistry ; Anthracenes/pharmacology ; Phytochemicals/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
Chemical Substances	barbaloin (1415-73-2) ; Anthracenes ; Phytochemicals ; alloin (W41H6S09F4) ; Plant Extracts
Language	English
Publishing date	2022-09-29
Publishing country	Germany
Document type	Journal Article ; Review ; Retracted Publication
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-022-02294-4
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Article ; Online: Harnessing and bioprospecting botanical-based herbal medicines against potential drug targets for COVID-19: a review coupled molecular docking studies.

Pal, Tarun / Anand, Uttpal / Sikdar Mitra, Shreya / Biswas, Protha / Tripathi, Vijay / Proćków, Jarosław / Dey, Abhijit / Pérez de la Lastra, José M

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–23

Abstract: Since the end of February 2020, the world has come to a standstill due to the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Since then, the global scientific community has explored various remedies and treatments against this virus, ...

Abstract	Since the end of February 2020, the world has come to a standstill due to the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Since then, the global scientific community has explored various remedies and treatments against this virus, including natural products that have always been a choice because of their many benefits. Various known phytochemicals are well documented for their antiviral properties. Research is being carried out to discover new natural plant products or existing ones as a treatment measure for this disease. The three important targets in this regard are-papain like protease (PLpro), spike protein, and 3 chymotrypsin like proteases (3CLpro). Various docking studies are also being elucidated to identify the phytochemicals that modulate crucial proteins of the virus. The paper is simultaneously a comprehensive review that covers recent advances in the domain of the effect of various botanically derived natural products as an alternative treatment approach against Coronavirus Disease 2019 (COVID-19). Furthermore, the docking analyses revealed that rutin (inhibitor of the major protease of SARS-CoV-2), gallocatechin (e.g., interacting with 03 hydrogen bonds with a spike-like protein), lycorine (showing the best binding affinity with amino acids GLN498, THR500 and GLY446 of the spike-like protein), and quercetrin (inhabiting at its residues ASP216, PHE219, and ILE259) are promising inhibitors of SARS‑CoV‑2.Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2187634
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Article: Phytotherapy for Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis.

Dutta, Tusheema / Anand, Uttpal / Mitra, Shreya Sikdar / Ghorai, Mimosa / Jha, Niraj Kumar / Shaikh, Nusratbanu K / Shekhawat, Mahipal S / Pandey, Devendra Kumar / Proćków, Jarosław / Dey, Abhijit

Frontiers in pharmacology

2022 Volume 13, Page(s) 827411

Abstract: Attention deficit hyperactivity disorder (ADHD) is commonly a neurodevelopmental behavioural disorder in children and adolescents. Mainly characterized by symptoms like lack of attention, hyperactivity, and impulsiveness, it can impact the overall mental ...

Abstract	Attention deficit hyperactivity disorder (ADHD) is commonly a neurodevelopmental behavioural disorder in children and adolescents. Mainly characterized by symptoms like lack of attention, hyperactivity, and impulsiveness, it can impact the overall mental development of the one affected. Several factors, both genetic and non-genetic, can be responsible for this disorder. Although several traditional treatment methods involve medication and other counselling techniques, they also come with different side effects. Hence, the choice is now shifting to alternative treatment techniques. Herbal treatments are considered one of the most popular complementary and alternative medicine (CAM) administered. However, issues related to the safety and efficacy of herbal remedies for the treatment of ADHD need to be investigated further. This study aims to find out the recent advancement in evidence-based use of herbal remedies for ADHD by a comprehensive and systematic review that depicts the results of the published works on herbal therapy for the disorder. The electronic databases and the references retrieved from the included studies present related randomized controlled trials (RCTs) and open-label studies. Seven RCTs involving children and adolescents diagnosed with ADHD met the inclusion criteria. There is a fair indication of the efficacy and safety of Melissa officinalis L., Bacopa monnieri (L.) Wettst., Matricaria chamomilla L., and Valeriana officinalis L. from the studies evaluated in this systematic review for the treatment of various symptoms of ADHD. Limited evidence was found for Ginkgo biloba L. and pine bark extract. However, various other preparations from other plants did not show significant efficacy. There is inadequate proof to strongly support and recommend the administration of herbal medicines for ADHD, but more research is needed in the relevant field to popularize the alternative treatment approach.
Language	English
Publishing date	2022-05-03
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.827411
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Article: On shrimp, salt and security: livelihood risks and responses in South Bangladesh and East India

Vivekananda, Janani / Schilling, Janpeter / Mitra, Shreya / Pandey, Nisha

Environment, development and sustainability. 2014 Dec., v. 16, no. 6

2014

Abstract: Bangladesh and India are among the world’s most populous but also most vulnerable countries to environmental risks. In addition to storms, sea-level rise, floods and droughts, local communities face a multitude of pre-existing and concomitant economic ... ...

Abstract	Bangladesh and India are among the world’s most populous but also most vulnerable countries to environmental risks. In addition to storms, sea-level rise, floods and droughts, local communities face a multitude of pre-existing and concomitant economic and socio-political risks. To understand these risks and how communities respond to them is critical in securing community livelihoods. We therefore ask what are the livelihood risks; how do they impact the human security of environment sensitive communities in Satkhira, Bangladesh and in Odisha, India; and, what are the responses of these communities to the livelihood risks? The communities studied in Bangladesh depend mainly on the shrimp and fish resources of the Sundarbans mangrove forest. The two communities researched at Lake Chilika in India depend on fishing and salt farming, respectively. The field research, conducted in 2012 and 2013, shows that the communities face multiple and interacting livelihood risks. While storms and floods are common environmental risks in both countries, related livelihood risks are case-specific. In Bangladesh, attacks by criminals are the major threat to human well-being, while in India, it is violent conflict between lake users. Unsustainable resource extraction is found in both study countries. In Bangladesh, shrimp farming weakens the flood protection, while in India, illegal prawn farming marginalizes poorer lake users. Accessing loans and labor migration are responses observed in both countries. We conclude that adaptation to environmental changes needs to be sensitive to the interaction between governance, local institutions and socio-economic developments.
Keywords	anthropogenic activities ; drought ; farming systems ; fish ; flood control ; floods ; governance ; humans ; labor ; lakes ; livelihood ; loans ; mangrove forests ; risk ; sea level ; shrimp ; shrimp culture ; socioeconomics ; storms ; Bangladesh ; India
Language	English
Dates of publication	2014-12
Size	p. 1141-1161.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1438730-x
ISSN	1387-585X
ISSN	1387-585X
DOI	10.1007/s10668-014-9517-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance.

Mitra, Shreya / Molina, Jennifer / Mills, Gordon B / Dennison, Jennifer B

Methods in molecular biology (Clifton, N.J.)

2015 Volume 1298, Page(s) 195–205

Abstract: Rab25, by altering trafficking of critical cellular resources, influences cell metabolism and survival during stress conditions. Overall, perturbations in the vesicular trafficking machinery change cellular bioenergetics that can be directly measured in ... ...

Abstract	Rab25, by altering trafficking of critical cellular resources, influences cell metabolism and survival during stress conditions. Overall, perturbations in the vesicular trafficking machinery change cellular bioenergetics that can be directly measured in real time as Oxygen Consumption Rate, OCR (mitochondrial respiration) and Extracellular Acidification Rate, ECAR (glycolysis) by an extracellular flux analyzer (XF96, Seahorse Biosciences, MA). Additionally, overall turnover of glucose, lactate, as well as glutamine and glutamate can be measured biochemically using the YSI2900 Biochemistry Analyzer (YSI Incorporated, Life Sciences, OH). A combination of these two methods allows a precise and quantitative approach to interrogate the role of Rab25 as well as other Rab GTPases in central carbon energy metabolism.
MeSH term(s)	Cell Line, Tumor ; Energy Metabolism ; Extracellular Space/metabolism ; Humans ; Metabolic Flux Analysis/methods ; rab GTP-Binding Proteins/metabolism
Chemical Substances	Rab25 protein, human ; rab GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-2569-8_17
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Article ; Online: Rab25 in cancer: a brief update.

Mitra, Shreya / Cheng, Kwai W / Mills, Gordon B

Biochemical Society transactions

2012 Volume 40, Issue 6, Page(s) 1404–1408

Abstract: Derailed endocytosis is a hallmark of cancer. The endocytic pathway, as demonstrated by our laboratory, is a frequent target of genomic aberrations in cancer and plays a critical role in the maintenance of cellular polarity, stem cell function, ... ...

Abstract	Derailed endocytosis is a hallmark of cancer. The endocytic pathway, as demonstrated by our laboratory, is a frequent target of genomic aberrations in cancer and plays a critical role in the maintenance of cellular polarity, stem cell function, bioenergetics, proliferation, motility, invasion, metastasis, apoptosis and autophagy. The Rab GTPases, along with their effectors, are critical regulators of this endocytic machinery and can have a huge impact on the cellular itinerary of growth and metabolism. Rab25 is an epithelial-cell-specific member of the Rab GTPase superfamily, sharing close homology with Rab11a, the endosomal recycling Rab GTPase. RAB25 has been implicated in various cancers, with reports presenting it as both an oncogene and a tumour-suppressor gene. At the cellular level, Rab25 was shown to contribute to invasiveness of cancer cells by regulating integrin trafficking. Recently, our laboratory uncovered a critical role for Rab25 in cellular energetics. Assimilating all of the existing evidence, in the present review, we give an updated overview of the complex and often context-dependent role of Rab25 in cancer.
MeSH term(s)	Animals ; Disease Progression ; Genes, Tumor Suppressor ; Humans ; Neoplasms/enzymology ; Neoplasms/genetics ; Neoplasms/pathology ; Oncogenes ; Protein Transport ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism ; rab GTP-Binding Proteins/physiology
Chemical Substances	Rab25 protein, human ; rab GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2012-11-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/BST20120249
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Article: Rab GTPases implicated in inherited and acquired disorders

Mitra, Shreya / Cheng, Kwai W / Mills, Gordon B

Seminars in cell & developmental biology. 2011 Feb., v. 22, no. 1

2011

Abstract: The endocytotic machinery imports, transports and exports receptors and associated molecules between the plasma membrane and various cytoplasmic chambers resulting in selective recycling, degradation, or secretion of molecules and signaling complexes. ... ...

Abstract	The endocytotic machinery imports, transports and exports receptors and associated molecules between the plasma membrane and various cytoplasmic chambers resulting in selective recycling, degradation, or secretion of molecules and signaling complexes. Trafficking of receptors, growth factors, nutrients, cytokines, integrins as well as pathogens dictates the kinetics and magnitude of signal transduction cascades. Understandably, alterations in the ‘fate’ of such cargo complexes have profound physiologic and pathophysiologic implications. Rab GTPases regulate endocytosis by decorating intracellular vesicles and targeting these vesicles along with their cargoes to appropriate subcellular compartments. In the last decade, the number of genetic diseases driven by germline mutations in Rab GTPases or their interacting proteins [1–3], has increased and there is growing evidence of aberrant Rab GTPase function in acquired pathophysiologies such as immune deficiency, infection, obesity, diabetes and cancer.
Keywords	guanosinetriphosphatase ; germ cells ; secretion ; immunosuppression ; nutrients ; cytokines ; mutation ; endocytosis ; genetic disorders ; receptors ; signal transduction ; obesity ; plasma membrane ; diabetes ; integrins ; growth factors ; pathogens
Language	English
Dates of publication	2011-02
Size	p. 57-68.
Publishing place	Elsevier Ltd
Document type	Article
Note	2019-12-04
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2010.12.005
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Article ; Online: Rab GTPases implicated in inherited and acquired disorders.

Mitra, Shreya / Cheng, Kwai W / Mills, Gordon B

Seminars in cell & developmental biology

2010 Volume 22, Issue 1, Page(s) 57–68

Abstract	The endocytotic machinery imports, transports and exports receptors and associated molecules between the plasma membrane and various cytoplasmic chambers resulting in selective recycling, degradation, or secretion of molecules and signaling complexes. Trafficking of receptors, growth factors, nutrients, cytokines, integrins as well as pathogens dictates the kinetics and magnitude of signal transduction cascades. Understandably, alterations in the 'fate' of such cargo complexes have profound physiologic and pathophysiologic implications. Rab GTPases regulate endocytosis by decorating intracellular vesicles and targeting these vesicles along with their cargoes to appropriate subcellular compartments. In the last decade, the number of genetic diseases driven by germline mutations in Rab GTPases or their interacting proteins, has increased and there is growing evidence of aberrant Rab GTPase function in acquired pathophysiologies such as immune deficiency, infection, obesity, diabetes and cancer.
MeSH term(s)	Animals ; Biological Transport ; Endocytosis ; Genetic Predisposition to Disease ; Humans ; Mutation ; Transport Vesicles/enzymology ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
Chemical Substances	rab GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2010-12-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2010.12.005
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