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  1. Article ; Online: Being an Oncologist-How I Evolved.

    Mitra, Swarupa

    Practical radiation oncology

    2024  

    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2024.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lipstick Beneath My Cast.

    Mitra, Swarupa

    Practical radiation oncology

    2022  Volume 12, Issue 6, Page(s) e474–e475

    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2022.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mending the Rent: Knife Versus Rays Versus Syringe.

    Dewan, Abhinav / Mitra, Swarupa

    International journal of radiation oncology, biology, physics

    2022  Volume 113, Issue 4, Page(s) 714–715

    MeSH term(s) Humans ; Syringes
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Translating the COVID-19 experience in widening the HPV vaccination campaign for cervical cancer in India.

    Ghose, Aruni / Agarwal, Anisha / Sirohi, Bhawna / Nag, Shona / Chuang, Linus / Mitra, Swarupa

    Gynecologic oncology reports

    2023  Volume 48, Page(s) 101247

    Abstract: India has proven by the success of COVID vaccination that it has a huge production and distribution capacity, availability of professionally trained medical staff, world renowned digital infrastructure to enrol people, conduct camps and maintain records, ...

    Abstract India has proven by the success of COVID vaccination that it has a huge production and distribution capacity, availability of professionally trained medical staff, world renowned digital infrastructure to enrol people, conduct camps and maintain records, and a positive mindset among the people towards vaccination. There is an unmet need to enforce that cervical cancer is a "preventable tragedy," and vaccination is an invaluable way ahead. With this article, we hope to attract attention to translating India's successful COVID-19 vaccination campaign experience to developing the HPV vaccination campaign.
    Language English
    Publishing date 2023-07-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2023.101247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Carcinosarcoma prostate with osteosarcomatous differentiation: a rare de novo presentation.

    Aggarwal, Sumeet / Mitra, Swarupa / Dewan, Abhinav / Durga, Garima

    BMJ case reports

    2019  Volume 12, Issue 6

    Abstract: Carcinosarcoma is a rare histological event in the history of prostatic malignancies. Historically aggressive tumours with dismal outcomes reported in scarce literature available so far. Very few recent studies suggest good outcomes with modern era ... ...

    Abstract Carcinosarcoma is a rare histological event in the history of prostatic malignancies. Historically aggressive tumours with dismal outcomes reported in scarce literature available so far. Very few recent studies suggest good outcomes with modern era surgery and radiotherapy techniques in localised disease. The case presented here had no history of known risk factors like prior adenocarcinoma or prior radiation therapy. This case presented with obstructive urinary symptoms with no prostate-specific antigen elevation, diagnosed with imaging, managed aggressively with robotic surgery. Detailed immunohistochemistry and pathological review suggested diagnosis as carcinosarcoma with osteosarcomatous differentiation. Very rare such cases were reported in the past with complete clinical, radiological, pathological details and managed aggressively with good outcomes. The patient is disease free after 6 months of follow-up.
    MeSH term(s) Bone Neoplasms/pathology ; Carcinosarcoma/pathology ; Humans ; Male ; Middle Aged ; Osteosarcoma/pathology ; Prostate/pathology ; Prostatic Neoplasms/pathology
    Language English
    Publishing date 2019-06-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-230116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multimodality management of gallbladder cancer can lead to a better outcome: Experience from a tertiary care oncology centre in North India.

    Goel, Shaifali / Aggarwal, Abhishek / Iqbal, Assif / Talwar, Vineet / Mitra, Swarupa / Singh, Shivendra

    World journal of gastroenterology

    2021  Volume 27, Issue 45, Page(s) 7813–7830

    Abstract: Background: Surgical resection is a treatment of choice for gallbladder cancer (GBC) patients but only 10% of patients have a resectable disease at presentation. Even after surgical resection, overall survival (OS) has been poor due to high rates of ... ...

    Abstract Background: Surgical resection is a treatment of choice for gallbladder cancer (GBC) patients but only 10% of patients have a resectable disease at presentation. Even after surgical resection, overall survival (OS) has been poor due to high rates of recurrence. Combination of surgery and systemic therapy can improve outcomes in this aggressive disease.
    Aim: To summarize our single-center experience with multimodality management of resectable GBC patients.
    Methods: Data of all patients undergoing surgery for suspected GBC from January 2012 to December 2018 was retrieved from a prospectively maintained electronic database. Information extracted included demographics, operative and perioperative details, histopathology, neoadjuvant/adjuvant therapy, follow-up, and recurrence. To know the factors associated with recurrence and OS, univariate and multivariate analysis was done using log rank test and cox proportional hazard analysis for categorical and continuous variables, respectively. Multivariate analysis was done using multiple regression analysis.
    Results: Of 274 patients with GBC taken up for surgical resection, 172 (62.7%) were female and the median age was 56 years. On exploration, 102 patients were found to have a metastatic or unresectable disease (distant metastasis in 66 and locally unresectable in 34). Of 172 patients who finally underwent surgery, 93 (54%) underwent wedge resection followed by anatomical segment IVb/V resection in 66 (38.4%) and modified extended right hepatectomy in 12 (7%) patients. The postoperative mortality at 90 d was 4.6%. During a median follow-up period of 20 mo, 71 (41.2%) patients developed recurrence. Estimated 1-, 3-, and 5-years OS rates were 86.5%, 56%, and 43.5%, respectively. Estimated 1- and 3-year disease free survival (DFS) rates were 75% and 49.2%, respectively. On multivariate analysis, inferior OS was seen with pT3/T4 tumor (
    Conclusion: Multimodality treatment significantly improves the 5-year survival rate of patients with GBC up to 43%. R+ resection, higher T stage, and perineural invasion adversely affect the outcome and should be considered for systemic therapy in addition to surgery to optimize the outcomes. Multimodality treatment of GBC has potential to improve the survival of GBC patients.
    MeSH term(s) Female ; Gallbladder Neoplasms/pathology ; Gallbladder Neoplasms/surgery ; Hepatectomy ; Humans ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Retrospective Studies ; Survival Rate ; Tertiary Healthcare
    Language English
    Publishing date 2021-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v27.i45.7813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dosimetric analysis of intensity-modulated radiation therapy and volumetric-modulated arc therapy in comparison with conventional box technique in the treatment of carcinoma cervix: An impact of prosthetic implant.

    Bhushan, Manindra / Tripathi, Deepak / Yadav, Girigesh / Kumar, Lalit / Chowdhary, Rahul Lal / Pahuja, Anjali K / Suhail, Mahamood / Mitra, Swarupa / Gairola, Munish

    Journal of cancer research and therapeutics

    2022  Volume 18, Issue 6, Page(s) 1504–1512

    Abstract: Introduction: The number of patients for carcinoma cervix with implanted hip prostheses has been increasing worldwide during the past several decades. Technological advancements are useful for delivering higher doses, i.e., dose escalation to the target, ...

    Abstract Introduction: The number of patients for carcinoma cervix with implanted hip prostheses has been increasing worldwide during the past several decades. Technological advancements are useful for delivering higher doses, i.e., dose escalation to the target, but the presence of high-density implanted hip prosthesis creates challenges for the planner.
    Materials and methods: A population of 25 patients was selected for the study. Plans were generated using the MONACO treatment planning system keeping the isocenter same. The parameters evaluated for planning target volume (PTV) were D
    Results: D
    Discussion: Radiotherapy is standard care of practice for known cases of cervical malignancies. As per our investigations, VMAT has generated comparable plans in terms of target coverage (D
    Conclusion: VMAT has an edge over other techniques in terms of target coverage and sparing of critical organs in the presence of metallic prosthesis. Information about the geometry and density of prosthesis will be beneficial for treatment planning.
    MeSH term(s) Female ; Humans ; Radiotherapy, Intensity-Modulated/methods ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy Dosage ; Uterine Cervical Neoplasms/radiotherapy ; Cervix Uteri ; Carcinoma ; Prostheses and Implants
    Language English
    Publishing date 2022-11-22
    Publishing country India
    Document type Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.JCRT_835_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Survival and Recurrence Patterns in Patients With Stomach Adenocarcinoma Receiving Chemotherapy or Chemoradiotherapy After D2 Gastrectomy in a Tertiary Care Cancer Institute: A Retrospective Real-World Evidence Cohort Study.

    Mitra, Swarupa / Simson, David K / Gehani, Manish / Barik, Soumitra / Khurana, Ruparna / Singh, Shivendra / Talwar, Vineet / Goel, Varun / Khurana, Himanshi / Mishra, Manindra / Dewan, Abhinav / Mukhi, M Jwala

    Advances in radiation oncology

    2023  Volume 8, Issue 6, Page(s) 101280

    Abstract: Purpose: Clinical trials comparing the efficacy of adjuvant chemotherapy (CT) and chemo radiation therapy (CTRT) for stomach adenocarcinoma have reported equivocal results. Hence, the current retrospective cohort study assessed the long-term survival ... ...

    Abstract Purpose: Clinical trials comparing the efficacy of adjuvant chemotherapy (CT) and chemo radiation therapy (CTRT) for stomach adenocarcinoma have reported equivocal results. Hence, the current retrospective cohort study assessed the long-term survival and recurrence outcomes of these therapies, to generate evidence in a real-world scenario.
    Methods and materials: Pathologically confirmed patients with stomach adenocarcinoma aged ≥18 years who underwent gastrectomy and D2 lymph nodal dissection at a tertiary cancer hospital from January 2010 to October 2017 were enrolled. Hospital-based follow-up was performed until December 2021. Data were gathered from electronic medical records, supplemented by telephonic interviews for patients who could not come for physical follow-up. CT-alone and CTRT cohorts were compared in terms of survival and recurrence outcomes.
    Results: The analysis included 158 patients (mean age, 56.42 years; 63.9% male; CT-alone cohort, 69; CTRT cohort, 89). Patients in the CTRT cohort had significantly worse tumor characteristics at baseline (29.2% had the diffuse type of tumor, 94.4% had stage II or III, 68.5% had lympho-vascular space invasion, and 85.4% had lymph node involvement). Recurrence was observed in 13 (19.7%) of the 76 followed-up patients. Although locoregional recurrence was higher in the CT-alone cohort (7 vs 2), distant metastasis was higher in the CTRT cohort (3 vs 1). The overall 5-year survival was 67.0% (SE, 5.0%) and 5-year recurrence-free survival (RFS) was 75.0% (SE, 5.0%). On multivariate Cox regression, no variable was significantly associated with the overall survival, whereas age, positive lymph nodes without extracapsular extension, and lymph node-negative were significantly associated with RFS. The CTRT cohort had significantly (84.0%) higher RFS (hazard ratio, 0.161; 95% CI, 0.056-0.464;
    Conclusions: Patients who received adjuvant CTRT after D2 dissection showed similar overall survival but significantly higher RFS than the CT-alone cohort, despite having worse baseline tumor characteristics.
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2023.101280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Management of cervical cancer during the corona virus disease-19 (COVID-19) era.

    Dewan, Abhinav / Mitra, Swarupa / Aggarwal, Sumeet / Barik, Soumitra / Kaur, Inderjeet / Umesh, Preetha / Dewan, Rupali

    The British journal of radiology

    2020  Volume 94, Issue 1117, Page(s) 20200686

    Abstract: COVID-19 pandemic has had a catastrophic impact on the society, economy and heath-care system all over the globe with virus showing no signs of losing potency. As the situation appears to worsen, extra burden on other specialities like oncology seems to ... ...

    Abstract COVID-19 pandemic has had a catastrophic impact on the society, economy and heath-care system all over the globe with virus showing no signs of losing potency. As the situation appears to worsen, extra burden on other specialities like oncology seems to increase. Specific recommendations are necessary for management of cervical cancer in the current context. All concerned specialities must work together in the best interest of the patient. Attempts should be made at managing cervical cancer while limiting the viral spread among the patients and health-care workers without the loss of opportunity. Surgical intervention for early cervical cancer should be postponed or alternative modalities be considered. In a locally advanced disease, concurrent chemoradiation is the treatment of choice. In addition, the following under mentioned suggestions aim to discuss ways of minimizing infection spread, workload rationalization and providing guidance for management of cervical cancer in the presence of COVID-19 infection.
    MeSH term(s) COVID-19/prevention & control ; COVID-19/transmission ; Female ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Uterine Cervical Neoplasms/radiotherapy
    Language English
    Publishing date 2020-11-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20200686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Combination of Radiomics and Machine Learning with Diffusion-Weighted MR Imaging for Clinical Outcome Prognostication in Cervical Cancer.

    Jajodia, Ankush / Gupta, Ayushi / Prosch, Helmut / Mayerhoefer, Marius / Mitra, Swarupa / Pasricha, Sunil / Mehta, Anurag / Puri, Sunil / Chaturvedi, Arvind

    Tomography (Ann Arbor, Mich.)

    2021  Volume 7, Issue 3, Page(s) 344–357

    Abstract: Objectives: To explore the potential of Radiomics alone and in combination with a diffusion-weighted derived quantitative parameter, namely the apparent diffusion co-efficient (ADC), using supervised classification algorithms in the prediction of ... ...

    Abstract Objectives: To explore the potential of Radiomics alone and in combination with a diffusion-weighted derived quantitative parameter, namely the apparent diffusion co-efficient (ADC), using supervised classification algorithms in the prediction of outcomes and prognosis.
    Materials and methods: Retrospective evaluation of the imaging was conducted for a study cohort of uterine cervical cancer, candidates for radical treatment with chemo radiation. ADC values were calculated from the darkest part of the tumor, both before (labeled preADC) and post treatment (labeled postADC) with chemo radiation. Post extraction of 851 Radiomics features and feature selection analysis-by taking the union of the features that had Pearson correlation >0.35 for recurrence, >0.49 for lymph node and >0.40 for metastasis-was performed to predict clinical outcomes.
    Results: The study enrolled 52 patients who presented with variable FIGO stages in the age range of 28-79 (Median = 53 years) with a median follow-up of 26.5 months (range: 7-76 months). Disease recurrence occurred in 12 patients (23%). Metastasis occurred in 15 patients (28%). A model generated with 24 radiomics features and preADC using a monotone multi-layer perceptron neural network to predict the recurrence yields an AUC of 0.80 and a Kappa value of 0.55 and shows that the addition of radiomics features to ADC values improves the statistical metrics by approximately 40% for AUC and approximately 223% for Kappa. Similarly, the neural network model for prediction of metastasis returns an AUC value of 0.84 and a Kappa value of 0.65, thus exceeding performance expectations by approximately 25% for AUC and approximately 140% for Kappa. There was a significant input of GLSZM features (SALGLE and LGLZE) and GLDM features (SDLGLE and DE) in correlation with clinical outcomes of recurrence and metastasis.
    Conclusions: The study is an effort to bridge the unmet need of translational predictive biomarkers in the stratification of uterine cervical cancer patients based on prognosis.
    MeSH term(s) Child ; Child, Preschool ; Diffusion Magnetic Resonance Imaging ; Female ; Humans ; Machine Learning ; Neoplasm Recurrence, Local/diagnostic imaging ; Retrospective Studies ; Uterine Cervical Neoplasms/diagnostic imaging
    Language English
    Publishing date 2021-08-05
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography7030031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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