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Article ; Online: Modulation of the expression of connexins 37, 40, and 43 in endothelial cells in a culture.

Zhuang, Wenqing / Mitrou, Nick G A / Kulak, Steve / Cupples, William A / Braam, Branko

Frontiers in network physiology

2024  Volume 4, Page(s) 1199198

Abstract: Connexin (Cx) 37, 40, and 43 are implicated in vascular function, specifically in the electrical coupling of endothelial cells and vascular smooth-muscle cells. In the present study, we investigated whether factors implicated in vascular dysfunction can ... ...

Abstract Connexin (Cx) 37, 40, and 43 are implicated in vascular function, specifically in the electrical coupling of endothelial cells and vascular smooth-muscle cells. In the present study, we investigated whether factors implicated in vascular dysfunction can modulate the gene expression of Cx37, Cx40, and Cx43 and whether this is associated with changes in endothelial layer barrier function in human microvascular endothelial cells (HMEC-1). First, HMEC-1 were subjected to stimuli for 4 and 8 h. We tested their responses to DETA-NONOate, H
Language English
Publishing date 2024-03-15
Publishing country Switzerland
Document type Journal Article
ISSN 2674-0109
ISSN (online) 2674-0109
DOI 10.3389/fnetp.2024.1199198
Database MEDical Literature Analysis and Retrieval System OnLINE

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