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  1. Article ; Online: Immunotherapy in allergic diseases - improved understanding and innovation for enhanced effectiveness.

    Mitsias, Dimitrios I / Xepapadaki, Paraskevi / Makris, Michael / Papadopoulos, Nikolaos G

    Current opinion in immunology

    2020  Volume 66, Page(s) 1–8

    Abstract: Allergen immunotherapy leads to tolerance through multiple mechanisms that include tolerogenic dendritic cells and T and B regulatory cells. These induced cellular populations produce mediators to skew the immune response to a tolerogenic milieu that, ... ...

    Abstract Allergen immunotherapy leads to tolerance through multiple mechanisms that include tolerogenic dendritic cells and T and B regulatory cells. These induced cellular populations produce mediators to skew the immune response to a tolerogenic milieu that, among others, results in IgG4 blocking antibodies formation and lowered FcE receptors. All lead in decreased effector responses from mast cells, eosinophils, and basophils thus limiting the allergic inflammation. Clinically, this results in better allergic rhinitis control and, of importance, asthma prevention. Newer approaches include modified allergens, second generation adjuvants/carriers and routes of administration, all aiming to increased efficacy with parallel no compromise of safety.
    MeSH term(s) Animals ; Asthma/immunology ; Asthma/prevention & control ; B-Lymphocytes/immunology ; Dendritic Cells/immunology ; Desensitization, Immunologic ; Humans ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/therapy ; T-Lymphocytes/immunology
    Language English
    Publishing date 2020-04-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.02.005
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  2. Article: Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes.

    Mitsias, Dimitrios I / Dimou, Maria V / Lakoumentas, John / Alevizopoulos, Konstantinos / Sousa-Pinto, Bernardo / Fonseca, Joao A / Bousquet, Jean / Papadopoulos, Nikolaos G

    Clinical and translational allergy

    2020  Volume 10, Page(s) 9

    Abstract: Background: Nasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.: Methods: An open-label, controlled, non-randomized, real-life ... ...

    Abstract Background: Nasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.
    Methods: An open-label, controlled, non-randomized, real-life study was conducted to evaluate the effectiveness of NI with a new hypertonic solution as add-on treatment for AR. Children and adolescents with AR were prescribed symptomatic treatment. The active group also received an additional sea-water NI solution supplemented with algae extracts. The primary endpoint was symptom control, assessed by the control of allergic rhinitis and asthma test (CARAT) questionnaires. Moreover, the MASK/Allergy Diary was used to track symptoms and daily medication use that were combined in a novel total symptom/medication score (TSMS).
    Results: We assessed 76 patients. Overall, there was a significant improvement of CARAT results (median Z-score change of 1.1 in the active/NI group vs. 0.4 in the control group;
    Conclusion: Addition of NI with a sea-water solution to regular treatment improved AR symptom control. CARAT questionnaires and MASK application can be useful outcome tools in real-life studies.
    Language English
    Publishing date 2020-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1186/s13601-020-00313-2
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  3. Article ; Online: The Nose as a Route for Therapy: Part 1. Pharmacotherapy.

    Cingi, Cemal / Bayar Muluk, Nuray / Mitsias, Dimitrios I / Papadopoulos, Nikolaos G / Klimek, Ludger / Laulajainen-Hongisto, Anu / Hytönen, Maija / Toppila-Salmi, Sanna Katriina / Scadding, Glenis Kathleen

    Frontiers in allergy

    2021  Volume 2, Page(s) 638136

    Abstract: This article reviews nasal structure and function in the light of intranasal pharmacotherapy. The nose provides an accessible, fast route for local treatment of nose and sinus diseases, with lower doses than are necessary systemically and few adverse ... ...

    Abstract This article reviews nasal structure and function in the light of intranasal pharmacotherapy. The nose provides an accessible, fast route for local treatment of nose and sinus diseases, with lower doses than are necessary systemically and few adverse effects. It can also be used for other medications as it has sufficient surface area protected from local damage by mucociliary clearance, absence of digestive enzymes, responsive blood flow, and provides a rapid route to the central nervous system.
    Language English
    Publishing date 2021-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2021.638136
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  4. Article ; Online: Levels of Immunoglobulin E Sensitization Drive Symptom Thresholds in Allergic Rhinitis.

    Dimou, Maria V / Xepapadaki, Paraskevi / Lakoumentas, John / Mageiros, Leonardos / Aggelidis, Xenophon / Antonopoulou, Maria / Bakakos, Petros / Βotskariova, Sophia / Chliveros, Konstantinos / Chrysoulakis, Spyridon / Dimas, Dionysios / Douladiris, Nikolaos / Gaga, Mina / Grigoreas, Christos / Kalogiros, Lampros / Katotomichelakis, Michael / Kompoti, Evangelia / Constantinidis, Jannis / Koutsogianni, Zoi /
    Loukides, Stelios / Makris, Michael / Manousakis, Emmanouil / Marangoudakis, Pavlos / Marmara, Maria / Mikos, Nikolaos / Mitsakou, Paraskevi / Mitsias, Dimitrios / Pagalos, Aris / Papanikolaou, Vasilios / Paraskevopoulos, Ioannis / Pitsios, Constantinos / Psarros, Fotis / Rovina, Nikoletta / Samitas, Konstantinos / Stefanaki, Evaggelia / Vallianatou, Mina / Vourdas, Dimitrios / Tsiligianni, Ioanna / Bousquet, Jean / Papadopoulos, Nikolaos G

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2024  

    Abstract: Background: Allergic rhinitis (AR) is a common respiratory disease encompassing a variety of phenotypes. Patients can be sensitized to one or more allergens. There are indications that polysensitization is associated with more severe disease. However, ... ...

    Abstract Background: Allergic rhinitis (AR) is a common respiratory disease encompassing a variety of phenotypes. Patients can be sensitized to one or more allergens. There are indications that polysensitization is associated with more severe disease. However, the extent to which the level of sensitization is associated to clinical disease variability, underlying the distinct nature of AR from AR+ conjunctivitis or AR+ asthma, is not known.
    Objective: The aim of this study was to evaluate phenotypical differences between mono- and poly-sensitized patients with AR and to quantify their symptomatic variability.
    Methods: 565 patients with a confirmed diagnosis of AR were included in this cross-sectional study. 155 were mono-sensitized and 410 poly-sensitized. Interactions between sensitization levels and reporting of different symptoms of AR and co-morbidities, disease duration and impact, were assessed. Furthermore, patients were stratified into mono- oligo- and poly-sensitized to assess whether the effect of sensitization on phenotype was ranked.
    Results: Poly-sensitized patients reported significantly more often itchy eyes (p=0.001) and had higher number of ocular (p=0.005), itch-related (p=0.036) and total symptoms (p=0.007) than mono-sensitized patients. In addition, polysensitized adults and children more often reported wheeze (p=0.015) and throat-clearing (p=0.04), respectively. Polysensitization was associated with more burdensome AR according to VAS (p=0.005). Increasing sensitization level was reflected in more itchy eyes, number of ocular, itch-related and total number of symptoms, as well as disease burden.
    Conclusion: With increasing number of sensitizations, AR patients experience an increased diversity of symptoms. Multimorbidity-related symptoms increase with sensitization rank, suggesting organ-specific thresholds.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2024.04.026
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  5. Article: The Allergen Immunotherapy Adverse Events Registry: Setup & methodology of a European Academy of Allergy and Clinical Immunology taskforce project.

    Asllani, Julijana / Mitsias, Dimitrios / Konstantinou, George / Priftanji, Alfred / Hoxha, Mehmet / Sinani, Gerta / Christoff, George / Zlatko, Dimitrov / Makris, Michael / Aggelidis, Xenofon / Stipic, Asja / Popovic-Grle, Sanja / Deleanu, Diana / Tomic-Spiric, Vesna / Plavsic, Aleksandra / Mungan, Dilsad / Kosnik, Mitja / Popov, Todor A / Papadopoulos, Nikolaos G /
    Calderon, Moises

    Clinical and translational allergy

    2023  Volume 13, Issue 6, Page(s) e12266

    Language English
    Publishing date 2023-06-25
    Publishing country England
    Document type Letter
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12266
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  6. Article: Adverse events in children and adolescents undergoing allergen immunotherapy for respiratory allergies-Report from the Allergen Immunotherapy Adverse Events Registry (ADER), a European Academy of Allergy and Clinical Immunology taskforce.

    Asllani, Julijana / Mitsias, Dimitrios / Konstantinou, George / Mesonjesi, Eris / Xhixha, Fatmira / Shehu, Esmeralda / Christoff, George / Noleva, Katia / Makris, Michael / Aggelidis, Xenofon / Turkalj, Mirjana / Damir, Erceg / Agache, Ioana / Tomic-Spiric, Vesna / Stosovic, Rajica / Misirligil, Zeynep / Kosnik, Mitja / Popov, Todor A / Calderon, Moises /
    Papadopoulos, Nikolaos G

    Clinical and translational allergy

    2023  Volume 13, Issue 6, Page(s) e12250

    Abstract: Background: Although it has been shown that allergen immunotherapy (AIT) is well-tolerated in children, systematic and prospective surveillance of AIT safety in real life settings is needed.: Methods: The multinational Allergen Immunotherapy Adverse ... ...

    Abstract Background: Although it has been shown that allergen immunotherapy (AIT) is well-tolerated in children, systematic and prospective surveillance of AIT safety in real life settings is needed.
    Methods: The multinational Allergen Immunotherapy Adverse Events Registry (ADER) was designed to address AIT safety in real life clinical practice. Data on children ≤18 years old with respiratory allergies undergoing AIT were retrieved. Patient- and AIT-related features were collected and analyzed. The characteristics of adverse events (AE) and risk factors were evaluated.
    Results: A total of 851 patients, 11.3 ± 3.4 years old, with rhinitis only (47.6%); asthma and rhinitis (44.5%); asthma (7.9%), receiving 998 AIT courses were analyzed. Sublingual immunotherapy (SLIT) accounted for 51% of the courses. In 84.5% of patients only one AIT treatment was prescribed. Pollen was the most frequent sensitizer (57.1%), followed by mites (53.4%), molds (18.2%) and epithelia (16.7%). Local and systemic AEs were reported in 85 patients (9.9%). Most AEs (83.1%) were mild and occurred in <30 min (87%). Respiratory and cutaneous symptoms were more frequent. Only 4 patients (0.47%) had severe AE (none after 6 weeks of maintenance). The risk of AE was higher in patients undergoing SCIT.
    Conclusions: AIT is safe and well tolerated in children and adolescents with respiratory allergies in real-life clinical practice. Though SCIT is more prone to AE compared to SLIT, overall severe reactions are rare and occur during build-up and early maintenance.
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12250
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  7. Article ; Online: A molecular diagnostic algorithm to guide pollen immunotherapy in southern Europe: towards component-resolved management of allergic diseases.

    Douladiris, Nikolaos / Savvatianos, Savvas / Roumpedaki, Irene / Skevaki, Chrysanthi / Mitsias, Dimitrios / Papadopoulos, Nikolaos G

    International archives of allergy and immunology

    2013  Volume 162, Issue 2, Page(s) 163–172

    Abstract: Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and ... ...

    Abstract Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allergen extracts, which consist of mixtures of various proteins that may be allergenic or not, specific for the allergen source or widely distributed (panallergens). New technologies offer the opportunity for a more accurate component-resolved diagnosis, of benefit especially to polysensitized allergic patients. The basic elements of molecular diagnostics with potential relevance to immunotherapy prescription are reviewed here, with a focus on Southern European sensitization patterns to pollen allergens. We propose a basic algorithm regarding component-resolved diagnostic work-up for pollen allergen-specific immunotherapy candidates in Southern Europe; this and similar algorithms can form the basis of improved patient management, conceptually a 'Component-Resolved Allergy Management'.
    MeSH term(s) Algorithms ; Allergens/administration & dosage ; Allergens/immunology ; Antigens, Plant/administration & dosage ; Antigens, Plant/immunology ; Desensitization, Immunologic/methods ; Europe ; Humans ; Immunoglobulin E/immunology ; Molecular Diagnostic Techniques/methods ; Plant Proteins/administration & dosage ; Plant Proteins/immunology ; Pollen/immunology ; Rhinitis, Allergic, Seasonal/diagnosis ; Rhinitis, Allergic, Seasonal/therapy
    Chemical Substances Allergens ; Antigens, Plant ; Plant Proteins ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2013
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000353113
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  8. Article: A Molecular Diagnostic Algorithm to Guide Pollen Immunotherapy in Southern Europe: Towards Component-Resolved Management of Allergic Diseases

    Douladiris, Nikolaos / Savvatianos, Savvas / Roumpedaki, Irene / Skevaki, Chrysanthi / Mitsias, Dimitrios / Papadopoulos, Nikolaos G.

    International Archives of Allergy and Immunology

    2013  Volume 162, Issue 2, Page(s) 163–172

    Abstract: Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and ... ...

    Institution Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Abstract Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allergen extracts, which consist of mixtures of various proteins that may be allergenic or not, specific for the allergen source or widely distributed (panallergens). New technologies offer the opportunity for a more accurate component-resolved diagnosis, of benefit especially to polysensitized allergic patients. The basic elements of molecular diagnostics with potential relevance to immunotherapy prescription are reviewed here, with a focus on Southern European sensitization patterns to pollen allergens. We propose a basic algorithm regarding component-resolved diagnostic work-up for pollen allergen-specific immunotherapy candidates in Southern Europe; this and similar algorithms can form the basis of improved patient management, conceptually a ‘Component-Resolved Allergy Management'.
    Keywords Allergen-specific immunotherapy ; Molecular diagnosis ; Panallergens ; Pollen
    Language English
    Publishing date 2013-07-31
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Paper
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000353113
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  9. Article: Is diet partly responsible for differences in COVID-19 death rates between and within countries?

    Bousquet, Jean / Anto, Josep M. / Iaccarino, Guido / Czarlewski, Wienczyslawa / Haahtela, Tari / Anto, Aram / Akdis, Cezmi A. / Blain, Hubert / Canonica, G. Walter / Cardona, Victoria / Cruz, Alvaro A. / Illario, Maddalena / Ivancevich, Juan Carlos / Jutel, Marek / Klimek, Ludger / Kuna, Piotr / Laune, Daniel / Larenas-Linnemann, Désirée / Mullol, Joaquim /
    Papadopoulos, Nikos G. / Pfaar, Oliver / Samolinski, Boleslaw / Valiulis, Arunas / Yorgancioglu, Arzu / Zuberbier, Torsten / Abdul Latiff, Amir Hamzah / Abdullah, Baharudin / Aberer, Werner / Abusada, Nancy / Adcock, Ian / Afani, Alejandro / Agache, Ioana / Aggelidis, Xenofon / Agustin, Jenifer / Akdis, Cezmi / Akdis, Mübeccel / Al-Ahmad, Mona / Al-Zahab Bassam, Abou / Aldrey-Palacios, Oscar / Alvarez Cuesta, Emilio / Alzaabi, Ashraf / Amad, Salma / Ambrocio, Gene / Annesi-Maesano, Isabella / Ansotegui, Ignacio / Anto, Josep / Arshad, Hasan / Artesani, Maria Cristina / Asayag, Estrella / Avolio, Francesca / Azhari, Khuzama / Baiardini, Ilaria / Bajrović, Nissera / Bakakos, Petros / Bakeyala Mongono, Sergio / Balotro-Torres, Christine / Barba, Sergio / Barbara, Cristina / Barbosa, Elsa / Barreto, Bruno / Bartra, Joan / Bateman, Eric D. / Battur, Lkhagvaa / Bedbrook, Anna / Bedolla Barajas, Martín / Beghé, Bianca / Bel, Elizabeth / Ben Kheder, Ali / Benson, Mikael / Berghea, Camelia / Bergmann, Karl-Christian / Bernstein, David / Bewick, Mike / Bialek, Slawomir / Białoszewski, Artur / Bieber, Thomas / Billo, Nils / Bilo, Maria Beatrice / Bindslev-Jensen, Carsten / Bjermer, Leif / Bochenska Marciniak, Malgorzata / Bond, Christine / Boner, Attilio / Bonini, Matteo / Bonini, Sergio / Bosnic-Anticevich, Sinthia / Bosse, Isabelle / Botskariova, Sofia / Bouchard, Jacques / Boulet, Louis-Philippe / Bourret, Rodolphe / Bousquet, Philippe / Braido, Fulvio / Briggs, Andrew / Brightling, Christopher / Brozek, Jan / Buhl, Roland / Bumbacea, Roxana / Burguete Cabañas, María Teresa / Bush, Andrew / Busse, William W. / Buters, Jeroen / Caballero-Fonseca, Fernan / Calderon, Moïses A. / Calvo, Mario / Camargos, Paulo / Camuzat, Thierry / Cano, Antonio / Capriles-Hulett, Arnaldo / Caraballo, Luis / Cardona, Vicky / Carlsen, Kai-Hakon / Caro, Jorge / Carr, Warner / Carreon-Asuncion, Fredelita / Carriazo, Ana Maria / Casale, Thomas / Castor, Mary Ann / Castro, Elizabeth / Cecchi, Lorenzo / Cepeda Sarabia, Alfonso / Chandrasekharan, Ramanathan / Chang, Yoon-Suk / Chato-Andeza, Victoria / Chatzi, Lida / Chatzidaki, Christina / Chavannes, Niels H. / Chen, Yuzhi / Cheng, Lei / Chivato, Tomas / Chkhartishvili, Ekaterine / Christoff, George / Chrystyn, Henry / Chu, Derek K. / Chua, Antonio / Chuchalin, Alexander / Chung, Kian Fan / Cicerán, Alberto / Cingi, Cemal / Ciprandi, Giorgio / Cirule, Ieva / Coelho, Ana Carla / Constantinidis, Jannis / Correia De Sousa, Jaime / Costa, Elisio / Costa, David / Costa Domínguez, María Del Carmen / Coste, André / Cox, Linda / Cullen, John / Custovic, Adnan / Cvetkovski, Biljana / D039, / Amato, Gennaro / Da Silva, Jane / Dahl, Ronald / Dahlen, Sven-Erik / Daniilidis, Vasilis / Darjazini Nahhas, Louei / Darsow, Ulf / De Blay, Frédéric / De Guia, Eloisa / De Los Santos, Chato / De Manuel Keenoy, Esteban / De Vries, Govert / Deleanu, Diana / Demoly, Pascal / Denburg, Judah / Devillier, Philippe / Didier, Alain / Dimou, Maria / Dinh-Xuan, Anh Tuan / Djukanovic, Ratko / Dokic, Dejan / Domínguez Silva, Margarita Gabriela / Douagui, Habib / Douladiris, Nikolaos / Doulaptsi, Maria / Dray, Gérard / Dubakiene, Ruta / Durham, Stephen / Dykewicz, Mark / Ebo, Didier / Edelbaher, Natalija / Eklund, Patrik / El-Gamal, Yehia / El-Sayed, Zeinab A. / El-Sayed, Shereen S. / El-Seify, Magda / Emuzyte, Regina / Enecilla, Lourdes / Espinoza, Heidilita / Espinoza Contreras, Jesús Guillermo / Farrell, John / Fernandez, Lenora / Fink Wagner, Antje / Fiocchi, Alessandro / Fokkens, Wytske J. / Fontaine, Jean-François / Forastiere, Francesco / Fuentes Pèrez, Jose Miguel / Gaerlan-Resureccion, Emily / Gaga, Mina / Gálvez Romero, José Luis / Gamkrelidze, Amiran / Garcia, Alexis / García Cobas, Cecilia Yvonne / García Cruz, María De La Luz Hortensia / Gayraud, Jacques / Gemicioglu, Bilun / Genova, Sonya / Gereda, José / Gerth Van Wijk, Roy / Gomez, Maximiliano / González Diaz, Sandra / Gotua, Maia / Grigoreas, Christos / Grisle, Ineta / Guidacci, Marta / Guldemond, Nick / Gutter, Zdenek / Guzmán, Antonieta / Halloum, Ramsa / Hamelmann, Eckard / Hammadi, Suleiman / Harvey, Richard / Heinrich, Joachim / Hejjaoui, Adnan / Hellquist-Dahl, Birthe / Hernández Velázquez, Luiana / Hew, Mark / Hossny, Elham / Howarth, Peter / Hrubiško, Martin / Huerta Villalobos, Yunuen Rocío / Humbert, Marc / Hyland, Michael / Ibrahim, Moustafa / Ilyina, Natalia / Irani, Carla / Ispayeva, Zhanat / Jares, Edgardo / Jarvis, Deborah / Jassem, Ewa / Jenko, Klemen / Jiméneracruz Uscanga, Rubén Darío / Johnston, Sebastian / Joos, Guy / Jošt, Maja / Julge, Kaja / Jung, Ki-Suck / Just, Jocelyne / Kaidashev, Igor / Kalayci, Omer / Kalyoncu, Fuat / Kapsali, Jeni / Kardas, Przemyslaw / Karjalainen, Jussi / Kasala, Carmela A. / Katotomichelakis, Michael / Kazi, Bennoor / Keil, Thomas / Keith, Paul / Khaitov, Musa / Khaltaev, Nikolai / Kim, You-Young / Kleine-Tebbe, Jorg / N039, Koffi / Goran, Bernard / Kompoti, Evangelia / Kopač, Peter / Koppelman, Gerard / Koren Jeverica, Anja / Košnik, Mitja / Kostov, Kosta V. / Kowalski, Marek L. / Kralimarkova, Tanya / Kramer Vrščaj, Karmen / Kraxner, Helga / Kreft, Samo / Kritikos, Vicky / Kudlay, Dmitry / Kull, Inger / Kupczyk, Maciej / Kvedariene, Violeta / Kyriakakou, Marialena / Lalek, Nika / Lane, Stephen / Larenas-Linnemann, Désiree / Latiff, Amir / Lau, Susanne / Lavrut, Jorge / Le, Lan / Lessa, Marcus / Levin, Michael / Li, Jing / Lieberman, Philip / Liotta, Giuseppe / Lipworth, Brian / Liu, Xuandao / Lobo, Rommel / Lodrup Carlsen, Karin C. / Lombardi, Carlo / Louis, Renaud / Loukidis, Stelios / Lourenço, Olga / Luna Pech, Jorge A. / Madjar, Bojan / Magnan, Antoine / Mahboub, Bassam / Mair, Alpana / Mais, Yassin / Maitland Van Der Zee, Anke-Hilse / Makela, Mika / Makris, Michael / Malling, Hans-Jorgen / Mandajieva, Mariana / Manning, Patrick / Manousakis, Manolis / Maragoudakis, Pavlos / Marshall, Gailen / Martinsmartins, Pedro / Masjedi, Mohammad Reza / Máspero, Jorge F. / Matta Campos, Juan José / Maurer, Marcus / Mavale-Manuel, Sandra / Meço, Cem / Melén, Erik / Melo-Gomes, Elisabete / Meltzer, Eli O. / Menditto, Enrica / Menzies-Gow, Andrew / Merk, Hans / Michel, Jean-Pierre / Miculinic, Neven / Midão, Luís / Mihaltan, Florin / Mikael, Kuitunen / Mikos, Nikolaos / Milenkovic, Branislava / Mitsias, Dimitrios / Moalla, Bassem / Moda, Giuliana / Mogica Martínez, María Dolores / Mohammad, Yousser / Moin, Mostafa / Molimard, Mathieu / Momas, Isabelle / Monaco, Alessandro / Montefort, Steve / Mora, Dory / Morais-Almeida, Mario / Mösges, Ralph / Mostafa, Badr Eldin / Münter, Lars / Muraro, Antonella / Murray, Ruth / Mustakov, Tihomir / Naclerio, Robert / Nadif, Rachel / Nakonechna, Alla / Namazova-Baranova, Leyla / Navarro-Locsin, Gretchen / Neffen, Hugo / Nekam, Kristof / Neou, Angelos / Nicod, Laurent / Niederberger-Leppin, Verena / Niedoszytko, Marek / Nieto, Antonio / Novellino, Ettore / Nunes, Elizabete / Nyembue, Dieudonné / O039, / Hehir, Robyn / Odjakova, Cvetanka / Ohta, Ken / Okamoto, Yoshitaka / Okubo, Kimi / Oliver, Brian / Onorato, Gabrielle L. / Orru, Maria Pia / Ouédraogo, Solange / Ouoba, Kampadilemba / Paggiaro, Pier Luigi / Pagkalos, Aris / Palaniappan, S. P. / Pali-Schöll, Isabella / Palkonen, Susanna / Palmer, Stephen / Panaitescu Bunu, Carmen / Panzner, Petr / Papanikolaou, Vasilis / Papi, Alberto / Paralchev, Bojidar / Paraskevopoulos, Giannis / Park, Hae Sim / Passalacqua, Giovanni / Patella, Vincenzo / Pavord, Ian / Pawankar, Ruby / Pedersen, Soren / Peleve, Susete / Pereira, Ana / Pérez, Tamara / Pham-Thi, Nhân / Pigearias, Bernard / Pin, Isabelle / Piskou, Konstantina / Pitsios, Constantinos / Pitsios, Kostas / Plavec, Davor / Poethig, Dagmar / Pohl, Wolfgang / Poplas Susic, Antonija / Popov, Todor A. / Portejoie, Fabienne / Potter, Paul / Poulsen, Lars / Prados-Torres, Alexandra / Prarros, Fotis / Price, David / Prokopakis, Emmanuel / Puy, Robert / Rabe, Klaus / Raciborski, Filip / Ramos, Josephine / Recto, Marysia T. / Reda, Shereen M. / Regateiro, Frederico / Reider, Norbert / Reitsma, Sietze / Repka-Ramirez, Susana / Rimmer, Janet / Rivero Yeverino, Daniela / Rizzo, José Angelo / Robalo-Cordeiro, Carlos / Roberts, Graham / Roche, Nicolas / Rodríguez González, Mónica / Rodríguez Zagal, Eréndira / Rolland, Christine / Roller-Wirnsberger, Regina / Roman Rodriguez, Miguel / Romano, Antonino / Rombaux, Philippe / Romualdez, Joel / Rosado-Pinto, Jose / Rosario, Nelson / Rosenwasser, Lanny / Rottem, Menachem / Rouadi, Philip / Rovina, Nikoleta / Rozman Sinur, Irma / Ruiz, Mauricio / Ruiz Segura, Lucy Tania / Ryan, Dermot / Sagara, Hironori / Sakai, Daiki / Sakurai, Daiju / Saleh, Wafaa / Salimaki, Johanna / Salina, Husain / Samitas, Konstantinos / Sánchez Coronel, María Guadalupe / Sanchez-Borges, Mario / Sanchez-Lopez, Jaime / Sarafoleanu, Codrut / Sarquis Serpa, Faradiba / Sastre-Dominguez, Joaquin / Scadding, Glenis / Scheire, Sophie / Schmid-Grendelmeier, Peter / Schuhl, Juan Francisco / Schunemann, Holger / Schvalbová, Maria / Scichilone, Nicola / Sepúlveda, Cecilia / Serrano, Elie / Sheikh, Aziz / Shields, Mike / Shishkov, Vasil / Siafakas, Nikos / Simeonov, Alexander / Simons, Estelle F. / Sisul, Juan Carlos / al., et

    Clin. Transl. Allergy

    Abstract: Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the ... ...

    Abstract Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #378138
    Database COVID19

    Kategorien

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  10. Article ; Online: Cabbage and fermented vegetables

    Bousquet, Jean / Anto, Josep M. / Czarlewski, Wienczyslawa / Haahtela, Tari / Fonseca, Susana C. / Iaccarino, Guido / Blain, Hubert / Vidal, Alain / Sheikh, Aziz / Akdis, Cezmi A. / Zuberbier, Torsten / Hamzah Abdul Latiff, Amir / Abdullah, Baharudin / Aberer, Werner / Abusada, Nancy / Adcock, Ian / Afani, Alejandro / Agache, Ioana / Aggelidis, Xenofon /
    Agustin, Jenifer / Akdis, Mübeccel / Al‐Ahmad, Mona / Al‐Zahab Bassam, Abou / Alburdan, Hussam / Aldrey‐Palacios, Oscar / Alvarez Cuesta, Emilio / Alwan Salman, Hiba / Alzaabi, Ashraf / Amade, Salma / Ambrocio, Gene / Angles, Rosana / Annesi‐Maesano, Isabella / Ansotegui, Ignacio J. / Anto, Josep / Ara Bardajo, Paula / Arasi, Stefania / Arshad, Hasan / Cristina Artesani, Maria / Asayag, Estrella / Avolio, Francesca / Azhari, Khuzama / Bachert, Claus / Bagnasco, Diego / Baiardini, Ilaria / Bajrović, Nissera / Bakakos, Petros / Bakeyala Mongono, Sergio / Balotro‐Torres, Christine / Barba, Sergio / Barbara, Cristina / Barbosa, Elsa / Barreto, Bruno / Bartra, Joan / Bateman, Eric D / Battur, Lkhagvaa / Bedbrook, Anna / Bedolla Barajas, Martín / Beghé, Bianca / Bekere, Antra / Bel, Elizabeth / Ben Kheder, Ali / Benson, Mikael / Berghea, Emilia Camelia / Bergmann, Karl‐Christian / Bernardini, Roberto / Bernstein, David / Bewick, Mike / Bialek, Slawomir / Białoszewski, Artur / Bieber, Thomas / Billo, Nils E. / Bilo, Maria Beatrice / Bindslev‐Jensen, Carsten / Bjermer, Leif / Bobolea, Irina / Bochenska Marciniak, Malgorzata / Bond, Christine / Boner, Attilio / Bonini, Matteo / Bonini, Sergio / Bosnic‐Anticevich, Sinthia / Bosse, Isabelle / Botskariova, Sofia / Bouchard, Jacques / Boulet, Louis‐Philippe / Bourret, Rodolphe / Bousquet, Philippe / Braido, Fulvio / Briggs, Andrew / Brightling, Christopher E. / Brozek, Jan / Brussino, Luisa / Buhl, Roland / Bumbacea, Roxana / Buquicchio, Rosalva / Burguete Cabañas, María‐Teresa / Bush, Andrew / Busse, William W / Buters, Jeroen / Caballero‐Fonseca, Fernan / Calderon, Moïses A. / Calvo, Mario / Camargos, Paulo / Camuzat, Thierry / Canevari, F.R. / Cano, Antonio / Canonica, G Walter / Capriles‐Hulett, Arnaldo / Caraballo, Luis / Cardona, Vicky / Carlsen, Kai‐Hakon / Carmon Pirez, Jonas / Caro, Jorge / Carr, Warner / Carreiro‐Martins, Pedro / Carreon‐Asuncion, Fredelita / Carriazo, Ana‐Maria / Casale, Thomas / Castor, Mary‐Ann / Castro, Elizabeth / Caviglia, A.G. / Cecchi, Lorenzo / Cepeda Sarabia, Alfonso / Chandrasekharan, Ramanathan / Chang, Yoon‐Seok / Chato‐Andeza, Victoria / Chatzi, Lida / Chatzidaki, Christina / Chavannes, Niels H. / Chaves Loureiro, Claudia / Chelninska, Marta / Chen, Yuzhi / Cheng, Lei / Chinthrajah, Sharon / Chivato, Tomas / Chkhartishvili, Ekaterine / Christoff, George / Chrystyn, Henry / Chu, Derek K. / Chua, Antonio / Chuchalin, Alexander / Chung, Kian Fan / Cicerán, Alberto / Cingi, Cemal / Ciprandi, Giorgio / Cirule, Ieva / Coelho, Ana Carla / Compalati, Enrico / Constantinidis, Jannis / Correia de Sousa, Jaime / Costa, Elisio Manuel / Costa, David / Costa Domínguez, María del Carmen / Coste, André / Cottini, M. / Cox, Linda / Crisci, Carlos / Crivellaro, Maria Angiola / Cruz, Alvaro A. / Cullen, John / Custovic, Adnan / Cvetkovski, Biljana / D'Amato, Gennaro / Silva, Jane / Dahl, Ronald / Dahlen, Sven‐Erik / Daniilidis, Vasilis / DarjaziniNahhas, Louei / Darsow, Ulf 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Carla / Ispayeva, Zhanat / Ivancevich, Juan‐Carlos / E.J. Jares, Edgardo / Jarvis, Deborah / Jassem, Ewa / Jenko, Klemen / Jiméneracruz Uscanga, Rubén Darío / Johnston, Sebastian L. / Joos, Guy / Jošt, Maja / Julge, Kaja / Jung, Ki‐Suck / Just, Jocelyne / Jutel, Marek / Kaidashev, Igor / Kalayci, Omer / Kalyoncu, Fuat / Kapsali, Jeni / Kardas, Przemyslaw / Karjalainen, Jussi / Kasala, Carmela A. / Katotomichelakis, Michael / Kavaliukaite, Loreta / Kazi, Bennoor S. / Keil, Thomas / Keith, Paul / Khaitov, Musa / Khaltaev, Nikolai / Kim, You‐Young / Kirenga, Bruce / Kleine‐Tebbe, Jorg / Klimek, Ludger / Koffi N’Goran, Bernard / Kompoti, Evangelia / Kopač, Peter / Koppelman, Gerard / KorenJeverica, Anja / Koskinen, Seppo / Košnik, Mitja / Kostov, Kosta V. / Kowalski, Marek L. / Kralimarkova, Tanya / Kramer Vrščaj, Karmen / Kraxner, Helga / Kreft, Samo / Kritikos, Vicky / Kudlay, Dmitry / Kuitunen, Mikael / Kull, Inger / Kuna, Piotr / Kupczyk, Maciej / Kvedariene, Violeta / Kyriakakou, Marialena / Lalek, Nika / Landi, Massimo / Lane, Stephen / 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    Allergy ; ISSN 0105-4538 1398-9995

    From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID‐19

    2020  

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/all.14549
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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