Article ; Online: Underlying Disorders in Children With Infection-Related Acute Encephalopathy.
2024 Volume 155, Page(s) 126–132
Abstract: Background: Various factors contribute to the development of infection-related acute encephalopathy (AE) in children, such as infectious agents and chronic underlying disorders. We studied underlying disorders in children with AE to identify ... ...
| Abstract | Background: Various factors contribute to the development of infection-related acute encephalopathy (AE) in children, such as infectious agents and chronic underlying disorders. We studied underlying disorders in children with AE to identify predisposing factors of AE. Methods: We investigated underlying disorders or past histories in patients with two types of AE from the database in the Tokai area of Japan between 2009 and 2022: 204 patients with AE with reduced subcortical diffusion (AED) and 137 with clinically mild encephalopathy with a reversible splenial lesion (MERS). We compared them with 89 patients with acute disseminated encephalomyelitis (ADEM) to clarify the specific disorders in the two AE types. Results: The prevalence of underlying disorders in AED (34%, 70 patients) was significantly higher than that in ADEM (12%, 11 patients) (P < 0.01). The prevalence of underlying disorders in MERS was 23% (32 patients). The underlying disorders included seizure disorders, premature birth, genetic/congenital disorders, and endocrine/renal diseases. In patients with seizure disorders in AED, five patients (18%) had Dravet syndrome and four (15%) had West syndrome, whereas none with MERS had these syndromes. Twenty-five (12%) of 204 patients with AED, three (2%) with MERS, and one (1%) with ADEM were preterm or low birth weight. Conclusions: The high prevalence of seizure disorders suggests that seizure susceptibility is an important predisposing factor in AED. Premature birth also has an impact on the development of AED. Caution is required regarding the development of AE in patients with chronic seizure disorders or premature birth. |
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| MeSH term(s) | Humans ; Male ; Female ; Child, Preschool ; Infant ; Child ; Brain Diseases/epidemiology ; Brain Diseases/etiology ; Brain Diseases/complications ; Adolescent ; Japan/epidemiology ; Prevalence ; Infant, Newborn ; Encephalomyelitis, Acute Disseminated/epidemiology ; Encephalomyelitis, Acute Disseminated/etiology ; Encephalomyelitis, Acute Disseminated/complications |
| Language | English |
| Publishing date | 2024-03-22 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 639164-3 |
| ISSN | 1873-5150 ; 0887-8994 |
| ISSN (online) | 1873-5150 |
| ISSN | 0887-8994 |
| DOI | 10.1016/j.pediatrneurol.2024.03.017 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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