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  1. AU="Mitsushima, Toru"
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  1. Article ; Online: Risk factors for gastric cancer in Japan in the 2010s: a large, long-term observational study.

    Takahashi, Yu / Yamamichi, Nobutake / Kubota, Dai / Shimamoto, Takeshi / Nagao, Sayaka / Sakuma, Nobuyuki / Sakaguchi, Yoshiki / Yakabi, Seiichi / Tsuji, Yosuke / Wada, Ryoichi / Mitsushima, Toru / Ichinose, Masao / Fujishiro, Mitsuhiro

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

    2022  Volume 25, Issue 3, Page(s) 481–489

    Abstract: Background: The numbers of Helicobacter pylori (HP)-infected individuals and deaths due to gastric cancer are decreasing in Japan. We aimed to determine whether the serological test for chronic gastritis (the ABC method) is still useful for gastric ... ...

    Abstract Background: The numbers of Helicobacter pylori (HP)-infected individuals and deaths due to gastric cancer are decreasing in Japan. We aimed to determine whether the serological test for chronic gastritis (the ABC method) is still useful for gastric cancer risk stratification in the 2010s and to analyze risk factors for developing gastric cancer in Japan.
    Methods: In this prospective study, we monitored 20773 individuals for the incidence of gastric cancer from 2010 to 2019. The relationships between blood sampling results, physical examination, and lifestyle in 2010 and the cumulative incidence of gastric cancer were analyzed.
    Results: A total of 19343 participants who met the study criteria were analyzed. Overall, 0.08% of participants in group A (9/11717), 0.63% in group B (28/4452), 2.05% in group C (43/2098), 1.52% in group D (1/66), and 0.30% in group E (3/1010) developed gastric cancer. Cox hazard analysis showed that age ≥ 50 years; groups B, C, and D according to the ABC method; and current smoking habits were independent risk factors for gastric cancer. The hazard ratios (HRs) of the incidence of gastric cancer were 6.7 in group B and 21.7 in groups C and D, while the HRs of group E was 2.8, which was not significantly different from that of group A. The incidence of gastric cancer was not statistically significantly different between those with and without successful HP eradication in groups B, C, and D during follow-up.
    Conclusions: The ABC method was still useful for gastric cancer risk stratification in the 2010s.
    MeSH term(s) Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Japan/epidemiology ; Middle Aged ; Pepsinogen A ; Prospective Studies ; Risk Factors ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/etiology
    Chemical Substances Pepsinogen A (9001-10-9)
    Language English
    Publishing date 2022-01-24
    Publishing country Japan
    Document type Journal Article ; Observational Study
    ZDB-ID 1463526-4
    ISSN 1436-3305 ; 1436-3291
    ISSN (online) 1436-3305
    ISSN 1436-3291
    DOI 10.1007/s10120-021-01273-7
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  2. Article ; Online: The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach.

    Shimamoto, Takeshi / Yamamichi, Nobutake / Gondo, Kenta / Takahashi, Yu / Takeuchi, Chihiro / Wada, Ryoichi / Mitsushima, Toru / Koike, Kazuhiko

    PloS one

    2020  Volume 15, Issue 6, Page(s) e0234433

    Abstract: Background: Several previous studies have suggested that Helicobacter pylori (H. pylori) infection affects the serum lipid profile. However, it remains controversial and the mechanism has not been elucidated. The purpose of this study is to use an ... ...

    Abstract Background: Several previous studies have suggested that Helicobacter pylori (H. pylori) infection affects the serum lipid profile. However, it remains controversial and the mechanism has not been elucidated. The purpose of this study is to use an epidemiological perspective to evaluate the association between H. pylori infection and the serum lipid profile.
    Methods: Multivariate analysis was performed using the data of serum lipid profile, infection status of H. pylori, fitness/lifestyle habits, and various subjects' characteristics which were derived from the 15,679 generally healthy individuals in Japan. The average treatment effects (ATEs) of H. pylori infection on the serum lipid profile were estimated using augmented inverse probability weighting (AIPW). A meta-analysis was also performed using the 27 studies worldwide in which the status of H. pylori infection and at least one serum examination value (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), or triglyceride (TG)) were described.
    Results: The ATEs determined with AIPW showed that H. pylori infection has significant positive effects on LDL-C and TC (ATE (95% confidence interval [95%CI]) = 3.4 (2.36-4.49) and 1.7 (0.58-2.88), respectively) but has significant negative effects on HDL-C and TG (ATE (95%CI) = -1.2 (-1.74 to -0.72) and -3.5 (-5.92 to -1.06), respectively). The meta-analysis to estimate the association between H. pylori infection and the serum lipid profile revealed that H. pylori infection is positively associated with LDL-C, TC, and TG (standardized mean difference [SMD] (95%CI) = 0.11 (0.09-0.12), 0.09 (0.07-0.10) and 0.06 (0.05-0.08), respectively) and negatively associated with HDL-C (SMD = -0.13 (-0.14 to -0.12)).
    Conclusion: Both our multivariate analyses and meta-analysis showed that H. pylori infection significantly affects the serum lipid profile, which might lead to various dyslipidemia-induced severe diseases like coronary thrombosis or cerebral infarction.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Dyslipidemias/blood ; Dyslipidemias/diagnosis ; Dyslipidemias/epidemiology ; Dyslipidemias/etiology ; Female ; Helicobacter Infections/blood ; Helicobacter Infections/complications ; Helicobacter Infections/diagnosis ; Helicobacter Infections/microbiology ; Helicobacter pylori/isolation & purification ; Humans ; Japan/epidemiology ; Male ; Meta-Analysis as Topic ; Middle Aged ; Propensity Score ; Risk Factors ; Triglycerides/blood ; Young Adult
    Chemical Substances Cholesterol, HDL ; Cholesterol, LDL ; Triglycerides
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Journal Article ; Observational Study
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0234433
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  3. Article ; Online: Pulse-wave velocity, the ankle-brachial index, and the visceral fat area are highly associated with colorectal adenoma.

    Yamaji, Yutaka / Mitsushima, Toru / Koike, Kazuhiko

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2014  Volume 46, Issue 10, Page(s) 943–949

    Abstract: Background: Although both colorectal neoplasms and atherosclerosis may be induced by visceral fat accumulation, no association between these factors has yet been elucidated.: Methods: Among Japanese participants in our colonoscopic screening and ... ...

    Abstract Background: Although both colorectal neoplasms and atherosclerosis may be induced by visceral fat accumulation, no association between these factors has yet been elucidated.
    Methods: Among Japanese participants in our colonoscopic screening and annual surveillance programs, asymptomatic subjects were investigated. Visceral fat area was measured by computed tomography, and the ankle-brachial index and pulse-wave velocity (markers of systemic atherosclerosis) were also estimated. Colorectal findings during screening were investigated in association with these parameters.
    Results: Nine hundred and seven subjects (males: 71.9%; mean age: 57.3±8.7 years) were enrolled. Colorectal adenomas were identified during colorectal screening of 407 subjects (44.9%). The prevalence of all colorectal adenoma and advanced neoplasia increased with an elevated pulse-wave velocity from 32.2% (advanced neoplasia, 2.6) to 62.1% (8.4%) in higher quartiles (p<0.001 and p=0.003). The risk of advanced neoplasia was higher in subjects with an abnormal ankle-brachial index (33% vs. 4.6%, p<0.001). Upon multivariate analysis, visceral fat area and pulse-wave velocity were associated with all adenoma, and the ankle-brachial index with advanced neoplasia.
    Conclusions: The risk of colorectal adenoma was strongly associated with visceral fat area and markers of atherosclerosis. Colorectal adenoma and atherosclerosis may share a common pathogenesis and the same populations are at high-risk.
    MeSH term(s) Adenoma/diagnosis ; Adenoma/etiology ; Adult ; Ankle Brachial Index ; Atherosclerosis/diagnosis ; Atherosclerosis/etiology ; Body Mass Index ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/etiology ; Early Detection of Cancer ; Female ; Humans ; Intra-Abdominal Fat ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Obesity, Abdominal/complications ; Pulse Wave Analysis ; Risk Factors ; Waist Circumference
    Language English
    Publishing date 2014-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2014.05.012
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  4. Article ; Online: Clinicopathological features and prognosis of developed gastric cancer based on the diagnosis of mucosal atrophy and enlarged folds of stomach by double-contrast upper gastrointestinal barium X-ray radiography.

    Yamamichi, Nobutake / Shimamoto, Takeshi / Hirano, Chigaya / Takahashi, Yu / Minatsuki, Chihiro / Takeuchi, Chihiro / Takahashi, Mami / Sakaguchi, Yoshiki / Tsuji, Yosuke / Niimi, Keiko / Wada, Ryoichi / Mitsushima, Toru / Koike, Kazuhiko

    Clinical journal of gastroenterology

    2021  Volume 14, Issue 4, Page(s) 947–954

    Abstract: Background: Mucosal atrophy and enlarged folds of stomach by double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) are two major features of Helicobacter pylori-induced chronic gastritis. These were previously shown to be risk ... ...

    Abstract Background: Mucosal atrophy and enlarged folds of stomach by double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) are two major features of Helicobacter pylori-induced chronic gastritis. These were previously shown to be risk indicators of gastric cancer, but their predictability for clinicopathological characters of developed gastric cancer is unelucidated. In addition, evidence for decreasing the mortality of gastric cancer by appropriate follow-up of UGI screening is needed.
    Methods: The 5134 generally healthy UGI-XR examinees, who underwent follow-up UGI-XR or upper gastrointestinal endoscopy (UGI-ES) more than once, were prospectively observed for 10 years.
    Results: At the beginning of follow-up, 1515 (29.5%) had mucosal atrophy and 990 (19.5%) had enlarged folds. For the serum anti-H. pylori IgG, 1301 (25.3%) were positive, 177 (3.4%) were possibly positive, and 3656 (71.2%) were negative. During the 10-year observation period, gastric cancer developed in 15 subjects, among which 13 had mucosal atrophy and 10 had enlarged folds. These two features were expectedly useful indicators for gastric cancer incidence, but they showed no significant association with tumor stage or histological type of developed cancer. Only one of the 5134 subjects died of gastric cancer during 10 years, which was significantly lower than the predicted number of gastric cancer death (6.78 for 10 years) according to the mortality rate in Japan.
    Conclusions: Neither mucosal atrophy nor enlarged folds of stomach showed a significant association with clinicopathological features of developed gastric tumors. Appropriate follow-up of cancer screening by UGI-XR or UGI-ES can reduce the risk of gastric cancer-related death.
    MeSH term(s) Atrophy/pathology ; Barium ; Gastric Mucosa/diagnostic imaging ; Gastric Mucosa/pathology ; Helicobacter Infections/complications ; Helicobacter Infections/diagnostic imaging ; Helicobacter pylori ; Humans ; Japan ; Prognosis ; Radiography ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/pathology ; X-Rays
    Chemical Substances Barium (24GP945V5T)
    Language English
    Publishing date 2021-05-20
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-021-01445-z
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  5. Article ; Online: Gastric polyps diagnosed by double-contrast upper gastrointestinal barium X-ray radiography mostly arise from the Helicobacter pylori-negative stomach with low risk of gastric cancer in Japan.

    Takeuchi, Chihiro / Yamamichi, Nobutake / Shimamoto, Takeshi / Takahashi, Yu / Mitsushima, Toru / Koike, Kazuhiko

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

    2017  Volume 20, Issue 2, Page(s) 314–321

    Abstract: Background: Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is a method broadly used for gastric cancer screening in Japan. Gastric polyp is one of the most frequent findings detected by UGI-XR, but how to handle it remains ... ...

    Abstract Background: Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is a method broadly used for gastric cancer screening in Japan. Gastric polyp is one of the most frequent findings detected by UGI-XR, but how to handle it remains controversial.
    Methods: Gastric polyps of the 17,264 generally healthy subjects in Japan who underwent UGI-XR or upper gastrointestinal endoscopy (UGI-ES) in 2010 were analyzed.
    Results: Of the 6,433 UGI-XR examinees (3,405 men and 3,028 women, 47.4 ± 9.0 years old), gastric polyps were detected in 464 men (13.6 %) and 733 women (24.2 %) and were predominantly developed on the non-atrophic gastric mucosa (p < 0.0001). Multiple logistic regression analysis showed that the presence of gastric polyps has significant association with lower value of serum anti-Helicobacter pylori IgG titer, female gender, lighter smoking habit, older age, and normal range of body mass index (≥18.5 and <25), but not with drinking or serum pepsinogen I/II ratio. During the 3-year follow-up, gastric cancer occurred in 7 subjects (0.11 %), but none of them had gastric polyps at the beginning of the follow-up period. Of the 2,722 subjects with gastric polyps among the 10,831 UGI-ES examinees in the same period, 2,446 (89.9 %) had fundic, 267 (9.8 %) had hyperplastic, and 9 (0.3 %) had adenomatous/cancerous polyps.
    Conclusions: Gastric polyps diagnosed by UGI-XR predominantly arise on the Helicobacter pylori-negative gastric mucosa with a low risk of gastric cancer in Japan. In the prospective observation, none of the UGI-XR examinees with gastric polyps developed gastric cancer for at least 3 years subsequently.
    MeSH term(s) Adenomatous Polyps/diagnosis ; Adenomatous Polyps/diagnostic imaging ; Adenomatous Polyps/microbiology ; Adult ; Aged ; Barium/metabolism ; Female ; Follow-Up Studies ; Gastric Mucosa/diagnostic imaging ; Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Gastrointestinal Tract/diagnostic imaging ; Helicobacter Infections/complications ; Helicobacter Infections/diagnostic imaging ; Helicobacter Infections/microbiology ; Helicobacter pylori/pathogenicity ; Humans ; Hyperplasia/diagnosis ; Hyperplasia/diagnostic imaging ; Hyperplasia/microbiology ; Japan ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Prospective Studies ; Radiography, Abdominal/methods ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/pathology ; X-Rays
    Chemical Substances Barium (24GP945V5T)
    Language English
    Publishing date 2017-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1463526-4
    ISSN 1436-3305 ; 1436-3291
    ISSN (online) 1436-3305
    ISSN 1436-3291
    DOI 10.1007/s10120-016-0607-3
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  6. Article ; Online: Computed tomographic colonography in diagnosis of asymptomatic pneumatosis cystoides intestinalis.

    Masuda, Noriko / Nagata, Koichi / Mitsushima, Toru / Fujiwara, Masanori

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2013  Volume 45, Issue 1, Page(s) 79

    MeSH term(s) Aged ; Biopsy ; Colonography, Computed Tomographic ; Colonoscopy ; Female ; Humans ; Pneumatosis Cystoides Intestinalis/diagnosis ; Pneumatosis Cystoides Intestinalis/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2013-01
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2012.07.016
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  7. Article ; Online: Colonic distention at CT colonography: randomized evaluation of both IV hyoscine butylbromide and automated carbon dioxide insufflation.

    Nagata, Koichi / Fujiwara, Masanori / Shimamoto, Takeshi / Iida, Nao / Mogi, Tomohiro / Mitsushima, Toru

    AJR. American journal of roentgenology

    2015  Volume 204, Issue 1, Page(s) 76–82

    Abstract: Objective: The purpose of this article is to evaluate the efficacy of IV hyoscine butylbromide as a bowel relaxant and automated carbon dioxide insufflation in CT colonography in terms of colonic distention and perceived burden. SUBJECTS AND METHODS; ... ...

    Abstract Objective: The purpose of this article is to evaluate the efficacy of IV hyoscine butylbromide as a bowel relaxant and automated carbon dioxide insufflation in CT colonography in terms of colonic distention and perceived burden. SUBJECTS AND METHODS; Two hundred twenty-four participants were randomly allocated to one of four groups: control (no bowel relaxant and IV saline placebo before CT colonography with manual carbon dioxide insufflation), hyoscine butylbromide (IV hyoscine butylbromide before examination with manual carbon dioxide insufflation), automated (no bowel relaxant before examination with automated carbon dioxide insufflation), and combined (hyoscine butylbromide before examination with automated carbon dioxide insufflation). The degree of colonic distention on a 4-point scale, examination time, and participants' satisfaction, as measured by their responses to a questionnaire, were assessed.
    Results: The mean distention grades of all the colonic segments and both positions were 3.22 in the control group, 3.28 in the hyoscine butylbromide group, 3.77 in the automated group, and 3.74 in the combined group. Compared with manual carbon dioxide insufflation, automated carbon dioxide insufflation significantly improved the clinical adequacy of colonic distention and shortened examination time. No statistically significant difference was seen in the clinical adequacy of distention between participants who received hyoscine butylbromide and those who did not, or in examination time. Overall, the participants' experiences were not different.
    Conclusion: Colonic distention was statistically significantly improved by automated carbon dioxide insufflation, but not by the administration of hyoscine butylbromide. The participants' tolerance was similar in each group.
    MeSH term(s) Aged ; Butylscopolammonium Bromide/administration & dosage ; Carbon Dioxide/administration & dosage ; Colon/diagnostic imaging ; Colon/drug effects ; Colonography, Computed Tomographic/methods ; Colorectal Neoplasms/diagnostic imaging ; Contrast Media/administration & dosage ; Female ; Humans ; Image Enhancement/methods ; Insufflation/methods ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity
    Chemical Substances Contrast Media ; Carbon Dioxide (142M471B3J) ; Butylscopolammonium Bromide (2Z3E1OF81V)
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.14.12772
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  8. Article ; Online: Evaluation of dose reduction and image quality in CT colonography: comparison of low-dose CT with iterative reconstruction and routine-dose CT with filtered back projection.

    Nagata, Koichi / Fujiwara, Masanori / Kanazawa, Hidenori / Mogi, Tomohiro / Iida, Nao / Mitsushima, Toru / Lefor, Alan T / Sugimoto, Hideharu

    European radiology

    2014  Volume 25, Issue 1, Page(s) 221–229

    Abstract: Objective: To prospectively evaluate the radiation dose and image quality comparing low-dose CT colonography (CTC) reconstructed using different levels of iterative reconstruction techniques with routine-dose CTC reconstructed with filtered back ... ...

    Abstract Objective: To prospectively evaluate the radiation dose and image quality comparing low-dose CT colonography (CTC) reconstructed using different levels of iterative reconstruction techniques with routine-dose CTC reconstructed with filtered back projection.
    Methods: Following institutional ethics clearance and informed consent procedures, 210 patients underwent screening CTC using automatic tube current modulation for dual positions. Examinations were performed in the supine position with a routine-dose protocol and in the prone position, randomly applying four different low-dose protocols. Supine images were reconstructed with filtered back projection and prone images with iterative reconstruction. Two blinded observers assessed the image quality of endoluminal images. Image noise was quantitatively assessed by region-of-interest measurements.
    Results: The mean effective dose in the supine series was 1.88 mSv using routine-dose CTC, compared to 0.92, 0.69, 0.57, and 0.46 mSv at four different low doses in the prone series (p < 0.01). Overall image quality and noise of low-dose CTC with iterative reconstruction were significantly improved compared to routine-dose CTC using filtered back projection. The lowest dose group had image quality comparable to routine-dose images.
    Conclusions: Low-dose CTC with iterative reconstruction reduces the radiation dose by 48.5 to 75.1% without image quality degradation compared to routine-dose CTC with filtered back projection.
    Key points: • Low-dose CTC reduces radiation dose ≥ 48.5% compared to routine-dose CTC. • Iterative reconstruction improves overall CTC image quality compared with FBP. • Iterative reconstruction reduces overall CTC image noise compared with FBP. • Automated exposure control with iterative reconstruction is useful for low-dose CTC.
    MeSH term(s) Clinical Protocols ; Colonic Diseases ; Colonography, Computed Tomographic/methods ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography/methods ; Prospective Studies ; Radiation Dosage ; Radiographic Image Interpretation, Computer-Assisted/methods
    Language English
    Publishing date 2014-08-06
    Publishing country Germany
    Document type Evaluation Study ; Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-014-3350-3
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  9. Article ; Online: Effect of listening to music and essential oil inhalation on patients undergoing screening CT colonography: a randomized controlled trial.

    Nagata, Koichi / Iida, Nao / Kanazawa, Hidenori / Fujiwara, Masanori / Mogi, Tomohiro / Mitsushima, Toru / Lefor, Alan T / Sugimoto, Hideharu

    European journal of radiology

    2014  Volume 83, Issue 12, Page(s) 2172–2176

    Abstract: Objective: To prospectively evaluate the effect of listening to music and inhaling aroma oil on patients undergoing screening computed tomography colonography.: Materials and methods: Two hundred and twenty four participants were randomly allocated ... ...

    Abstract Objective: To prospectively evaluate the effect of listening to music and inhaling aroma oil on patients undergoing screening computed tomography colonography.
    Materials and methods: Two hundred and twenty four participants were randomly allocated to one of the four groups including: (1) combined music and aroma, (2) music alone, (3) aroma alone, and (4)control. The visual analog scale for pain and a questionnaire were used for subjective outcomes. We also used a pre-test–post-test design to compare the differences in blood pressure and heart rate as objective outcomes.
    Results: There were no statistical differences between the control group and other groups in the visual analog scale or changes in heart rate. Changes in blood pressure were similar. Participants reported good overall experiences. There were no differences in terms of overall satisfaction, pain rating, willingness to repeat the computed tomography colonography procedure in the future, or preference between colonoscopy and computed tomography colonography. More participants using music and/or aroma requested music and/or aroma during the next computed tomography colonography (P < 0.0001).
    Conclusion: Although audio and olfactory intervention had little effect on perceived pain or discomfort and vital signs, participants who listened to music and inhaled aroma during the computed tomography colonography preferred music and aroma during the next computed tomography colonography.
    MeSH term(s) Adult ; Aromatherapy ; Blood Pressure ; Colonography, Computed Tomographic ; Colorectal Neoplasms/diagnostic imaging ; Female ; Heart Rate ; Humans ; Male ; Middle Aged ; Music Therapy ; Oils, Volatile/administration & dosage ; Oils, Volatile/therapeutic use ; Pain/prevention & control ; Pain Measurement ; Patient Satisfaction ; Prospective Studies ; Surveys and Questionnaires
    Chemical Substances Oils, Volatile
    Language English
    Publishing date 2014-12
    Publishing country Ireland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2014.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan.

    Shimamoto, Takeshi / Yamamichi, Nobutake / Kodashima, Shinya / Takahashi, Yu / Fujishiro, Mitsuhiro / Oka, Masashi / Mitsushima, Toru / Koike, Kazuhiko

    PloS one

    2013  Volume 8, Issue 6, Page(s) e65996

    Abstract: Probably due to caffeine-induced gastric acid secretion, negative effects of coffee upon various upper-gastrointestinal diseases have been precariously accepted, despite the inadequate epidemiological evidence. Our aim is to evaluate the effect of coffee ...

    Abstract Probably due to caffeine-induced gastric acid secretion, negative effects of coffee upon various upper-gastrointestinal diseases have been precariously accepted, despite the inadequate epidemiological evidence. Our aim is to evaluate the effect of coffee consumption on four major acid-related diseases: gastric ulcer (GU), duodenal ulcer (DU), reflux esophagitis (RE), and non-erosive reflux disease (NERD) based on the large-scale multivariate analysis. Of the 9,517 healthy adults, GU, DU, and RE were diagnosed by endoscopy, and NERD was diagnosed by the symptoms of heartburn and regurgitation without esophageal erosion. Associations between coffee consumption and the four disorders were evaluated, together with age, gender, body mass index (BMI), Helicobacter pylori (HP) infection status, pepsinogen I/II ratio, smoking, and alcohol. We further performed meta-analysis using the random effects model to redefine the relationship between coffee intake and peptic ulcer disease. The eligible 8,013 study subjects comprised of 5,451 coffee drinkers and 2,562 non-coffee drinkers. By univariate analysis, age, BMI, pepsinogen I/II ratio, smoking, and alcohol showed significant associations with coffee consumption. By multiple logistic regression analysis, positively correlated factors with significance were HP infection, current smoking, BMI, and pepsinogen I/II ratio for GU; HP infection, pepsinogen I/II ratio, and current smoking for DU; HP non-infection, male, BMI, pepsinogen I/II ratio, smoking, age, and alcohol for RE; younger age, smoking, and female for NERD. The meta-analyses could detect any association of coffee consumption with neither GU nor DU. In conclusion, there are no significant relationship between coffee consumption and the four major acid-related upper gastrointestinal disorders.
    MeSH term(s) Adult ; Age Factors ; Alcohol Drinking ; Body Mass Index ; Coffee/adverse effects ; Cross-Sectional Studies ; Duodenal Ulcer/epidemiology ; Duodenal Ulcer/etiology ; Endoscopy ; Esophagitis, Peptic/epidemiology ; Esophagitis, Peptic/etiology ; Female ; Helicobacter Infections/epidemiology ; Humans ; Japan/epidemiology ; Male ; Pepsinogen A/metabolism ; Pepsinogen C/metabolism ; Risk Factors ; Sex Factors ; Smoking ; Stomach Ulcer/epidemiology ; Stomach Ulcer/etiology
    Chemical Substances Coffee ; Pepsinogen C (61536-72-9) ; Pepsinogen A (9001-10-9)
    Language English
    Publishing date 2013-06-12
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0065996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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