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Article: Comparative Analysis of US Guidelines for the Management of Cutaneous Squamous Cell and Basal Cell Carcinoma.

Mittal, Amit / Mittal, Bharat B

2024 Volume 2024, Page(s) 3859066

Abstract: Background: This study presents a comparative analysis of recently published guidelines to manage cutaneous squamous cell carcinoma (cSCC) and cutaneous basal cell carcinoma (cBCC) within the United States (US).: Methods: A PubMed database search was ...

Abstract	Background: This study presents a comparative analysis of recently published guidelines to manage cutaneous squamous cell carcinoma (cSCC) and cutaneous basal cell carcinoma (cBCC) within the United States (US). Methods: A PubMed database search was performed for the time period between June 1, 2016, and December 1, 2022. A comprehensive comparison was performed in the following clinical interest areas: staging and risk stratification, management of primary tumor and regional nodes with curative intent, and palliative treatment. Results: Guidelines from 3 organizations were analyzed: the American Academy of Dermatology (AAD), the National Comprehensive Cancer Network (NCCN), and the American Society for Radiation Oncology (ASTRO). The guidelines used different methodologies to grade evidence, making comparison difficult. There was agreement that surgery is the preferred treatment for curative cBCC and cSCC. For patients ineligible for surgery, there was a consensus to recommend definitive radiation. AAD and NCCN recommended consideration of other topical modalities in selected low-risk cBCC. Postoperative radiation therapy (PORT) was uniformly recommended in patients with positive margins that could not be cleared with surgery and in patients with nerve invasion. The definition and extent of nerve invasion varied. All guidelines recommended surgery as the primary treatment in patients with lymph node metastases in a curative setting. The criteria used for PORT varied; NCCN and ASTRO used lymph node size, number of nodes, and extracapsular extension for recommending PORT. Both NCCN and ASTRO recommend consideration of systemic treatment along with PORT in patients with extracapsular extension. Conclusion: US guidelines provide contemporary and complementary information on the management of cBCC and cSCC. There are opportunities for research, particularly in the areas of staging, indications for adjuvant treatment in curative settings, extent of nerve invasion and prognosis, and the role of systemic treatments in curative and palliative settings.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2581531-3
ISSN	2090-2913 ; 2090-2905
ISSN (online)	2090-2913
ISSN	2090-2905
DOI	10.1155/2024/3859066
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Adverse effects of Cosmetics on the Women Health

Kohli Ruchi / Mittal Anu / Mittal Amit

BIO Web of Conferences, Vol 86, p

2024 Volume 01026

Abstract: The Cosmetics used for beautification or enhancement of appearance are in high demand especially among the women but these products have deep dark side. Many additive chemicals in cosmetics like parabens, phthalates, polyethylene glycol, hydroquinone, ... ...

Abstract	The Cosmetics used for beautification or enhancement of appearance are in high demand especially among the women but these products have deep dark side. Many additive chemicals in cosmetics like parabens, phthalates, polyethylene glycol, hydroquinone, resorcinol, 1,4 dioxane, trace heavy metals etc. are hazardous and pose a variety of health risks ranging from neurotoxicity, nephrotoxicity, carcinogenicity, endocrine disruption, reproductive disorders etc. Hence the safety of the cosmetics is an issue of prime concern. It is necessary to make people aware of cosmetic chemicals and their deleterious effects. The present study analyses the current scenario of cosmetic use in India, the behaviour of women consumers in Indian Cosmetic market in terms of age group using cosmetics, reasons for using cosmetics and expenditure on beauty products etc. The harmful chemical ingredients in cosmetics are discussed along with their adverse effects on health. The study is carried out with objective of making women aware of large number of toxic chemicals used in cosmetics and their negative health impacts. It will also draw attention of researchers and clinicians to investigate the likely causes of their negative consequences. A relatively new concept of green cosmetics is also mentioned, which are associated with less toxicity to human health and is suggested to be promoted and adopted by women.
Keywords	Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
Subject code	360
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of the Skewed Sex Ratio and Female Foeticide in India

Mittal Anu / Kohli Ruchi / Mittal Amit

BIO Web of Conferences, Vol 86, p

2024 Volume 01025

Abstract: The present study is aimed at drawing attention and concern of the readers towards nefarious female foeticide problem in India. Female Foeticide is the death sentence to a girl even before her birth. The objectives of the study are met by analysing the ... ...

Abstract	The present study is aimed at drawing attention and concern of the readers towards nefarious female foeticide problem in India. Female Foeticide is the death sentence to a girl even before her birth. The objectives of the study are met by analysing the problem of female foeticide by studying skewed sex ratio and child sex ratio in India and its states. The primary causes of female foeticide are addressed along with its adverse consequences on society. Study on the status of sex ratio in countries of world lists India at 4rth rank in most skewed sex ratio. Although sex ratio has improved recently yet child sex ratio is still the worst in India. The Northern Indian states & union territories have lowest sex ratio. The rural areas with less literacy have more sex ratio than urban areas with higher literacy. Indian government has taken many initiatives to promote girl child birth and enacted a number of laws to curb female foeticide, yet the immoral female foeticide is still in practice. Present study also suggests some measures to prevent this malpractice and hence empower the Women.
Keywords	Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: High-Throughput Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry Method Validation for the Estimation of Atorvastatin and Active Metabolites in Human Plasma.

Agrawal, Nikhil / Mittal, Amit

Assay and drug development technologies

2023 Volume 21, Issue 3, Page(s) 110–125

Abstract: A highly selective, sensitive, rugged, and rapid ultra high-performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) is optimized and validated for reliable quantification of atorvastatin (ATR) and its active metabolites, 2-hydroxy ... ...

Abstract	A highly selective, sensitive, rugged, and rapid ultra high-performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) is optimized and validated for reliable quantification of atorvastatin (ATR) and its active metabolites, 2-hydroxy atorvastatin (2-ATR) and 4-hydroxy atorvastatin (4-ATR) in human plasma using atorvastatin-D5 (ATR-D5), 2-hydroxy atorvastatin-D5 (2-ATR-D5), and 4-hydroxy atorvastatin-D5 (4-ATR-D5) as deuterium-labeled internal standards (ISTDs), respectively. Isocratic mode chromatographic separation was used with a reverse-phase C
MeSH term(s)	Humans ; Atorvastatin ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Calibration ; Reproducibility of Results
Chemical Substances	Atorvastatin (A0JWA85V8F)
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article
ISSN	1557-8127
ISSN (online)	1557-8127
DOI	10.1089/adt.2022.113
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Article ; Online: Recent Progress in Selective COX-2 Inhibitor Formulations and Therapeutic Applications - A Patent Review (2012-2022).

Mittal, Roopal / Sharma, Shailesh / Mittal, Anu / Mittal, Amit

Mini reviews in medicinal chemistry

2023 Volume 23, Issue 22, Page(s) 2130–2141

Abstract: Introduction: Cyclooxygenase (COX), in literature, known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for the formation of prostanoids, including thromboxane and prostaglandins from arachidonic acid. COX-1 does ... ...

Abstract	Introduction: Cyclooxygenase (COX), in literature, known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for the formation of prostanoids, including thromboxane and prostaglandins from arachidonic acid. COX-1 does housekeeping activity, whereas COX- 2 induces inflammation. Continuous rise in COX-2 gives birth to chronic pain-associated disorders, i.e., arthritis, cardiovascular complications, macular degeneration, cancer, and neurodegenerative disorders. Despite their potent anti-inflammatory effects, the detrimental effects of COX-2 inhibitors coexist in healthy tissues. Non-preferential NSAIDs cause gastrointestinal discomfort, whereas selective COX-2 inhibitors exert higher cardiovascular risk and renal impairment on chronic use. Methods: This review paper covers key patents published between 2012-2022 on NSAIDs and coxibs, highlighting their importance, mechanism of action, and patents related to formulation and drug combination. So far, several drug combinations with NSAIDS have been used in clinical trials to treat chronic pain besides combating the side effects. Conclusion: Emphasis has been given on the formulation, drug combination, administration routesmodification, and alternative routes, i.e., parenteral, topical, and ocular DEPOT, improving its riskbenefit ratio of NSAIDs to improvise their therapeutic availability and minimize the adverse effects. Considering the wide area of research on COX-2 and ongoing studies, and future scope of view for the better use of the NSAIDs in treating debilitating disease-associated algesia.
Language	English
Publishing date	2023-04-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2104081-3
ISSN	1875-5607 ; 1389-5575
ISSN (online)	1875-5607
ISSN	1389-5575
DOI	10.2174/1389557523666230417102123
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Article ; Online: TGR5 agonists for diabetes treatment: a patent review and clinical advancements (2012-present).

Bhimanwar, Rachana S / Mittal, Amit

Expert opinion on therapeutic patents

2021 Volume 32, Issue 2, Page(s) 191–209

Abstract: Introduction: A cell surface bile acid receptor TGR5 is expressed in various tissues, including the liver, kidney, intestine, and adrenal glands, causing its effect in each tissue to differ. A major role for TGR5 is to maintain blood sugar levels and ... ...

Abstract	Introduction: A cell surface bile acid receptor TGR5 is expressed in various tissues, including the liver, kidney, intestine, and adrenal glands, causing its effect in each tissue to differ. A major role for TGR5 is to maintain blood sugar levels and increase in energy expenditure. These benefits make it a potential candidate for the treatment of type 2 diabetes, obesity, and other metabolic diseases. Area covered: This paper highlights recent advances in the development of potent steroidal and non-steroidal TGR5 agonists and the peer-reviewed scientific articles that have led to understanding the structure-activity relationship for TGR5 agonists (2012-2020). The review also discusses the clinical progress made by some TGR5 agonists over the past eight years. Expert opinion: In preclinical studies, TGR5 has been found to play a crucial role in GLP-1 secretion and has shown promise for weight loss, anti-diabetic outcomes etc. Semi synthetic and synthetic derivatives can be considered a potential avenue for discovering novel TGR5 agonists. Currently, few TGR5 agonists have reached the clinical trial stage, and, likely, soon novel TGR5 modulator will be discovered with fewer adverse effects. In silico studies can also be performed with various heterocyclic scaffolds to discover selective and safe TGR5 agonists.
MeSH term(s)	Bile Acids and Salts ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide 1/metabolism ; Humans ; Obesity/drug therapy ; Patents as Topic ; Receptors, G-Protein-Coupled/agonists
Chemical Substances	Bile Acids and Salts ; Receptors, G-Protein-Coupled ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2021-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1186201-4
ISSN	1744-7674 ; 0962-2594 ; 1354-3776
ISSN (online)	1744-7674
ISSN	0962-2594 ; 1354-3776
DOI	10.1080/13543776.2022.1994551
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Article ; Online: Gold Nanoparticle-based Biosensors for Point-of-Care Diagnostics: A Review of Sensing Nanoparticle Applications and Future Prospects.

Chauhan, Sakshi / Mittal, Roopal / Kumar, Manish / Mittal, Amit / Kushwah, Ajay Singh

Combinatorial chemistry & high throughput screening

2024

Abstract: Point of Care Diagnostics (POCD) is quintessential in hospitals and the healthcare sector as the secants uplift the quality of medical care and the life of a patient by facilitating quick identification of the underlying pathological condition. ... ...

Abstract	Point of Care Diagnostics (POCD) is quintessential in hospitals and the healthcare sector as the secants uplift the quality of medical care and the life of a patient by facilitating quick identification of the underlying pathological condition. Nanotechnology can provide opportunities and has potential in the development of new-age sensing/diagnostic tools. Owing to extraordinary features (e.g., higher density, effective catalysis, good conduction, biocompatibility, inertness, and greater surface-to-volume ratio), gold nanoparticles (AuNPs) are frequently employed in POCT (Point-of-Care-Testing). Gold nanoparticles-based colorimetric methods are widely used in the rapid, sensitive, and selective detection of analytes/target molecules. AuNPs description is critical for their possible utility in prophylaxis, diagnostics, and treatment of an ailment. AuNPs interact with organic/inorganic target molecules to generate colorimetric shift that enables the accurate, precise, and subtle recognition of biologicals (e.g., microorganisms, cellular components, and proteins) and metal ions. This review focused on the need for AuNPs-based colorimetric application in prophylaxis, diagnostics, and treatment in healthcare and reviewed the future outlook of these AuNPs for biological applications. Different synthesis methods of AuNPs, their morphology, and characterization, including their surface functionalization, will be discussed in detail. AuNPs are very much preferable nanomaterials owing to exclusive optical, electrical, and photothermal features. AuNPs-based colorimetric biosensors are simple and possess great utility, yet these offer a robust technique to enable visual, quantitative analysis.
Language	English
Publishing date	2024-03-27
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073293557240320065128
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Article ; Online: Diffusion tensor imaging in patients with diabetic peripheral neuropathy: Fractional anisotropy and apparent diffusion coefficient dataset of posterior tibial nerve.

Goyal, Manu / Samuel, Asir John / Mittal, Amit

Data in brief

2022 Volume 43, Page(s) 108421

Abstract: The data in this article described quantitative values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) for 23 (46 extremities) normal healthy males and females, for 46 patients with bilateral diabetic peripheral neuropathy. 1.5 ... ...

Abstract	The data in this article described quantitative values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) for 23 (46 extremities) normal healthy males and females, for 46 patients with bilateral diabetic peripheral neuropathy. 1.5 Tesla (T) MR System Multiva - Philips magnets (Baltimore, Netherland, Holland) imaging with axial T1WSE, sagittal T2WSE and STIR sequences by means of diffusion weighted neurography
Language	English
Publishing date	2022-06-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.108421
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Article ; Online: Oral insulin delivery: a patent review.

Sharma, Shivani / Mittal, Amit / Mehra, Anuradha

Pharmaceutical patent analyst

2022 Volume 11, Issue 6, Page(s) 199–212

Abstract: Insulin, on oral administration, is very troublesome because of its limited bioavailability. The evolution of oral insulin delivery formulations is greatly desired for non-invasive therapy by overcoming its low bioavailability, GIT enzymatic deactivation, ...

Abstract	Insulin, on oral administration, is very troublesome because of its limited bioavailability. The evolution of oral insulin delivery formulations is greatly desired for non-invasive therapy by overcoming its low bioavailability, GIT enzymatic deactivation, poor lipophilicity and low stability. Different approaches have been proposed to boost oral insulin bioavailability in insulin-delivery systems and emerging effective therapies by using nanoparticle formulation, nanocapsid, modified chitosan particles, polydopamine microcapsules and nanoliposomes. The present review includes patents and patent applications that were published between 2017 and January 2022.
MeSH term(s)	Insulin ; Drug Delivery Systems ; Administration, Oral ; Chitosan ; Nanoparticles
Chemical Substances	Insulin ; Chitosan (9012-76-4)
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Review ; Journal Article
ISSN	2046-8962
ISSN (online)	2046-8962
DOI	10.4155/ppa-2022-0017
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Article: Diffusion Tensor Imaging in patients with diabetic peripheral neuropathy: Fractional Anisotropy and Apparent Diffusion Coefficient dataset of posterior tibial nerve

Goyal, Manu / Samuel, Asir John / Mittal, Amit

Data in Brief. 2022 June 21,

2022

Abstract	The data in this article described quantitative values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) for 23 (46 extremities) normal healthy males and females, for 46 patients with bilateral diabetic peripheral neuropathy. 1.5 Tesla (T) MR System Multiva - Philips magnets (Baltimore, Netherland, Holland) imaging with axial T1WSE, sagittal T2WSE and STIR sequences by means of diffusion weighted neurography b values of 0 and 800 s/mm². The data obtained as FA and ADC values in healthy adults and patient population can be referred by researchers, clinicians for early diagnosis, to determine intervention effectiveness and patient management.
Keywords	anisotropy ; data collection ; diffusivity ; early diagnosis ; nerve tissue ; patients ; peripheral nervous system diseases ; tibia
Language	English
Dates of publication	2022-0621
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.108421
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