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  1. Article ; Online: Parastomal Hernia Repair with a 3D Funnel Intraperitoneal Mesh Device and Same-Sided Stoma Relocation: Results of 56 Cases.

    Fischer, Ines / Wundsam, Helwig / Mitteregger, Martin / Köhler, Gernot

    World journal of surgery

    2017  Volume 41, Issue 12, Page(s) 3212–3217

    Abstract: Background: Parastomal hernias (PSHs) are a common and challenging issue. In previous studies, three-dimensional (3D) funnel mesh devices have been used successfully for the repair of PSHs.: Methods: We performed an analysis of prospectively ... ...

    Abstract Background: Parastomal hernias (PSHs) are a common and challenging issue. In previous studies, three-dimensional (3D) funnel mesh devices have been used successfully for the repair of PSHs.
    Methods: We performed an analysis of prospectively collected data of patients who underwent a same-sided stoma reposition with 3D funnel-shaped mesh augmentation in intraperitoneal (IPOM) position at our department between the years of 2012 and 2015. Primary outcome parameters were intra- and postoperative surgical complications and recurrence rate during the follow-up period.
    Results: Fifty-six patients could be included in this analysis. PSH repair was performed in 89.3% as elective surgery and in 73% in laparoscopic technique. A concomitant incisional hernia (EHS type 2 and 4) was found in 50% and repaired in a single-step procedure with PSH. Major postoperative complications requiring redo surgery (Clavien-Dindo ≥3b) were identified in 8.9% (5/56). Overall recurrence rate was 12.5% (7/56). Median follow-up time was 38 months, and a 1-year follow-up rate of 96.4% was reached.
    Conclusion: PSH repair with 3D funnel mesh in IPOM technique is safe, efficient and easy to perform in laparoscopic and open surgical approaches providing advantageous results compared to other techniques. Furthermore, simultaneous detection and treatment of concomitant incisional hernias has shown favorable. However, the mesh funnel distends and becomes shortened encasing a bulky bowel mesentery and further shrinkage happens eccentric. Changing mesh construction according to lengthening the funnel could possibly lead to reduction in recurrence.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Hernia, Abdominal/etiology ; Hernia, Abdominal/surgery ; Herniorrhaphy/adverse effects ; Herniorrhaphy/instrumentation ; Herniorrhaphy/methods ; Humans ; Incisional Hernia/etiology ; Incisional Hernia/surgery ; Laparoscopy ; Male ; Middle Aged ; Postoperative Complications/etiology ; Prostheses and Implants/adverse effects ; Recurrence ; Reoperation ; Surgical Mesh/adverse effects ; Surgical Stomas/adverse effects
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-017-4130-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Serum 1,3-Beta-D-Glucan Values During and After Laparoscopic and Open Intestinal Surgery.

    Szyszkowitz, Alexander / Zurl, Christoph / Herzeg, Anna / Berger, Anton / Gemes, Geza / Mitteregger, Martin / Prüller, Florian / Prattes, Juergen / Zollner-Schwetz, Ines / Valentin, Thomas / Hoenigl, Martin / Krause, Robert

    Open forum infectious diseases

    2018  Volume 5, Issue 12, Page(s) ofy296

    Abstract: Background: 1,3-beta-D Glucan (BDG) assay has good accuracy for distinguishing patients with invasive fungal infections from patients without. Some procedures and medications affect BDG levels, resulting in false-positive BDG results. The extent of ... ...

    Abstract Background: 1,3-beta-D Glucan (BDG) assay has good accuracy for distinguishing patients with invasive fungal infections from patients without. Some procedures and medications affect BDG levels, resulting in false-positive BDG results. The extent of intestinal surgery on BDG kinetics is unknown. We evaluated the influence of laparoscopic and open intestinal surgery on peri- and postsurgical serum BDG values.
    Methods: BDG was determined in 346 samples from 50 patients undergoing laparoscopic (24) or open (26) intestinal surgery at the following time points: after insertion of arterial but before skin incision, after skin incision but before dissection of the intestinal mucosa, after completion of anastomosis, after completion of skin sutures, in the evening after surgery, day 2 after surgery, 4-5 days after surgery.
    Results: BDG was positive (ie, concentration ≥80 pg/mL) in 54% to 61% of patients during laparoscopic and open surgery (highest rates after completion of skin sutures). BDG was still positive in 12% (open) to 17% (laparoscopic) of patients without any suspected or proven fungal infection or anastomotic leakage 4-5 days after surgery. After completion of gut anastomosis, the BDG increase was higher in open compared with laparoscopic intestinal surgery.
    Conclusions: The value of positive BDG tests in the perioperative setting up to 5 days postsurgery seems to be limited due to BDG elevations from intestinal surgical procedures.
    Language English
    Publishing date 2018-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofy296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.

    Zaborowski, Alexandra M / Abdile, Ahmed / Adamina, Michel / Aigner, Felix / d'Allens, Laura / Allmer, Caterina / Álvarez, Andrea / Anula, Rocio / Andric, Mihailo / Atallah, Sam / Bach, Simon / Bala, Miklosh / Barussaud, Marie / Bausys, Augustinas / Bebington, Brendan / Beggs, Andrew / Bellolio, Felipe / Bennett, Melissa-Rose / Berdinskikh, Anton /
    Bevan, Vicki / Biondo, Sebastiano / Bislenghi, Gabriele / Bludau, Marc / Boutall, Adam / Brouwer, Nelleke / Brown, Carl / Bruns, Christiane / Buchanan, Daniel D / Buchwald, Pamela / Burger, Jacobus W A / Burlov, Nikita / Campanelli, Michela / Capdepont, Maylis / Carvello, Michele / Chew, Hwee-Hoon / Christoforidis, Dimitri / Clark, David / Climent, Marta / Cologne, Kyle G / Contreras, Tomas / Croner, Roland / Daniels, Ian R / Dapri, Giovanni / Davies, Justin / Delrio, Paolo / Denost, Quentin / Deutsch, Michael / Dias, Andre / D'Hoore, André / Drozdov, Evgeniy / Duek, Daniel / Dunlop, Malcolm / Dziki, Adam / Edmundson, Aleksandra / Efetov, Sergey / El-Hussuna, Alaa / Elliot, Brodie / Emile, Sameh / Espin, Eloy / Evans, Martyn / Faes, Seraina / Faiz, Omar / Fleming, Fergal / Foppa, Caterina / Fowler, George / Frasson, Matteo / Figueiredo, Nuno / Forgan, Tim / Frizelle, Frank / Gadaev, Shamil / Gellona, Jose / Glyn, Tamara / Gong, Jianping / Goran, Barisic / Greenwood, Emma / Guren, Marianne G / Guillon, Stephanie / Gutlic, Ida / Hahnloser, Dieter / Hampel, Heather / Hanly, Ann / Hasegawa, Hirotoshi / Iversen, Lene Hjerrild / Hill, Andrew / Hill, James / Hoch, Jiri / Hoffmeister, Michael / Hompes, Roel / Hurtado, Luis / Iaquinandi, Fabiano / Imbrasaite, Ugne / Islam, Rumana / Jafari, Mehrenah Dorna / Kanemitsu, Yukihide / Karachun, Aleksei / Karimuddin, Ahmer A / Keller, Deborah S / Kelly, Justin / Kennelly, Rory / Khrykov, Gleb / Kocian, Peter / Koh, Cherry / Kok, Neils / Knight, Katrina A / Knol, Joep / Kontovounisios, Christos / Korner, Hartwig / Krivokapic, Zoran / Kronberger, Irmgard / Kroon, Hidde Maarten / Kryzauskas, Marius / Kural, Said / Kusters, Miranda / Lakkis, Zaher / Lankov, Timur / Larson, Dave / Lázár, György / Lee, Kai-Yin / Lee, Suk Hwan / Lefèvre, Jérémie H / Lepisto, Anna / Lieu, Christopher / Loi, Lynette / Lynch, Craig / Maillou-Martinaud, Helene / Maroli, Annalisa / Martin, Sean / Martling, Anna / Matzel, Klaus E / Mayol, Julio / McDermott, Frank / Meurette, Guillaume / Millan, Monica / Mitteregger, Martin / Moiseenko, Andrei / Monson, John R T / Morarasu, Stefan / Moritani, Konosuke / Möslein, Gabriela / Munini, Martino / Nahas, Caio / Nahas, Sergio / Negoi, Ionut / Novikova, Anastasia / Ocares, Misael / Okabayashi, Koji / Olkina, Alexandra / Oñate-Ocaña, Luis / Otero, Jaime / Ozen, Cihan / Pace, Ugo / São Julião, Guilherme Pagin / Panaiotti, Lidiia / Panis, Yves / Papamichael, Demetris / Park, Jason / Patel, Swati / Patrón Uriburu, Juan Carlos / Pera, Miguel / Perez, Rodrigo O / Petrov, Alexei / Pfeffer, Frank / Phang, P Terry / Poskus, Tomas / Pringle, Heather / Proud, David / Raguz, Ivana / Rama, Nuno / Rasheed, Shahnawaz / Raval, Manoj J / Rega, Daniela / Reissfelder, Christoph / Reyes Meneses, Juan Carlos / Ris, Frederic / Riss, Stefan / Rodriguez-Zentner, Homero / Roxburgh, Campbell S / Saklani, Avanish / Salido, Andrea Jiménez / Sammour, Tarik / Saraste, Deborah / Schneider, Martin / Seishima, Ryo / Sekulic, Aleksandar / Seppala, Toni / Sheahan, Kieran / Shine, Rebecca / Shlomina, Alexandra / Sica, Guiseppe S / Singnomklao, Tongplaew / Siragusa, Leandro / Smart, Neil / Solis, Alejandro / Spinelli, Antonino / Staiger, Roxane D / Stamos, Michael J / Steele, Scott / Sunderland, Michael / Tan, Ker-Kan / Tanis, Pieter J / Tekkis, Paris / Teklay, Biniam / Tengku, Sabrina / Jiménez-Toscano, Marta / Tsarkov, Petr / Turina, Matthias / Ulrich, Alexis / Vailati, Bruna B / van Harten, Meike / Verhoef, Cornelis / Warrier, Satish / Wexner, Steve / de Wilt, Hans / Weinberg, Benjamin A / Wells, Cameron / Wolthuis, Albert / Xynos, Evangelos / You, Nancy / Zakharenko, Alexander / Zeballos, Justino / Winter, Des C

    JAMA surgery

    2021  Volume 156, Issue 9, Page(s) 865–874

    Abstract: Importance: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular ... ...

    Abstract Importance: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer.
    Observations: Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts.
    Conclusions and relevance: The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.
    MeSH term(s) Adult ; Age of Onset ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/pathology ; Humans ; Incidence ; Middle Aged ; Risk Factors
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2021.2380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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