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  1. Article ; Online: Discovery of three-dimensional bicyclo[3.3.1]nonanols as novel heat shock protein 90 inhibitors.

    Miura, Kazuki / Joshi, Manjusha / Morita, Taiki / Nakamura, Hiroyuki

    Bioorganic & medicinal chemistry

    2023  Volume 93, Page(s) 117463

    Abstract: We developed an efficient synthetic method for constructing bicyclo[3.3.1]nonane, an ... ...

    Abstract We developed an efficient synthetic method for constructing bicyclo[3.3.1]nonane, an sp
    MeSH term(s) Humans ; Alkanes ; Antineoplastic Agents ; Carbon ; HSP90 Heat-Shock Proteins
    Chemical Substances nonane (T9W3VH6G10) ; Alkanes ; Antineoplastic Agents ; Carbon (7440-44-0) ; HSP90 Heat-Shock Proteins
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2023.117463
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Discovery of Disubstituted Carboranes as Inhibitors of Heat Shock Protein 90-Heat Shock Factor 1 Interaction.

    Shao, Yujie / Miura, Kazuki / Asawa, Yasunobu / Morita, Taiki / Li, Guangzhe / Nakamura, Hiroyuki

    ACS medicinal chemistry letters

    2024  Volume 15, Issue 5, Page(s) 619–625

    Abstract: Efficient synthesis of ... ...

    Abstract Efficient synthesis of disubstituted
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.4c00022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Synthesis of the diazatricycloundecane scaffold

    Doi, Tomoya / Umedera, Kohei / Miura, Kazuki / Morita, Taiki / Nakamura, Hiroyuki

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 43, Page(s) 8716–8726

    Abstract: The bridged diazatricycloundecane ... ...

    Abstract The bridged diazatricycloundecane sp
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01534c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Mori et al. Involvement of DPY19L3 in Myogenic Differentiation of C2C12 Myoblasts.

    Mori, Kento / Sun, Hongkai / Miura, Kazuki / Simizu, Siro

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 11

    Abstract: In the original article [ ... ]. ...

    Abstract In the original article [...].
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27113534
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Photodynamic Therapy by Glucose Transporter 1-Selective Light Inactivation.

    Miura, Kazuki / Wen, Yijin / Tsushima, Michihiko / Nakamura, Hiroyuki

    ACS omega

    2022  Volume 7, Issue 38, Page(s) 34685–34692

    Abstract: Chromophore-assisted light inactivation (CALI) was applied to molecule-targeted photodynamic therapy (PDT). In order to identify organic photosensitizers suitable for CALI, the carbonic anhydrase II (CAII) ligand, 4-sulfamoylbenzoic ... ...

    Abstract Chromophore-assisted light inactivation (CALI) was applied to molecule-targeted photodynamic therapy (PDT). In order to identify organic photosensitizers suitable for CALI, the carbonic anhydrase II (CAII) ligand, 4-sulfamoylbenzoic acid
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c05042
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  6. Article: Inheritance pattern of the flightless characteristic in Harmonia axyridis

    Seko, Tomokazu / Miura, Kazuki

    BioControl. 2020 Apr., v. 65, no. 2

    2020  

    Abstract: The genetic basis of the flightless characteristic in Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae) was studied using two crossbreeding experiments to verify the inheritance of the flightless character which may be relevant if mating with wild ... ...

    Abstract The genetic basis of the flightless characteristic in Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae) was studied using two crossbreeding experiments to verify the inheritance of the flightless character which may be relevant if mating with wild populations takes place. In the first experiment, the segregating population (F2) was obtained by random mating within each F1 line. The proportion of flightless individuals reached 24–29% in the F2 generation. In the second experiment, the F1 individuals were crossed with the flightless individuals to develop a backcross (BC) population, which showed that the proportion of flightless individuals reached 33–59% in the BC population. Although the quantitative variation of flight ability in H. axyridis could also be due to a large proportion of loci with small effects, our results suggest that the flightless mutation is largely controlled by a single locus and that only H. axyridis individuals homozygous for the recessive alleles show the flightless characteristic.
    Keywords Harmonia axyridis ; alleles ; backcrossing ; biological control ; homozygosity ; inheritance (genetics) ; loci ; mutation ; random mating
    Language English
    Dates of publication 2020-04
    Size p. 175-183.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 1452737-6
    ISSN 1573-8248 ; 1386-6141
    ISSN (online) 1573-8248
    ISSN 1386-6141
    DOI 10.1007/s10526-020-09995-w
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    In stock of ZB MED Bonn / Germany

    Z 1420: Show issues

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  7. Article ; Online: Involvement of DPY19L3 in Myogenic Differentiation of C2C12 Myoblasts.

    Mori, Kento / Sun, Hongkai / Miura, Kazuki / Simizu, Siro

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 18

    Abstract: DPY19L3 has been identified as ... ...

    Abstract DPY19L3 has been identified as a
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Cell Line ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Knockdown Techniques ; Glycosylation ; Mannosyltransferases/genetics ; Mannosyltransferases/physiology ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Myoblasts/cytology ; Myoblasts/physiology ; Phosphorylation/genetics ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Signal Transduction/genetics ; Up-Regulation/genetics
    Chemical Substances Dpy19l3 protein, mouse (EC 2.4.1.-) ; Mannosyltransferases (EC 2.4.1.-) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
    Language English
    Publishing date 2021-09-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26185685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article ; Online: Simplified capture, extraction, and amplification of cellular DNA from water samples.

    Kawaguchi, Mai / Aoki, Hiroshi / Kamo, Hiroki / Miura, Kazuki / Hiruta, Yuki / Simizu, Siro / Citterio, Daniel

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2023  Volume 40, Issue 3, Page(s) 501–510

    Abstract: DNA analysis in water samples is attracting attention in various fields. However, conventional methods for DNA analysis require a work-intensive and time-consuming sample pre-treatment. In this study, a simplified pre-treatment method for analyzing DNA ... ...

    Abstract DNA analysis in water samples is attracting attention in various fields. However, conventional methods for DNA analysis require a work-intensive and time-consuming sample pre-treatment. In this study, a simplified pre-treatment method for analyzing DNA in water samples was evaluated. The process consists of filtration, DNA extraction, and amplification, which can be achieved within a short time. In the filtration process, two types of filters, firstly a tissue paper (Kimwipe) and then a glass filter (GF/F), were used in sequence. The first large pore size filter enabled a reduction in filtration time by removing large particulate matter impurities present in river water matrix. Cells spiked into 1 L of river water were recovered at more than 90% within approximately 5 min filtration time. Also, DNA was extracted from the captured cells directly on the surface of the filter in only 5 min. Thus, DNA collection and extraction from a water sample can be completed within about 10 min. Furthermore, PCR amplification was performed directly from DNA-attached filter sections, which greatly reduced the number of required pre-treatment steps. Finally, we succeeded in establishing a simple and fast on-site pre-treatment system by using a hand-driven syringe filtration method. This pre-treatment system is expected to offer the possibility for the future establishment of a rapid and easy DNA analysis method applicable to various types of water samples.
    MeSH term(s) DNA/genetics ; Fresh Water ; Filtration/methods ; Water
    Chemical Substances DNA (9007-49-2) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 1348-2246
    ISSN (online) 1348-2246
    ISSN 1348-2246
    DOI 10.1007/s44211-023-00482-7
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  9. Article: Intracellular photocatalytic-proximity labeling for profiling protein–protein interactions in microenvironments

    Tsushima, Michihiko / Sato, Shinichi / Miura, Kazuki / Niwa, Tatsuya / Taguchi, Hideki / Nakamura, Hiroyuki

    Chemical communications. 2022 Feb. 8, v. 58, no. 12

    2022  

    Abstract: Intracellular photocatalytic-proximity labeling (iPPL) was developed to profile protein–protein interactions in the microenvironment of living cells. Acriflavine was found to be an efficient cell-membrane-permeable photocatalyst for introduction into the ...

    Abstract Intracellular photocatalytic-proximity labeling (iPPL) was developed to profile protein–protein interactions in the microenvironment of living cells. Acriflavine was found to be an efficient cell-membrane-permeable photocatalyst for introduction into the genetically HaloTag-fused protein of interest for iPPL with a radical labeling reagent, 1-methyl-4-arylurazole. iPPL was applied to the histone-associated protein H2B in HaloTag-H2B expressing HEK293FT cells. The proteins directly interacting with histones and RNA-binding proteins were selectively labeled in the intracellular environment, suggesting that the iPPL method has a smaller labeling radius (ca. 6 nm) than the BioID and APEX methods.
    Keywords acriflavine ; histones ; photocatalysts
    Language English
    Dates of publication 2022-0208
    Size p. 1926-1929.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc05764b
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  10. Article: Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model

    Utomo, Rohmad Yudi / Sugie, Atsushi / Okada, Satoshi / Miura, Kazuki / Nakamura, Hiroyuki

    Chemical communications. 2022 Feb. 17, v. 58, no. 15

    2022  

    Abstract: Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued ...

    Abstract Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.
    Keywords Alzheimer disease ; Drosophila ; amyloid ; curcumin ; locomotion ; models
    Language English
    Dates of publication 2022-0217
    Size p. 2576-2579.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc07000b
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