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Article ; Online: Numerical assessment of the applicability of geometry-based force inference on homogeneous and heterogeneous cells.

Miyasaka, Shou / Izumi, Keita / Okuda, Satoru / Miki, Yuichiro

2024 Volume 19, Issue 4, Page(s) e0299016

Abstract: The measurement of cellular forces, which reflect crucial biological attributes, has the potential to replace conventional cell assessment methods, such as morphology, proliferation, and molecular expression analysis, in medical cell diagnosis and cell ... ...

Abstract	The measurement of cellular forces, which reflect crucial biological attributes, has the potential to replace conventional cell assessment methods, such as morphology, proliferation, and molecular expression analysis, in medical cell diagnosis and cell culture studies. In medical cell evaluations, force inference techniques have gained prominence due to their non-invasiveness and lack of requirement for specialized equipment. Among those techniques, the method proposed by Ishihara et al., which estimates forces in densely packed cells based only on cell geometry, is a promising method. However, its applicability range of this method has not been fully established. In this study, we employed a two-dimensional vertex model to numerically assess the applicability of this method on homogeneous and heterogeneous cells. Our comparisons between the true values from numerical simulations and the estimated values from the inference method revealed a significant correlation between estimation accuracy and cell roundness in systems of homogeneous cell. Moreover, the method demonstrated efficient force estimations in heterogeneous-cell systems. These findings may be useful when the force inference method is employed to evaluate medical cells.
MeSH term(s)	Biomechanical Phenomena ; Mechanical Phenomena
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Primary angiosarcoma arising in the sinus of Valsalva: A case report.

Morimoto, Kenichi / Miyasaka, Shigeto / Ikeda, Yosuke / Nii, Rikuto / Fujiwara, Yoshikazu

International journal of surgery case reports

2024 Volume 115, Page(s) 109308

Abstract: Introduction: Primary angiosarcoma of the aorta, particularly within the sinus of Valsalva, is uncommon, with no documented instances of primary angiosarcoma. The absence of apparent clinical manifestations in this severe condition makes it challenging ... ...

Abstract	Introduction: Primary angiosarcoma of the aorta, particularly within the sinus of Valsalva, is uncommon, with no documented instances of primary angiosarcoma. The absence of apparent clinical manifestations in this severe condition makes it challenging to diagnose, often resulting in a poor prognosis. Case presentation: A 60-year-old patient underwent procedures for fistula closure and coronary artery bypass grafting, which resulted in the rupture of an aneurysm within the sinus of Valsalva. Computed tomography examination 5 years after the procedure suggested no pathological abnormalities. Nevertheless, the patient required repeat surgery at 67 years due to the observed expansion of the sinus of Valsalva aneurysm noted during a clinical evaluation, prompted by elevated levels of inflammatory markers. Exploration of the residual aneurysmal locus within the sinus of Valsalva revealed an intraluminal thrombus devoid of any demonstrable hemodynamic access into the aneurysmal sac. Histopathological assessment of the aneurysmal wall confirmed a definitive diagnosis of primary angiosarcoma within the sinus of Valsalva. After surgery, the patient exhibited pyrexia. Magnetic resonance imaging substantiated multifocal osseous metastases, corroborated by histological analysis following a bone biopsy, confirming a diagnosis of angiosarcoma. Therefore, adjuvant chemotherapy with paclitaxel was initiated. After 1 year, a sustained state of disease stability was noted. Discussion: In this case, the need for surgical intervention, based on an expanded sinus of Valsalva aneurysm, culminated in the unanticipated detection of primary angiosarcoma. Conclusion: Neoplastic etiologies may plausibly underlie the pathogenesis of aneurysm formation in cases where the etiology remains obscure in the early stages of therapeutic intervention.
Language	English
Publishing date	2024-01-30
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2024.109308
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Article ; Online: Taf1 N-terminal domain 2 (TAND2) of TFIID promotes formation of stable and mobile unstable TBP-TATA complexes.

Miyasaka, Shinji / Kitada, Ryota / Kokubo, Tetsuro

Gene

2023 Volume 889, Page(s) 147800

Abstract: In eukaryotes, TATA-binding protein (TBP) occupancy of the core promoter globally correlates with transcriptional activity of class II genes. Elucidating how TBP is delivered to the TATA box or TATA-like element is crucial to understand the mechanisms of ...

Abstract	In eukaryotes, TATA-binding protein (TBP) occupancy of the core promoter globally correlates with transcriptional activity of class II genes. Elucidating how TBP is delivered to the TATA box or TATA-like element is crucial to understand the mechanisms of transcriptional regulation. A previous study demonstrated that the inhibitory DNA binding (IDB) surface of human TBP plays an indispensable role during the two-step formation of the TBP-TATA complex, first assuming an unstable and unbent intermediate conformation, and subsequently converting slowly to a stable and bent conformation. The DNA binding property of TBP is altered by physical contact of this surface with TBP regulators. In the present study, we examined whether the interaction between Taf1 N-terminal domain 2 (TAND2) and the IDB surface affected DNA binding property of yeast TBP by exploiting TAND2-fused TBP derivatives. TAND2 promoted formation of two distinct types of TBP-TATA complexes, which we arbitrarily designated as complex I and II. While complex I was stable and similar to the well-characterized original TBP-TATA complex, complex II was unstable and moved along DNA. Removal of TAND2 from TBP after complex formation revealed that continuous contact of TAND2 with the IDB surface was required for formation of complex II but not complex I. Further, TFIIA could be incorporated into the complex of TAND2-fused TBP and the TATA box, which was dependent on the amino-terminal non-conserved region of TBP, implying that this region could facilitate the exchange between TAND2 and TFIIA on the IDB surface. Collectively, these findings provide novel insights into the mechanism by which TBP is relieved from the interaction with TAND to bind the TATA box or TATA-like element within promoter-bound TFIID.
MeSH term(s)	Humans ; Transcription Factor TFIID/genetics ; Transcription Factor TFIIA/genetics ; Transcription Factor TFIIA/metabolism ; TATA-Box Binding Protein/chemistry ; Gene Expression Regulation ; DNA/metabolism ; Saccharomyces cerevisiae/genetics ; TATA Box/genetics
Chemical Substances	Transcription Factor TFIID ; Transcription Factor TFIIA ; TATA-Box Binding Protein ; DNA (9007-49-2)
Language	English
Publishing date	2023-09-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147800
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Article: [Minimally Invasive Cardiac Surgery-Coronary Artery Bypass Grafting by Left Small Intercostal Thoracotomy for Very Elderly Patients:Report of Two Cases].

Tokutome, Junpei / Shiraya, Suguru / Sakaguchi, Yuki / Miyasaka, Shigeto

Kyobu geka. The Japanese journal of thoracic surgery

2021 Volume 74, Issue 2, Page(s) 125–129

Abstract: The increase in the age of patients undergoing operations has become more prominent in recent years. We report our experience of minimally invasive cardiac surgery-coronary artery bypass grafting (MICS-CABG) by left small intercostal thoracotomy for very ...

Abstract	The increase in the age of patients undergoing operations has become more prominent in recent years. We report our experience of minimally invasive cardiac surgery-coronary artery bypass grafting (MICS-CABG) by left small intercostal thoracotomy for very elderly patients. Case 1:The patient was a 91-year-old woman with a history of percutaneous coronary intervention (PCI) for left anterior descending artery (LAD) and right coronary arteries at different timings. Due to her contrast media allergy, we performed MICS-CABG to treat 75% stenosis of LAD. Blood transfusion was not required. She was discharged on the 13th day. Case 2:The patient was a 92-year-old man. We performed MICS-CABG for 75% stenosis of the left main trunk and 90~99% stenosis of the LAD with severe calcification. Blood transfusion was not required. He was discharged on the 21th day. MICS-CABG can be performed with less invasiveness in comparison to the conventional method and therefore seems to be an effective method of surgery for very elderly patients.
MeSH term(s)	Aged ; Aged, 80 and over ; Coronary Artery Bypass ; Female ; Humans ; Male ; Minimally Invasive Surgical Procedures ; Percutaneous Coronary Intervention ; Thoracotomy ; Treatment Outcome
Language	Japanese
Publishing date	2021-05-11
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	603899-2
ISSN	0021-5252
ISSN	0021-5252
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Book ; Online: Estimation of the leaf area density distribution of individual trees using high-resolution and multi-return airborne LiDAR data

Oshio, Haruki / Asawa, Takashi / Hoyano, Akira / Miyasaka, Satoshi

2022

Abstract: The three-dimensional structures of individual trees are important pieces of information necessary to understand the effect of trees on urban environments. In this study, we demonstrate a method for estimating the leaf area density (LAD) distribution of ... ...

Abstract	The three-dimensional structures of individual trees are important pieces of information necessary to understand the effect of trees on urban environments. In this study, we demonstrate a method for estimating the leaf area density (LAD) distribution of individual trees using high-resolution airborne LiDAR. This method improves upon the previously proposed method, which calculates LAD based on the contact frequency between the laser beams and leaves by tracing the paths of the laser beams. The proposed method in this study exploits the last and intermediate pulses in addition to the first and single pulses to capture the foliage distribution in the inner part of the crown. Each laser beam is traced from a point derived by the last pulse to the point derived by the first or intermediate pulse that is recorded immediately before the last pulse. The laser beam interceptions and intersections can thus be accurately reproduced while considering the last and intermediate pulses. We verify the estimation accuracy of the three-dimensional LAD distribution using terrestrial LiDAR data from a single tree (Z. serrata). The appropriate voxel size for representing the LAD distribution from the airborne LiDAR is first determined by comparing the distribution of voxels containing one or more airborne LiDAR points with that containing one or more terrestrial LiDAR points. The estimated LAD distribution with a voxel size of 1 m by 1 m by 0.5 m is subsequently compared to the terrestrial LiDAR-derived LAD distribution. When only the first and single pulses are used, the LAD is overestimated and underestimated in the upper and lower part of the crown, respectively. We confirmed that using the last and intermediate pulses improves the estimation accuracy of the entire crown area. Comment: 43 pages, 10 figures, Accepted manuscript of https://www.sciencedirect.com/science/article/pii/S0034425715300018
Keywords	Physics - Geophysics
Subject code	333
Publishing date	2022-06-23
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Economic Benefits from Managing Coffee Berry Borer (

Lee, Donna / Johnson, Melissa A / Aristizábal, Luis F / Shriner, Suzanne / Chan, Catherine / Miyasaka, Susan / Wall, Marisa

Insects

2023 Volume 14, Issue 4

Abstract: Coffee berry borer (CBB) is considered the most damaging insect pest of coffee worldwide. CBB was first detected on Hawai'i Island in 2010, and quickly spread throughout the state's coffee-growing regions. With the introduction of this pest, Hawaii's ... ...

Abstract	Coffee berry borer (CBB) is considered the most damaging insect pest of coffee worldwide. CBB was first detected on Hawai'i Island in 2010, and quickly spread throughout the state's coffee-growing regions. With the introduction of this pest, Hawaii's small yet economically important coffee industry was changed forever with growers facing significantly higher production and labor costs, as well as decreased yield and coffee quality. We assessed the economic benefits of managing CBB based on three strategies that emerged in Hawaii over the last decade: (1) the use of the entomopathogenic fungus
Language	English
Publishing date	2023-04-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects14040350
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Article: Evaluation of insecticides for the management of rough sweetpotato weevil, Blosyrus asellus (Coleoptera: Curculionidae) in Hawaii island

Pulakkatu-Thodi, I. / Motomura-Wages, S. / Miyasaka, S.

Crop protection

2018 Volume 114, Issue -, Page(s) 223

Language	English
Document type	Article
ZDB-ID	786839-x
ISSN	0261-2194
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Immunohistochemical staining of skin-expressed proteins to identify exfoliated epidermal cells for forensic purposes.

Akutsu, Tomoko / Ikegaya, Hiroshi / Watanabe, Ken / Miyasaka, Sachio

Forensic science international

2019 Volume 303, Page(s) 109940

Abstract: The determination of cell type in biological casework samples would be helpful to identify the type of body fluids and interpret the DNA source in forensic laboratories. Exfoliated epidermal cells are considered to be a reasonable source of touch DNA; ... ...

Abstract	The determination of cell type in biological casework samples would be helpful to identify the type of body fluids and interpret the DNA source in forensic laboratories. Exfoliated epidermal cells are considered to be a reasonable source of touch DNA; therefore, we developed and assessed an immunohistochemistry (IHC) procedure for identifying exfoliated epidermal cells as a screening test of touch DNA samples. Among five candidate protein markers investigated in this study, keratin 10 and kallikrein-related peptidase 5 were strongly expressed in the stratum corneum layer of the skin; however, their specificity was insufficient to identify epidermal cells. In contrast, IHC for corneodesmosin (CDSN), desmocollin 1 (DSC1), and filaggrin (FLG) was considered to be applicable because of their detectability and specificity on skin swab samples. Actually, CDSN and DSC1 could be good markers for exfoliated epidermal cells on touched contact traces that were contaminated with many unidentified impurities. Besides, positivity for FLG on mock casework samples appeared to be lower than for the other markers, which might be caused by its instability. Finally, the relationship between positivity for IHC and DNA yield was analyzed using skin swab samples. Although it was difficult to determine these correlations quantitatively because of the heterogeneous distribution of cells and the presence of cell-free DNA, the DNA-quantifiable samples analyzed in this study contained at least some of IHC-positive epidermal cells. In conclusion, IHC detection of skin-enriched proteins, especially CDSN and DSC1, could be useful for screening samples that have been handled or touched by someone before DNA analysis.
MeSH term(s)	Biomarkers/metabolism ; Blood Chemical Analysis ; Cervix Mucus/chemistry ; DNA/analysis ; Desmocollins/metabolism ; Epidermal Cells/cytology ; Forensic Sciences ; Humans ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins/metabolism ; Intermediate Filament Proteins/metabolism ; Kallikreins/metabolism ; Keratin-10/metabolism ; Real-Time Polymerase Chain Reaction ; Saliva/chemistry ; Semen/chemistry ; Skin/metabolism ; Staining and Labeling ; Touch
Chemical Substances	Biomarkers ; CDSN protein, human ; DSC1 protein, human ; Desmocollins ; Intercellular Signaling Peptides and Proteins ; Intermediate Filament Proteins ; KRT10 protein, human ; filaggrin ; Keratin-10 (147785-83-9) ; DNA (9007-49-2) ; KLK5 protein, human (EC 3.4.21.-) ; Kallikreins (EC 3.4.21.-)
Language	English
Publishing date	2019-09-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2019.109940
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Zs.B 1104: Show issues

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Article: Progress in Facial Reconstruction Technology.

Miyasaka, S

Forensic science review

1999 Volume 11, Issue 1, Page(s) 51–90

Abstract: This paper mainly focuses on anatomical knowledge, methodological aspects and their utility in forensic facial reconstruction, along with a survey of the related literature. In view of increased computerization in facial reconstruction, some unique ... ...

Abstract	This paper mainly focuses on anatomical knowledge, methodological aspects and their utility in forensic facial reconstruction, along with a survey of the related literature. In view of increased computerization in facial reconstruction, some unique computer technologies are reviewed. In addition, the latest data concerning facial soft tissue thickness, the positional relation between facial features and the underlying skull, and the morphological correlation between face type and facial components in Japanese population are also introduced, with the hope that the information will find efficient use in attaining a reasonable facial reconstruction.
Language	English
Publishing date	1999-06
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Review
ZDB-ID	1161793-7
ISSN	1042-7201
ISSN	1042-7201
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Zs.A 4320: Show issues

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Article ; Online: Isolation and characterization of peptides with dipeptidyl peptidase IV (DPPIV) inhibitory activity from natto using DPPIV from Aspergillus oryzae.

Sato, Kousuke / Miyasaka, Syogo / Tsuji, Akira / Tachi, Hiroshi

Food chemistry

2018 Volume 261, Page(s) 51–56

Abstract: Human-derived dipeptidyl peptidase IV (DPPIV) is a costly material used in the discovery of drugs for diabetes. In this study, we demonstrated the efficacy of DPPIV from Aspergillus oryzae as an alternative to human-derived DPPIV for identifying DPPIV ... ...

Abstract	Human-derived dipeptidyl peptidase IV (DPPIV) is a costly material used in the discovery of drugs for diabetes. In this study, we demonstrated the efficacy of DPPIV from Aspergillus oryzae as an alternative to human-derived DPPIV for identifying DPPIV inhibitors. Fermented soybean, also called natto, suppresses blood glucose levels in humans; however, the underlying mechanism remains unknown. This study determined the in vitro DPPIV inhibitory activity of isolated peptides from natto. Amino acid sequences of two peptides isolated from natto were identified by LC/MS/MS as Lys-Leu and Leu-Arg. These isolated peptides inhibited DPPIV in a dose-dependent manner, with IC
MeSH term(s)	Amino Acid Sequence ; Aspergillus oryzae/enzymology ; Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/isolation & purification ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Fermentation ; Food Handling ; Humans ; Peptides/chemistry ; Peptides/isolation & purification ; Peptides/pharmacology ; Soy Foods/analysis
Chemical Substances	Dipeptidyl-Peptidase IV Inhibitors ; Peptides ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
Language	English
Publishing date	2018-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2018.04.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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