Article ; Online: Perioperative serum syndecan-1 concentrations in patients who underwent cardiovascular surgery with cardiopulmonary bypass and its association with the occurrence of postoperative acute kidney injury: a retrospective observational study.
2024 Volume 24, Issue 1, Page(s) 154
Abstract: Background: Various factors can cause vascular endothelial damage during cardiovascular surgery (CVS) with cardiopulmonary bypass (CPB), which has been suggested to be associated with postoperative complications. However, few studies have specifically ... ...
| Abstract | Background: Various factors can cause vascular endothelial damage during cardiovascular surgery (CVS) with cardiopulmonary bypass (CPB), which has been suggested to be associated with postoperative complications. However, few studies have specifically investigated the relationship between the degree of vascular endothelial damage and postoperative acute kidney injury (pAKI). The objectives of this study were to measure perioperative serum syndecan-1 concentrations in patients who underwent CVS with CPB, evaluate their trends, and determine their association with pAKI. Methods: This was a descriptive and case‒control study conducted at the National University Hospital. Adult patients who underwent CVS with CPB at a national university hospital between March 15, 2016, and August 31, 2020, were included. Patients who were undergoing preoperative dialysis, had preoperative serum creatinine concentrations greater than 2.0 mg dl Results: Fifty-two patients were included. pAKI occurred in 18 (34.6%) of those patients. The serum syndecan-1 concentration increased after CPB initiation and exhibited bimodal peak values. The serum syndecan-1 concentration at all time points was significantly elevated compared to that after the induction of anesthesia. The serum syndecan-1 concentration at 30 min after weaning from CPB and on postoperative day 1 was associated with the occurrence of pAKI (OR = 1.10 [1.01 to 1.21], P = 0.03]; OR = 1.16 [1.01 to 1.34], P = 0.04]; and the cutoff values of the serum syndecan-1 concentration that resulted in pAKI were 101.0 ng ml Conclusion: The serum syndecan-1 concentration at all time points was significantly greater than that after the induction of anesthesia. The serum syndecan-1 concentration on postoperative day 1 was significantly associated with the occurrence of pAKI. Trial registration: This study is not a clinical trial and is not registered with the registry. |
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| MeSH term(s) | Humans ; Syndecan-1/blood ; Male ; Cardiopulmonary Bypass/adverse effects ; Female ; Acute Kidney Injury/blood ; Acute Kidney Injury/etiology ; Retrospective Studies ; Middle Aged ; Postoperative Complications/blood ; Aged ; Case-Control Studies ; Cardiovascular Surgical Procedures/adverse effects |
| Chemical Substances | Syndecan-1 ; SDC1 protein, human |
| Language | English |
| Publishing date | 2024-04-22 |
| Publishing country | England |
| Document type | Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2091252-3 |
| ISSN | 1471-2253 ; 1471-2253 |
| ISSN (online) | 1471-2253 |
| ISSN | 1471-2253 |
| DOI | 10.1186/s12871-024-02546-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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