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Article: The Pressor Response to the Drinking of Cold Water and Cold Carbonated Water in Healthy Younger and Older Adults.

Kubota, Satoshi / Endo, Yutaka / Kubota, Mitsue / Miyazaki, Hiroko / Shigemasa, Tomohiko

2022 Volume 12, Page(s) 788954

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2022-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.788954
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Article ; Online: Risk prediction of inappropriate implantable cardioverter-defibrillator therapy using machine learning.

Tateishi, Ryo / Suzuki, Makoto / Shimizu, Masato / Shimada, Hiroshi / Tsunoda, Takahiro / Miyazaki, Hiroko / Misu, Yoshiki / Yamakami, Yosuke / Yamaguchi, Masao / Kato, Nobutaka / Isshiki, Ami / Kimura, Shigeki / Fujii, Hiroyuki / Nishizaki, Mitsuhiro / Sasano, Tetsuo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19586

Abstract: We aimed to develop machine learning-based predictive models for identifying inappropriate implantable cardioverter-defibrillator (ICD) therapy. Our study included 182 consecutive cases (average age 62.2 ± 4.5 years, 169 men) and employed 14 non-deep ... ...

Abstract	We aimed to develop machine learning-based predictive models for identifying inappropriate implantable cardioverter-defibrillator (ICD) therapy. Our study included 182 consecutive cases (average age 62.2 ± 4.5 years, 169 men) and employed 14 non-deep learning models for prediction (hold-out method). These models utilized selected electrocardiogram parameters and clinical features collected after ICD implantation. From the feature importance analysis of the best ML model, we established easily calculable scores. Among the patients, 25 (13.7%) experienced inappropriate therapy, and we identified 16 significant predictors. Using recursive feature elimination with cross-validation, we reduced the features to six with high feature importance: history of atrial arrhythmia (Atr-arrhythm), ischemic cardiomyopathy (ICM), absence of diabetes mellitus (DM), lack of cardiac resynchronization therapy (CRT), V3 ST level at J point (V3 STJ), and V5 R-wave amplitudes (V5R amp). The extra-trees classifier yielded the highest area under receiver operating characteristics curve (AUROC; 0.869 on test data). Thus, the Cardi35 score was defined as [+ 5.5Atr-arrhythm - 1.5CRT + 1.0V3STJ + 1.0V5R - 1.0ICM - 0.5DM], which demonstrated a hazard ratio of 1.62 (P < 0.001). A cut-off value of the score + 5.5 showed high AUROC (0.826). The ML approach can yield a robust prediction model, and the Cardi35 score was a convenient predictor for inappropriate therapy.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Defibrillators, Implantable/adverse effects ; Electric Countershock/adverse effects ; Cardiac Resynchronization Therapy/adverse effects ; Cardiac Resynchronization Therapy/methods ; Arrhythmias, Cardiac/therapy ; Cardiac Resynchronization Therapy Devices ; Diabetes Mellitus/therapy ; Risk Factors ; Treatment Outcome ; Heart Failure/therapy
Language	English
Publishing date	2023-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46095-y
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Article ; Online: Possible association of papillary muscle hypertrophy with the genesis of J-waves.

Ebata, Yuki / Nakagawa, Mikiko / Kondo, Hidekazu / Ezaki, Kaori / Miyazaki, Hiroko / Shinohara, Tetsuji / Teshima, Yasushi / Yufu, Kunio / Takahashi, Naohiko

Journal of cardiology

2019 Volume 75, Issue 1, Page(s) 90–96

Abstract: Background: Although J-waves have been known to be associated with vulnerability to ventricular fibrillation, their electrophysiologic mechanism remains to be elucidated. The papillary muscles (PMs) of the left ventricle (LV) have been recognized as the ...

Abstract	Background: Although J-waves have been known to be associated with vulnerability to ventricular fibrillation, their electrophysiologic mechanism remains to be elucidated. The papillary muscles (PMs) of the left ventricle (LV) have been recognized as the target site of radiofrequency ablation for ventricular arrhythmias. However, the relationship between PM hypertrophy and J-waves has not been investigated. Objective: To investigate the electrocardiographic characteristics, including the J-waves, in patients with solitary PM hypertrophy. Methods: We studied 101 patients with PM hypertrophy without LV hypertrophy (PMH group) and 159 age- and sex-matched control subjects (control group). The parameters of the 12-lead electrocardiogram and the echocardiogram were compared between the two groups. Results: Compared with the control group, the PMH group had significantly higher incidence (15% vs. 33%, p=0.001) and amplitude (0.17±0.06mV vs. 0.28±0.17mV, p<0.01) of J-waves; significantly longer QRS, QTc, and JTc intervals (p=0.0001, p<0.0001, and p<0.05, respectively); significantly greater Sokolow-Lyon index (p<0.001); and significantly greater LV wall thickness and LV mass index (p<0.0001 for each). Multivariate logistic regression analysis showed that only the PM hypertrophy was an independent predictor of the presence of J-waves. Conclusion: PM hypertrophy was related to the genesis of J-waves.
MeSH term(s)	Aged ; Aged, 80 and over ; Echocardiography ; Electrocardiography ; Female ; Humans ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/pathology ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Middle Aged ; Papillary Muscles/diagnostic imaging ; Papillary Muscles/pathology ; Papillary Muscles/physiopathology
Language	English
Publishing date	2019-07-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2019.07.001
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Zs.A 1794: Show issues

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Article: [Successful treatment of dysphagia due to Wallenberg syndrome using intermittent air stretching method with balloon catheter: a case report].

Miyamoto, Junichi / Niijima, Kyo / Kubo, Yousuke / Miyazaki, Hiroko / Iguchi, Fukuichiro

No shinkei geka. Neurological surgery

2014 Volume 42, Issue 3, Page(s) 227–231

Abstract: A 69-year-old woman presented with dysphagia due to Wallenberg syndrome. Videofluorography revealed unilateral dysfunction of the cricopharyngeal muscle, which caused stenosis of the esophageal entrance on the affected side. Pharyngeal fiberscopy ... ...

Abstract	A 69-year-old woman presented with dysphagia due to Wallenberg syndrome. Videofluorography revealed unilateral dysfunction of the cricopharyngeal muscle, which caused stenosis of the esophageal entrance on the affected side. Pharyngeal fiberscopy indicated that glottal function and the cough reflex were preserved and that the pharyngeal reflex was lost. The stenosis of the esophageal entrance due to dysfunction of the cricopharyngeal muscle on the affected side and the loss of the pharyngeal reflex were considered to cause the patient's dysphagia. Based on above mentioned findings, the intermittent air stretching method with balloon catheter(IASM)was performed. As a result, dysphagia showed rapid improvement without any complications such as aspiration or bleeding. Thus, the IASM may be effective in some cases of dysphagia due to Wallenberg syndrome.
MeSH term(s)	Aged ; Catheters ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Deglutition Disorders/rehabilitation ; Deglutition Disorders/therapy ; Female ; Humans ; Lateral Medullary Syndrome/complications ; Lateral Medullary Syndrome/diagnosis ; Lateral Medullary Syndrome/therapy ; Muscle Stretching Exercises/methods ; Treatment Outcome
Language	Japanese
Publishing date	2014-03
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	197053-7
ISSN	1882-1251 ; 0301-2603
ISSN (online)	1882-1251
ISSN	0301-2603
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Zs.B 1834: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 268: Show issues

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Article ; Online: Common variants of HNF1A gene are associated with diabetic retinopathy and poor glycemic control in normal-weight Japanese subjects with type 2 diabetes mellitus.

Morita, Kazunori / Saruwatari, Junji / Tanaka, Takahiro / Oniki, Kentaro / Kajiwara, Ayami / Miyazaki, Hiroko / Yoshida, Akira / Jinnouchi, Hideaki / Nakagawa, Kazuko

Journal of diabetes and its complications

2017 Volume 31, Issue 2, Page(s) 483–488

Abstract: Aim: This study investigated the associations between the common hepatocyte nuclear factor-1A (HNF1A) variants and the risk of diabetic retinopathy (DR) in relation to the glycemic control and weight status.: Methods: A retrospective longitudinal ... ...

Abstract	Aim: This study investigated the associations between the common hepatocyte nuclear factor-1A (HNF1A) variants and the risk of diabetic retinopathy (DR) in relation to the glycemic control and weight status. Methods: A retrospective longitudinal analysis was conducted among 354 Japanese patients with type 2 diabetes mellitus (T2DM) (mean follow-up duration: 5.8±2.5 years). The multivariable-adjusted hazard ratio (HR) for the cumulative incidence of DR was calculated using a Cox proportional hazard model. During the observation period, the longitudinal associations of the HNF1A diplotypes with the risk of DR and the clinical parameters were also analyzed using the generalized estimating equations approach. Results: The combination of risk variants, i.e., rs1169288-C, rs1183910-A and rs2464196-A, was defined as the H1 haplotype. The incidence of DR was higher in the H1/H1 diplotype cases than in the others (HR 2.75 vs. non-H1/non-H1; p=0.02). Only in normal-weight subjects, the risks of DR and poor glycemic control were higher in the H1/H1 diplotype cases than in the others [odds ratio 4.08 vs. non-H1/non-H1, p=0.02; odds ratio 3.03, p=0.01; respectively]. Conclusions: This study demonstrated that the common HNF1A diplotype of three risk variants may be an independent risk factor for the development of DR resulting from poor glycemic control in normal-weight patients with T2DM. These results need to be replicated in larger and more varied study populations.
Language	English
Publishing date	2017-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2016.06.007
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Article: Surface-displayed antibodies as a tool for simultaneously controlling the arrangement and morphology of multiple cell types with microscale precision.

Miyazaki, Hiroko / Maki, Takeshi / Kato, Koichi / Iwata, Hiroo

ACS applied materials & interfaces

2009 Volume 1, Issue 1, Page(s) 53–55

Abstract: Cell-cell interactions are considered to play critical roles in the development and physiology of most tissues. However, it is not straightforward to analyze cell-cell interactions with conventional cell culture in which cells are randomly distributed. ... ...

Abstract	Cell-cell interactions are considered to play critical roles in the development and physiology of most tissues. However, it is not straightforward to analyze cell-cell interactions with conventional cell culture in which cells are randomly distributed. To overcome this limitation, we employed here an antibody display to sort different cell types onto separate regions on a single substrate with microscale precision, taking advantage of the specific recognition of cell surface markers by surface-displayed antibodies. The results obtained with two sets of cell combinations, T cell/myelomonocytoid cell and neuron/astrocyte, demonstrate that antibody displays are feasible to establish a site-addressable coculture.
MeSH term(s)	Animals ; Antibodies/analysis ; Antibodies/chemistry ; Antigens, CD/analysis ; Astrocytes/cytology ; Biomarkers/analysis ; Cell Communication ; Cell Line ; Coculture Techniques/methods ; Cytological Techniques/methods ; Fluorescent Antibody Technique/methods ; Humans ; Membrane Proteins/analysis ; Microtechnology/methods ; Neural Cell Adhesion Molecules/analysis ; Neurons/cytology ; Rats ; T-Lymphocytes/cytology
Chemical Substances	Antibodies ; Antigens, CD ; Biomarkers ; Membrane Proteins ; Neural Cell Adhesion Molecules
Language	English
Publishing date	2009-01
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ISSN	1944-8244
ISSN	1944-8244
DOI	10.1021/am800147x
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Article ; Online: Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes.

Kajiwara, Ayami / Kita, Ayana / Saruwatari, Junji / Miyazaki, Hiroko / Kawata, Yuki / Morita, Kazunori / Oniki, Kentaro / Yoshida, Akira / Jinnouchi, Hideaki / Nakagawa, Kazuko

Journal of diabetes research

2016 Volume 2016, Page(s) 4626382

Abstract: Aims. We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction. Methods. A clinic-based ... ...

Abstract	Aims. We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction. Methods. A clinic-based retrospective longitudinal study (follow-up duration: 8.1 ± 1.4 years) was conducted to assess the sex differences in the annual estimated glomerular filtration rate (eGFR) change in 344 (247 male and 97 female) Japanese T2DM patients. The sex differences in the risk factors of annual eGFR decline were subjected to linear regression analyses. Results. The mean annual eGFR change was -3.5 ± 2.7%/year in females and -2.0 ± 2.2%/year in males (P < 0.001). Baseline retinopathy and proteinuria were significantly associated with a larger eGFR decline, irrespective of sex, while HbA1c and LDL-cholesterol levels were significantly associated with an eGFR decline in females only. Interactive effects were observed between sex and the HbA1c, LDL-cholesterol, retinopathy, or proteinuria levels on the annual eGFR decline. Conclusions. The increased susceptibility to poor metabolic control seemed to contribute to a higher risk of renal dysfunction in females with T2DM. Our study highlights the importance of aggressive therapeutic intervention to improve metabolic profiles at early stage, especially in females.
MeSH term(s)	Adult ; Aged ; Cholesterol, LDL/metabolism ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Nephropathies/epidemiology ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/physiopathology ; Diabetic Retinopathy/epidemiology ; Female ; Glomerular Filtration Rate ; Glycated Hemoglobin/metabolism ; Humans ; Japan/epidemiology ; Linear Models ; Longitudinal Studies ; Male ; Middle Aged ; Multivariate Analysis ; Proteinuria/epidemiology ; Renal Insufficiency/epidemiology ; Renal Insufficiency/etiology ; Renal Insufficiency/physiopathology ; Retrospective Studies ; Sex Factors
Chemical Substances	Cholesterol, LDL ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
Language	English
Publishing date	2016-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2711897-6
ISSN	2314-6753 ; 2314-6753
ISSN (online)	2314-6753
ISSN	2314-6753
DOI	10.1155/2016/4626382
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Article ; Online: A collagen-binding mimetic of neural cell adhesion molecule.

Miyazaki, Hiroko / Kato, Koichi / Teramura, Yuji / Iwata, Hiroo

Bioconjugate chemistry

2008 Volume 19, Issue 6, Page(s) 1119–1123

Abstract: A chimeric protein consisting of a cell-adhesive peptide derived from a neural cell adhesion molecule and a collagen-binding domain was synthesized using recombinant DNA technology. Here, we demonstrate that the chimeric protein binds to type I collagen ... ...

Abstract	A chimeric protein consisting of a cell-adhesive peptide derived from a neural cell adhesion molecule and a collagen-binding domain was synthesized using recombinant DNA technology. Here, we demonstrate that the chimeric protein binds to type I collagen and promotes the adhesion and neurite extension of hippocampus neurons. These results suggest that the chimeric protein has potential to provide microenvironments for neurons to adhere and survive in collagen-based matrices for use in cell-based therapies for central nervous disorders.
MeSH term(s)	Amino Acid Sequence ; Animals ; Cell Adhesion ; Cells, Cultured ; Collagen/metabolism ; Feasibility Studies ; Hippocampus/cytology ; Hippocampus/metabolism ; Humans ; Mice ; Neural Cell Adhesion Molecules/chemistry ; Neural Cell Adhesion Molecules/metabolism ; Neurites/metabolism ; Peptides/chemistry ; Peptides/metabolism ; Protein Binding ; Protein Structure, Tertiary ; Rats ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Surface Plasmon Resonance
Chemical Substances	Neural Cell Adhesion Molecules ; Peptides ; Recombinant Fusion Proteins ; Collagen (9007-34-5)
Language	English
Publishing date	2008-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/bc700470v
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Article ; Online: False tendons may be associated with the genesis of J-waves: prospective study in young healthy male.

Nakagawa, Mikiko / Ezaki, Kaori / Miyazaki, Hiroko / Ebata, Yuki / Shinohara, Tetsuji / Teshima, Yasushi / Yufu, Kunio / Takahashi, Naohiko / Saikawa, Tetsunori

International journal of cardiology

2014 Volume 172, Issue 2, Page(s) 428–433

Abstract: Background: Recent studies showed that J-waves are associated with vulnerability to ventricular fibrillation. Recently we reported the association between false tendons (FTs) and J-waves in a retrospective study.: Methods and results: We ... ...

Abstract	Background: Recent studies showed that J-waves are associated with vulnerability to ventricular fibrillation. Recently we reported the association between false tendons (FTs) and J-waves in a retrospective study. Methods and results: We prospectively studied 50 young healthy men (mean age 24.6±2.7 years). FTs were detected echocardiographically and classified based on their points of attachment as type 1 (longitudinal type), type 2 (diagonal type), and type 3 (transverse type). J-waves were defined as terminal QRS notching or slurring with ≥0.1 mV. The filtered QRS duration (fQRSd), RMS40, and LAS40 were measured on signal-averaged ECGs. FTs were detected in 37 of the 50 subjects (74%). The incidence of J-waves was significantly higher in subjects with type 1 or type 2 FTs than those with no- or type 3 FTs (61% vs. 26%, p<0.05). The leads with J-waves were closely associated with the location of the FT. While no late potential was recorded in any study subjects, fQRSd and LAS40 were significantly longer in subjects with type 1 or type 2 FTs (p<0.05). Univariate and multivariate logistic regression analysis revealed that only the existence of FTs (type 1 or 2) was an independent predictor of the presence of J-waves. Conclusions: Our results suggest that FTs were related to the genesis of J-waves with conduction delay.
MeSH term(s)	Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/physiopathology ; Echocardiography ; Electrocardiography ; Heart Conduction System/physiopathology ; Heart Ventricles/abnormalities ; Humans ; Male ; Prospective Studies ; Young Adult
Language	English
Publishing date	2014-03-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2014.01.101
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Article ; Online: Impact of CYP2C19 polymorphism on clinical outcome following coronary stenting is more important in non-diabetic than diabetic patients.

Mizobe, Michio / Hokimoto, Seiji / Akasaka, Tomonori / Arima, Yuichiro / Kaikita, Koichi / Morita, Kazunori / Miyazaki, Hiroko / Oniki, Kentaro / Nakagawa, Kazuko / Ogawa, Hisao

Thrombosis research

2014 Volume 134, Issue 1, Page(s) 72–77

Abstract: Objective: The aim of this study was to examine the impact of CYP2C19 genotype on clinical outcome in coronary artery disease (CAD) patients with or without diabetes mellitus (DM).: Methods: CYP2C19 polymorphism and DM are associated with increased ... ...

Abstract	Objective: The aim of this study was to examine the impact of CYP2C19 genotype on clinical outcome in coronary artery disease (CAD) patients with or without diabetes mellitus (DM). Methods: CYP2C19 polymorphism and DM are associated with increased risk of cardiovascular events during antiplatelet therapy following stent implantation. Platelet reactivity during clopidogrel therapy and CYP2C19 polymorphism were measured in 519 CAD patients (males 70%, age 69 years) treated with stent placement. Patients were divided into two groups; DM (n=249), and non-DM (n=270), and clinical events were evaluated according to the carrier state, which included at least one CYP2C19 loss-of-function allele. Results: The level of platelet reactivity and incidence of cardiovascular events were significantly different between Carriers and non-Carriers of the non-DM (platelet reactivity: 4501+/-1668 versus 3691+/-1714AU min, P<0.01; events, 32/178 versus 2/92, P<0.01, respectively), however, there was no difference in clinical outcome in the DM group (events, 34/168 versus 14/81, respectively, P=0.57). Multivariate analysis identified CYP2C19 loss-of-function allele carriage as an independent predictor of cardiovascular events in non-DM, but not in DM (non-DM, HR 7.180, 95% CI, 1.701 to 30.298, P=0.007; DM, HR 1.374, 95% CI, 0.394 to 4.792, P=0.618). Conclusion: The impact of CYP2C19 polymorphism on clinical outcome seems to be more significant in non-DM compared with DM in patients with coronary stents.
MeSH term(s)	Aged ; Coronary Artery Disease/enzymology ; Coronary Artery Disease/genetics ; Coronary Artery Disease/surgery ; Cytochrome P-450 CYP2C19/genetics ; Diabetes Mellitus/enzymology ; Female ; Genotype ; Humans ; Male ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/therapeutic use ; Polymorphism, Genetic ; Prospective Studies ; Stents ; Ticlopidine/analogs & derivatives ; Ticlopidine/therapeutic use
Chemical Substances	Platelet Aggregation Inhibitors ; clopidogrel (A74586SNO7) ; CYP2C19 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Ticlopidine (OM90ZUW7M1)
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2014.04.020
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