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Article ; Online: Optimal Intermittent Administration Interval of Abaloparatide for Bone Morphogenetic Protein-Induced Bone Formation in a Rat Spinal Fusion Model.

Abe, Tetsutaro / Miyazaki, Masashi / Sako, Noriaki / Kanezaki, Shozo / Tsubouchi, Yuta / Kaku, Nobuhiro

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Both bone morphogenetic protein 2 (BMP-2) and abaloparatide are used to promote bone formation. However, there is no consensus about their optimal administration. We investigated the optimal administration theory for the pairing of BMP-2 and ... ...

Abstract	Both bone morphogenetic protein 2 (BMP-2) and abaloparatide are used to promote bone formation. However, there is no consensus about their optimal administration. We investigated the optimal administration theory for the pairing of BMP-2 and abaloparatide in a rat spinal fusion model. Group I was only implanted in carriers and saline. Carriers with 3 µg of recombinant human BMP-2 (rhBMP-2) were implanted in other groups. Abaloparatide injections were administered three times a week for group III (for a total amount of 120 µg/kg in a week) and six times a week for group IV (for a total amount of 120 µg/kg in a week) after surgery. They were euthanized 8 weeks after the surgery, and we explanted their spines at that time. We assessed them using manual palpation tests, radiography, high-resolution micro-computed tomography (micro-CT), and histological analysis. We also analyzed serum bone metabolism markers. The fusion rate in Groups III and IV was higher than in Group I, referring to the manual palpation tests. Groups III and IV recorded greater radiographic scores than those in Groups I and II, too. Micro-CT analysis showed that Tbs. Sp in Groups III and IV was significantly lower than in Group I. Tb. N in Group IV was significantly higher than in Group I. Serum marker analysis showed that bone formation markers were higher in Groups III and IV than in Group I. On the other hand, bone resorption markers were lower in Group IV than in Group I. A histological analysis showed enhanced trabecular bone osteogenesis in Group IV. Frequent administration of abaloparatide may be suitable for the thickening of trabecular bone structure and the enhancement of osteogenesis in a rat spinal fusion model using BMP-2 in insufficient doses.
MeSH term(s)	Humans ; Animals ; Rats ; Osteogenesis ; Spinal Fusion ; X-Ray Microtomography ; Bone Morphogenetic Proteins ; Parathyroid Hormone-Related Protein
Chemical Substances	abaloparatide (AVK0I6HY2U) ; Bone Morphogenetic Proteins ; Parathyroid Hormone-Related Protein
Language	English
Publishing date	2024-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073655
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Article: Asymmetric Implant Design for Posterolateral Overhang of the Femoral Component in Total Knee Arthroplasty: A Retrospective Computed Tomography-Based Study.

Hirakawa, Masashi / Miyazaki, Masashi / Nagashima, Yu / Akase, Hiroya / Matsuda, Shogo / Kaku, Nobuhiro

Cureus

2024 Volume 16, Issue 3, Page(s) e56862

Abstract: Introduction During total knee arthroplasty (TKA), also referred to as total knee replacement (TKR), patients may experience pain in the posterolateral knee. One possible cause is the impingement between the popliteus tendon and the femoral components. ... ...

Abstract	Introduction During total knee arthroplasty (TKA), also referred to as total knee replacement (TKR), patients may experience pain in the posterolateral knee. One possible cause is the impingement between the popliteus tendon and the femoral components. The purpose of this study was to analyze the posterolateral overhang of the femoral component using 3D template software. Methods Preoperative CT scan images of 50 knees (11 males and 39 females) with osteoarthritis of grade 2 or lower according to the Kellgren-Lawrence classification were analyzed. The mean age of the subjects was 73.8±7.6 years (range 52-84 years). The Athena (Soft Cube Co., Ltd., Osaka, Japan) knee 3D image-matching software was used for the analysis. The positions of the two femoral components (symmetrical and asymmetrical) were simulated. In the coronal plane, the component overhang was measured between the resected lateral part of the posterior femur and its corresponding component size, and the two designs were compared in three zones (proximal, central, and distal). Results In the simulated femoral component, the asymmetric design had a significantly lower component overhang than the symmetric design in the proximal zone of the lateral posterior condyle (0.2±1.9 mm vs. 3.5±1.6 mm, p<0.01). In the proximal zone, significant overhang (>3 mm) was observed in 30 knees (60.0%) with the symmetric design, but only three knees (6.0%) had asymmetric designs (p<0.01). Conclusions The posterolateral overhang of the lateral posterior condyle occurs when a symmetrical prosthesis is used. The use of an asymmetric implant with a small, rounded proximal portion of the lateral posterior condyle improves this overhang and is expected to decrease problems such as impingement of the popliteus tendon and improve patient satisfaction.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56862
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Article ; Online: Analysis of accuracy of pedicle screw placement in dysplastic pedicles in adolescent idiopathic scoliosis using the pedicle expansion technique with CT-based navigation.

Miyazaki, Masashi / Abe, Tetsutaro / Sako, Noriaki / Kanezaki, Shozo / Tsumura, Hiroshi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2023

Abstract: Background: This study aimed to study the accuracy of pedicle screw (PS) insertion into dysplastic pedicles in adolescent idiopathic scoliosis (AIS) comparing cannulated screw using the pedicle expansion technique (PET) versus conventional technique.: ...

Abstract	Background: This study aimed to study the accuracy of pedicle screw (PS) insertion into dysplastic pedicles in adolescent idiopathic scoliosis (AIS) comparing cannulated screw using the pedicle expansion technique (PET) versus conventional technique. Methods: Forty-two AIS patients with 766 PSs were evaluated. In total, 236 screws were inserted into dysplastic pedicles: 138 and 98 screws were inserted using the PET (PET group) and standard technique (conventional group), respectively. Both methods used CT-based navigation to determine the insertion point. In the PET, a rigid ball tip feeler was tapped with a mallet to create an insertion route, a guide wire was passed through the tap, the pedicle was enlarged, and then a cannulated PS with a diameter of 4.35 mm was inserted. Postoperative CT was used to compare the accuracy of PS insertion. Results: In total, 23/236 (9.7%) perforations occurred. Regarding overall perforation, there were six (4.3%) and 17 (17.3%) cases in the PET and conventional group, respectively (P = 0.008). In terms of medial perforation, the PET group (n = 2, 1.4%) was significantly better than the conventional group (n = 7, 7.1%) (P = 0.021). In terms of lateral perforation, the PET group (n = 4, 2.9%) was significantly better than conventional group (n = 10, 10.2%) (P = 0.030). Only grade 1 perforation had occurred in the PET group, whereas grades 2 and 3 perforation occurred in the conventional group. Conclusion: Use of the PET with CT-based navigation significantly increased the accuracy and safety of PS insertion in dysplastic pedicles in AIS.
Language	English
Publishing date	2023-04-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2023.03.019
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Article ; Online: Effectiveness of gelatin matrix with human thrombin for reducing blood loss in palliative decompressive surgery with posterior spinal fusion for metastatic spinal tumors.

Miyazaki, Masashi / Ishihara, Toshinobu / Abe, Tetsutaro / Kanezaki, Shozo / Tsumura, Hiroshi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2023 Volume 29, Issue 1, Page(s) 88–93

Abstract: Background: This study aimed to investigate the effect of gelatin matrix with human thrombin (GMHT) on blood loss and survival time in patients with metastatic spinal tumors treated with palliative decompression surgery with posterior spinal fusion.: ... ...

Abstract	Background: This study aimed to investigate the effect of gelatin matrix with human thrombin (GMHT) on blood loss and survival time in patients with metastatic spinal tumors treated with palliative decompression surgery with posterior spinal fusion. Methods: We retrospectively reviewed 67 consecutive patients with metastatic spinal tumors who underwent palliative decompression surgery with posterior spinal fusion. We compared patients in whom GMHT was not used during surgery with those in whom GMHT was used. The following baseline characteristics were evaluated: age, height, weight, sex, metastatic tumor diagnosis, medical history, use of antiplatelet drug, use of anticoagulant drug, use of NSAIDs, smoking, preoperative PLT value, preoperative APTT, preoperative PT-INR, Karnofsky Performance Status score, Charlson comorbidities index score, the percentage of patients who received perioperative chemotherapy, main tumor level, Frankel category, revised Tokuhashi score, spinal instability neoplastic score (SINS), number of fusion segments, operation time, intraoperative blood loss, drainage blood loss, red blood cell transfusion, hemoglobin level, total protein (TP), albumin values, total blood loss (TBL), hidden blood loss, postoperative bed rest and postoperative survival time. Perioperative complications were assessed. Results: Age, height, weight, sex, metastatic tumor diagnosis, medical history, use of antiplatelet drug, use of anticoagulant drug, use of NSAIDs, smoking, preoperative PLT value, preoperative APTT, preoperative PT-INR, CCI score, main level of tumors, SINS score, preoperative Tokuhashi score and number of fusion segments did not differ significantly between the two groups. Operation time, intraoperative blood loss, postoperative drainage blood loss, and TBL were significantly decreased in the group with GMHT than in the group without GMHT. The total number of perioperative complications was significantly lesser in the group with GMHT than in the group without GMHT. The median postoperative survival time was significantly longer in the GMHT group than in the group without GMHT. Conclusion: GMHT should be considered a valid option for the treatment of patients with metastatic spinal tumors with a short life expectancy.
MeSH term(s)	Humans ; Spinal Neoplasms/complications ; Thrombin/therapeutic use ; Gelatin ; Retrospective Studies ; Spinal Fusion ; Platelet Aggregation Inhibitors ; Spinal Cord Neoplasms ; Blood Loss, Surgical/prevention & control ; Postoperative Hemorrhage ; Anticoagulants ; Anti-Inflammatory Agents, Non-Steroidal ; Treatment Outcome
Chemical Substances	Thrombin (EC 3.4.21.5) ; Gelatin (9000-70-8) ; Platelet Aggregation Inhibitors ; Anticoagulants ; Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2023-01-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2022.12.011
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Article ; Online: Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients.

Oka, Yoshinari / Miyazaki, Masashi / Takatsu, Shigeko / Matsuda, Hiroaki

Journal of the American Society of Nephrology : JASN

2022 Volume 33, Issue 7, Page(s) 1427

MeSH term(s)	Calcium ; Chelating Agents/therapeutic use ; Humans ; Hyperphosphatemia ; Kidney Failure, Chronic/therapy ; Oxalates ; Phosphates ; Renal Dialysis ; Sevelamer
Chemical Substances	Chelating Agents ; Oxalates ; Phosphates ; Sevelamer (9YCX42I8IU) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-05-02
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2022030248
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Zs.A 3344: Show issues

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Article ; Online: Anesthetic effect of ultrasound-guided block of the musculocutaneous nerve during endovascular treatment of dysfunctional radiocephalic arteriovenous fistulas.

Matsuda, Hiroaki / Oka, Yoshinari / Takatsu, Shigeko / Miyazaki, Masashi

The journal of vascular access

2022 Volume 24, Issue 6, Page(s) 1314–1321

Abstract: Background: Delivering requisite and minimal anesthesia for endovascular treatment (EVT) of dysfunctional arteriovenous fistulas (AVFs) under the target nerve block can achieve reasonable analgesia. We evaluated the anesthetic efficacy of ultrasound (US) ...

Abstract	Background: Delivering requisite and minimal anesthesia for endovascular treatment (EVT) of dysfunctional arteriovenous fistulas (AVFs) under the target nerve block can achieve reasonable analgesia. We evaluated the anesthetic efficacy of ultrasound (US)-guided selective block of the musculocutaneous nerve (MCN) during the EVT of runoff venous strictures in the forearm through the radiocephalic (RC)-AVF at the wrist or the anatomical snuff box and analyzed the factors inhibiting the analgesia achieved under the MCN block. Methods: We enrolled 30 adult patients undergoing hemodialysis who had received 78 EVT sessions in an outpatient clinic mainly for long and/or multiple outflow-venous strictures in the forearm under US-guided blocks of the MCN, which provides sensory innervation to the anterolateral forearm where the cephalic vein courses. We assessed patients' pain during balloon dilations using the Wong-Baker FACES Results: In 25 EVT sessions (32.1%) out of 78 sessions, patients complained of stronger pain (WBFRS score ⩾4), while in the other 53 sessions (67.9%), presented with no pain and slight pain (WBFRS score = 0 or 2). Univariate analysis clarified that dilation of the AVF anastomosis, presence of dilated stenosis >4 cm, and a single block of the MCN or its sensory terminal significantly triggered more pain ( Conclusion: US-guided selective block of the MCN could be a leading anesthetic option for EVT for multiple long stenoses of the cephalic vein draining through the RC-AVF in the wrist or anatomical snuff box.
MeSH term(s)	Adult ; Humans ; Constriction, Pathologic ; Musculocutaneous Nerve/diagnostic imaging ; Arteriovenous Shunt, Surgical/adverse effects ; Treatment Outcome ; Pain/etiology ; Anesthetics ; Renal Dialysis/adverse effects ; Ultrasonography, Interventional/adverse effects ; Arteriovenous Fistula ; Vascular Patency ; Retrospective Studies
Chemical Substances	Anesthetics
Language	English
Publishing date	2022-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2252820-9
ISSN	1724-6032 ; 1129-7298
ISSN (online)	1724-6032
ISSN	1129-7298
DOI	10.1177/11297298221075178
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Zs.A 6414: Show issues

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Article ; Online: Severe hypoprothrombinemia caused by cefmetazole sodium in a patient undergoing hemodialysis: A case report.

Oka, Yoshinari / Matsuda, Hiroaki / Miyazaki, Masashi

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

2022 Volume 26, Issue 4, Page(s) 844–845

MeSH term(s)	Cefmetazole ; Humans ; Hypoprothrombinemias ; Renal Dialysis
Chemical Substances	Cefmetazole (3J962UJT8H)
Language	English
Publishing date	2022-03-23
Publishing country	Australia
Document type	Case Reports ; Letter
ZDB-ID	2119809-3
ISSN	1744-9987 ; 1091-6660 ; 1744-9979
ISSN (online)	1744-9987
ISSN	1091-6660 ; 1744-9979
DOI	10.1111/1744-9987.13837
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Article ; Online: Influence of etching mode on bonding performance of self-adhesive flowable resin composites to bovine teeth.

Hayashi, Kana / Ishii, Ryo / Takamizawa, Toshiki / Aoki, Ryota / Muto, Rei / Suda, Shunichi / Kamimoto, Atsushi / Miyazaki, Masashi

Dental materials journal

2024

Abstract: This study aimed to evaluate the bonding performance of self-adhesive flowable resin composites (SARs) to bovine teeth. Three SARs, one experimental, and two commercially available products, were used. The study parameters were shear bond strength (SBS), ...

Abstract	This study aimed to evaluate the bonding performance of self-adhesive flowable resin composites (SARs) to bovine teeth. Three SARs, one experimental, and two commercially available products, were used. The study parameters were shear bond strength (SBS), microleakage, and scanning electron microscopy (SEM) evaluation of bonding interfaces. The SBS of the materials was 14.1-15.1 MPa to enamel, 22.2-23.2 MPa to etched enamel, and 7.4-10.7 MPa to dentin. Specimens with pre-etching showed lower microleakage scores than those without pre-etching. SEM images of the interfaces of the materials showed excellent adaptation regardless of the substrate or etching mode. The study results indicate that enamel pre-etching can improve the bonding performance of SARs.
Language	English
Publishing date	2024-04-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	605650-7
ISSN	1881-1361 ; 0287-4547
ISSN (online)	1881-1361
ISSN	0287-4547
DOI	10.4012/dmj.2023-226
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Zs.B 2687: Show issues

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Article ; Online: Scanning electron microscopy observation of dentin bond interfaces in different types of resin luting cements.

Takamizawa, Toshiki / Aoki, Ryota / Hayashi, Kana / Shoji, Mone / Kasahara, Yuta / Barkmeier, Wayne W / Latta, Mark A / Kamimoto, Atsushi / Miyazaki, Masashi

Dental materials journal

2024 Volume 43, Issue 2, Page(s) 179–190

Abstract: This study aimed to observe and compare the resin luting cement (RLC)/dentin interfaces of different types of RLC systems with scanning electron microscopy (SEM). This study evaluated six self-adhesive resin luting cement systems (SARLCs), four systems ... ...

Abstract	This study aimed to observe and compare the resin luting cement (RLC)/dentin interfaces of different types of RLC systems with scanning electron microscopy (SEM). This study evaluated six self-adhesive resin luting cement systems (SARLCs), four systems combining a SARLC with a tooth primer (SARLCPs), and six conventional resin luting cement systems (CVRLCs). Cured resin composite rods were bonded to bovine dentin using RLCs in different etching modes. The morphological features at the interfaces were observed using SEM. Although all RLCs in etch-&-rinse (ER) mode showed a clear hybrid layer, most SARLCs had a thinner and more porous hybrid layer than the SARLCPs and CVRLCs. All SARLCPs with primer and CVRLCs showed a thin high-density layer below the primer layer in both etching modes. CVRLCs and SARLCPs with primer treatment systems may be more versatile and reliable when compared to simplified RLC systems.
MeSH term(s)	Animals ; Cattle ; Microscopy, Electron, Scanning ; Resin Cements/chemistry ; Dental Cements ; Dentin-Bonding Agents/chemistry ; Dental Bonding ; Composite Resins/chemistry ; Dentin ; Materials Testing ; Surface Properties
Chemical Substances	Resin Cements ; Dental Cements ; Dentin-Bonding Agents ; Composite Resins
Language	English
Publishing date	2024-01-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	605650-7
ISSN	1881-1361 ; 0287-4547
ISSN (online)	1881-1361
ISSN	0287-4547
DOI	10.4012/dmj.2023-219
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Article ; Online: Influence of different curing modes on the bonding effectiveness of self-adhesive resin luting cements in combination with universal adhesives.

Aoki, Ryota / Takamizawa, Toshiki / Hayashi, Kana / Arai, Yuiko / Ishii, Ryo / Shoji, Mone / Kamimoto, Atsushi / Miyazaki, Masashi

Dental materials : official publication of the Academy of Dental Materials

2024 Volume 40, Issue 2, Page(s) 379–385

Abstract: Objectives: This study aimed to investigate the immediate dentin bond performance and bond durability of self-adhesive resin luting cements (RLCs) in combination with universal adhesives in different curing modes.: Methods: Two self-adhesive RLCs ... ...

Abstract	Objectives: This study aimed to investigate the immediate dentin bond performance and bond durability of self-adhesive resin luting cements (RLCs) in combination with universal adhesives in different curing modes. Methods: Two self-adhesive RLCs were used with universal adhesives as primers. They were also used alone as self-adhesive RLCs. Two multiple-step RLC systems were used as comparison materials. To measure the shear bond strength (SBS) in different curing modes, 12 specimens were prepared for each group. Stainless-steel rods were bonded to bovine dentin, and the bonded specimens were assigned to the baseline group (stored for 24 h) and artificially aged group (thermal cycling [TC], 10,000 cycles). After each storage period, the SBS of the bonded specimens was measured. The Knoop hardness number (KHN) of the cured RLCs was measured with or without primer application in different curing modes at 24 h and after 10,000 TC. The representative RLC/dentin interfaces were observed using scanning electron microscopy (SEM). Results: Dentin SBS was significantly influenced by the RLC system but not by the curing mode. Self-adhesive RLCs alone showed significantly lower SBS values than self-adhesive RLCs with primer regardless of the curing mode or storage period. The storage period, curing mode, and RLC system significantly influenced the KHN. Significance: The use of universal adhesives as a primer may help enhance the immediate dentin bond performance and bond durability of self-adhesive RLCs.
MeSH term(s)	Animals ; Cattle ; Resin Cements/chemistry ; Dental Cements ; Dental Bonding ; Dentin-Bonding Agents/chemistry ; Materials Testing ; Shear Strength ; Dentin ; Adhesives
Chemical Substances	Resin Cements ; Dental Cements ; Dentin-Bonding Agents ; Adhesives
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	605995-8
ISSN	1879-0097 ; 0109-5641
ISSN (online)	1879-0097
ISSN	0109-5641
DOI	10.1016/j.dental.2023.12.016
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