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Book: Biomaterials and engineering for implantology

Oshida, Yoshiki / Miyazaki, Takashi

in medicine and dentistry

(De Gruyter STEM)

2022

Author's details	Yoshiki Oshida, Takashi Miyazaki
Series title	De Gruyter STEM
Keywords	Biomaterialien ; Anatomie ; Physiologie ; Implantologie ; Biotechnologie ; Anatomy ; Biomaterials ; Biotechnology ; Implantology ; Physiology ; Implantatwerkstoff ; Biokompatibilität ; Zahnmedizin ; Biomaterial
Subject	Odontologie ; Zahn-, Mund- und Kieferheilkunde ; Zahn-Mund-Kieferheilkunde ; Zahnheilkunde ; Biomedizinisches Material ; Bioverträglichkeit
Language	English
Size	XVI, 555 Seiten, Illustrationen, 24 cm x 17 cm
Publisher	De Gruyter
Publishing place	Berlin
Publishing country	Germany
Document type	Book
HBZ-ID	HT021350665
ISBN	978-3-11-074011-0 ; 3-11-074011-7 ; 9783110740233 ; 9783110740134 ; 3110740230 ; 3110740133
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: In vitro characterization of primary osteoblasts on titanium surfaces processed with wire-type electric discharge machining.

Kurosaka, Masao / Kataoka, Yu / Miyazaki, Takashi

Dental materials journal

2022 Volume 41, Issue 5, Page(s) 655–659

Abstract: The fixation of titanium implants in bone tissue is affected by the presence of a passive titanium oxide ( ... ...

Abstract	The fixation of titanium implants in bone tissue is affected by the presence of a passive titanium oxide (TiO
MeSH term(s)	Hydrogen Peroxide ; Osteoblasts/metabolism ; Protein-Lysine 6-Oxidase/metabolism ; Surface Properties ; Titanium/chemistry
Chemical Substances	titanium dioxide (15FIX9V2JP) ; Hydrogen Peroxide (BBX060AN9V) ; Titanium (D1JT611TNE) ; Protein-Lysine 6-Oxidase (EC 1.4.3.13)
Language	English
Publishing date	2022-04-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	605650-7
ISSN	1881-1361 ; 0287-4547
ISSN (online)	1881-1361
ISSN	0287-4547
DOI	10.4012/dmj.2021-231
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Article ; Online: Direct Quantification of Attogram Levels of Strontium-90 in Microscale Biosamples Using Isotope Dilution-Thermal Ionization Mass Spectrometry Assisted by Quadrupole Energy Filtering

Aoki, Jo / Wakaki, Shigeyuki / Ishiniwa, Hiroko / Kawakami, Tomohiko / Miyazaki, Takashi / Suzuki, Katsuhiko / Takagai, Yoshitaka

Analytical Chemistry. 2023 Mar. 12, v. 95, no. 11 p.4932-4939

2023

Abstract: Although thermal ionization mass spectrometry (TIMS) has been employed for the high-precision analysis of isotope ratios, direct quantification of artificial mono-nuclide in the environment is difficult by even using isotope dilution (ID) due to the ... ...

Abstract	Although thermal ionization mass spectrometry (TIMS) has been employed for the high-precision analysis of isotope ratios, direct quantification of artificial mono-nuclide in the environment is difficult by even using isotope dilution (ID) due to the coexistence of the great magnitude of natural stable nuclides or isobars. In traditional TIMS and ID-TIMS, a sufficient amount of stable Sr doped on a filament is required to realize a stable and adequate ion-beam intensity (i.e., thermally ionized beams). However, the background noise (BGN) at m/z 90, detected by an electron multiplier, disturbs ⁹⁰Sr analysis at low concentration levels due to peak tailing of a significant ⁸⁸Sr ion beam dependent on the ⁸⁸Sr-doping amount. Here, TIMS assisted by quadruple energy filtering was successfully employed for the direct quantification of attogram levels of an artificial monoisotopic radionuclide strontium-90 (⁹⁰Sr) in microscale biosamples. Direct quantification was achieved by integrating the ID quantification of natural Sr and simultaneous ⁹⁰Sr/⁸⁶Sr isotope ratio analysis. Additionally, the measurement amount calculated by the combination of the ID and intercalibration was corrected for the net result amount of ⁹⁰Sr by subtracting dark noise and the detected amount derived from the survived ⁸⁸Sr, which are equivalent with the BGN intensity at m/z 90. Background correction revealed that the detection limits were in the range of 6.15 × 10–²–3.90 × 10–¹ ag (0.31–1.95 μBq), depending on the concentration of natural Sr in a 1 μL sample, and the quantification of 0.98 ag (5.0 μBq) of ⁹⁰Sr in 0–300 mg/L of natural Sr was successful. This method could analyze small sample quantities (1 μL), and the quantitative results were verified against authorized radiometric analysis techniques. Furthermore, the amount of ⁹⁰Sr in actual teeth was successfully quantified. This method will be a powerful tool for measuring ⁹⁰Sr in the measurement of micro-samples, which are required to assess and understand the degree of internal radiation exposure.
Keywords	analytical chemistry ; energy ; ionization ; isotope dilution technique ; isotopes ; mass spectrometry ; multipliers ; radiometry
Language	English
Dates of publication	2023-0312
Size	p. 4932-4939.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c04844
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Article ; Online: Direct Quantification of Attogram Levels of Strontium-90 in Microscale Biosamples Using Isotope Dilution-Thermal Ionization Mass Spectrometry Assisted by Quadrupole Energy Filtering.

Aoki, Jo / Wakaki, Shigeyuki / Ishiniwa, Hiroko / Kawakami, Tomohiko / Miyazaki, Takashi / Suzuki, Katsuhiko / Takagai, Yoshitaka

Analytical chemistry

2023 Volume 95, Issue 11, Page(s) 4932–4939

Abstract	Although thermal ionization mass spectrometry (TIMS) has been employed for the high-precision analysis of isotope ratios, direct quantification of artificial mono-nuclide in the environment is difficult by even using isotope dilution (ID) due to the coexistence of the great magnitude of natural stable nuclides or isobars. In traditional TIMS and ID-TIMS, a sufficient amount of stable Sr doped on a filament is required to realize a stable and adequate ion-beam intensity (i.e., thermally ionized beams). However, the background noise (BGN) at
Language	English
Publishing date	2023-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c04844
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Article: Transparent dentin region in the tooth root.

Inoue, Toshiko / Saito, Makoto / Nishimura, Fumio / Miyazaki, Takashi

Clinical case reports

2020 Volume 8, Issue 9, Page(s) 1831–1832

Abstract: Transparent dentin in the tooth root forms during the aging process. The transparent dentin is weaker than normal opaque dentin, which may explain the occurrence of root dentin fractures in aged individuals. Tooth fractures are caused by the brittleness ... ...

Abstract	Transparent dentin in the tooth root forms during the aging process. The transparent dentin is weaker than normal opaque dentin, which may explain the occurrence of root dentin fractures in aged individuals. Tooth fractures are caused by the brittleness of the transparent dentin. Clinical procedures in aged persons require modification to accommodate the reduced strength of the dentin tissue.
Language	English
Publishing date	2020-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.2937
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Article ; Online: Shear bond strength of an acrylic resin to a ceria-stabilized zirconia-alumina nanocomposite.

Tanaka, Shinpei / Kobayashi-Hisamatsu, Mari / Miyazaki, Takashi / Baba, Kazuyoshi

The Journal of prosthetic dentistry

2021 Volume 128, Issue 4, Page(s) 815–821

Abstract: Statement of problem: Ceria-stabilized zirconia-alumina nanocomposite (Ce-TZP-Al: Purpose: The purpose of this in vitro study was to determine the optimal surface treatment for Ce-TZP-Al: Material and methods: The surface of Ce-TZP-Al: Results: ...

Abstract	Statement of problem: Ceria-stabilized zirconia-alumina nanocomposite (Ce-TZP-Al Purpose: The purpose of this in vitro study was to determine the optimal surface treatment for Ce-TZP-Al Material and methods: The surface of Ce-TZP-Al Results: After placement in deionized water for 24 hours, the shear bond strengths of Group MDP and 2 types of combination treatment (Groups CBT-P and CBT-S) were significantly higher than those of Groups SLP, TRB-P, and TRB-S (P<.05). Moreover, the fractured surface of all the treatment conditions except Group APA showed cohesive failure. The shear bond strength as a result of all treatment conditions decreased significantly after thermocycling (P<.05). Group CBT-S showed the highest shear bond strength; however, no significant differences were found between Groups CBT-S and MDP (P=.908). In particular, the area of resin remaining on the fractured surfaces of Group CBT-S was 100% (cohesive failure). Conclusions: The combined surface treatment of alumina airborne-particle abrasion and tribochemical treatment, along with primer treatment using silane coupling and an MDP monomer, improved the adhesion strength and adhesion durability between base resins and Ce-TZP-Al
MeSH term(s)	Humans ; Aluminum Oxide/chemistry ; Resin Cements/chemistry ; Dental Bonding/methods ; Acrylic Resins ; Surface Properties ; Materials Testing ; Zirconium/chemistry ; Shear Strength ; Nanocomposites ; Dental Stress Analysis
Chemical Substances	zirconium oxide (S38N85C5G0) ; Aluminum Oxide (LMI26O6933) ; Resin Cements ; Acrylic Resins ; Zirconium (C6V6S92N3C) ; methacryloyloxydecyl dihydrogen phosphate (85590-00-7)
Language	English
Publishing date	2021-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2021.01.019
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Article: [New methods for the evaluation of bone quality. Nanoindentation protocol for measurement of bone mechanical properties of material level.]

Shibata, Yo / Miyazaki, Takashi

Clinical calcium

2017 Volume 27, Issue 8, Page(s) 1139–1145

Abstract: Bone is an inhomogeneous, anisotropic natural biomaterial with complex, multiscale structural variations. Thus, experiments on the bulk scale using a universal testing machine are not applicable for localized precision mechanical testing of bone. ... ...

Abstract	Bone is an inhomogeneous, anisotropic natural biomaterial with complex, multiscale structural variations. Thus, experiments on the bulk scale using a universal testing machine are not applicable for localized precision mechanical testing of bone. Nanoscale mechanical testing technologies such as nanoindentation enables to assess the intrinsic toughening mechanism of bone, which is a function of the highly-organized matrix proteins within the mineralized nanostructure. Understanding the basic nanomechanical properties of calcified tissues will help us to appreciate general concepts associated with the excellent design of advanced engineering materials and engineered tissues.
Language	Japanese
Publishing date	2017
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	2386417-5
ISSN	0917-5857
ISSN	0917-5857
DOI	CliCa170811391145
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Article ; Online: Klotho Supplementation Reverses Renal Dysfunction and Interstitial Fibrosis in Remnant Kidney.

Takenaka, Tsuneo / Hasan, Arif / Marumo, Takeshi / Inoue, Tsutomu / Miyazaki, Takashi / Suzuki, Hiromichi / Kurosaki, Yoshifumi / Ishii, Naohito / Nishiyama, Akira / Hayashi, Matsuhiko

Kidney & blood pressure research

2023 Volume 48, Issue 1, Page(s) 326–337

Abstract: Introduction: While recent investigations show that klotho exerts renoprotective actions, it has not been fully addressed whether klotho protein supplementation reverses renal damage.: Methods: The impacts of subcutaneous klotho supplementation on ... ...

Abstract	Introduction: While recent investigations show that klotho exerts renoprotective actions, it has not been fully addressed whether klotho protein supplementation reverses renal damage. Methods: The impacts of subcutaneous klotho supplementation on rats with subtotal nephrectomy were examined. Animals were divided into 3 groups: group 1 (short remnant [SR]): remnant kidney for 4 weeks, group 2 (long remnant [LR]): remnant kidney for 12 weeks, and group 3 (klotho supplementation [KL]): klotho protein (20 μg/kg/day) supplementation on the remnant kidney. Blood pressure, blood and urine compositions with conventional methods such as enzyme-linked immunosorbent assay and radioimmunoassay, kidney histology, and renal expressions of various genes were analyzed. In vitro studies were also performed to support in vivo findings. Results: Klotho protein supplementation decreased albuminuria (-43%), systolic blood pressure (-16%), fibroblast growth factor (FGF) 23 (-51%) and serum phosphate levels (-19%), renal angiotensin II concentration (-43%), fibrosis index (-70%), renal expressions of collagen I (-55%), and transforming growth factor β (-59%) (p < 0.05 for all). Klotho supplementation enhanced fractional excretion of phosphate (+45%), glomerular filtration rate (+76%), renal expressions of klotho (+148%), superoxide dismutase (+124%), and bone morphogenetic protein (BMP) 7 (+174%) (p < 0.05 for all). Conclusion: Our data indicated that klotho protein supplementation inactivated renal renin-angiotensin system, reducing blood pressure and albuminuria in remnant kidney. Furthermore, exogenous klotho protein supplementation elevated endogenous klotho expression to increase phosphate excretion with resultant reductions in FGF23 and serum phosphate. Finally, klotho supplementation reversed renal dysfunction and fibrosis in association with improved BMP7 in remnant kidney.
MeSH term(s)	Animals ; Rats ; Albuminuria/metabolism ; Dietary Supplements ; Fibrosis ; Kidney/pathology ; Kidney Diseases/pathology ; Klotho Proteins/therapeutic use ; Phosphates/metabolism
Chemical Substances	Klotho Protein, rat (EC 3.2.1.31) ; Klotho Proteins (EC 3.2.1.31) ; Phosphates
Language	English
Publishing date	2023-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1326018-2
ISSN	1423-0143 ; 1420-4096
ISSN (online)	1423-0143
ISSN	1420-4096
DOI	10.1159/000530469
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Article ; Online: Antiferromagnetism in perfectly ordered L1

Sato, Suguru / Irie, Shuichiro / Nagamine, Yuki / Miyazaki, Takashi / Umeda, Yuji

Scientific reports

2020 Volume 10, Issue 1, Page(s) 12489

Abstract: Manganese (Mn)-based strong magnets have long been a challenge because their 3d half-filled nature, owing to the close proximity of Mn atoms, results in antiferromagnetic ordering. Among various Mn magnetic materials, ... ...

Abstract	Manganese (Mn)-based strong magnets have long been a challenge because their 3d half-filled nature, owing to the close proximity of Mn atoms, results in antiferromagnetic ordering. Among various Mn magnetic materials, L1
Language	English
Publishing date	2020-07-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-69538-2
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Article: Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone.

Zhou, Jun / He, Zhiyi / Cui, Jiarui / Liao, Xiaoling / Cao, Hui / Shibata, Yo / Miyazaki, Takashi / Zhang, Jiaming

Bone & joint research

2022 Volume 11, Issue 6, Page(s) 362–370

Abstract: Aims: Osteoarthritis (OA) is a common degenerative joint disease. The osteocyte transcriptome is highly relevant to osteocyte biology. This study aimed to explore the osteocyte transcriptome in subchondral bone affected by OA.: Methods: Gene ... ...

Abstract	Aims: Osteoarthritis (OA) is a common degenerative joint disease. The osteocyte transcriptome is highly relevant to osteocyte biology. This study aimed to explore the osteocyte transcriptome in subchondral bone affected by OA. Methods: Gene expression profiles of OA subchondral bone were used to identify disease-relevant genes and signalling pathways. RNA-sequencing data of a bone loading model were used to identify the loading-responsive gene set. Weighted gene co-expression network analysis (WGCNA) was employed to develop the osteocyte mechanics-responsive gene signature. Results: A group of 77 persistent genes that are highly relevant to extracellular matrix (ECM) biology and bone remodelling signalling were identified in OA subchondral lesions. A loading responsive gene set, including 446 principal genes, was highly enriched in OA medial tibial plateaus compared to lateral tibial plateaus. Of this gene set, a total of 223 genes were identified as the main contributors that were strongly associated with osteocyte functions and signalling pathways, such as ECM modelling, axon guidance, Hippo, Wnt, and transforming growth factor beta (TGF-β) signalling pathways. We limited the loading-responsive genes obtained via the osteocyte transcriptome signature to identify a subgroup of genes that are highly relevant to osteocytes, as the mechanics-responsive osteocyte signature in OA. Based on WGCNA, we found that this signature was highly co-expressed and identified three clusters, including early, late, and persistently responsive genes. Conclusion: In this study, we identified the mechanics-responsive osteocyte signature in OA-lesioned subchondral bone. Cite this article:
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2669244-2
ISSN	2046-3758
ISSN	2046-3758
DOI	10.1302/2046-3758.116.BJR-2021-0436.R1
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