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  1. Article: [Primary sclerosing cholangitis -up to date].

    Mizuno, Suguru

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2024  Volume 121, Issue 1, Page(s) 26–32

    MeSH term(s) Humans ; Cholangitis, Sclerosing/therapy ; Liver Transplantation
    Language Japanese
    Publishing date 2024-01-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.121.26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui V Zs.34: Show issues Location:
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    Zs.MO 477: Show issues

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  2. Article ; Online: Raccoon Eye Sign in Amyloid Light-chain Amyloidosis.

    Mizuno, Shinichi

    Internal medicine (Tokyo, Japan)

    2022  Volume 61, Issue 15, Page(s) 2393

    MeSH term(s) Amyloid ; Animals ; Ecchymosis/diagnosis ; Humans ; Immunoglobulin Light-chain Amyloidosis/complications ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Raccoons
    Chemical Substances Amyloid
    Language English
    Publishing date 2022-08-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.8927-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 240: Show issues Location:
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  3. Article ; Online: Inhibition of Bacterial Growth on Sinks of a Paediatric Intensive Care Unit using a 222-nm Far Ultraviolet Irradiation Device (Care222®

    Mizuno, Shinsuke / Kasai, Masashi

    The Journal of hospital infection

    2024  

    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Letter
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2024.03.016
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    Zs.A 1586: Show issues Location:
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  4. Article ; Online: Urinary Crystals with 2,8-Dihydroxyadeninuria.

    Mizuno, Shinichi

    Internal medicine (Tokyo, Japan)

    2020  Volume 60, Issue 6, Page(s) 963

    MeSH term(s) Adenine Phosphoribosyltransferase/deficiency ; Humans ; Metabolism, Inborn Errors ; Nephrolithiasis ; Urolithiasis
    Chemical Substances Adenine Phosphoribosyltransferase (EC 2.4.2.7)
    Language English
    Publishing date 2020-10-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.5939-20
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  5. Article ; Online: Know endoscopic retrograde cholangiopancreatography and yourself, then you need not fear the result of a hundred cases.

    Mizuno, Suguru / Mochida, Satoshi

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2023  Volume 36, Issue 1, Page(s) 86–88

    MeSH term(s) Humans ; Cholangiopancreatography, Endoscopic Retrograde
    Language English
    Publishing date 2023-12-28
    Publishing country Australia
    Document type Editorial
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14732
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    Zs.A 3854: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Hospital burden and characteristics of coronavirus disease 2019 at a children's hospital.

    Mizuno, Shinsuke / Kasai, Masashi

    Pediatrics international : official journal of the Japan Pediatric Society

    2023  Volume 65, Issue 1, Page(s) e15528

    MeSH term(s) Child ; Humans ; COVID-19 ; SARS-CoV-2 ; Hospitals ; Hospitalization
    Language English
    Publishing date 2023-03-20
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15528
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    Zs.A 848: Show issues Location:
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  7. Article ; Online: Cellular behavior and extracellular matrix turnover in bovine annulus fibrosus cells under hydrostatic pressure and deviatoric strain.

    Taiji, Ryo / Kang, James D / Mizuno, Shuichi

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    2024  Volume 42, Issue 6, Page(s) 1326–1334

    Abstract: Intervertebral disc herniation is a common spinal disorder that is often treated with discectomy when conservative measures fail. To devise therapeutic strategies for tears in the annulus fibrosus (AF), the regenerative capability of AF cells under ... ...

    Abstract Intervertebral disc herniation is a common spinal disorder that is often treated with discectomy when conservative measures fail. To devise therapeutic strategies for tears in the annulus fibrosus (AF), the regenerative capability of AF cells under spinal loading needs to be addressed. We hypothesized that the compressive loading associated with deformation in AF cells reduces synthetic and degradative activities in extracellular matrix and cell proliferation. We evaluated expression of key matrix molecules and cell proliferation by RT-PCR and immunohistochemistry by inner and outer bovine AF cells incubated under hydrostatic pressure (HP), arc-bending strain (Strain), and combined HP and Strain (HP/Strain) mimicking spinal loading. Inner AF cells showed significantly increased levels of aggrecan core protein, chondroitin sulfate N-acetylgalactosaminyltransferase-1, and tissue inhibitor of metalloproteinases-2 by 6 days under HP (p < 0.05), with a tendency toward increased matrix metalloproteinase-13. Outer AF cells demonstrated a significant decline in collagen type-2 under Strain and HP/Strain (p < 0.05) and a tendency toward suppression of collagen type-1 and elastin expression compared to HP and unloaded control. On the other hand, proliferating cell nucleus antigen increased significantly under Strain and HP/Strain in inner AF and declined under unloaded and HP in outer AF (p < 0.05). Immunohistology findings supported reductions in gene expressions of matrix molecules. Thus, changes in HP/Strain in AF appear to diminish synthetic and degradative activities while increasing cell proliferation. To promote regeneration, continuous overloading should be avoided, as it converts the synthetic activity to a state in which tissue repair is limited.
    MeSH term(s) Animals ; Cattle ; Hydrostatic Pressure ; Annulus Fibrosus/metabolism ; Extracellular Matrix/metabolism ; Cell Proliferation ; Cells, Cultured ; Aggrecans/metabolism ; Stress, Mechanical ; Tissue Inhibitor of Metalloproteinase-2/metabolism ; Collagen Type II/metabolism
    Chemical Substances Aggrecans ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Collagen Type II
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 605542-4
    ISSN 1554-527X ; 0736-0266
    ISSN (online) 1554-527X
    ISSN 0736-0266
    DOI 10.1002/jor.25779
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    Zs.A 1879: Show issues Location:
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  8. Article ; Online: Shear-Induced Nonequilibrium Patterns in Lipid Bilayer Membranes Exhibiting Phase Separation.

    Hamada, Tsutomu / Mizuno, Shino / Kitahata, Hiroyuki

    Langmuir : the ACS journal of surfaces and colloids

    2024  Volume 40, Issue 17, Page(s) 8843–8850

    Abstract: The nonequilibrium dynamics of a fluid lipid membrane under external stimuli is an important issue that spans disciplines such as soft matter, biophysical chemistry, and interface science. This study investigated the dynamic response of lipid vesicles ... ...

    Abstract The nonequilibrium dynamics of a fluid lipid membrane under external stimuli is an important issue that spans disciplines such as soft matter, biophysical chemistry, and interface science. This study investigated the dynamic response of lipid vesicles with order-disorder phase separation, which mimics a plasma membrane heterogeneity, to shear flow. Lipid vesicles were immobilized in a microfluidic chamber, and shear-induced nonequilibrium patterns on the membrane surface were observed by an optical microscope. We found that phase-separated membranes exhibit a dissipative structure of stripe patterns along the vortex flow on the membrane surface, and the number of stripes increased with the flow rate. At a high flow rate, the membrane exhibited a stripe-to-wave transition, where striped domains often migrated and the replacement of two different phases happened at vortex centers with time. We obtained a dynamic phase diagram of the shear-induced wave pattern by changing the flow rate, membrane components, and temperature. These findings could provide insight into the dissipative structures of lipid membranes out of equilibrium and flow-mediated mechanotransduction of biological membranes.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c03970
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  9. Article: [Multiple Myeloma: from Diagnosis to the Up-to-date Treatment. Topics: IV. Multiple Myeloma with Renal Impairment and Monoclonal Gammopathy of Renal Significance].

    Mizuno, Shinichi

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2018  Volume 105, Issue 7, Page(s) 1224–1230

    MeSH term(s) Biomarkers/analysis ; Humans ; Multiple Myeloma/complications ; Paraproteinemias/etiology ; Paraproteinemias/therapy ; Proteinuria/etiology ; Renal Insufficiency/etiology
    Chemical Substances Biomarkers
    Language Japanese
    Publishing date 2018-10-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
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    Zs.B 594: Show issues Location:
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  10. Article ; Online: Hydrostatic pressure mimicking diurnal spinal movements maintains anabolic turnover in bovine nucleus pulposus cells in vitro.

    Vieira, F / Kang, J / Ferreira, L / Mizuno, S

    European cells & materials

    2021  Volume 42, Page(s) 246–263

    Abstract: Treatment strategies for progressive intervertebral-disc degeneration often alleviate pain and other symptoms. With the goal of developing strategies to promote the regeneration of the nucleus pulposus (NP), the present study tried to identify the ... ...

    Abstract Treatment strategies for progressive intervertebral-disc degeneration often alleviate pain and other symptoms. With the goal of developing strategies to promote the regeneration of the nucleus pulposus (NP), the present study tried to identify the biological effects of hydrostatic (HP) and osmotic pressures on NP cells. The study hypothesis was that a repetitive regimen of cyclic HP followed by constant HP in high-osmolality medium would increase anabolic molecules in NP cells. Bovine NP cells/clusters were enclosed within semi-permeable membrane pouches and incubated under a regimen of cyclic HP for 2 d followed by constant HP for 1 d, repeated 6 times over 18 d. NP cells showed a significantly increased expression of anabolic genes over time: aggrecan, chondroitin sulfate N-acetylgalactosaminyltransferase 1, hyaluronan synthase 2, collagen type 2 (p < 0.05). In addition, the expression of catabolic or degenerative genes (matrix metalloproteinase 13, collagen type 1) and cellular characteristic genes (proliferating cell nucleic antigen, E-cadherin) was suppressed. The amount of sulfated glycosaminoglycan increased significantly at day 18 compared to day 3 (p < 0.01). Immunostaining revealed deposition of extracellular-matrix molecules and localization of other specific molecules corresponding to their genetic expression. An improved understanding of how cells respond to physicochemical stresses will help to better treat the degenerating disc using either cell- or gene-based therapies as well as other potential matrix-enhancing therapies. Efforts to apply these tissue-engineering and regenerative-medicine strategies will need to consider these important physicochemical stresses that may have a major impact on the survivability of such treatments.
    MeSH term(s) Animals ; Cattle ; Extracellular Matrix ; Hydrostatic Pressure ; Intervertebral Disc ; Intervertebral Disc Degeneration ; Nucleus Pulposus
    Language English
    Publishing date 2021-10-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2046669-9
    ISSN 1473-2262 ; 1473-2262
    ISSN (online) 1473-2262
    ISSN 1473-2262
    DOI 10.22203/eCM.v042a18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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