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Article ; Online: [The Functional Roles and the Potential as Drug Targets of Glycoproteins Regulating Complement and Coagulation Pathways].

Mizuno, Tomohiro

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2023 Volume 143, Issue 9, Page(s) 707–712

Abstract: Complement (C) activation occurs via three pathways, namely the classical, lectin, and alternative pathways. Intercommunication occurs between the complement and coagulation systems, which can trigger tissue injury and inflammation. Disseminated ... ...

Abstract	Complement (C) activation occurs via three pathways, namely the classical, lectin, and alternative pathways. Intercommunication occurs between the complement and coagulation systems, which can trigger tissue injury and inflammation. Disseminated intravascular coagulation (DIC) is a life-threatening disease characterized by disordered coagulation and systemic inflammation; here, the intercommunication between the complement and coagulation systems contributes to the development of DIC. Extracellular histones, which are contributors to the damage-associated molecular pattern, induce severe thrombosis. C5 is a key molecule in the intercommunication between the complement and coagulation systems and is associated with the development of lethal histone-induced thrombosis. Heparin and chondroitin sulfate (CS) are negatively charged, allowing them to bind to extracellular histones. As the coagulation system is less affected by CS than heparin, CS shows potential as an effective drug for the treatment of patients with DIC who have a high risk of bleeding. Complement receptor type-1-related gene Y (Crry) inhibits the complement pathway via binding to C3b and C4b. Hence, Crry is a potent inhibitor of the classical and alternative C pathways. The expression of Crry is decreased by the endothelial damage induced by extracellular histones. Crry dysfunction promotes the activation of C on the surface of endothelial cells. The prevention of C3 cleavage on endothelial cells might be a useful therapy targeting acute lung injury.
MeSH term(s)	Humans ; Histones ; Endothelial Cells ; Glycoproteins ; Heparin ; Inflammation
Chemical Substances	Histones ; Glycoproteins ; Heparin (9005-49-6)
Language	Japanese
Publishing date	2023-09-04
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.23-00112
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Article ; Online: Macrophage-1 antigen exacerbates histone-induced acute lung injury and promotes neutrophil extracellular trap formation.

Mizuno, Tomohiro / Nagano, Fumihiko / Takahashi, Kazuo / Yamada, Shigeki / Fruhashi, Kazuhiro / Maruyama, Shoichi / Tsuboi, Naotake

FEBS open bio

2024 Volume 14, Issue 4, Page(s) 574–583

Abstract: Acute lung injury (ALI), which occurs in association with sepsis, trauma, and coronavirus disease 2019 (COVID-19), is a serious clinical condition with high mortality. Excessive platelet-leukocyte aggregate (PLA) formation promotes neutrophil ... ...

Abstract	Acute lung injury (ALI), which occurs in association with sepsis, trauma, and coronavirus disease 2019 (COVID-19), is a serious clinical condition with high mortality. Excessive platelet-leukocyte aggregate (PLA) formation promotes neutrophil extracellular trap (NET) release and thrombosis, which are involved in various diseases, including ALI. Macrophage-1 antigen (Mac-1, CD11b/CD18), which is expressed on the surface of leukocytes, is known to promote NET formation. This study aimed to elucidate the role of Mac-1 in extracellular histone-induced ALI. Exogenous histones were administered to Mac-1-deficient mice and wild-type (WT) mice with or without neutrophil or platelet depletion, and several parameters were investigated 1 h after histone injection. Depletion of neutrophils or platelets improved survival time and macroscopic and microscopic properties of lung tissues, and decreased platelet-leukocyte formation and plasma myeloperoxidase levels. These improvements were also observed in Mac-1
MeSH term(s)	Animals ; Mice ; Extracellular Traps/metabolism ; Macrophage-1 Antigen/metabolism ; Histones ; Neutrophils/metabolism ; Acute Lung Injury
Chemical Substances	Macrophage-1 Antigen ; Histones
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13779
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Article ; Online: Authors' reply to the letter to the editor on "Managing geriatric syndromes: necessity of pharmacists' involvements" by Kojima.

Mizokami, Fumihiro / Hasegawa, Sho / Mizuno, Tomohiro / Yabu, Takeshi / Kameya, Yoshitaka / Hayakawa, Yuji / Arai, Hidenori

Geriatrics & gerontology international

2024 Volume 24, Issue 4, Page(s) 448–450

MeSH term(s)	Humans ; Aged ; Pharmacists ; Syndrome
Language	English
Publishing date	2024-03-11
Publishing country	Japan
Document type	Letter
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14859
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Article ; Online: Bovine pericardial patch repair for abdominal aortic pseudoaneurysm to preserve lumbar arteries.

Nabeshima, Junya / Mizuno, Tomohiro / Nagaoka, Eiki

Interactive cardiovascular and thoracic surgery

2022 Volume 35, Issue 6

Abstract: We describe a case of aortic repair using bovine pericardium for a pseudoaneurysm of a dissecting abdominal aorta. A 71-year-old man had undergone several aortic replacement surgeries for type B aortic dissection. He developed paraparesis after thoraco- ... ...

Abstract	We describe a case of aortic repair using bovine pericardium for a pseudoaneurysm of a dissecting abdominal aorta. A 71-year-old man had undergone several aortic replacement surgeries for type B aortic dissection. He developed paraparesis after thoraco-abdominal aortic surgery and recovered. After 3 years, the scheduled computed tomography scan showed a pseudoaneurysm of the dissecting abdominal aorta. Because he was at high risk of spinal cord ischaemia, aortic repair using bovine pericardium was performed, and all lumbar arteries were preserved. During the 12-month follow-up, he was asymptomatic, and computed tomography scans showed no dilation of the aorta.
MeSH term(s)	Male ; Cattle ; Animals ; Humans ; Aged ; Aortic Aneurysm, Thoracic/surgery ; Aorta, Abdominal/diagnostic imaging ; Aorta, Abdominal/surgery ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/surgery ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/surgery ; Pericardium ; Treatment Outcome
Language	English
Publishing date	2022-10-31
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivac261
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Zs.A 5730: Show issues

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Article ; Online: COVID-19 mRNA vaccination is associated with IgA nephropathy: an analysis of the Japanese adverse drug event report database.

Nakao, Hiroka / Koseki, Takenao / Kato, Koki / Yamada, Shigeki / Tsuboi, Naotake / Takahashi, Kazuo / Mizuno, Tomohiro

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2023 Volume 26, Page(s) 11453

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/prevention & control ; Glomerulonephritis, IGA/genetics ; COVID-19 Vaccines/adverse effects ; East Asian People ; Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions ; Vaccination/adverse effects ; mRNA Vaccines
Chemical Substances	COVID-19 Vaccines ; mRNA Vaccines
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422972-9
ISSN	1482-1826 ; 1482-1826
ISSN (online)	1482-1826
ISSN	1482-1826
DOI	10.3389/jpps.2023.11453
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Article ; Online: [Factors Related to Submission of Tracing Reports Regarding Cancer Chemotherapy by Pharmacy Pharmacists].

Matsumoto, Noriaki / Mizuno, Tomohiro / Aimiya, Yukinori / Sakakibara, Mikio / Sugiura, Shinya / Mase, Hiroki

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2023 Volume 144, Issue 1, Page(s) 143–150

Abstract: In Japan, use of a report for providing information from pharmacies to medical institutions called as "tracing report (TR)" is not widespread especially in the field of cancer chemotherapy. Identification of the factors related to submission of TRs could ...

Abstract	In Japan, use of a report for providing information from pharmacies to medical institutions called as "tracing report (TR)" is not widespread especially in the field of cancer chemotherapy. Identification of the factors related to submission of TRs could enhance the necessity of TRs. The purpose of this study is to clarify the factors related to submission of TRs regarding cancer chemotherapy through a questionnaire survey. A questionnaire survey was conducted at the live web-based seminar regarding cancer chemotherapy held for pharmacists in January 2023. After the questionnaire survey, the participants were divided into those who had submitted at least one TR regarding cancer chemotherapy within one month before the seminar (TR group) and those who had not (non-TR group). The multivariate analysis was conducted to identify factors related to submission of TRs regarding cancer chemotherapy. Of 118 participants, the responses from 93 pharmacy pharmacists involved in dispensing drugs who agreed to participate in this study and fulfilled all questionnaire were analyzed. TR group included 21 participants and non-TR group included 72. As a result of multivariate analysis, "Years of experience in counseling and following-up with patients undergoing cancer chemotherapy (odds ratio: 4.81, p=0.02)" and "Types of workplaces (odds ratio: 3.79, p=0.02)" significantly increased the incidence of submission of TRs regarding cancer chemotherapy. It was revealed that experience of intervention in cancer chemotherapy cases and an environment in which prescriptions for cancer chemotherapy can be handled on a daily basis are important for submission of TRs regarding cancer chemotherapy.
MeSH term(s)	Humans ; Pharmacists ; Pharmacies ; Neoplasms/drug therapy ; Pharmacy ; Surveys and Questionnaires ; Community Pharmacy Services
Language	Japanese
Publishing date	2023-12-14
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.23-00146
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Article ; Online: Investigation of geriatric syndromes associated with medication in Japan using insurance claims data.

Hasegawa, Sho / Mizokami, Fumihiro / Mizuno, Tomohiro / Yabu, Takeshi / Kameya, Yoshitaka / Hayakawa, Yuji / Arai, Hidenori

Geriatrics & gerontology international

2023 Volume 24, Issue 1, Page(s) 61–67

Abstract: Aim: Multiple risk factors are involved in geriatric syndrome (GS) occurring in older adults. Although drug therapy often contributes to GS, the specific causes among older adults in Japan remain unclear. In this study, we examined the possible ... ...

Abstract	Aim: Multiple risk factors are involved in geriatric syndrome (GS) occurring in older adults. Although drug therapy often contributes to GS, the specific causes among older adults in Japan remain unclear. In this study, we examined the possible prescribing cascade rate among older outpatients eligible for Late-stage Elderly Health Insurance and elucidated the differences between GS and GS associated with medication (GSAM) trends. Methods: This retrospective study enrolled patients from health insurance claims data in Japan between October 2018 and March 2019; hospitalized patients were excluded. Two groups were identified among the participants with GS: GS (no use of GS-causing medications) and possible-GSAM (p-GSAM; use of GS-causing medications). The collected data were analyzed using the Bell Curve for Excel, and statistical significance was set at P < 0.05. Results: In total, 137 781 outpatients were enrolled. Of the 32 259 outpatients who did not use GS-causing medications, 7342 were classified into the GS group. Among 105 522 outpatients who used GS-causing medications, 8347 were classified as having p-GSAM. The mean number of prescriptions was significantly higher in the p-GSAM group than in the GS group (P < 0.01). Furthermore, all GS symptoms showed significant differences, with impaired appetite being the most prevalent in the p-GSAM group than in the GS group (P < 0.01). A possible prescribing cascade was suspected in 2826 (33.9%) of 8347 outpatients in the p-GSAM group. Conclusion: Impaired appetite in patients taking GS-causing medications might lead to prescribing cascades. Further studies are needed to prevent such prescribing cascades. Geriatr Gerontol Int 2024; 24: 61-67.
MeSH term(s)	Humans ; Aged ; Retrospective Studies ; Japan/epidemiology ; Risk Factors ; Outpatients ; Insurance
Language	English
Publishing date	2023-12-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14755
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Article ; Online: Ring annuloplasty, optionally combined with edge-to-edge leaflet plications, should be amended with subvalvular repair techniques to efficaciously treat tricuspid regurgitation with severe tethering.

Takeshita, Masashi / Arai, Hirokuni / Nagaoka, Eiki / Oi, Keiji / Fujiwara, Tatsuki / Oishi, Kiyotoshi / Mizuno, Tomohiro

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2023 Volume 63, Issue 6

Abstract: Objectives: This study aimed to evaluate the outcomes of tricuspid annuloplasty with/without additional edge-to-edge plications in patients with functional tricuspid regurgitation (TR) and to clarify the impact of tethering on surgical outcomes.: ... ...

Abstract	Objectives: This study aimed to evaluate the outcomes of tricuspid annuloplasty with/without additional edge-to-edge plications in patients with functional tricuspid regurgitation (TR) and to clarify the impact of tethering on surgical outcomes. Methods: This retrospective observational study included patients with moderate or greater functional TR who underwent initial tricuspid valve repair between January 2008 and December 2021. The patients were divided into 2 groups based on whether they had tethering (preoperative tethering area ≥0.75 cm2). All patients underwent annuloplasty, and edge-to-edge plications were added at the regurgitant leakage site identified by saline tests. The surgical outcomes of each group and the effect of tethering on recurrent moderate or greater TR were evaluated. Results: One hundred and thirty-three patients were included in this study. During the follow-up period of 55.3 (standard deviation: 44.9) months, the 5-year survival rates were 78.4% in patients without tethering and 76.1% in patients with tethering (P = 0.78). The 5-year cumulative incidence rates of readmission for heart failure and recurrent TR were 10.8% and 1.3% in patients without tethering and 23.0% and 29.5% in patients with tethering, respectively (P = 0.12 and <0.001). Multivariable analyses revealed that the preoperative and predischarge tethering areas predicted recurrent TR. A large tethering area remained postoperatively in patients with tethering. Conclusions: In patients without tethering, annuloplasty and additional edge-to-edge plications are effective in avoiding recurrent TR with satisfactory midterm clinical outcomes. However, in patients with tethering, these procedures resulted in residual tethering, which could be leading to recurrent TR.
MeSH term(s)	Humans ; Tricuspid Valve Insufficiency ; Tricuspid Valve/surgery ; Mitral Valve/surgery ; Aortic Valve ; Retrospective Studies ; Treatment Outcome ; Cardiac Valve Annuloplasty/methods
Language	English
Publishing date	2023-03-23
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezad108
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Article ; Online: Effect of fat emulsion administration on blood coagulation in terminal lung cancer patients.

Kanie, Takaki / Futamura, Akihiko / Mizuno, Tomohiro / Yamada, Shigeki / Usui, Masanobu

Fujita medical journal

2022 Volume 9, Issue 2, Page(s) 73–79

Abstract: Objectives: Patients with cancer, especially those with lung cancer, are at high risk of developing thrombosis. Intralipos: Methods: The subjects were patients with terminal lung cancer in the Department of Surgery and Palliative Medicine, Fujita ... ...

Abstract	Objectives: Patients with cancer, especially those with lung cancer, are at high risk of developing thrombosis. Intralipos Methods: The subjects were patients with terminal lung cancer in the Department of Surgery and Palliative Medicine, Fujita Health University Nanakuri Memorial Hospital between January 2016 and December 2019. We compared changes in their blood coagulation profile before hospitalization and one month later. Results: There were a total of 213 patients with lung cancer-139 who were administered fat emulsion and 74 who were not-with no significant differences in baseline characteristics. In the fat emulsion administration group (n=27), the prothrombin time-international normalized ratio (PT-INR) and activated partial thromboplastin time (APTT), respectively, were 1.17±0.26 (mean±standard deviation) and 30.5±5.0 s at hospitalization and 1.16±0.12 and 31.2±4.2 s one month later with no significant differences. In the non-administration group (n=6), the PT-INR and APTT, respectively, were 1.44±0.43 and 30.6±5.2 s before hospitalization and 1.28±0.18 and 33.0±7.5 s one month later with no significant differences. Conclusions: We did not identify any changes in PT-INR and APTT after fat emulsion administration in patients with terminal lung cancer. There were also no new cases of thrombosis, suggesting that fat emulsions were administered safely in patients with terminal lung cancer.
Language	English
Publishing date	2022-07-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	3011241-2
ISSN	2189-7255 ; 2189-7247
ISSN (online)	2189-7255
ISSN	2189-7247
DOI	10.20407/fmj.2021-012
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Article ; Online: Remote follow-up by pharmacists for blood pressure control in patients with hypertension: a systematic review and a meta-analysis of randomized controlled trials.

Matsumoto, Noriaki / Nakai, Tsuyoshi / Sakakibara, Mikio / Aimiya, Yukinori / Sugiura, Shinya / Lee, Jeannie K / Yamada, Shigeki / Mizuno, Tomohiro

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2535

Abstract: Hypertension is a major cause of cardiovascular diseases. Several recent studies reported that pharmacists' remote follow-up reduced hypertension patients' blood pressure (BP). This meta-analysis aims to verify whether remote follow-up by pharmacists ... ...

Abstract	Hypertension is a major cause of cardiovascular diseases. Several recent studies reported that pharmacists' remote follow-up reduced hypertension patients' blood pressure (BP). This meta-analysis aims to verify whether remote follow-up by pharmacists improves BP levels and reveal the factors that make the intervention effective. The search, conducted using PubMed/Medline, Embase, and Cochrane Library from June to July 2023, targeted articles published between October 1982 and June 2023, using terms including "pharmacist", "hypertension", and "randomized controlled trial (RCT)". The inclusion criteria were: (a) RCTs involving hypertension patients with or without comorbidities, (b) pharmacists using remote communication tools to conduct follow-up encounter during the intervention period, (c) reporting systolic blood pressure (SBP) at baseline and during intervention. SBP was the primary outcome for the meta-analysis. Thirteen studies (3969 participants) were included in this meta-analysis. The mean difference of SBP between intervention group and control group was - 7.35 mmHg (P < 0.0001). Subgroup analyses showed the greater reduction of SBP in the "regularly scheduled follow-up cohort" (- 8.89 mmHg) compared with the "as needed follow-up cohort" (- 3.23 mmHg, P < 0.0001). The results revealed that remote follow-up by pharmacists reduced SBP levels in hypertension patients and scheduled remote follow-up may contribute to the effectiveness.
MeSH term(s)	Humans ; Blood Pressure ; Pharmacists ; Follow-Up Studies ; Randomized Controlled Trials as Topic ; Hypertension/drug therapy ; Hypotension
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52894-8
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