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Article ; Online: The Impact of Nutrition and Oral Function Exercise on among Community-Dwelling Older People.

Tani, Asuka / Mizutani, Shinsuke / Kishimoto, Hiro / Oku, Saori / Iyota, Kiyomi / Chu, Tianshu / Liu, Xin / Kashiwazaki, Haruhiko

Nutrients

2023 Volume 15, Issue 7

Abstract: Oral function (OF) decline in older people is associated with nutritional deficiencies, which increases frailty risk and the need for nursing care. We investigated whether the delivery of an oral function improvement program on a tablet device was as ... ...

Abstract	Oral function (OF) decline in older people is associated with nutritional deficiencies, which increases frailty risk and the need for nursing care. We investigated whether the delivery of an oral function improvement program on a tablet device was as effective as delivery through a paper-based program. We also investigated the association between tongue pressure (TP) improvement and nutritional status at the baseline. The participants involved in the study were 26 community-dwelling older people with low TP, <30 kPa, aged ≥65 years, who were enrolled in a randomized controlled trial for a month in Itoshima City, Fukuoka, Japan. Oral and physical functions and body composition were measured at the baseline and at follow-up. Two-way analysis of variance revealed that body mass index (
MeSH term(s)	Nutritional Status ; Independent Living ; Pressure ; Tongue ; Exercise
Language	English
Publishing date	2023-03-26
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15071607
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Article: Progressive Multifocal Leukoencephalopathy Initially Suspected As Brain Relapse From Classical Hodgkin's Lymphoma.

Onishi, Akio / Muramatsu, Ayako / Shimura, Yuji / Murao, Taichi / Fujino, Takahiro / Mizutani, Shinsuke / Tsukamoto, Taku / Shishido-Hara, Yukiko / Kuroda, Junya

Cureus

2023 Volume 15, Issue 8, Page(s) e44000

Abstract: HIV-negative progressive multifocal leukoencephalopathy (PML) has a poor prognosis due to a lack of standard treatment. Herein, we report a patient with HIV-negative PML which occurred after the treatment for classical Hodgkin's lymphoma (CHL). A 71-year- ...

Abstract	HIV-negative progressive multifocal leukoencephalopathy (PML) has a poor prognosis due to a lack of standard treatment. Herein, we report a patient with HIV-negative PML which occurred after the treatment for classical Hodgkin's lymphoma (CHL). A 71-year-old male patient was admitted to our hospital due to various neurological symptoms, including memory disturbance, dysgraphia, ataxia, and ideomotor apraxia, at 16 months after high-dose salvage chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) for primary treatment-refractory CHL. The patient's blood and serological examination results were mainly normal, including CD4-positive T lymphocyte count and serum immunoglobulin levels. T2-weighted fluid-attenuated inversion recovery MRI showed high-intensity lesions from the left occipital lobe to the corpus callosum. Moreover, the rapid intraoperative pathological assessment of biopsy specimens obtained from abnormal brain lesions suggested brain relapse of CHL. The patient's symptoms progressed rapidly; therefore, treatment with high-dose methotrexate was started, which significantly improved the patient's symptoms and MRI findings within a week. However, further examinations of the biopsy specimens with in situ hybridization and immunohistochemical examinations showed reactivation of the John Cunningham virus (JCV) in the astrocytes. Further, cells initially believed to be Hodgkin cells based on the rapid intraoperative pathological assessment were found to be destructive astrocytes, thereby confirming the diagnosis of PML. The patient was then successfully treated with combined mefloquine and mirtazapine and did not have any fatal outcomes. Based on this case, a differential diagnosis of PML from CNS involvement of CHL is important even in cases without evident biomarkers for immunodeficiency. Moreover, methotrexate was likely to be effective in improving neurological symptoms by decreasing brain parenchyma inflammation in the acute phase in this particular patient.
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44000
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Article ; Online: Management of Acquired Factor X Deficiency Caused by In Vitro Non-neutralizing Anti-factor X Autoantibodies with Pre-emptive Corticosteroid Therapy.

Onishi, Akio / Shimura, Yuji / Nakamura, Takahisa / Souri, Masayoshi / Osaki, Tsukasa / Mizutani, Shinsuke / Tsukamoto, Taku / Kobayashi, Tsutomu / Ichinose, Akitada / Kuroda, Junya

Internal medicine (Tokyo, Japan)

2023 Volume 62, Issue 16, Page(s) 2401–2406

Abstract: Coagulation factor X (FX) deficiency causes severe hemorrhagic symptoms. We herein report a 90-year-old man with hemorrhagic symptoms and prolongation of prothrombin time (PT) and activated partial thromboplastin time (APTT). Cross-mixing tests showed a ... ...

Abstract	Coagulation factor X (FX) deficiency causes severe hemorrhagic symptoms. We herein report a 90-year-old man with hemorrhagic symptoms and prolongation of prothrombin time (PT) and activated partial thromboplastin time (APTT). Cross-mixing tests showed a factor deficiency pattern, but administration of plasma products was not effective. Acquired coagulation factor deficiency was suspected, and immunosuppressive therapy was started. After the intervention, his hemorrhagic symptoms improved. A decrease in FX activity was later confirmed, and anti-FX autoantibody was retrospectively detected by an enzyme-linked immunosorbent assay. Immediate intervention is important for patients suspected of having acquired coagulation factor deficiency.
MeSH term(s)	Male ; Humans ; Aged, 80 and over ; Factor X Deficiency/drug therapy ; Retrospective Studies ; Adrenal Cortex Hormones ; Autoantibodies ; Blood Coagulation Factors
Chemical Substances	Adrenal Cortex Hormones ; Autoantibodies ; Blood Coagulation Factors
Language	English
Publishing date	2023-08-15
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.0849-22
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Article ; Online: Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning.

Oku, Saori / Futatsuki, Toshiko / Imamura, Yoshiko / Hikita, Haruna / Inada, Akemi / Mizutani, Shinsuke / Mori, Yasuo / Kashiwazaki, Haruhiko

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2023 Volume 31, Issue 9, Page(s) 521

Abstract: Purpose: Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo- ... ...

Abstract	Purpose: Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients; thus, the current study aimed to examine the efficacy of cryotherapy among allo-HSCT recipients treated with Mel-containing regimens. Methods: Medical records of 78 consecutive allo-HSCT recipients were retrospectively analyzed. Baseline characteristics and clinical courses between the patients who received cryotherapy (cryotherapy group, n = 42) and those who did not (control group, n = 36) were compared, especially focusing on methotrexate (MTX) use as a part of graft-versus-host disease (GVHD) prophylaxis. Results: Binary logistic regression analysis revealed that a higher dose of Mel (OR, 3.82; 95%CI, 1.085-13.46; P = 0.037) or MTX use (OR, 7.61; 95% CI, 2.41-23.97; P < 0.001) was associated with the incidence of OM. MTX use was also significantly associated with the duration of OM (β = 0.515; 95% CI, 9.712-21.636; P < 0.001). Among 31 patients without MTX use, cryotherapy was associated with a significant reduction of OM development (0% in the cryotherapy group vs 35% in the control group, P = 0.021). We did not find such an association in 47 patients with MTX use. Conclusion: Cryotherapy was useful to prevent the incidence of OM in allo-HSCT recipients in the cases without MTX for GVHD prophylaxis.
MeSH term(s)	Humans ; Melphalan/adverse effects ; Retrospective Studies ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Stomatitis/prevention & control ; Stomatitis/chemically induced ; Methotrexate/therapeutic use ; Cryotherapy/methods ; Transplantation Conditioning/adverse effects ; Transplantation Conditioning/methods ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control
Chemical Substances	Melphalan (Q41OR9510P) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2023-08-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-023-07989-9
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Zs.A 3697: Show issues

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Article ; Online: Skeletal muscle index impacts the treatment outcome of elderly patients with diffuse large B cell lymphoma.

Niiyama-Uchibori, Yui / Okamoto, Haruya / Miyashita, Akihiro / Mizuhara, Kentaro / Kanayama-Kawaji, Yuka / Fujino, Takahiro / Tsukamoto, Taku / Mizutani, Shinsuke / Shimura, Yuji / Teramukai, Satoshi / Kuroda, Junya

Hematological oncology

2024 Volume 42, Issue 1, Page(s) e3252

Abstract: Sarcopenia is a crucial factor in the physical fitness of elderly individuals. This study investigated the prognostic values of multiple parameters of sarcopenia in association with established prognostic factors in elderly Japanese patients with diffuse ...

Abstract	Sarcopenia is a crucial factor in the physical fitness of elderly individuals. This study investigated the prognostic values of multiple parameters of sarcopenia in association with established prognostic factors in elderly Japanese patients with diffuse large B cell lymphoma (DLBCL). As candidate indicators for sarcopenia, the skeletal muscle index (SMI) (cm
MeSH term(s)	Male ; Female ; Humans ; Aged ; Aged, 80 and over ; Sarcopenia/etiology ; Sarcopenia/diagnosis ; Sarcopenia/drug therapy ; Rituximab/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Retrospective Studies ; Cyclophosphamide/adverse effects ; Treatment Outcome ; Prognosis ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/pathology ; Lymphoma, Large B-Cell, Diffuse/complications ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/therapy
Chemical Substances	Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	604884-5
ISSN	1099-1069 ; 0278-0232
ISSN (online)	1099-1069
ISSN	0278-0232
DOI	10.1002/hon.3252
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Zs.A 1816: Show issues

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Article ; Online: Prognostic model for relapsed/refractory transplant-ineligible diffuse large B-cell lymphoma utilizing the lymphocyte-to-monocyte ratio.

Ide, Daisuke / Fujino, Takahiro / Kobayashi, Tsutomu / Egashira, Aya / Miyashita, Akihiro / Mizuhara, Kentaro / Isa, Reiko / Tsukamoto, Taku / Mizutani, Shinsuke / Uchiyama, Hitoji / Kaneko, Hiroto / Uoshima, Nobuhiko / Kawata, Eri / Taniwaki, Masafumi / Shimura, Yuji / Kuroda, Junya

International journal of hematology

2024

Abstract: We conducted a multi-institutional retrospective study in 100 transplant-ineligible (TI) patients with diffuse large B-cell lymphoma (DLBCL) that relapsed or progressed after first-line R-CHOP (or -like) therapy to develop a robust predictive model for ... ...

Abstract	We conducted a multi-institutional retrospective study in 100 transplant-ineligible (TI) patients with diffuse large B-cell lymphoma (DLBCL) that relapsed or progressed after first-line R-CHOP (or -like) therapy to develop a robust predictive model for TI relapsed/refractory (r/r) DLBCL, which has a heterogeneous but poor prognosis by currently available treatment modalities other than chimeric antigen receptor T-cell (CAR-T) therapy or bispecific antibodies. The median age at relapse or progression was 76 years. The median progression-free survival (PFS) and overall survival (OS) from the first progression were 11.5 months and 21.9 months, respectively. Multivariate analysis identified low lymphocyte-to-monocyte ratio (LMR), elevated high lactate dehydrogenase, and elevated C-reactive protein at progression as independent predictors of OS. A predictive model based on these three factors, here designated as the Kyoto Prognostic Index for r/r DLBCL (KPI-R), successfully stratified their OS and PFS with statistical significance. In addition, event-free survival less than 24 months for R-CHOP and low LMR were identified as significant predictive factors for non-response in any sequence of salvage therapy. We concluded that LMR is a bonafide predictor of treatment response and prognosis in patients with TI r/r DLBCL, and may be helpful in treatment decision-making.
Language	English
Publishing date	2024-03-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-024-03750-y
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Zs.A 269: Show issues

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Article ; Online: GSK3β is involved in promoting Alzheimer's disease pathologies following chronic systemic exposure to Porphyromonas gingivalis lipopolysaccharide in amyloid precursor protein

Jiang, Muzhou / Zhang, Xinwen / Yan, Xu / Mizutani, Shinsuke / Kashiwazaki, Haruhiko / Ni, Junjun / Wu, Zhou

Brain, behavior, and immunity

2021 Volume 98, Page(s) 1–12

Abstract: In line with the strong association between periodontitis and Alzheimer's disease (AD) clinically, preclinical studies have shown that systemic exposure to Porphyromonas gingivalis (Pg) initiates AD pathologies. However, the involvement of periodontitis ... ...

Abstract	In line with the strong association between periodontitis and Alzheimer's disease (AD) clinically, preclinical studies have shown that systemic exposure to Porphyromonas gingivalis (Pg) initiates AD pathologies. However, the involvement of periodontitis in promoting AD pathologies is unclear. In the present study, we provided evidence that chronic systemic exposure to lipopolysaccharide derived from Pg (PgLPS, 1 mg/kg, daily, intraperitoneally) prompted neuroinflammation and tau hyperphosphorylation in 10-month-old of amyloid precursor protein (APP) knock-in mice, a model of AD, carrying the Swedish and Beyreuther/Iberian mutation (APP
MeSH term(s)	Alzheimer Disease ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Disease Models, Animal ; Glycogen Synthase Kinase 3 beta ; Lipopolysaccharides ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neuroinflammatory Diseases ; Phosphorylation ; Porphyromonas gingivalis ; tau Proteins/metabolism
Chemical Substances	Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Lipopolysaccharides ; tau Proteins ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1)
Language	English
Publishing date	2021-08-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2021.08.213
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 327: Show issues

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Article ; Online: Association between oral function and physical pre-frailty in community-dwelling older people: a cross-sectional study.

Tani, Asuka / Mizutani, Shinsuke / Oku, Saori / Yatsugi, Harukaze / Chu, Tianshu / Liu, Xin / Iyota, Kiyomi / Kishimoto, Hiro / Kashiwazaki, Haruhiko

BMC geriatrics

2022 Volume 22, Issue 1, Page(s) 726

Abstract: Background: Few studies have examined the relationship between oral functions and the physical pre-frailty status, classified using physical function tests. This cross-sectional study aimed to clarify this association among community-dwelling older ... ...

Abstract	Background: Few studies have examined the relationship between oral functions and the physical pre-frailty status, classified using physical function tests. This cross-sectional study aimed to clarify this association among community-dwelling older people from the Itoshima Frail Study in Itoshima Fukuoka Prefecture. Methods: Of the 1,555 individuals invited to join the study, 381 (188 males and 193 females) enrolled. Their physical pre-frailty was assessed with a classification system consisting of two physical indicators (fatigue and unintentional weight loss, determined with a questionnaire), two functional components (declined walking speed and muscle weakness, determined using a body function measuring instrument), and declined physical activity (examined using a triaxial accelerometer). Subsequently, the individuals were classified into three groups: robust, pre-frailty, and frailty. Along with the number of teeth remaining, oral functions, such as masticatory performance, tongue pressure strength, and oral diadochokinesis (ODK), were examined. Data regarding social activity and exercise habits were collected, and the individuals' body compositions were measured. Odds ratios (ORs) and 95% confidence intervals (CIs) for the physical pre-frailty were calculated using logistic regression models. Results: In this study, 126 (33%) participants presented with physical pre-frailty. The participants in the robust group were younger, had stronger maximum handgrip strength, and walked faster than those in the physical pre-frailty group (p < 0.001). The robust group presented with better oral functions (masticatory performance, p = 0.015; oral ODK /ta/, p = 0.004). The physical pre-frailty status was significantly associated with age (OR, 1.111; 95% CI, 1.048-1.178; p < 0.001), masticatory performance (OR, 0.819; 95% CI, 0.680-0.986; p = 0.035), low ODK/ta/ (OR, 1.864; 95% CI, 1.069-3.250; p = 0.028), and low social activity (OR, 2.273; 95% CI, 1.308-3.951; p = 0.004). Conclusion: This study indicated that older people with higher age, lower anterior tongue movement, lower masticatory performance, and lower social activity are positively associated with physical pre-frailty.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Female ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Geriatric Assessment ; Hand Strength ; Humans ; Independent Living ; Male ; Pressure ; Tongue
Language	English
Publishing date	2022-09-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-022-03409-5
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Article ; Online: Neurolymphomatosis of cranial nerves as the responsible lesions for the vocal cord paralysis and facial nerve palsy in a patient with diffuse large B-cell lymphoma.

Inoue, Yu / Hirakawa, Koichi / Hayata, Hiroki / Nishiyama, Daichi / Fujino, Takahiro / Tsukamoto, Taku / Mizutani, Shinsuke / Shimura, Yuji / Kuroda, Junya

Annals of hematology

2022 Volume 102, Issue 2, Page(s) 481–482

MeSH term(s)	Humans ; Vocal Cord Paralysis/etiology ; Vocal Cord Paralysis/pathology ; Neurolymphomatosis ; Facial Nerve/pathology ; Cranial Nerves/pathology ; Lymphoma, Large B-Cell, Diffuse/complications ; Lymphoma, Large B-Cell, Diffuse/pathology
Language	English
Publishing date	2022-11-14
Publishing country	Germany
Document type	Letter
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-022-05038-9
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Uh III Zs.181: Show issues

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Article ; Online: Relationship between Type D personality and dropout from dental treatment in middle-aged adults.

Kato, Tomotaka / Mizutani, Shinsuke / Umezaki, Yojiro / Sugiyama, Seiichi / Naito, Toru

Journal of oral science

2019 Volume 61, Issue 2, Page(s) 264–269

Abstract: Type D personality-the tendency toward combined negative affectivity and social inhibition-is a risk factor for coronary heart disease. Although Type D personality has been linked to low adherence to diabetic care, it is unclear whether it is related to ... ...

Abstract	Type D personality-the tendency toward combined negative affectivity and social inhibition-is a risk factor for coronary heart disease. Although Type D personality has been linked to low adherence to diabetic care, it is unclear whether it is related to adherence to dental therapy. Thus, study examined the relationship between Type D personality and withdrawal from dental therapy. A web-based questionnaire was used to compare a treatment dropout group (n = 225) and maintenance group(n = 236). The questionnaire was designed to assess Type D personality traits, reasons for dropout, and respondent sociodemographic characteristics and attitudes. There were no significant differences in the sociodemographic characteristics of the two groups. However, the proportion of respondents with a Type D personality was significantly larger in the dropout group than in the maintenance group (P = 0.04). The most common reasons for dental therapy dropout were "improvement of symptoms" (46.2%) and "busy with business or study" (30.7%). The most frequent attitude reported in the dropout group was negative feelings toward dental practice. In conclusion, Type D personality might be related to dropout from dental therapy.
MeSH term(s)	Adult ; Dental Care ; Humans ; Middle Aged ; Risk Factors ; Surveys and Questionnaires ; Type D Personality
Language	English
Publishing date	2019-06-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1434462-2
ISSN	1880-4926 ; 1343-4934
ISSN (online)	1880-4926
ISSN	1343-4934
DOI	10.2334/josnusd.18-0068
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