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Article ; Online: Internally Stented Bioprosthetic Heart Valves Should Not Be Used Any More.

Toggweiler, Stefan / Moccetti, Federico / Matt, Peter

2023 Volume 16, Issue 5, Page(s) 555–557

MeSH term(s)	Humans ; Treatment Outcome ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Bioprosthesis ; Heart Valve Prosthesis ; Prosthesis Failure ; Transcatheter Aortic Valve Replacement ; Prosthesis Design
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2023.02.009
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Article ; Online: Acute Pulmonary Edema During Impella RP Support: Too Much of a Good Thing.

Moccetti, Federico / Bloch, Andreas / Toggweiler, Stefan / Cuculi, Florim

Circulation. Heart failure

2023 Volume 16, Issue 9, Page(s) e010745

MeSH term(s)	Humans ; Heart Failure/diagnosis ; Heart Failure/therapy ; Pulmonary Edema/diagnosis ; Pulmonary Edema/etiology ; Pulmonary Edema/therapy ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Treatment Outcome ; Heart-Assist Devices/adverse effects ; Retrospective Studies
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/CIRCHEARTFAILURE.123.010745
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Article ; Online: Basal Septal Bulge as Risk Factor for New Conduction Disorders After Transcatheter Aortic Valve Replacement.

Koch, Tanja / Brunner, Stephanie / Moccetti, Federico / Wolfrum, Mathias / Toggweiler, Stefan

JACC. Cardiovascular interventions

2023 Volume 16, Issue 13, Page(s) 1701–1702

MeSH term(s)	Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Risk Factors ; Heart Valve Prosthesis ; Pacemaker, Artificial
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2023.04.041
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Article ; Online: Global Ischemia After Complicated Transcatheter Aortic Valve Replacement.

Toggweiler, Stefan / Mury, Raymond / Wolfrum, Mathias / Moccetti, Federico

JACC. Cardiovascular interventions

2022 Volume 15, Issue 11, Page(s) 1181–1182

MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Humans ; Ischemia/diagnostic imaging ; Ischemia/etiology ; Prosthesis Design ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2022.02.030
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Article ; Online: Amplatzer or Figulla Flex II Occluder: a comparative study of outcomes after transcatheter patent foramen ovale closure.

Toggweiler, Stefan / Moccetti, Federico / Conrad, Nina / Loretz, Lucca / Madanchi, Mehdi / Bossard, Matthias / Attiger-Toller, Adrian / Cuculi, Florim / Wolfrum, Mathias

The Journal of invasive cardiology

2024 Volume 36, Issue 4

Abstract: Objectives: Percutaneous closure of a patent foramen ovale (PFO) for the prevention of recurrent paradoxical thromboembolic events has been shown to be safe and effective in randomized controlled trials. However, it remains uncertain if differences in ... ...

Abstract	Objectives: Percutaneous closure of a patent foramen ovale (PFO) for the prevention of recurrent paradoxical thromboembolic events has been shown to be safe and effective in randomized controlled trials. However, it remains uncertain if differences in the structure and design of the occluder devices impact the outcomes. The aim of this study was to compare results of percutaneous PFO closure using 2 widely used double-disc occluders. Methods: Consecutive patients who underwent percutaneous PFO closure with the Abbott Amplatzer occluder (APO) or the Occlutech Figulla-Flex-II occluder (OPO) at the Heart Center Lucerne between February 2017 and December 2022 were included in a registry. The primary endpoint was effective closure of the PFO, defined as a residual shunt grade 0 or 1, assessed by contrast echocardiogram at 6-month follow-up. Secondary endpoints included procedural efficacy/safety and major adverse cardiovascular events during the hospital stay and at 6-month follow-up. Results: One hundred ninety-three consecutive patients (mean age 51.7 ± 12.5 years; 39% women; Risk of Paradoxical Embolism (RoPE) score = 7, IQR = 6-8) underwent percutaneous PFO closure with the APO (120 patients, 62.2%) or the OPO (73 patients, 37.8%). Main indications for closure were crypotogenic stroke in 168 patients (87.1%) and peripheral embolism in 13 patients (6.7%). At baseline, right-to-left shunt (RLS) greater than or equal to grade 2 was present in 189 patients (97.9%). Immediate procedural success was 99.5%. In 1 patient, an air embolism occurred during positioning of the APO occluder with transient chest pain and electrocardiogram changes, but without further sequelae to the patient. At 6-month follow-up, effective closure was achieved in 185 patients (95.8%; APO: 96.6% vs OPO: 94.5%, P = .30). Rates of atrial fibrillation and recurrent thromboembolic events were 4.2 and 0.5%, respectively. Conclusions: PFO closure is safe and effective when performed with either the self-expanding Abbott Amplatzer or Occlutech Figulla Flex II PFO occluder.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Male ; Foramen Ovale, Patent/diagnosis ; Foramen Ovale, Patent/surgery ; Foramen Ovale, Patent/complications ; Treatment Outcome ; Echocardiography ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Septal Occluder Device/adverse effects ; Thromboembolism/etiology ; Cardiac Catheterization/methods
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
DOI	10.25270/jic/23.00291
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Zs.A 3701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Cerebral embolic protection during transcatheter aortic valve replacement: Insights from a consecutive series with the Sentinel cerebral protection device.

Wolfrum, Mathias / Moccetti, Federico / Loretz, Lucca / Bossard, Matthias / Attiger, Adrian / Cuculi, Florim / Toggweiler, Stefan

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2023 Volume 102, Issue 2, Page(s) 339–347

Abstract: Background: Growing interest in neuroprotection in transcatheter aortic valve replacement (TAVR) has catalyzed the development of cerebral protection systems (CPS).: Objectives: Report insights from consecutive real-world patients undergoing TAVR ... ...

Abstract	Background: Growing interest in neuroprotection in transcatheter aortic valve replacement (TAVR) has catalyzed the development of cerebral protection systems (CPS). Objectives: Report insights from consecutive real-world patients undergoing TAVR with the Sentinel-CPS. Methods: Patients with severe aortic stenosis undergoing TAVR from April 2019 to May 2022 were enrolled in a prospective registry. The reason for unsuccessful Sentinel-CPS deployment and the amount of debris captured by the filters were prospectively recorded. Results: The Sentinal CPS was successfully deployed in 330 patients (85%, Group 1). Deployment was not attempted, unsuccessful or only partially successful in 59 patients (15%, Group 2), caused by anatomical factors such as tortuosity, heavy calcification or small dimensions of radial or brachial artery in 46, technical aspects such as puncture failure or dissection in 5 or use of right radial access for the pigtail in 6. Debris was captured in 98% of patients in Group 1. In 40%, the amount of debris was graded moderate or extensive. Predictors for moderate/extensive debris were moderate/severe aortic calcification (OR 1.50, CI 1.05-2.15, p = 0.03), pre- and postdilatation (OR 1.97, CI 1.02-3.79, p = 0.04 and OR 1.71, CI 1.01-2.89, p = 0.048). The risk of stroke was numerically lower in patients who underwent TAVR with the Sentinel CPS (2.1 vs. 5.1%, respectively, p = 0.15). There was no stroke during CPS deployment, but one patient had a stroke immediately after device retrieval. Conclusions: The Sentinel-CPS was successfully deployed in 85% of patients. Predictors for moderate/extensive debris captured were moderate/severe aortic calcification, pre- and postdilatation.
MeSH term(s)	Humans ; Transcatheter Aortic Valve Replacement ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/etiology ; Treatment Outcome ; Stroke/etiology ; Embolic Protection Devices ; Risk Factors
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30697
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Article ; Online: Cerebral embolic protection during transcatheter aortic valve replacement: a systematic review and meta-analysis of propensity score matched and randomized controlled trials using the Sentinel cerebral embolic protection device.

Wolfrum, Mathias / Handerer, Immanuel Justus / Moccetti, Federico / Schmeisser, Alexander / Braun-Dullaeus, Ruediger C / Toggweiler, Stefan

BMC cardiovascular disorders

2023 Volume 23, Issue 1, Page(s) 306

Abstract: Background: The Sentinel cerebral embolic protection device (CEP) aims to reduce the risk of stroke during transcatheter aortic valve replacement (TAVR). We performed a systematic review and meta-analysis of propensity score matched (PSM) and randomized ...

Abstract	Background: The Sentinel cerebral embolic protection device (CEP) aims to reduce the risk of stroke during transcatheter aortic valve replacement (TAVR). We performed a systematic review and meta-analysis of propensity score matched (PSM) and randomized controlled trials (RCT) investigating the effect of the Sentinel CEP to prevent strokes during TAVR. Methods: Eligible trials were searched through PubMed, ISI Web of science databases, Cochrane database, and proceedings of major congresses. Primary outcome was stroke. Secondary outcomes included all-cause mortality, major or life-threatening bleeding, major vascular complications and acute kidney injury at discharge. Fixed and random effect models were used to calculate the pooled risk ratio (RR) with 95% confidence intervals (CI) and absolute risk difference (ARD). Results: A total of 4066 patients from 4 RCTs (3'506 patients) and 1 PSM study (560 patients) were included. Use of Sentinel CEP was successful in 92% of patients and was associated with a significantly lower risk of stroke (RR: 0.67, 95% CI: 0.48-0.95, p = 0.02. ARD: -1.3%, 95% CI: -2.3 - -0.2, p = 0.02, number needed to treat (NNT) = 77), and a reduced risk of disabling stroke (RR: 0.33, 95% CI: 0.17-0.65. ARD: -0.9%, 95% CI: -1.5 - -0.3, p = 0.004, NNT = 111). Use of Sentinel CEP was associated with a lower risk of major or life-threatening bleeding (RR: 0.37, 95% CI: 0.16-0.87, p = 0.02). Risk for nondisabling stroke (RR: 0.93, 95% CI: 0.62-1.40, p = 0.73), all-cause mortality (RR: 0.70, 95% CI: 0.35-1.40, p = 0.31), major vascular complications (RR: 0.74, 95% CI: 0.33-1.67, p = 0.47) and acute kidney injury (RR: 0.74, 95% CI: 0.37-1.50, p = 0.40) were similar. Conclusions: The use of CEP during TAVR was associated with lower risks of any stroke and disabling stroke with an NNT of 77 and 111, respectively.
MeSH term(s)	Humans ; Transcatheter Aortic Valve Replacement ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/complications ; Propensity Score ; Risk Factors ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Stroke/etiology ; Stroke/prevention & control ; Embolic Protection Devices ; Intracranial Embolism/diagnostic imaging ; Intracranial Embolism/etiology ; Intracranial Embolism/prevention & control
Language	English
Publishing date	2023-06-17
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-023-03338-0
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Article ; Online: Effect of Additionally Integrating Clinical Information Into the Brugada Algorithm.

Moccetti, Federico / Brugada, Pedro / Tersalvi, Gregorio / Yadava, Mrinal / Latifi, Yllka / Berte, Benjamin / Kobza, Richard / Sticherling, Christian / Reichlin, Tobias

JACC. Clinical electrophysiology

2023 Volume 9, Issue 6, Page(s) 868–870

Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Letter
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2022.12.017
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Article ; Online: The Allegra transcatheter heart valve: Long-term clinical and echocardiographic outcomes.

Wolfrum, Mathias / Moccetti, Federico / Conrad, Nina / Loretz, Lucca / Bossard, Matthias / Attiger-Toller, Adrian / Cuculi, Florim / Toggweiler, Stefan

The Journal of invasive cardiology

2023 Volume 35, Issue 12

Abstract: Objectives: The Allegra-THV is a novel, self-expanding THV with supra-annular bovine leaflets. The valve is available in 3 different sizes and is delivered through an 18 French sheath. To determine the safety and efficacy of the Allegra transcatheter ... ...

Abstract	Objectives: The Allegra-THV is a novel, self-expanding THV with supra-annular bovine leaflets. The valve is available in 3 different sizes and is delivered through an 18 French sheath. To determine the safety and efficacy of the Allegra transcatheter heart valve (THV; Biosensors) for the treatment of severe aortic valve stenosis under real-world conditions. Methods: Consecutive patients undergoing transcatheter aortic valve replacement (TAVR) at the Heart-Centre Lucerne with the Allegra-THV were included. Echocardiographic data were collected at baseline, before discharge, and at 1-year follow-up; clinical outcomes were recorded for up to 3 years. Clinical endpoints were defined according to the definitions of the Valve-Academic-Research-Consortium. Results: One hundred-three patients (age 81 ± 7 years, 63% women) were enrolled. Median European System for Cardiac Operative Risk Evaluation II score was 4.1% (IQR 1.8%-4.2%). Mean aortic valve gradient was 6.9 ± 3.3 mm Hg and 7.7 ± 3.3 mm Hg, and an effective orifice area was 2.1 ± 0.5 cm2 and 2.0 ± 0.5 cm2 at 30 days and 1-year follow-up, respectively. More than mild paravalvular leak was observed in 2.0% of patients at 30 days and 3.3% at 1 year. At 1-year follow-up, 14.7% of patients required implantation of a new permanent pacemaker, 1 patient had endocarditis with an uneventful clinical course and good THV-function after antibiotic therapy, and no thrombosis, structural-valve-detoriation (SVD), or non-SVD had occurred. At 3-year follow-up, rates of all-cause and cardiovascular mortality were 31.4% and 18.8%, respectively. Conclusions: Transfemoral implantation of the Allegra-THV resulted in favorable clinical and echocardiographic outcomes at up to 3-year follow-up. Head-to-head randomized clinical trials are necessary to determine if the Allegra-THV valve performs as well as current generation valves.
MeSH term(s)	Humans ; Animals ; Cattle ; Female ; Aged ; Aged, 80 and over ; Male ; Heart Valves ; Echocardiography ; Terfenadine ; Catheters
Chemical Substances	fexofenadine (E6582LOH6V) ; Terfenadine (7BA5G9Y06Q)
Language	English
Publishing date	2023-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
DOI	10.25270/jic/23.00163
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Article ; Online: Chest pain and plaque rupture without high-sensitive troponin elevation.

Moccetti, Federico / Bossard, Matthias / Kobza, Richard / Cuculi, Florim

Cardiology journal

2019 Volume 26, Issue 2, Page(s) 194–195

MeSH term(s)	Adult ; Biomarkers/blood ; Chest Pain/blood ; Chest Pain/diagnosis ; Chest Pain/etiology ; Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Diagnosis, Differential ; Drug-Eluting Stents ; Electrocardiography ; Humans ; Male ; Percutaneous Coronary Intervention/methods ; Plaque, Atherosclerotic/blood ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/diagnosis ; Plaque, Atherosclerotic/surgery ; Rupture, Spontaneous/complications ; Rupture, Spontaneous/diagnosis ; Rupture, Spontaneous/surgery ; Tomography, Optical Coherence ; Troponin I/blood
Chemical Substances	Biomarkers ; Troponin I
Language	English
Publishing date	2019-04-26
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	2488680-4
ISSN	1897-5593 ; 1897-5593
ISSN (online)	1897-5593
ISSN	1897-5593
DOI	10.5603/CJ.2019.0040
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