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Book ; Thesis: Computergestützte Gesichtsschädelrekonstruktion mittels mikrovaskulärem Fibula- und Beckenkammstransplantat

Modabber, Ali

[kumulative Habilitationsschrift]

2015

Author's details	vorgelegt von Ali Modabber
Language	German
Size	120 Bl. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Aachen, Techn. Hochsch., Habil.-Schr., 2015
Note	Zeitschriftenartikel in englischer Sprache ; Enth.: 1 Habilitationsschrift und 6 Sonderabdr.
HBZ-ID	HT018709034
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Book ; Thesis: Three-dimensional evaluation of postoperative swelling in treatment of zygomatic bone fractures using two different cooling therapy methods

Modabber, Ali

a randomized, observer blind, prospective study

2013

Title variant	Three dimensional ; observer-blind
Author's details	vorgelegt von Ali Modabber
Language	English
Size	10 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Aachen, Techn. Hochsch., Diss., 2013
HBZ-ID	HT018171279
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2014 D 253	order for loan	Magazin

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Article ; Online: Evaluation of bone contact area and intercondylar distance changes in orthognathic surgery - a comparison between BSSO and HSSO technique depending on mandibular displacement extent.

Möhlhenrich, Stephan Christian / Kniha, Kristian / Peters, Florian / Heitzer, Marius / Szalma, Josef / Prescher, Andreas / Danesh, Gholamreza / Hölzle, Frank / Modabber, Ali

Clinical oral investigations

2024 Volume 28, Issue 3, Page(s) 182

Abstract: Objectives: The present study aims to assess the impact of bilateral and high oblique sagittal split osteotomy (BSSO/HSSO), as well as displacement distances and directions on the expected and achievable bone contact area (BCA) and changes in the ... ...

Abstract	Objectives: The present study aims to assess the impact of bilateral and high oblique sagittal split osteotomy (BSSO/HSSO), as well as displacement distances and directions on the expected and achievable bone contact area (BCA) and changes in the intercondylar distance (ICD). The primary question addressed is whether mandibular splitting through BSSO results in a greater BCA and/or ICD when compared to splitting through HSSO. Materials and methods: Totally 80 mandibular displacements were performed on 20 fresh cadavers, for each subject, four splints were produces to facilitate mandibular advancement as well as setbacks of 4 and 8 mm. Pre- and postoperative CBCT scans were performed to plan the surgical procedures and to analyze the expected and achieved BCA and ICD. Results: Regarding the maximum mandibular displacement, the expected BCA for HSSO/BSSO were 352.58 ± 96.55mm Conclusions: Compared to the virtual planning, the predictability regarding BCA and ICD was limited. ICD showed smaller clinical changes, BCA decreased significantly in the BSSO group. Clinical relevance: BCA and ICD might have been less important in choosing the suitable split technique. in orthognathic surgery.
MeSH term(s)	Humans ; Orthognathic Surgery ; Osteotomy, Sagittal Split Ramus/methods ; Mandible/surgery ; Malocclusion ; Mandibular Advancement ; Sitosterols
Chemical Substances	beta-sitosterol oleate (3712-16-1) ; Sitosterols
Language	English
Publishing date	2024-03-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-024-05584-8
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Article ; Online: Assessment of the Electrolyte Heterogeneity of Tissues in Mandibular Bone-Infiltrating Head and Neck Cancer Using Laser-Induced Breakdown Spectroscopy.

Winnand, Philipp / Boernsen, Klaus Olaf / Ooms, Mark / Heitzer, Marius / Vohl, Nils / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: Laser-induced breakdown spectroscopy (LIBS) was recently introduced as a rapid bone analysis technique in bone-infiltrating head and neck cancers. Research efforts on laser surgery systems with controlled tissue feedback are currently limited to animal ... ...

Abstract	Laser-induced breakdown spectroscopy (LIBS) was recently introduced as a rapid bone analysis technique in bone-infiltrating head and neck cancers. Research efforts on laser surgery systems with controlled tissue feedback are currently limited to animal specimens and the use of nontumorous tissues. Accordingly, this study aimed to characterize the electrolyte composition of tissues in human mandibular bone-infiltrating head and neck cancer. Mandible cross-sections from 12 patients with bone-invasive head and neck cancers were natively investigated with LIBS. Representative LIBS spectra (n = 3049) of the inferior alveolar nerve, fibrosis, tumor stroma, and cell-rich tumor areas were acquired and histologically validated. Tissue-specific differences in the LIBS spectra were determined by receiver operating characteristics analysis and visualized by principal component analysis. The electrolyte emission values of calcium (Ca) and potassium (K) significantly (
MeSH term(s)	Animals ; Humans ; Spectrum Analysis/methods ; Lasers ; Head and Neck Neoplasms ; Electrolytes ; Mandible ; Fibrosis
Chemical Substances	Electrolytes
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052607
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Article ; Online: Development of a universal cutting guide for raising deep circumflex iliac artery flaps.

Peters, Florian / Raith, Stefan / Bock, Anna / Kniha, Kristian / Möhlhenrich, Stephan Christian / Heitzer, Marius / Hölzle, Frank / Modabber, Ali

International journal of computer assisted radiology and surgery

2024

Abstract: Purpose: The deep circumflex iliac crest flap (DCIA) is used for the reconstruction of the jaw. For fitting of the transplant by computer-aided planning (CAD), a computerized tomography (CT) of the jaw and the pelvis is necessary. Ready-made cutting ... ...

Abstract	Purpose: The deep circumflex iliac crest flap (DCIA) is used for the reconstruction of the jaw. For fitting of the transplant by computer-aided planning (CAD), a computerized tomography (CT) of the jaw and the pelvis is necessary. Ready-made cutting guides save a pelvic CT and healthcare resources while maintaining the advantages of the CAD planning. Methods: A total of 2000 CTs of the pelvis were divided into groups of 500 by sex and age (≤ 45 and > 45 years). Three-dimensional (3D) pelvis models were aligned and averaged. Cutting guides were designed on the averaged pelvis for each group and an overall averaged pelvis. The cutting guides and 50 randomly selected iliac crests (10 from each group and 10 from the whole collective) were 3D printed. The appropriate cutting guide was mounted to the iliac crest and a cone beam CT was performed. The thickness of the space between the iliac crest and the cutting guide was evaluated. Results: Overall the mean thickness of the space was 2.137 mm and the mean volume of the space was 4513 mm Conclusion: Ready-made cutting guides for the DCIA flap fit to the iliac crest and make quick and accurate flap raising possible while radiation dose and resources can be saved. The cutting guides fit sufficient to the iliac crest and should keep the advantages of a standard CAD planning.
Language	English
Publishing date	2024-04-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2365628-1
ISSN	1861-6429 ; 1861-6410
ISSN (online)	1861-6429
ISSN	1861-6410
DOI	10.1007/s11548-024-03144-9
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Article ; Online: A Biodegradable Tissue Adhesive for Post-Extraction Alveolar Bone Regeneration under Ongoing Anticoagulation-A Microstructural Volumetric Analysis in a Rodent Model.

Heitzer, Marius / Winnand, Philipp / Ooms, Mark / Magnuska, Zuzanna / Kiessling, Fabian / Buhl, Eva Miriam / Hölzle, Frank / Modabber, Ali

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive ... ...

Abstract	In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive effect on soft tissue regeneration and hemostasis. However, the regenerative potential of VIVO in terms of bone regeneration has not yet been explored. The present rodent study compared the post-extraction bone healing of a collagen sponge (COSP) and VIVO in the context of ongoing anticoagulation therapy. According to a split-mouth design, a total of 178 extraction sockets were generated under rivaroxaban treatment, of which 89 extraction sockets were treated with VIVO and 89 with COSP. Post-extraction bone analysis was conducted via in vivo micro-computed tomography (µCT), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) after 5, 10, and 90 days. During the observation time of 90 days, µCT analysis revealed that VIVO and COSP led to significant increases in both bone volume and bone density (
MeSH term(s)	Animals ; Bone Regeneration/drug effects ; Tooth Extraction/adverse effects ; Rats ; X-Ray Microtomography ; Male ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Tissue Adhesives/pharmacology ; Alveolar Bone Loss/etiology ; Alveolar Bone Loss/diagnostic imaging ; Alveolar Bone Loss/drug therapy ; Collagen/metabolism
Chemical Substances	Anticoagulants ; Tissue Adhesives ; Collagen (9007-34-5)
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084210
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Article ; Online: Mandible segmentation from CT data for virtual surgical planning using an augmented two-stepped convolutional neural network.

Pankert, Tobias / Lee, Hyun / Peters, Florian / Hölzle, Frank / Modabber, Ali / Raith, Stefan

International journal of computer assisted radiology and surgery

2023 Volume 18, Issue 8, Page(s) 1479–1488

Abstract: Purpose: For computer-aided planning of facial bony surgery, the creation of high-resolution 3D-models of the bones by segmenting volume imaging data is a labor-intensive step, especially as metal dental inlays or implants cause severe artifacts that ... ...

Abstract	Purpose: For computer-aided planning of facial bony surgery, the creation of high-resolution 3D-models of the bones by segmenting volume imaging data is a labor-intensive step, especially as metal dental inlays or implants cause severe artifacts that reduce the quality of the computer-tomographic imaging data. This study provides a method to segment accurate, artifact-free 3D surface models of mandibles from CT data using convolutional neural networks. Methods: The presented approach cascades two independently trained 3D-U-Nets to perform accurate segmentations of the mandible bone from full resolution CT images. The networks are trained in different settings using three different loss functions and a data augmentation pipeline. Training and evaluation datasets consist of manually segmented CT images from 307 dentate and edentulous individuals, partly with heavy imaging artifacts. The accuracy of the models is measured using overlap-based, surface-based and anatomical-curvature-based metrics. Results: Our approach produces high-resolution segmentations of the mandibles, coping with severe imaging artifacts in the CT imaging data. The use of the two-stepped approach yields highly significant improvements to the prediction accuracies. The best models achieve a Dice coefficient of 94.824% and an average surface distance of 0.31 mm on our test dataset. Conclusion: The use of two cascaded U-Net allows high-resolution predictions for small regions of interest in the imaging data. The proposed method is fast and allows a user-independent image segmentation, producing objective and repeatable results that can be used in automated surgical planning procedures.
MeSH term(s)	Humans ; Image Processing, Computer-Assisted/methods ; Neural Networks, Computer ; Tomography, X-Ray Computed ; Mandible/diagnostic imaging ; Mandible/surgery ; Artifacts
Language	English
Publishing date	2023-01-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2365628-1
ISSN	1861-6429 ; 1861-6410
ISSN (online)	1861-6429
ISSN	1861-6410
DOI	10.1007/s11548-022-02830-w
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Article ; Online: Real-time detection of bone-invasive oral cancer with laser-induced breakdown spectroscopy: A proof-of-principle study.

Winnand, Philipp / Ooms, Mark / Heitzer, Marius / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

Oral oncology

2023 Volume 138, Page(s) 106308

Abstract: Objectives: Intraoperative definition of resection margin status in bone-invasive oral cancer is a fundamental problem in oncologic surgery due to the lack of rapid bone analysis methods. Laser-induced breakdown spectroscopy (LIBS) provides direct ... ...

Abstract	Objectives: Intraoperative definition of resection margin status in bone-invasive oral cancer is a fundamental problem in oncologic surgery due to the lack of rapid bone analysis methods. Laser-induced breakdown spectroscopy (LIBS) provides direct measurement with real-time examination of a minimal tissue sample. This proof-of-principle study aimed to evaluate the possibility of distinguishing tumorous and healthy areas with LIBS. Materials and methods: LIBS experiments were executed on native segmental mandibulectomy specimens from 15 patients with bone-invasive oral cancer. Normalized and intensity-matched spectra were compared. Under biological derivation, peak area calculation and principal component analysis (PCA) were applied. The discriminatory power of the PCAs was correlated with the architectural and cytological characteristics of the lasered tumor tissue. Receiver operating characteristics analysis was used to evaluate the performance of LIBS in the real-time detection of bone-invasive cancer. Results: Calcium (Ca), which is high in healthy bone, is replaced by potassium (K) and sodium (Na) in bone-invasive cancer. The degree of stromal induction is significantly correlated with the discriminatory power between healthy and tumorous spectra. In this study, LIBS ensured an overall sensitivity of 95.51% and a specificity of 98.64% via the intracellular detection of K and Na. Conclusion: This study demonstrated robust real-time detection of bone-invasive oral cancer with LIBS, which may lay the foundation for establishing LIBS as a rapid bone analysis method. Further development of a LIBS-guided assessment of bone tumor resection margins might reduce the extent of bony resection without compromising oncologic safety.
MeSH term(s)	Humans ; Spectrum Analysis/methods ; Lasers ; Mouth Neoplasms ; Bone Neoplasms
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2023.106308
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A prospective randomized comparative trial evaluating postoperative nutritional intervention in patients with oral cancer.

Nett, Hannah / Steegmann, Julius / Tollkühn-Prott, Birgit / Hölzle, Frank / Modabber, Ali

Scientific reports

2022 Volume 12, Issue 1, Page(s) 14213

Abstract: Extensive surgical treatment of oral cancer results in significant deterioration of nutritional status with concomitant increased nutrient requirements. The consequences are an elevated risk of postoperative complaints as well as morbidity and mortality. ...

Abstract	Extensive surgical treatment of oral cancer results in significant deterioration of nutritional status with concomitant increased nutrient requirements. The consequences are an elevated risk of postoperative complaints as well as morbidity and mortality. The aim of this study was to investigate an additional postoperative nutritional intervention through professional nutritional advice and nutritional supplementation in patients with oral cancer for at least six months. 62 patients with oral cancer in the department of oral and maxillofacial surgery were randomized into two groups. The intervention group received nutritional supplements, protein-rich, high-fiber diet and care by a professional nutritionist in addition to the standard treatment. The control group received only the standard treatment. Statistical analysis includes the evaluation of means and standard deviations as well as the calculation of p values with a significance level of 0.05. A deficiency of protein, albumin, vitamin D, zinc and iron was noticed in both groups immediately after surgery. Patients in the intervention group recorded significantly less weight loss (pT2 = 0.0031, pT4 = 0.0424), a more stable BMI (pT2 = 0.0496), better values for albumin (pT2 = 0.0265), vitamin A (pT3 = 0.0248, pT4 = 0.0007) and calcium (pT3 = 0.0362) during the follow-ups. The patients in the intervention group showed significantly fewer digestive problems (p = 0.0062) and muscular complaints (p = 0.0448). They showed better eating habits (p = 0.0348) and were capable of more physical activity (p = 0.0045) than patients in the control group. Patients with oral cancer can have a benefit from postoperative nutritional intervention. Early screening, appropriate care by a nutritionist and supplementation with vitamin D, zinc, calcium and protein-rich food are recommended.
MeSH term(s)	Calcium/blood ; Calcium, Dietary ; Dietary Supplements ; Humans ; Mouth Neoplasms/diet therapy ; Mouth Neoplasms/surgery ; Nutritional Status ; Prospective Studies ; Serum Albumin ; Vitamin D ; Vitamins ; Zinc
Chemical Substances	Calcium, Dietary ; Serum Albumin ; Vitamins ; Vitamin D (1406-16-2) ; Zinc (J41CSQ7QDS) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-08-20
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-18292-8
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Article ; Online: Evaluation of electrolyte element composition in human tissue by laser-induced breakdown spectroscopy (LIBS).

Winnand, Philipp / Boernsen, K Olaf / Bodurov, Georgi / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

Scientific reports

2022 Volume 12, Issue 1, Page(s) 16391

Abstract: Laser-induced breakdown spectroscopy (LIBS) enables the direct measurement of cell electrolyte concentrations. The utility of LIBS spectra in biomarker studies is limited because these studies rarely consider basic physical principles. The aim of this ... ...

Abstract	Laser-induced breakdown spectroscopy (LIBS) enables the direct measurement of cell electrolyte concentrations. The utility of LIBS spectra in biomarker studies is limited because these studies rarely consider basic physical principles. The aim of this study was to test the suitability of LIBS spectra as an analytical method for biomarker assays and to evaluate the composition of electrolyte elements in human biomaterial. LIBS as an analytical method was evaluated by establishing KCl calibration curves to demonstrate linearity, by the correct identification of emission lines with corresponding reference spectra, and by the feasibility to use LIBS in human biomaterial, analyzing striated muscle tissues from the oral regions of two patients. Lorentzian peak fit and peak area calculations resulted in better linearity and reduced shot-to-shot variance. Correct quantitative measurement allowed for differentiation of human biomaterial between patients, and determination of the concentration ratios of main electrolytes within human tissue. The clinical significance of LIBS spectra should be evaluated using peak area rather than peak intensity. LIBS might be a promising tool for analyzing a small group of living cells. Due to linearity, specificity and robustness of the proposed analytical method, LIBS could be a component of future biomarker studies.
MeSH term(s)	Biocompatible Materials ; Calibration ; Electrolytes ; Humans ; Lasers ; Spectrum Analysis/methods
Chemical Substances	Biocompatible Materials ; Electrolytes
Language	English
Publishing date	2022-09-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20825-0
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