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  1. AU="Modak, Manisha A"
  2. AU="Ottolini, Matteo"
  3. AU="Douglas Hanahan"
  4. AU="Bieniaszewska, Maria"
  5. AU="Alovisi, Camilla"
  6. AU="Lijfering, Willem M."
  7. AU="Rademacher, Jessica"
  8. AU="Dartigues, Jean-François"
  9. AU="Denicola, Anthony J"
  10. AU="Zhang, Xuewei"
  11. AU="Li, Yanjiao"
  12. AU="Botelho Meireles de Souza, Guilherme"
  13. AU="Gong, Yu-Qing"
  14. AU="Eisch, J"
  15. AU=De Vito Eduardo L
  16. AU="Lowsky, Robert"
  17. AU="Lindner, M."
  18. AU="Mugnai, Giacomo"
  19. AU="Chollet-Krugler, Marylène"
  20. AU="Firsanov, Denis"
  21. AU="Jo, Dong-Gyu"
  22. AU="Greenland, John R"
  23. AU="J Natale"
  24. AU="Drost, Carolin Christina"
  25. AU="Silvera, Risset"
  26. AU="Zgubič, M"
  27. AU="Russo, Rosita"
  28. AU="Ruiz-Ortega, Marta"
  29. AU="T Talbot"
  30. AU="Emoto, Kasey C"
  31. AU="Moos, W H" AU="Moos, W H"
  32. AU=Singh Sweta AU=Singh Sweta
  33. AU="Pimentel, Mauricio"
  34. AU="Kim, Ji Hee"
  35. AU=Ross Jeffrey S
  36. AU=Malhotra Atul
  37. AU="Tiesler, Carla M T"
  38. AU="Merighi, Adalberto" AU="Merighi, Adalberto"

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  1. Artikel ; Online: Tissue specific oxidative stress profile in relation to glycaemic regulation in mice.

    Modak, Manisha A / Parab, P B / Ghaskadbi, Saroj S

    Diabetes/metabolism research and reviews

    2014  Band 30, Heft 1, Seite(n) 31–41

    Abstract: Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia resulting from uncontrolled glucose regulation. Reactive oxygen species are recognized as one link between hyperglycaemia and diabetic complications. Studies have ... ...

    Abstract Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia resulting from uncontrolled glucose regulation. Reactive oxygen species are recognized as one link between hyperglycaemia and diabetic complications. Studies have shown that diabetes mellitus is associated with decreases in antioxidant potential and increased formation of free radicals leading to oxidative stress. The present study was undertaken because an unequivocal demonstration that control of hyperglycaemia can reduce oxidative stress is still lacking.
    Methods: In the present study, we investigated oxidative stress profile of normal, streptozotocin-induced diabetic, insulin-treated and untreated diabetic animals. On the one hand, oxidative damage caused to lipids, proteins and DNA was measured. On other hand, antioxidant defense was measured in terms of specific activities of antioxidant enzymes (AOEs) and antioxidant molecules.
    Results: It was observed that the damage to lipids, proteins and DNA caused by free radicals increased in diabetic animals compared with that in controls. In diabetic animals not treated with insulin, damage to all biological molecules increased further significantly (p ≤ 0.005). Changes in AOEs from different tissues were complex depicting a varied AOE level in different tissues. Insulin treatment significantly improved the oxidative stress profile in all tissues studies.
    Conclusions: The control of hyperglycaemia improves oxidative stress profile, that is, the ability of cells to cope up with oxidative stress.
    Mesh-Begriff(e) Animals ; Antioxidants/metabolism ; Blood Glucose/metabolism ; DNA Damage ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/metabolism ; Female ; Hyperglycemia/physiopathology ; In Vitro Techniques ; Lipid Peroxidation ; Male ; Mice ; Oxidation-Reduction ; Oxidative Stress/physiology ; Protein Carbonylation/physiology ; Reactive Oxygen Species/metabolism ; Streptozocin
    Chemische Substanzen Antioxidants ; Blood Glucose ; Reactive Oxygen Species ; Streptozocin (5W494URQ81)
    Sprache Englisch
    Erscheinungsdatum 2014-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.2460
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Control of hyperglycemia significantly improves oxidative stress profile of pancreatic islets.

    Modak, Manisha A / Parab, Pradip B / Ghaskadbi, Saroj S

    Islets

    2011  Band 3, Heft 5, Seite(n) 234–240

    Abstract: Pancreatic islets are known to express low levels of antioxidant enzymes compared to other tissues and are therefore vulnerable to oxidative stress. Enhancing antioxidant defense mechanisms in pancreatic islets help them to cope better with oxidative ... ...

    Abstract Pancreatic islets are known to express low levels of antioxidant enzymes compared to other tissues and are therefore vulnerable to oxidative stress. Enhancing antioxidant defense mechanisms in pancreatic islets help them to cope better with oxidative stress. Persistent hyperglycemia under diabetic condition leads to continuous generation of reactive oxygen species, and different tissues exposed to this are oxidatively damaged depending on their antioxidant defense. Since islet cells are very poor in their antioxidant defense, our interest was to assess their antioxidant profile under normal, diabetic, insulin treated diabetic and untreated diabetic condition. On one hand, antioxidant defense was measured in terms of antioxidant enzymes and antioxidant molecules while on the other, damage caused to biomolecules was estimated. Our data demonstrate that oxidative damage to all biomolecules increased in islets cultured from diabetic animals, which enhanced further in islets from untreated diabetic animals. Insulin treatment significantly improved oxidative stress profile of islets indicating that the control of hyperglycemia leads to improvement in oxidative stress profile.
    Mesh-Begriff(e) Animals ; Antioxidants/metabolism ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Catalase/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Female ; Glutathione Peroxidase/metabolism ; Hyperglycemia/drug therapy ; Hyperglycemia/metabolism ; Hypoglycemic Agents/pharmacology ; Insulin/pharmacology ; Islets of Langerhans/drug effects ; Islets of Langerhans/enzymology ; Male ; Mice ; Organ Culture Techniques ; Oxidative Stress/physiology ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
    Chemische Substanzen Antioxidants ; Blood Glucose ; Hypoglycemic Agents ; Insulin ; Reactive Oxygen Species ; glutathione peroxidase GPX1 (EC 1.11.1.-) ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1)
    Sprache Englisch
    Erscheinungsdatum 2011-09-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1938-2022
    ISSN (online) 1938-2022
    DOI 10.4161/isl.3.5.15941
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Pancreatic islets are very poor in rectifying oxidative DNA damage.

    Modak, Manisha A / Parab, Pradeep Bhaskar / Ghaskadbi, Saroj S

    Pancreas

    2009  Band 38, Heft 1, Seite(n) 23–29

    Abstract: Objective: Free radicals that escape scavenging by antioxidant defense damage lipids, proteins, and DNA. Damage to DNA can be repaired. Therefore, both cells' antioxidant defense and their ability to repair oxidatively damaged DNA decide its fate to ... ...

    Abstract Objective: Free radicals that escape scavenging by antioxidant defense damage lipids, proteins, and DNA. Damage to DNA can be repaired. Therefore, both cells' antioxidant defense and their ability to repair oxidatively damaged DNA decide its fate to survive oxidative stress. Pancreatic islets cells with poor antioxidant defense were checked for their ability to remove oxidative damage form DNA.
    Methods: For ex vivo DNA repair, assay-cultured pancreatic islets and liver slices were treated with 1 and 10 mM H2O2, respectively, for 30 minutes. After incubation for different time intervals, 8-hydroxy-2'-deoxyguanosine (8-OHdG) in DNA of these cells was estimated using monoclonal antibody raised against 8-OHdG by competitive enzyme-linked immunosorbent assay. For in vitro DNA repair assay, oxidatively damaged pBR322 was incubated with nuclear extracts of islet and liver cells, and 8-OHdG retained in the plasmid was quantitated.
    Results: Oxidative damage induced by H2O2 was removed quickly and efficiently from DNA by liver cells compared with islet cells. The repair of oxidatively damaged plasmid DNA in vitro was also performed more efficiently (P < 0.05) by nuclear extracts from liver cells compared with islet cell.
    Conclusions: We clearly demonstrate that in addition to their low antioxidant defense, islets are very poor in rectifying the oxidative DNA damage.
    Mesh-Begriff(e) Animals ; Antibodies, Monoclonal ; Antioxidants/metabolism ; Biomarkers/metabolism ; Cell Survival ; Cells, Cultured ; DNA Damage ; DNA Repair ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/immunology ; Deoxyguanosine/metabolism ; Dose-Response Relationship, Drug ; Enzyme-Linked Immunosorbent Assay ; Female ; Hydrogen Peroxide/toxicity ; Islets of Langerhans/drug effects ; Islets of Langerhans/metabolism ; Islets of Langerhans/pathology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Oxidants/toxicity ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Time Factors ; Tissue Culture Techniques
    Chemische Substanzen Antibodies, Monoclonal ; Antioxidants ; Biomarkers ; Oxidants ; Reactive Oxygen Species ; 8-oxo-7-hydrodeoxyguanosine (88847-89-6) ; Hydrogen Peroxide (BBX060AN9V) ; Deoxyguanosine (G9481N71RO)
    Sprache Englisch
    Erscheinungsdatum 2009-01
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0b013e318181da4e
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2160: Hefte anzeigen Standort:
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  4. Artikel: Differential susceptibility of chick and mouse islets to streptozotocin and its co-relation with islet antioxidant status.

    Modak, Manisha A / Datar, Savita P / Bhonde, Ramesh R / Ghaskadbi, Saroj S

    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

    2007  Band 177, Heft 2, Seite(n) 247–257

    Abstract: Species differences in susceptibility of islets to STZ in different mammals have been well documented. Likewise, failure of diabetes induction in birds by streptozotocin has been reported. We hypothesized that the susceptibility of islets to STZ ... ...

    Abstract Species differences in susceptibility of islets to STZ in different mammals have been well documented. Likewise, failure of diabetes induction in birds by streptozotocin has been reported. We hypothesized that the susceptibility of islets to STZ treatment may be related to generation of reactive oxygen species (ROS) and their antioxidant defense mechanisms. To test this hypothesis, we measured the total ROS generated and estimated the damage caused to the chick islets due to STZ treatment, in terms of lipid peroxidation, protein carbonyl formation and DNA strand breaks and compared it with that of mouse islets. We also compared the activities of antioxidant enzymes like catalase, superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR) and amount of antioxidant molecules like reduced glutathione (GSH) and uric acid under control and STZ-treated conditions. These studies coupled with viability, functionality and presence of glucose transporter GLUT2 in chick and mouse islets clearly indicated that STZ treatment neither affects viability nor functionality of chick islets whereas those of mouse islets are affected significantly. Here we demonstrate for the first time a correlation between the generation of ROS on STZ treatment and antioxidant status with insensitivity of chick islets to STZ resulting into failure of diabetes induction in chick.
    Mesh-Begriff(e) Animals ; Antibiotics, Antineoplastic/pharmacology ; Antioxidants/metabolism ; Cell Survival/drug effects ; Chickens/metabolism ; DNA Damage/drug effects ; Diabetes Mellitus, Experimental ; Female ; Free Radicals/metabolism ; Glucose Transporter Type 2/metabolism ; Islets of Langerhans/cytology ; Islets of Langerhans/drug effects ; Islets of Langerhans/metabolism ; Lipid Peroxidation/drug effects ; Male ; Mice/physiology ; Reactive Oxygen Species ; Species Specificity ; Streptozocin/pharmacology
    Chemische Substanzen Antibiotics, Antineoplastic ; Antioxidants ; Free Radicals ; Glucose Transporter Type 2 ; Reactive Oxygen Species ; Streptozocin (5W494URQ81)
    Sprache Englisch
    Erscheinungsdatum 2007-02
    Erscheinungsland Germany
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 231245-1
    ISSN 1432-136X ; 0174-1578
    ISSN (online) 1432-136X
    ISSN 0174-1578
    DOI 10.1007/s00360-006-0126-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Differential susceptibility of chick and mouse islets to streptozotocin and its co-relation with islet antioxidant status

    Modak, Manisha A / Datar, Savita P / Bhonde, Ramesh R / Ghaskadbi, Saroj S

    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2007 Feb., v. 177, no. 2

    2007  

    Abstract: Species differences in susceptibility of islets to STZ in different mammals have been well documented. Likewise, failure of diabetes induction in birds by streptozotocin has been reported. We hypothesized that the susceptibility of islets to STZ ... ...

    Abstract Species differences in susceptibility of islets to STZ in different mammals have been well documented. Likewise, failure of diabetes induction in birds by streptozotocin has been reported. We hypothesized that the susceptibility of islets to STZ treatment may be related to generation of reactive oxygen species (ROS) and their antioxidant defense mechanisms. To test this hypothesis, we measured the total ROS generated and estimated the damage caused to the chick islets due to STZ treatment, in terms of lipid peroxidation, protein carbonyl formation and DNA strand breaks and compared it with that of mouse islets. We also compared the activities of antioxidant enzymes like catalase, superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR) and amount of antioxidant molecules like reduced glutathione (GSH) and uric acid under control and STZ-treated conditions. These studies coupled with viability, functionality and presence of glucose transporter GLUT2 in chick and mouse islets clearly indicated that STZ treatment neither affects viability nor functionality of chick islets whereas those of mouse islets are affected significantly. Here we demonstrate for the first time a correlation between the generation of ROS on STZ treatment and antioxidant status with insensitivity of chick islets to STZ resulting into failure of diabetes induction in chick.
    Sprache Englisch
    Erscheinungsverlauf 2007-02
    Umfang p. 247-257.
    Verlag Springer-Verlag
    Erscheinungsort Berlin/Heidelberg
    Dokumenttyp Artikel
    ZDB-ID 231245-1
    ISSN 1432-136X ; 0174-1578
    ISSN (online) 1432-136X
    ISSN 0174-1578
    DOI 10.1007/s00360-006-0126-3
    Datenquelle NAL Katalog (AGRICOLA)

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