Article ; Online: The Potential of miR-21 in Stem Cell Differentiation and its Application in Tissue Engineering and Regenerative Medicine.
2023 Volume 19, Issue 5, Page(s) 1232–1251
Abstract: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These molecules can regulate various biological processes, including stem cell differentiation and self-renewal. One of ...
| Abstract | MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These molecules can regulate various biological processes, including stem cell differentiation and self-renewal. One of the first known miRNAs in mammals is miR-21. Cancer-related studies have shown that this miRNA has proto-oncogene activity and is elevated in cancers. However, it is confirmed that miR-21 inhibits stem cell pluripotency and self-renewal and induces differentiation by targeting various genes. Regenerative medicine is a field of medical science that tries to regenerate and repair damaged tissues. Various studies have shown that miR-21 plays an essential role in regenerative medicine by affecting stem cell proliferation and differentiation. In this review, we will discuss the function of miR-21 in regenerative medicine of the liver, nerve, spinal cord, wound, bone, and dental tissues. In addition, the function of natural compounds and lncRNAs will be analyzed as potential regulators of miR-21 expression in regenerative medicine. |
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| MeSH term(s) | Animals ; Tissue Engineering ; Regenerative Medicine ; RNA, Long Noncoding ; Cell Differentiation/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mammals/metabolism | |||||
| Chemical Substances | RNA, Long Noncoding ; MicroRNAs | |||||
| Language | English | |||||
| Publishing date | 2023-03-11 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2495577-2 | |||||
| ISSN | 2629-3277 ; 1558-6804 ; 1550-8943 | |||||
| ISSN (online) | 2629-3277 ; 1558-6804 | |||||
| ISSN | 1550-8943 | |||||
| DOI | 10.1007/s12015-023-10510-8 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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