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Article: Protective Effects of Propolis and Chitosan Nanoparticles against Ibuprofen-Induced Hepatotoxicity in Albino Rats.

AlKandari, Fajer M / Mohamed, Hussein S / Ahmed, Sayed A / Mahmoud, Basant / Mahmoud, Asmaa M

2024 Volume 12, Issue 3

Abstract: Post-marketing hepatotoxicity findings are more common or occur much later. NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen are consumed in large quantities around the world. NSAIDs have a low incidence of hepatotoxicity but their wide use ... ...

Abstract	Post-marketing hepatotoxicity findings are more common or occur much later. NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen are consumed in large quantities around the world. NSAIDs have a low incidence of hepatotoxicity but their wide use makes them a major contributor to drug-induced liver injury. Hepatitis is linked to systemic oxidative stress which results in cellular necrosis and fibrosis, as well as tissue lipoprotein peroxidation and glutathione depletion. Given the lack of safe and effective anti-hepatitis drugs in medicine today, natural substances appear to be a promising and safe alternative. Propolis and chitosan are considered natural substances that have a protective effect on the hepatocytes. The purpose of this study was to validate the protective effect of propolis/chitosan nanoparticle extracts on ibuprofen-induced hepatotoxicity. Thirty (30) albino rats were used for the experiment. Animals were exposed to ibuprofen (400 mg/kg body weight/day) for 4 weeks (7 days/week) followed by treatment with propolis (200 mg/kg body weight/day) and chitosan extract (200 mg/kg body weight/day) separately and also in combination for consecutive 4 weeks. This study revealed a significant increase in serum transaminases, alkaline phosphatase, albumin, and total bilirubin in serum, as well as an increase in lipid peroxidation (MDA) and nitric oxide (NO). Furthermore, GSH, GST, and SOD decreased significantly in the group that was exposed to ibuprofen. Furthermore, there was a significant increase in pro-inflammatory parameters such as IL-1β and NF-ĸB, as well as low levels of anti-inflammatory parameters such as IL-6 and BCl-2. These alterations were improved by propolis and chitosan extracts, which was further confirmed in experimental animals. This study demonstrated that propolis and chitosan nanoparticle extracts have the potential to protect against hepatotoxicity induced by ibuprofen, due to their ability to regulate anti-inflammatory and anti-oxidative defense activities.
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720869-2
ISSN	2079-9721
ISSN	2079-9721
DOI	10.3390/diseases12030049
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dissipation of pyridaphenthion by cyanobacteria: Insights into cellular degradation, detoxification and metabolic regulation

Hamed, Seham M / Hozzein, Wael N / Selim, Samy / Mohamed, Hussein S / AbdElgawad, Hamada

Journal of hazardous materials. 2021 Jan. 15, v. 402

2021

Abstract: Excessive use of organophosphorus pesticides such as pyridaphenthion (PY) to constrain insects induced crop loss, results in soil and water sources contamination. Cyanobacteria are sensitive biological indicators and promising tools for bioremediation of ...

Abstract	Excessive use of organophosphorus pesticides such as pyridaphenthion (PY) to constrain insects induced crop loss, results in soil and water sources contamination. Cyanobacteria are sensitive biological indicators and promising tools for bioremediation of soil and water pollutants. To understand PY toxicity, detoxification and degradation in cyanobacteria, we performed a comparative study in the two diazotrophic cyanobacteria; Anabaena laxa and Nostoc muscorum. They were exposed to mild (5 mg/L) and high (10 mg/L) concentrations of PY for 7 days. Compared to A. laxa, N. muscorum efficiently showed high PY accumulation and degradation to a safe environmentally product; 6-hydroxy-2-phenylpyridazin-3(2 H)-one. PY inhibited cell growth and reduced Chl a content and photosynthesis related enzymes (PEPC and RuBisCo) activities in both species, but to less extend in N. muscorum. It also induced oxidative damage, particularly in A. laxa, as indicated by high H₂O₂, lipid peroxidation and protein oxidation levels and increased NADPH oxidase enzyme activity. N. muscorum invested more in antioxidants induction, i.e., induced ascorbate and glutathione cycle, however, these antioxidants increments in A. laxa were less pronounced. Overall, this study provides more in-deep insights into the PY toxicity and the role of N. muscorum as a promising PY remediator.
Keywords	Anabaena ; NAD(P)H oxidase (H2O2-forming) ; Nostoc muscorum ; bioremediation ; cell growth ; comparative study ; crop losses ; enzyme activity ; glutathione ; lipid peroxidation ; nitrogen-fixing cyanobacteria ; oxidation ; photosynthesis ; ribulose-bisphosphate carboxylase ; soil ; toxicity
Language	English
Dates of publication	2021-0115
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2020.123787
Database	NAL-Catalogue (AGRICOLA)

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Article: Computational and Molecular Docking Studies of New Benzene Sulfonamide Drugs with Anticancer and Antioxidant Effects.

Mohamed, Hussein S / Abdelgawad, Mohamed A / Hegab, Momtaz / Hamza, Zeinab S / Nagdy, Amany M / Ahmed, Sayed A / Ahmed, Osama M / Ghoneim, Mohammed M

Current organic synthesis

2022 Volume 20, Issue 3, Page(s) 339–350

Abstract: Background: The studies on the potential usage of benzene sulfonamide derivatives as anticancer agents are limited. benzene sulfonamide derivatives are currently used as anticancer agents against different breast cancer cell lines, such as MCF-7, lung ... ...

Abstract	Background: The studies on the potential usage of benzene sulfonamide derivatives as anticancer agents are limited. benzene sulfonamide derivatives are currently used as anticancer agents against different breast cancer cell lines, such as MCF-7, lung cancer cells (A549), prostate cancer cells (Du-145), and cervical cells (HeLa). Objective: A series of new sulfonamide drugs are synthesized by reacting aldehydes thio-semi-carbazones derivatives with benzene sulphonyl chloride to form benzylidene-N-(phenylsulfonyl) hydrazine-1-carbothioamide derivatives. Studying the anticancer effects against MCF-7 breast carcinoma cell lines and the antioxidant activities of these newly synthesized compounds. Methods: Studying the anticancer effects against MCF-7 breast carcinoma cell lines and the antioxidant activities of these newly synthesized compounds. To study the anti-breast cancer activity of the newly synthesized compounds, a molecular docking study is used to analyze the binding energy for the nonbonding interactions between the ligands (studied compounds) and receptor (4PYP (pdb code: 4FA2)) against human breast cancer (MCF-7) cells. The bioavailability of all studied compounds is confirmed by pharmacological investigations using Mol inspiration and absorption, distribution, metabolism, excretion, and toxicity online servers. Results: The two derivatives, 2-(4- methoxy benzylidene)-N-(phenylsulfonyl) hydrazine-1-carbothioamide (4c) and 2-(4-dimethylamino) benzylidene)-N-(phenylsulfonyl) hydrazine-1-carbothioamide (4e) show the most potent anticancer effects against MCF-7 breast carcinoma cell lines. Meanwhile, these two derivatives show the lowest antioxidant activities. Conclusion: The different spectral techniques were used to confirm the structure of the novel synthesized compounds. Further, 2-(4-(dimethyl amino) benzylidene)-N- (phenylsulfonyl)hydrazine-1-carbothioamide (4e) and 2-(4- methoxy benzylidene)-N-(phenylsulfonyl) hydrazine-1 carbothioamide (4c) were the most potent anticancer derivatives against MCF-7 breast carcinoma cell lines. Furthermore, they exhibited the most potent antioxidant activities. Meanwhile, the 2-benzylidene-N-(phenylsulfonyl) hydrazine-1-carbothioamide (4a) and 2-(4-chloro benzylidene)-N-(phenylsulfonyl) hydrazine-1-carbothioamide (4d) had the lowest antioxidant potentials. The estimated binding energies, inhibition constant, intermolecular energies, and reference RMSD produced from docking for all studied compounds were reported. These values showed that all studied compounds formed stable complexes with the receptor with high binding affinity. It was further noted from the ADMET analysis that compounds 4c, 4d, and 4e have good absorption, low toxicity in the human liver, and medium BBB penetration. Hence, these studied compounds (4c-4e) may be suggested as potential compounds against human breast cancer MCF-7 cells.
MeSH term(s)	Humans ; Female ; Antioxidants/pharmacology ; Structure-Activity Relationship ; Molecular Docking Simulation ; Benzene ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; MCF-7 Cells ; Sulfanilamide ; Breast Neoplasms ; Sulfonamides/pharmacology
Chemical Substances	Antioxidants ; Benzene (J64922108F) ; Antineoplastic Agents ; Sulfanilamide (21240MF57M) ; Sulfonamides
Language	English
Publishing date	2022-10-04
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1570-1794
ISSN	1570-1794
DOI	10.2174/1570179420666221007141937
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Article: Evaluation of the phycoremediation potential of microalgae for captan removal: Comprehensive analysis on toxicity, detoxification and antioxidants modulation

Hamed, Seham M. / Okla, Mohammad K. / Al-Saadi, Luma Shihab / Hozzein, Wael N. / Mohamed, Hussein S. / Selim, Samy / AbdElgawad, Hamada

Journal of hazardous materials. 2022 Apr. 05, v. 427

2022

Abstract: Captan is one of the most widely used organochlorine fungicides, its frequent application contaminates both terrestrial and aquatic ecosystems and negatively affects their key ecological processes. This study demonstrated the toxicity and efficient ... ...

Abstract	Captan is one of the most widely used organochlorine fungicides, its frequent application contaminates both terrestrial and aquatic ecosystems and negatively affects their key ecological processes. This study demonstrated the toxicity and efficient removal of captan by two different taxonomic species; the green microalga Scenedesmus obliquus and cyanobacterium Nostoc muscorum. After a week of exposure to mild (15 mg/L) and severe (30 mg/L) captan doses, the intracellular captan uptake, degradation and metabolic regulation of captan detoxification were studied. Compared to N. muscorum, S. obliquus accumulated more captan, but efficiently degraded it into two safe eco-friendly by-products; phthalic acid and 1,2,3,6-tetrahydro phthalimide. S. obliquus showed less decrease in cell growth, photosynthesis activity and related parameters including Chla content and activity of PEPC and RuBisCo enzymes. Captan at the severe dose induced oxidative damage particularly in N. muscorum, as expressed by the high levels of H₂O₂, MDA, NADPH oxidase and protein peroxidation. Both species invested glutathione-s-transferase enzyme in captan detoxification however, induction of antioxidant defence system e.g. ascorbate and glutathione cycle was more pronounced in S. obliquus which could explain its tolerance ability. This study provided a better understanding of the environmental risks of captan and introduced S. obliquus as a promising captan phycoremediator.
Keywords	NAD(P)H oxidase (H2O2-forming) ; Nostoc muscorum ; Scenedesmus obliquus ; antioxidant activity ; captan ; cell growth ; chlorinated hydrocarbons ; glutathione ; glutathione transferase ; microalgae ; peroxidation ; photosynthesis ; phthalic acid ; phthalimide ; ribulose-bisphosphate carboxylase ; toxicity
Language	English
Dates of publication	2022-0405
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.128177
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Article ; Online: Dissipation of pyridaphenthion by cyanobacteria: Insights into cellular degradation, detoxification and metabolic regulation.

Hamed, Seham M / Hozzein, Wael N / Selim, Samy / Mohamed, Hussein S / AbdElgawad, Hamada

Journal of hazardous materials

2020 Volume 402, Page(s) 123787

Abstract	Excessive use of organophosphorus pesticides such as pyridaphenthion (PY) to constrain insects induced crop loss, results in soil and water sources contamination. Cyanobacteria are sensitive biological indicators and promising tools for bioremediation of soil and water pollutants. To understand PY toxicity, detoxification and degradation in cyanobacteria, we performed a comparative study in the two diazotrophic cyanobacteria; Anabaena laxa and Nostoc muscorum. They were exposed to mild (5 mg/L) and high (10 mg/L) concentrations of PY for 7 days. Compared to A. laxa, N. muscorum efficiently showed high PY accumulation and degradation to a safe environmentally product; 6-hydroxy-2-phenylpyridazin-3(2 H)-one. PY inhibited cell growth and reduced Chl a content and photosynthesis related enzymes (PEPC and RuBisCo) activities in both species, but to less extend in N. muscorum. It also induced oxidative damage, particularly in A. laxa, as indicated by high H
MeSH term(s)	Anabaena ; Antioxidants ; Cyanobacteria ; Hydrogen Peroxide ; Organothiophosphorus Compounds ; Oxidative Stress
Chemical Substances	Antioxidants ; Organothiophosphorus Compounds ; pyridafenthion (98M0VDD56Z) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2020-09-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2020.123787
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Article ; Online: In silico

Ahmed Atto Al-Shuaeeb, Riyadh / Abd El-Mageed, H R / Ahmed, Shimaa / Mohamed, Hussein S / Hamza, Zeinab S / Rafi, Md Oliullah / Ahmad, Iqrar / Patel, Harun

Journal of biomolecular structure & dynamics

2023 Volume 41, Issue 23, Page(s) 14484–14496

Abstract: Microtubule affinity regulating kinase (MARK4) has been proposed as a potential therapeutic target for diabetes, cancer, and neurological diseases. We used a variety of computational studies techniques to examine the binding affinity and MARK4 inhibitory ...

Abstract	Microtubule affinity regulating kinase (MARK4) has been proposed as a potential therapeutic target for diabetes, cancer, and neurological diseases. We used a variety of computational studies techniques to examine the binding affinity and MARK4 inhibitory potential of several isoquinoline alkaloids. MARK4 has been associated with tau protein phosphorylation and, consequently, Alzheimer's disease. The three molecules with the highest binding affinities inside the 5ES1 receptor, according to molecular docking experiments, are isoliensinine, liensinine, and methylcorypalline. Isoliensinine had the highest drug score and drug likeness, coming in at 1.17, while Liensinine and Methylcorypalline came in at 1.15 and 1.07, respectively. The thesis claims that three compounds have a better chance than the others of being identified as therapeutic leads. The bulk of the compounds under investigation didn't break any of Lipinski's five rules, especially methylcorypalline, which did and is probably orally active. The majority of the compounds under investigation, particularly Isoliensinine, Liensinine, and Methylcorypalline, show the potential to exhibit drug-like behaviour, which is strongly confirmed by ADMET characteristics estimates. The chemicals Isoliensinine, Liensinine, and Methylcorypalline, especially Methylcorypalline, form the most stable combination with the 5ES1, according to a 100 ns molecular dynamics simulation of these compounds docked inside 5ES1 complexes. Methylcorypalline has a higher binding affinity inside 5ES1, according to additional MM/GBSA experiments using MD trajectories. Overall, research supports the use of the drug development tool methylcolipalin for its ability to inhibit MARK4, which may have implications for the treatment of neurodegenerative diseases.Communicated by Ramaswamy H. Sarma.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Neurodegenerative Diseases/drug therapy ; Isoquinolines/pharmacology ; Drug Design ; Alkaloids/pharmacology ; Molecular Dynamics Simulation
Chemical Substances	liensinine (2586-96-1) ; Isoquinolines ; Alkaloids
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2212778
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Article ; Online: Identification of potent COVID-19 main protease inhibitors by loading of favipiravir on Mg

Al-Shuaeeb, Riyadh Ahmed Atto / Abd El-Mageed, H R / Ahmed, Shimaa A / Mohamed, Hussein S / Hamza, Zeinab S / Rafi, Md Oliullah / Rahman, Md Shahedur

Journal of biomolecular structure & dynamics

2023 Volume 41, Issue 21, Page(s) 11437–11449

Abstract: Pandemic new severe acute respiratory syndrome coronavirus (SARS-CoV-2) virus has increased throughout the world. There is no effective treatment against this virus until now. Since its appearance in Wuhan, China in December 2019, SARS-CoV-2 becomes the ... ...

Abstract	Pandemic new severe acute respiratory syndrome coronavirus (SARS-CoV-2) virus has increased throughout the world. There is no effective treatment against this virus until now. Since its appearance in Wuhan, China in December 2019, SARS-CoV-2 becomes the largest challenge the world is opposite today, including the discovery of an antiviral drug for this virus. Several viral proteins have been prioritized as SARS-CoV-2 antiviral drug targets, among them the papain-like protease (PLpro) and the main protease (Mpro). Inhibition of these proteases would target viral replication, viral maturation and suppression of host innate immune responses. Potential candidates have been identified to show inhibitory effects against Mpro, both in biochemical assays and viral replication in cells. There are different molecules such as lopinavir and favipiravir considerably inhibit the activity of Mpro in vitro. Different studies have shown that structurally improved favipiravir and other similar compounds can inhibit SARS-CoV-2 main protease. In this work, we study the interactions between favipiravir with Mg
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; COVID-19 Drug Treatment ; Molecular Docking Simulation ; Endopeptidases ; Molecular Dynamics Simulation ; Protease Inhibitors/pharmacology ; Antiviral Agents/pharmacology ; Zinc
Chemical Substances	favipiravir (EW5GL2X7E0) ; Endopeptidases (EC 3.4.-) ; Protease Inhibitors ; Antiviral Agents ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2023-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2022.2162967
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Zs.A 2093: Show issues

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Article ; Online: Experimentally and theoretically approaches for disperse red 60 dye adsorption on novel quaternary nanocomposites.

Soliman, N K / Moustafa, A F / El-Mageed, H R Abd / Abdel-Gawad, Omima F / Elkady, Esraa T / Ahmed, Sayed A / Mohamed, Hussein S

Scientific reports

2021 Volume 11, Issue 1, Page(s) 10000

Abstract: A comprehensive study that combined both experimental and computational experiments was performed to evaluate the usage of organo-metal oxide nanocomposite for the elimination of disperse red 60 dye (DR) from aqueous solutions. Chitosan was modified by ... ...

Abstract	A comprehensive study that combined both experimental and computational experiments was performed to evaluate the usage of organo-metal oxide nanocomposite for the elimination of disperse red 60 dye (DR) from aqueous solutions. Chitosan was modified by Schiff base to form nanoneedles chitosan-4-chloroacetophenone derivative. The derivatives were then impregnated with CeO
Language	English
Publishing date	2021-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-89351-9
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Article ; Online: Author Correction: Experimentally and theoretically approaches for disperse red 60 dye adsorption on novel quaternary nanocomposites.

Soliman, N K / Moustafa, A F / El-Mageed, H R Abd / Abdel-Gawad, Omima F / Elkady, Esraa T / Ahmed, Sayed A / Mohamed, Hussein S

Scientific reports

2021 Volume 11, Issue 1, Page(s) 17034

Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-96498-y
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Article ; Online: Evaluation of the phycoremediation potential of microalgae for captan removal: Comprehensive analysis on toxicity, detoxification and antioxidants modulation.

Hamed, Seham M / Okla, Mohammad K / Al-Saadi, Luma Shihab / Hozzein, Wael N / Mohamed, Hussein S / Selim, Samy / AbdElgawad, Hamada

Journal of hazardous materials

2021 Volume 427, Page(s) 128177

Abstract	Captan is one of the most widely used organochlorine fungicides, its frequent application contaminates both terrestrial and aquatic ecosystems and negatively affects their key ecological processes. This study demonstrated the toxicity and efficient removal of captan by two different taxonomic species; the green microalga Scenedesmus obliquus and cyanobacterium Nostoc muscorum. After a week of exposure to mild (15 mg/L) and severe (30 mg/L) captan doses, the intracellular captan uptake, degradation and metabolic regulation of captan detoxification were studied. Compared to N. muscorum, S. obliquus accumulated more captan, but efficiently degraded it into two safe eco-friendly by-products; phthalic acid and 1,2,3,6-tetrahydro phthalimide. S. obliquus showed less decrease in cell growth, photosynthesis activity and related parameters including Chla content and activity of PEPC and RuBisCo enzymes. Captan at the severe dose induced oxidative damage particularly in N. muscorum, as expressed by the high levels of H
MeSH term(s)	Antioxidants ; Captan ; Ecosystem ; Hydrogen Peroxide ; Microalgae ; Nostoc ; Scenedesmus
Chemical Substances	Antioxidants ; Hydrogen Peroxide (BBX060AN9V) ; Captan (EOL5G26Q9F)
Language	English
Publishing date	2021-12-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.128177
Database	MEDical Literature Analysis and Retrieval System OnLINE

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