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  1. Article ; Online: Retraction Note: Rectal vs. sublingual misoprostol before cesarean section: double-blind, three-arm, randomized clinical trial.

    Sweed, Mohamed S / El-Saied, Mourad M / Abou-Gamrah, Amgad E / El-Sabaa, Haitham A / Abdel-Hamid, Mohamed M / Hemeda, Hossam / Mansour, Ahmed M / Shawky, Mohamed E / El-Sayed, Medhat A / Mohamed, Radwa M

    Archives of gynecology and obstetrics

    2024  Volume 309, Issue 5, Page(s) 2265

    Language English
    Publishing date 2024-03-12
    Publishing country Germany
    Document type Retraction of Publication
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-024-07428-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rectal vs. sublingual misoprostol before cesarean section: double-blind, three-arm, randomized clinical trial.

    Sweed, Mohamed S / El-Saied, Mourad M / Abou-Gamrah, Amgad E / El-Sabaa, Haitham A / Abdel-Hamid, Mohamed M / Hemeda, Hossam / Mansour, Ahmed M / Shawky, Mohamed E / El-Sayed, Medhat A / Mohamed, Radwa M

    publication RETRACTED

    Archives of gynecology and obstetrics

    2018  Volume 298, Issue 6, Page(s) 1115–1122

    Abstract: Purpose: The commonest surgical procedure for women is cesarean delivery. Postpartum hemorrhage and intra-operative blood during cesarean delivery is a major concern to all obstetricians. This study was conducted to assess the efficacy of the adjuvant ... ...

    Abstract Purpose: The commonest surgical procedure for women is cesarean delivery. Postpartum hemorrhage and intra-operative blood during cesarean delivery is a major concern to all obstetricians. This study was conducted to assess the efficacy of the adjuvant use of misoprostol and oxytocin in decreasing intra-operative blood loss in cesarean delivery.
    Methods: This was a double-blinded randomized clinical trial including 636 term pregnant woman scheduled for cesarean section at Ain Shams University Maternity Hospital, Cairo, Egypt, between February 2013 and February 2014. Participants received either 400-μg misoprostol rectally or sublingually or placebo before cesarean section together with 5-IU oxytocin IV. The main outcome measure was intra-operative blood loss. Difference between the three groups was analyzed using one-way ANOVA test (for numeric variables) and Chi-square test (for categorical variables). P < 0.05 was considered statistically significant.
    Results: Intra-operative blood loss was higher in patients who did not receive misoprostol (Placebo Group) (295-1075 ml, 641.7 ± 135.7) than those who received it, regardless the route of administration, rectal (135-830 ml, 457.5 ± 140.7; P < 0.001), and sublingual (135-680 ml, 357.8 ± 129.7; P < 0.001). In addition, sublingual route was associated with significantly lower estimated intra-operative blood loss compared to rectal administration (P < 0.001).
    Conclusions: Misoprostol with oxytocin is an effective drug-combination for decreasing intra-operative blood loss during cesarian section with clinical superiority to sublingual over rectal route.
    MeSH term(s) Administration, Rectal ; Administration, Sublingual ; Adult ; Cesarean Section/methods ; Double-Blind Method ; Female ; Humans ; Misoprostol/administration & dosage ; Misoprostol/pharmacology ; Misoprostol/therapeutic use ; Oxytocics/administration & dosage ; Oxytocics/pharmacology ; Oxytocics/therapeutic use ; Pregnancy ; Prospective Studies ; Young Adult
    Chemical Substances Oxytocics ; Misoprostol (0E43V0BB57)
    Language English
    Publishing date 2018-10-05
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-018-4894-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A preliminary pilot randomized crossover study of uzara (Xysmalobium undulatum) versus ibuprofen in the treatment of primary dysmenorrhea.

    Abd-El-Maeboud, Karim H I / Kortam, Mohamed A M F / Ali, Mohamed S / Ibrahim, Mostafa I / Mohamed, Radwa M M Z

    PloS one

    2014  Volume 9, Issue 8, Page(s) e104473

    Abstract: Objective: Preliminary evaluation of efficacy and safety of uzara use in treatment of moderate and severe primary dysmenorrhea in comparison to ibuprofen.: Materials and methods: This randomized, comparative two way cross-over study comprised 60 ... ...

    Abstract Objective: Preliminary evaluation of efficacy and safety of uzara use in treatment of moderate and severe primary dysmenorrhea in comparison to ibuprofen.
    Materials and methods: This randomized, comparative two way cross-over study comprised 60 single female students at Faculty of Medicine, Ain Shams University, Egypt, aged 19-28 years with moderate (n = 46) or severe (n = 14) primary dysmenorrhea. Participants were randomized to take either uzara (80 mg/8 hours for two doses, then 40 mg/8 hours) then ibuprofen (400 mg/6 hours) in two subsequent cycles or vice versa. The pain intensity, using VAS, was recorded immediately before taking the medication (0 hour) and after 4, 12, 24, 48-60, 96-120 hours. Main outcome measures included effectiveness of pain relief defined as drop of VAS to 3 or less, patient's global evaluation of the drug, absence from school, the use of a rescue medication, and, in those who continued the treatment, the pain intensity difference (PID) at different points after start of medication and its sum (SPID).
    Results: Uzara was comparably effective to ibuprofen (78.3% vs. 86.7% of cycles; respectively), with comparable rates of effectiveness on global evaluation (being around 50% for either drug), and rates of school absences (11.7% vs. 13.3%; respectively). The need for rescue medication was different (18.3% and 10%; respectively), albeit with no statistical significance. The means of PID at different time points and SPID were comparable, with significantly lower average mean of VAS scores compared to that felt with no medication (1.6 vs. 6.8, p<0.001). Side effects were less with uzara than ibuprofen (0% vs. 8.3%, p<0.05).
    Conclusions: Uzara might be as effective as ibuprofen in management of primary dysmenorrhea but with less side effects. These findings need to be confirmed by a properly designed trial with a larger sample size.
    Trial registration: Current Controlled Trials ISRCTN25618258.
    MeSH term(s) Adult ; Apocynaceae/chemistry ; Cross-Over Studies ; Dysmenorrhea/drug therapy ; Egypt ; Female ; Humans ; Ibuprofen/therapeutic use ; Pain Measurement ; Pilot Projects ; Plant Extracts/pharmacology ; Random Allocation ; Time Factors
    Chemical Substances Plant Extracts ; Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2014-08-13
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0104473
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  4. Article ; Online: Ovarian Reserve Following Laparoscopic Ovarian Cystectomy vs Cyst Deroofing for Endometriomas.

    Sweed, Mohamed S / Makled, Ahmed K / El-Sayed, Medhat A / Shawky, Mohamed E / Abd-Elhady, Hamdy A / Mansour, Ahmed M / Mohamed, Radwa M / Hemeda, Hossam / Nasr-Eldin, Eman A / Attia, Neveen S / Eltaieb, Ebtihal / Allam, Heba / Hussein, Ahmed

    Journal of minimally invasive gynecology

    2018  Volume 26, Issue 5, Page(s) 877–882

    Abstract: Study objective: Because laparoscopic ovarian cystectomy of endometriomas is known to adversely impact patient ovarian reserve, the search for other techniques of surgical management is ongoing. The present study was undertaken to evaluate laparoscopic ... ...

    Abstract Study objective: Because laparoscopic ovarian cystectomy of endometriomas is known to adversely impact patient ovarian reserve, the search for other techniques of surgical management is ongoing. The present study was undertaken to evaluate laparoscopic cyst deroofing as a feasible alternative.
    Study design: Prospective, randomized clinical trial (Canadian Task Force classification I).
    Setting: University maternity hospital.
    Patients: Women diagnosed with unilateral or bilateral ovarian endometriomas.
    Interventions: Patients were managed with either laparoscopic ovarian cystectomy or cyst deroofing.
    Measurements and main results: A total of 122 women with endometriomas were randomized to either laparoscopic cystectomy (group 1) or laparoscopic cyst deroofing (group 2). The primary endpoint was the effect on ovarian reserve based on changes in anti-Müllerian hormone (AMH) values. At 1 month postsurgery, anti-Müllerian hormone values were significantly decreased (p < .001) from preoperative values, from 4.25 ± 0.87 ng/mL to 1.66 ± 1.02 ng/mL in group 1 and from 4.2 ± 1.69 ng/mL to 2.15 ± 1.48 ng/mL in group 2. In addition, antral follicle count and ovarian volume decreased significantly (p < .001) in both groups by 1 month postsurgery. The decreases in these 3 parameters were more significant (p < .001) in group 1 than in group 2.
    Conclusion: Laparoscopic cyst deroofing of endometriomas appears to be a promising alternative to laparoscopic cystectomy, with less postoperative decrease in ovarian reserve; however, the higher rate of endometrioma recurrence warrants future clinical research to determine the optimal surgical management of endometriomas.
    MeSH term(s) Adult ; Anti-Mullerian Hormone/analysis ; Cystectomy/methods ; Cysts/surgery ; Endometriosis/surgery ; Female ; Humans ; Laparoscopy/methods ; Neoplasm Recurrence, Local ; Ovarian Cysts/surgery ; Ovarian Reserve ; Ovariectomy/methods ; Postoperative Period ; Prospective Studies ; Regression Analysis
    Chemical Substances Anti-Mullerian Hormone (80497-65-0)
    Language English
    Publishing date 2018-09-05
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2018.06.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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