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Article ; Online: Intravitreal bevacizumab versus intravitreal triamcinolone for diabetic macular edema-Systematic review, meta-analysis and meta-regression.

Mohamed Abdel-Maboud / Esraa Menshawy / Eshak I Bahbah / Oumaima Outani / Amr Menshawy

PLoS ONE, Vol 16, Iss 1, p e

2021 Volume 0245010

Abstract: Background The most frequent cause of vision loss from diabetic retinopathy is diabetic macular edema (DME). Earlier clinical trials tried to examine the role of intravitreal triamcinolone (IVT) and intravitreal bevacizumab (IVB) in DME; they either ... ...

Abstract	Background The most frequent cause of vision loss from diabetic retinopathy is diabetic macular edema (DME). Earlier clinical trials tried to examine the role of intravitreal triamcinolone (IVT) and intravitreal bevacizumab (IVB) in DME; they either qualified IVT over IVB or IVB over IVT or did not exhibit a significant difference. Objective This paper aims to compare the efficacy and safety of IVB versus IVT alone or combined IVB+IVT in the treatment of DME. Methods We systematically searched PubMed, CENTRAL, Scopus, Embase, Science Direct, OVID, and Web of Science for randomized controlled trials of IVB versus IVT alone or combined IVB+IVT and IVT versus the combined IVB+IVT in DME patients. Results A total of 1243 eyes of 17 trials were included in our meta-analysis and regression. Repeated injections of IVB were superior at improving VA comparing with those of IVT at 12, 24, 48-weeks, and IVB+IVT at 12, 24, 48-weeks. Single injections were comparable across the three arms regarding BCVA improvement. CMT reductions were also comparable across the three arms. Meanwhile, the overall safety regarding intraocular pressure and intraocular hypertension significantly favored the IVB group. Improvement in VA was best modified with CMT reduction from 480 um to 320um. This association was significant at 12-weeks in the three arms and persisted till 24-weeks and 48-weeks exclusively in the IVB group. Conclusions and relevance Our analysis reveals that repeated successive injections associate with better BCVA compared to single injection. Current evidence affirms that IVB is superior to IVT and IVB+IVT at improving BCVA, comparable at reducing CMT, and presents a better safety profile in the treatment of DME.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of venous Doppler evaluation of intrauterine growth retardation

Noha Mohamed AbdelMaboud / Hytham Haroon Elsaid

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 46, Iss 1, Pp 167-

2015 Volume 174

Abstract: Aim of the work: The aim of this work is to determine the role of venous Doppler Ultrasonography for the prediction of adverse perinatal outcome in “intrauterine growth restricted fetus”, providing the obstetrician with additional information about the ... ...

Abstract	Aim of the work: The aim of this work is to determine the role of venous Doppler Ultrasonography for the prediction of adverse perinatal outcome in “intrauterine growth restricted fetus”, providing the obstetrician with additional information about the time frame and significance of the IUGR to help determine the optimal time of delivery. Patients and methods: Sixty pregnant females with their age ranging between 28 and 35 years, gestational age between 27 and 37 weeks of gestation were enrolled in the study. All patients in the study were subjected to Doppler examination of the umbilical vein (UV), Ductus venosus (DV), right hepatic vein (HV) and umbilical artery (UA). Results: Abnormal UA Doppler was found in 40 patients. Abnormal DV Doppler was found in 40 patients. Abnormal UV Doppler was found in 10 patients. Abnormal Rt. HV Doppler was found in 20 patients. All parameters studied were strongly related to perinatal mortality, however, none had 100% sensitivity, the pulsatility index in the Rt. HV and DV were the best single indices to use in the prediction of perinatal mortality. Conclusion: We observed that venous Doppler is superior to arterial Doppler in predicting poor perinatal outcome and that the abnormal equivocal BPP scoring significantly correlated with adverse outcome. We also, concluded that multi-vessel Doppler Ultrasonography and BPP can effectively stratify IUGR fetuses with placental vascular insufficiency into risk categories. Fetal deterioration appears to be independently reflected in these two testing modalities; their combined use is likely to be complementary.
Keywords	Intrauterine growth restriction ; Small for date ; Fetal surveillance ; Fetal venous system ; Venous Doppler velocimetry ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2015-03-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of transvaginal ultrasonography and colour Doppler in the evaluation of postmenopausal bleeding

Noha Mohamed AbdelMaboud / Hytham Haroon Elsaid

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 46, Iss 1, Pp 235-

2015 Volume 243

Abstract: Aim of the work: The aim of this study is to evaluate the role of transvaginal ultrasonography and colour Doppler in postmenopausal bleeding. Patients and methods: In the study fifty female patients with their age ranging between 45 and 80 years were ... ...

Abstract	Aim of the work: The aim of this study is to evaluate the role of transvaginal ultrasonography and colour Doppler in postmenopausal bleeding. Patients and methods: In the study fifty female patients with their age ranging between 45 and 80 years were subjected to transvaginal US examination and transvaginal colour and pulsed Doppler examination. Results: All the malignant cases and 94.7% of the benign cases had endometrial thickness ⩾5 mm, however 90% of the control group with the remaining of the benign cases (5.2%) had endometrial thickness <5 mm. The mean uterine artery RI and PI were lower in cases with PMB than in control cases and in cases with malignant causes than benign causes. The mean spiral artery RI & PI were lower in cases with benign than in cases with malignant causes of PMB. Conclusion: In conclusion, transvaginal colour Doppler as a noninvasive method has a significant place in the diagnostic procedures for evaluation of PMB. Transvaginal colour Doppler can help in differentiating benign from malignant endometrial changes.
Keywords	Transvaginal ultrasound ; Postmenopausal bleeding ; Endometrial carcinoma ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2015-03-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk of cerebral venous thrombosis in oral contraceptives pills users

Noha Mohamed AbdelMaboud Ibrahim / Al-Shymaa Zakareya El-Shahawy / Abeer Elshabacy

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 49, Iss 3, Pp 727-

2018 Volume 731

Abstract: The aim of this study is to assess the relative risk of cerebral venous sinus thrombosis (CVST) in Oral contraceptive pills (OCP) users compared with a control group of non-hormone users. Patients & methods: This retrospective case-control, age – group ... ...

Abstract	The aim of this study is to assess the relative risk of cerebral venous sinus thrombosis (CVST) in Oral contraceptive pills (OCP) users compared with a control group of non-hormone users. Patients & methods: This retrospective case-control, age – group matched study done in about two years and included 40 female patients and 30 control females, aged 30–50 years-with 50% of them above the age of 35 years. All patients diagnosed as CVST with the consumption of OCP were included in the study. The diagnosis is based on the MRI & MRV study. T1, T2, FLAIR &Diffusion weighted image. The MRV was done using the 2 D-TOF technique. Results: The MRI result was negative (no parenchymal changes) in 16 patients (40%), and positive in the remaining 60%; 12 patients (30%) showed haemorrhagic infarction only, represented by heterogeneous mixed hypo and hyperintesity in the brain parenchyma with brain edema and 8 patients (20%) showed non-haemorrhagic infarction in the form of low SI in T1WI and a high SI in T2WI and FLAIR and restricted diffusion on DWI, 4 (10%) patients showed a parasagittal high T2 SI indicating superior sagittal sinus thrombosis. The control group showed no parenchymal changes in four (20%) females, but showed hemorrhagic infarction in eight (40%) females, and non-hemorrhagic infarction in six (30%) females and parasagittal high T2 SI in two (10%) females. Conclusion: The risk of CVST increased more in women taking OCP than in non-hormonal users. To reduce the risk, Knowledge of it is of crucial importance. Keywords: MRI, MRV, Cerebral venous sinus, Contraceptive pills
Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MRI imaging of posterior reversible encephalopathy syndrome associated with pregnancy

Noha Mohamed AbdelMaboud Ibrahim / Manal E. Badawy

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 45, Iss 2, Pp 505-

2014 Volume 510

Abstract: Purpose: Our purpose is to characterize MRI, and diffusion-weighted imaging (DWI) findings in pregnant patients who were identified clinically to have PRES. We study the conversion of reversible vasogenic edema to irreversible cytotoxic edema and predict ...

Abstract	Purpose: Our purpose is to characterize MRI, and diffusion-weighted imaging (DWI) findings in pregnant patients who were identified clinically to have PRES. We study the conversion of reversible vasogenic edema to irreversible cytotoxic edema and predict the progression to infarction. Patients and methods: Twenty two pregnant females, aged between 20 and 46 years with gestational age between 20 and 40 weeks of gestation and with neurological manifestations had undergone conventional MRI, diffusion weighted image study, and ADC map. Results: Lesions were mainly affecting the parieto-occipital regions, symmetrical or slightly asymmetrical distribution of the lesions in both cerebral hemispheres was found in most cases. The MRI findings in all the twenty two patients were: abnormal low SI in T1 WI, abnormal high SI on T2 and FLAIR WI. In DWI, hyperintensity with hyperintensity in ADC map was seen in 15 patients, hyperintensity with hypointensity in ADC map in 4 patients, normotensive in DWI with hyperintensity in ADC map in 3 patients. Conclusion: The diagnosis of PRES has important therapeutic and prognostic value. The use of diffusion-weighted imaging and ADC maps allows an earlier and clearer differentiation of cytotoxic and vasogenic edema, which can predict the development of infarction.
Keywords	PRES ; Posterior reversible encephalopathy syndrome ; MRI ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The comparative effectiveness of 55 interventions in obese patients with polycystic ovary syndrome

Mohamed Abdel-Maboud / Amr Menshawy / Elfatih A Hasabo / Mohamed Ibrahim Abdelraoof / Mohamed Alshandidy / Muhammad Eid / Esraa Menshawy / Oumaima Outani / Ahmed Menshawy

PLoS ONE, Vol 16, Iss 7, p e

A network meta-analysis of 101 randomized trials.

2021 Volume 0254412

Abstract: Background Polycystic ovary syndrome (PCOS) affects up to 18% of reproductive-age females. The prevalence of obesity in PCOS patients reaches up to 80%, which is 2-fold higher than the general population. Objective The present study aimed to compare the ... ...

Abstract	Background Polycystic ovary syndrome (PCOS) affects up to 18% of reproductive-age females. The prevalence of obesity in PCOS patients reaches up to 80%, which is 2-fold higher than the general population. Objective The present study aimed to compare the effectiveness of 55 pharmacological interventions across 17 different outcomes in overweight/obese PCOS patients with hyperandrogenism manifestations for both short- and long-term follow-ups. A comprehensive literature search was performed on PubMed, Scopus, Embase, Science Direct, Web of Science, and Cochrane CENTRAL for randomized controlled trials comparing any conventional pharmacological intervention as a monotherapy or a combination in overweight/obese patients with polycystic ovary syndrome and hyperandrogenism manifestations. Extracted data included three main parameters; I. Anthropometric parameters (BMI, Waist and Hip circumferences, and Waist/HIP ratio), II. Hormonal parameters (FSH, LH, FSG, SHBG, Estradiol, Total Testosterone, Free testosterone, DHEAS, Androstenedione), and III. Metabolic parameters (Total Cholesterol, LDL-C, HDL-C, Triglycerides, Fasting glucose, Fasting glucose, HOMA-IR). Critical appraisal and risk of bias assessments were performed using the modified Jadad scale, and the overall quality of this network meta-analysis was evaluated according to the CINeMA framework. We performed both a pairwise meta-analysis and a network meta-analysis to evaluate the effect sizes with 95% CI, and we calculated the surface under the cumulative ranking curve (SUCRA) for each intervention. Results Our final search on May 15th 2021 retrieved 23,305 unique citations from searching six electronic databases. Eventually, 101 RCTs of 108 reports with a total of 8,765 patients were included in our systematic review and multi-treatments meta-analysis. 55 different interventions were included: 22 monotherapies, and 33 combinations. The two-dimensional cluster ranking of the average SUCRA values for metabolic and hormonal parameters with significant estimates ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The role of diffusion – Weighted MRI in evaluation of prostate cancer

Noha Mohamed AbdelMaboud / Hytham Haroon Elsaid / Essam Aly Aboubeih

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 45, Iss 1, Pp 231-

2014 Volume 236

Abstract: The aim of work: To illustrate the role of T2WI combined with diffusion WI (DWI) in the evaluation of patients with prostate cancer. Patients and methods: This prospective study included 36 patients (mean age 61) with clinical suspicion of prostate ... ...

Abstract	The aim of work: To illustrate the role of T2WI combined with diffusion WI (DWI) in the evaluation of patients with prostate cancer. Patients and methods: This prospective study included 36 patients (mean age 61) with clinical suspicion of prostate cancer using surface coil at 1.5 T MR Unit. Axial, coronal, and sagittal high resolution (HR) T2WI were performed, DWI was applied using a single-shot echo-planar imaging sequence in axial orientation. Regions of interest were drawn on ADC maps on the site of visible restricted diffusion as well as the normal tissue, then the ADC value was calculated. Considering histopathological diagnosis the standard of reference, the results of T2WI alone were compared with those of combined T2WI and DWI. Results: In this prospective study, 36 men were examined and T2WI, DWI, ADC map and ADC values were measured. T2 low SI was detected in the peripheral zone of the prostate of 36 patients, and restricted diffusion in 31 patients. Conclusion: Our study indicates that the addition of the ADC map and DWI to T2WI provide significantly more accurate results for prostate cancer detection and staging.
Keywords	Diffusion weighted image ; Apparent diffusion coefficient ; Prostate cancer ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2014-03-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The accuracy of MDCT for staging of Wilms’ tumor

Noha Mohamed AbdelMaboud Ibrahim / Hytham Haroon Elsaid / Essam Aly aboubeih

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 45, Iss 2, Pp 575-

2014 Volume 581

Abstract: Aim of work: To evaluate the accuracy of multidetector computed tomography (MDCT) in staging of Wilms’ tumor. Patients and methods: This prospective study was performed on 32 children (age range 4–8 years), having renal mass lesion, were studied with ... ...

Abstract	Aim of work: To evaluate the accuracy of multidetector computed tomography (MDCT) in staging of Wilms’ tumor. Patients and methods: This prospective study was performed on 32 children (age range 4–8 years), having renal mass lesion, were studied with multidetector computed tomography (MDCT). Axial and multiplanar imaging were evaluated. All tumors were staged according to NWTS-4 classification. MDCT diagnosis was compared with surgical and pathohistological data. Results: All the cases were staged according to the fourth trial of the National Wilms’ tumor Studies (NWTS-4). The 32 cases were found to have 36 tumors (4 cases were bilateral masses), 4 tumors were diagnosed as stage I, 9 tumors were diagnosed as stage II, 7 tumors as stage III, 8 tumors stage IV and 8 tumors were stage V. Conclusion: In conclusion, MDCT represents a reliable diagnostic method for evaluating Wilms’ tumor and it is accurate and sensitive in diagnosing stages I, IV and V, but is not as accurate in the diagnosis of stages II and III and has poor correlation with histopathological data.
Keywords	Wilms’ tumor ; MDCT ; Staging ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Efficacy and safety of atazanavir/ritonavir-based antiretroviral therapy for HIV-1 infected subjects: a systematic review and meta-analysis

Menshawy, Amr / Ammar Ismail / Abdelrahman Ibrahim Abushouk / Hussien Ahmed / Esraa Menshawy / Ahmed Elmaraezy / Mohamed Gadelkarim / Mohamed Abdel-Maboud / Attia Attia / Ahmed Negida

Archives of virology. 2017 Aug., v. 162, no. 8

2017

Abstract: Atazanavir (ATZ) is a well-tolerated protease inhibitor that can be boosted with ritonavir (r) to treat infection with resistant strains of human immunodeficiency virus 1 (HIV-1). The aim of this meta-analysis was to compare the efficacy, safety, and ... ...

Abstract	Atazanavir (ATZ) is a well-tolerated protease inhibitor that can be boosted with ritonavir (r) to treat infection with resistant strains of human immunodeficiency virus 1 (HIV-1). The aim of this meta-analysis was to compare the efficacy, safety, and metabolic effects of ATZ/r regimen versus commonly used antiretroviral drugs such as lopinavir (LPV) and darunavir (DRV) in HIV-1-infected patients. We searched PubMed, Scopus, Embase and Cochrane CENTRAL, using relevant keywords. Data were extracted from eligible randomized trials and pooled as risk ratios (RR) or standardized mean differences (SMD) in a meta-analysis model using RevMan software. Nine randomized controlled trials (RCTs) (3292 patients) were eligible for the final analysis. After 96 weeks of treatment, the pooled effect estimate did not favor either ATZ/r or LPV/r in terms of virological failure rate (RR 1.11, 95% CI [0.74, 1.66]). However, ATZ/r was marginally superior to LPV/r in terms of increasing the proportion of patients with HIV RNA <50 copies/ml (RR 1.09, 95% CI [1.01, 1.17]). The pooled effect estimate did not favor ATZ/r over DRV/r regarding the change in plasma levels of total cholesterol, triglycerides, or high-density lipoprotein at 24, 48, and 96 weeks. Moreover, no significant difference was found between the two regimens (ATZ/r and DRV/r) in terms of change in visceral (SMD -0.06, 95%CI [-0.33, 0.21]) or subcutaneous adipose tissue (SMD 0.12, 95% CI [-0.15, 0.39]). The ATZ/r regimen was generally as effective and well-tolerated as the LPV/r regimen for the treatment of HIV-1 patients. Compared to the DRV/r regimen, ATZ/r has no favorable effect on the plasma lipid profile or adipose tissue distribution.
Keywords	HIV infections ; Human immunodeficiency virus 1 ; RNA ; adipose tissue ; antiretroviral agents ; blood lipids ; cholesterol ; computer software ; high density lipoprotein ; lipid composition ; meta-analysis ; models ; patients ; proteinase inhibitors ; systematic review ; therapeutics ; tissue distribution ; triacylglycerols
Language	English
Dates of publication	2017-08
Size	p. 2181-2190.
Publishing place	Springer Vienna
Document type	Article
Note	Review
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-017-3346-9
Database	NAL-Catalogue (AGRICOLA)

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