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  1. Article: Crystal structure, Hirshfeld surface analysis and inter-action energy, DFT and anti-bacterial activity studies of ethyl 2-[(2

    Sebbar, Ghizlane / Mohamed, Ellouz / Hökelek, Tuncer / Mague, Joel T / Sebbar, Nada Kheira / Essassi, El Mokhtar / Belkadi, Bouchra

    Acta crystallographica. Section E, Crystallographic communications

    2020  Volume 76, Issue Pt 5, Page(s) 629–636

    Abstract: The title compound, ... ...

    Abstract The title compound, C
    Language English
    Publishing date 2020-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S2056989020004119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Crystal structure of (E)-2-benzylidene-4-[(3-phenyl-4,5-dihydroisoxazol-5-yl)methyl]-2H-benzo[b][1,4]thiazin-3(4H)-one

    Nada Kheira Sebbar / Mohamed Ellouz / El Mokhtar Essassi / Mohamed Saadi / Lahcen El Ammari

    Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 6, Pp o423-o

    2015  Volume 424

    Abstract: In the title compound, C25H20N2O2S, the dihydroisoxazole ring exhibits an envelope conformation with the methine atom being the flap, while the 1,4-thiazine ring displays a screw-boat conformation. The six-membered ring fused to the 1,4-thiazine ring ... ...

    Abstract In the title compound, C25H20N2O2S, the dihydroisoxazole ring exhibits an envelope conformation with the methine atom being the flap, while the 1,4-thiazine ring displays a screw-boat conformation. The six-membered ring fused to the 1,4-thiazine ring makes dihedral angles of 63.04 (2) and 54.7 (2)° with the mean planes through the five-membered heterocycle and the attached phenyl ring, respectively. The phenyl group connected to the 1,4-thiazine ring is disordered over two sites [major component = 0.57 (2)]. The most prominent interactions in the crystal structure are C—H.O hydrogen bonds that link molecules, forming inversion dimers, and C—H.N hydrogen bonds that link the dimers into columns parallel to the b axis.
    Keywords crystal structure ; benzothiazine ; dihydroisoxazole ; C—H.O,N hydrogen bonding ; Chemistry ; QD1-999
    Language English
    Publishing date 2015-06-01T00:00:00Z
    Publisher International Union of Crystallography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Crystal structure of (Z)-2-benzylidene-4-methyl-2H-benzo[b][1,4]thiazin-3(4H)-one

    Mohamed Ellouz / Nada Kheira Sebbar / El Mokhtar Essassi / Mohamed Saadi / Lahcen El Ammari

    Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 11, Pp o862-o

    2015  Volume 863

    Abstract: In the title compound, C16H13NOS, the 1,4-thiazine ring displays a screw-boat conformation. The conformation about the ethene bond [1.344 (2) Å] is Z. The plane of the fused benzene ring makes a dihedral angle of 58.95 (9)° with the pendent phenyl ring, ... ...

    Abstract In the title compound, C16H13NOS, the 1,4-thiazine ring displays a screw-boat conformation. The conformation about the ethene bond [1.344 (2) Å] is Z. The plane of the fused benzene ring makes a dihedral angle of 58.95 (9)° with the pendent phenyl ring, indicating a twisted conformation in the molecule. In the crystal, molecules are linked by pairs of C—H.O hydrogen bonds, forming inversion dimers.
    Keywords crystal structure ; thiomorpholin-3-one derivative ; benzothiazine derivative ; hydrogen bonding ; Chemistry ; QD1-999
    Language English
    Publishing date 2015-11-01T00:00:00Z
    Publisher International Union of Crystallography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Synthesis and antibacterial activity of new 1,2,3-triazolylmethyl-2H-1,4-benzothiazin-3(4H)-one derivatives

    Mohamed Ellouz / Nada Kheira Sebbar / Ismail Fichtali / Younes Ouzidan / Zakaria Mennane / Reda Charof / Joel T. Mague / Martine Urrutigoïty / El Mokhtar Essassi

    Chemistry Central Journal, Vol 12, Iss 1, Pp 1-

    2018  Volume 12

    Abstract: Abstract Background A novel series of 1,2,3-triazole derivatives containing 1,4-benzothiazin-3-one ring (7a–9a, 7b–9b), (10a–12a, 10b–12b) and (13–15) were synthesized by 1,3-dipolar cycloaddition reactions of azides α-d-galactopyranoside azide F, 2,3,4, ... ...

    Abstract Abstract Background A novel series of 1,2,3-triazole derivatives containing 1,4-benzothiazin-3-one ring (7a–9a, 7b–9b), (10a–12a, 10b–12b) and (13–15) were synthesized by 1,3-dipolar cycloaddition reactions of azides α-d-galactopyranoside azide F, 2,3,4,6-tetra-O-acetyl-(d)-glucopyranosyl azide G and methyl-N-benzoyl-α-azidoglycinate H with compounds 4–6. Findings Initially, the reactions were conducted under thermal conditions in ethanol. The reaction leads, each time, to the formation of two regioisomers: (Schemes 2, 3) with yields of 17 to 21% for 1,5-disubstituted 1,2,3-triazole-regioisomers (7b–12b) and yields ranging from 61 to 65% for the 1,4-disubstituted regioisomers (7a–12a). In order to report an unequivocal synthesis of the 1,4-regioisomers and confirm the structures of the two regioisomers obtained in thermal conditions (Huisgen reactions), the method click chemistry (Copper-Catalyzed Azide-Alkyne Cycloaddition) has been used. Conclusions The newly synthesized compounds using cycloaddition reactions were evaluated in vitro for their antibacterial activities against some Gram positive and Gram negative microbial strains. Among the compounds tested, the compound 8a showed excellent antibacterial activities against PA ATCC and Acin ESBL (MIC = 31.2 μg/ml).
    Keywords 1,2,3-Triazole ; 1,4-Benzothiazine ; Antimicrobial activity ; Cycloaddition ; Spectroscopic methods ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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