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  1. Article ; Online: Changing Landscape of Liver Transplantation in the Post-DAA and Contemporary ART Era

    Huma Saeed / Edison J. Cano / Mohammad Qasim Khan / Zachary A. Yetmar / Byron Smith / Stacey A. Rizza / Andrew D. Badley / Maryam Mahmood / Michael D. Leise / Nathan W. Cummins

    Life, Vol 12, Iss 1755, p

    2022  Volume 1755

    Abstract: Combination anti-retroviral therapy has drastically improved solid organ transplantation outcomes in persons living with HIV. DAA therapy has led to the successful eradication of HCV. While recent data have suggested improvement in outcomes in HIV/HCV- ... ...

    Abstract Combination anti-retroviral therapy has drastically improved solid organ transplantation outcomes in persons living with HIV. DAA therapy has led to the successful eradication of HCV. While recent data have suggested improvement in outcomes in HIV/HCV-coinfected liver transplant recipients, temporal trends in patient survival within pre- and post-DAA eras are yet to be elucidated. The UNOS database was utilized to identify deceased donor liver transplant recipients between 1 January 2000 and 30 September 2020 and stratify them by HIV and HCV infection status. A total of 85,730 patients met the inclusion criteria. One-year and five-year patient survival improved (93% and 80%, respectively) for all transplants performed post-2015. For HIV/HCV-coinfected recipients, survival improved significantly from 78% (pre-2015) to 92% (post-2015). Multivariate regression analyses identified advanced recipient age, Black race, diabetes mellitus and decompensated cirrhosis as risk factors associated with higher one-year mortality. Liver transplant outcomes in HIV/HCV-coinfected liver transplant recipients have significantly improved over the last quinquennium in the setting of the highly effective combination of ART and DAA therapy. The presence of HIV, HCV, HIV/HCV-coinfection and active HCV viremia at the time of transplant do not cause higher mortality risk in liver transplant recipients in the current era.
    Keywords liver transplantation ; hepatitis C virus ; HIV/AIDS ; direct-acting antiviral therapy ; anti-retroviral therapy ; Science ; Q
    Subject code 610 ; 360
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: An audit of inpatient stool ova and parasite (O&P) testing in a multi-hospital health system

    Mohammad Qasim Khan / Nicole Gentile / Ying Zhou / Becky A. Smith / Richard B. Thomson / Eugene F. Yen

    Journal of Community Hospital Internal Medicine Perspectives, Vol 10, Iss 3, Pp 204-

    2020  Volume 209

    Abstract: Background & Objectives Stool ova and parasite (O&P) examinations are routinely ordered initial tests in patients admitted to the hospital with acute diarrhea, despite low test positivity rates. We examined the diagnostic yield of inpatient stool O&P ... ...

    Abstract Background & Objectives Stool ova and parasite (O&P) examinations are routinely ordered initial tests in patients admitted to the hospital with acute diarrhea, despite low test positivity rates. We examined the diagnostic yield of inpatient stool O&P exams and identified risk factors associated with positive tests. Methods A retrospective, case-control analysis of inpatients admitted with diarrhea, who underwent O&P examination, was conducted. Clinical and demographic variables of cases were compared with age-and gender-matched controls via uni- and multivariate conditional logistic regression analyses. Results The yield of inpatient O&P exams was 2.15% (37/1723). Blastocystisspp. represented the most common parasites. All patients with positive tests, excluding Blastocystisspp., had at least one of the following risk factors: smoking, prior parasitic disease, HIV-positive status, travel to an endemic area, and institutionalization. Conclusions Superfluous inpatient stool O&P exams confer a financial and labor burden to hospital systems. Stool O&P exams should be restricted to individuals admitted to the hospital for <3 days, having diarrhea >7 days and possessing at least one of the following risk factors: smoking, prior parasitic disease, HIV-positive status, travel to an endemic area, and institutionalization. Such selective testing can confer a 51% reduction in testing, costs, and labor.
    Keywords stool ova and parasite ; diarrhea ; parasitic gastroenteritis ; Internal medicine ; RC31-1245
    Subject code 360
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Hypothyroidism in children with Down’s syndrome

    Amir Mohammad / Inayatullah Khan / Mohammad Qasim Khan

    Gomal Journal of Medical Sciences, Vol 10, Iss

    a hospital based study

    2012  Volume 1

    Abstract: Background: Children with Down’s syndrome have a high incidence of associated treatable medical disorders. Hypothyroidism occurs with increased frequency in individuals with Down’s syndrome. The objective of this study was to determine the frequency of ... ...

    Abstract Background: Children with Down’s syndrome have a high incidence of associated treatable medical disorders. Hypothyroidism occurs with increased frequency in individuals with Down’s syndrome. The objective of this study was to determine the frequency of hypothyroidism in children with Down’s syndrome. Methods: This study was conducted at Department of Pediatrics, Lady Reading Hospital, Peshawar, from October 2006 to September 2007, on 50 children with Down’s syndrome to find out the frequency of hypothyroidism. Thyroid function tests were performed in all these children. Results: Among 50 children with Down’s syndrome 30(60%) were males and 20(40%) females. Age of majority 21(42%) was less than 1 year in 18(36%) cases age ranged from 1-5 years with mean age of 3.1291+3.65 years. Majority of the patient’s mothers 17 (34%) were in the age range of 31-35 years. Frequency of hypothyroidism was found to be 3 (6%). Conclusion: Frequency of hypothyroidism in children with Down’s syndrome is 6%.
    Keywords Medicine ; R
    Language English
    Publishing date 2012-07-01T00:00:00Z
    Publisher Gomal Medical College, D.I.Khan, Pakistan
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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