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  1. Article ; Online: Endophthalmitis in the Tertiary Referral Center in Iran; Etiology and Causative Organisms

    Hamidreza Torabi / Mohammad Riazi Esfahani / Seyed-Ali Tabatabai

    Hospital Practices and Research, Vol 2, Iss 3, Pp 79-

    2017  Volume 83

    Abstract: Background: Endophthalmitis is a severe and sight-threatening complication of ocular surgery or ocular trauma. The identification of common types and causative organisms is essential for prevention and management. Objective: The current study describes ... ...

    Abstract Background: Endophthalmitis is a severe and sight-threatening complication of ocular surgery or ocular trauma. The identification of common types and causative organisms is essential for prevention and management. Objective: The current study describes the prevalence of various types of endophthalmitis and the causative microbiological spectrum of each type treated in the Tertiary Referral Center in Iran. Methods: All cases of endophthalmitis admitted to the Emergency Department of Farabi Eye hospital (Tehran, Iran) between July 2013 and December 2014 were included in this study. The patients’ demographic data, type of endophthalmitis, aqueous or vitreous culture results, and treatment methods were recorded. Results: From 108 presumed endophthalmitis cases, post-operative endophthalmitis (68.5%) was the most frequent type followed by post-traumatic (25%), bleb-associated (4.6%), and endogenous (1.9%) types. Streptococcus viridians (37.5%) was the most common isolated organism in post-operative cases. In post-traumatic endophthalmitis patients, the most frequent causative organism was Staphylococcus epidermidis (70%). Conclusion: Many studies from other countries have reported that S. epidermidis is the leading cause of endophthalmitis after either intraocular surgeries or open-globe injuries, but the current study has shown that S. viridians is the most common isolated organism in post-operative endophthalmitis.
    Keywords Endophthalmitis ; Post-Cataract Endophthalmitis ; Posttraumatic Endophthalmitis ; Bleb-Associated Endophthalmitis ; Vitreous Culture ; Medicine ; R ; Internal medicine ; RC31-1245
    Subject code 616
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher Baqiyatallah University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Autofluorescence Imaging for Diagnosis and Follow-up of Cystoid Macular Edema

    Nazanin Ebrahimiadib / Mohammad Riazi-Esfahani

    Journal of Ophthalmic & Vision Research, Vol 7, Iss 3, Pp 261-

    2012  Volume 267

    Abstract: Lipofuscin results from digestion of photoreceptor outer segments by the retinal pigment epithelium (RPE) and is the principal compound that causes RPE fluorescence during autofluorescence imaging. Absorption of the 488-nanometer blue light by macular ... ...

    Abstract Lipofuscin results from digestion of photoreceptor outer segments by the retinal pigment epithelium (RPE) and is the principal compound that causes RPE fluorescence during autofluorescence imaging. Absorption of the 488-nanometer blue light by macular pigments, especially by the carotenoids lutein and zeaxanthin, causes normal macular hypo-autofluorescence. Fundus autofluorescence imaging is being increasingly employed in ophthalmic practice to diagnose and monitor patients with a variety of retinal disorders. In macular edema for example, areas of hyper-autofluorescence are usually present which are postulated to be due to dispersion of macular pigments by pockets of intraretinal fluid. For this reason, the masking effect of macular pigments is reduced and the natural autofluorescence of lipofuscin can be observed without interference. In cystic types of macular edema, e.g. cystoid macular edema due to retinal vein occlusion, diabetic macular edema and post cataract surgery, hyperautofluorescent regions corresponding to cystic spaces of fluid accumulation can be identified. In addition, the amount of hyper-autofluorescence seems to correspond to the severity of edema. Hence, autofluorescence imaging, as a noninvasive technique, can provide valuable information on cystoid macular edema in terms of diagnosis, followup and efficacy of treatment.
    Keywords Autofluorescence; Cystoid Macular Edema; Lipofuscin ; Medicine ; R ; Ophthalmology ; RE1-994
    Subject code 610
    Publishing date 2012-01-01T00:00:00Z
    Publisher Ophthalmic Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Macular surgery using intraoperative spectral domain optical coherence tomography

    Mohammad Riazi-Esfahani / Mohammad Reza Khademi / Mehdi Mazloumi / Alireza Khodabandeh / Hamid Riazi-Esfahani

    Journal of Ophthalmic & Vision Research, Vol 10, Iss 3, Pp 309-

    2015  Volume 315

    Abstract: Purpose: To report the use of intraoperative spectral domain optical coherence tomography (SD-OCT) for detecting anatomical changes during macular surgery. Methods: In a consecutive case series, 32 eyes of 32 patients undergoing concurrent pars plana ... ...

    Abstract Purpose: To report the use of intraoperative spectral domain optical coherence tomography (SD-OCT) for detecting anatomical changes during macular surgery. Methods: In a consecutive case series, 32 eyes of 32 patients undergoing concurrent pars plana vitrectomy and intraoperative SD-OCT for macular hole (MH), epiretinal membrane (ERM) and vitreomacular traction (VMT) were enrolled. Intraoperative changes in retinal thickness and dimensions of the macular hole were measured in patients with ERM and VMT following surgical manipulation using a hand-held SD-OCT device (iVue, Optovue Inc., Fremont, CA, USA). Results: SD-OCT images of sixteen eyes with macular hole were subjected to quantitative and qualitative analysis. All MH dimensions remained stable during consecutive stages of surgery except for MH apex diameter, which showed a significant decrease after internal limiting membrane (ILM) peeling (P=0.025). Quantitative analysis of ten patients with ERM showed a significant decrease in retinal thickness after membrane removal (P=0.018) which did not remain significant until the end of the procedure (P=0.8). In three cases, subretinal fluid was formed after ILM peeling. Quantitative analysis of five patients with VMT showed a decrease in retinal thickness during consecutive steps of the surgery, although these changes were not significant. In two cases, subretinal fluid was formed after ILM peeling. Conclusion: Intraoperative SD-OCT is a useful imaging technique which provides vitreoretinal surgeons with rapid awareness of changes in macular anatomy during surgery and may therefore result in better anatomical and visual outcomes.
    Keywords Intraoperative Optical Coherence Tomography; Macular Pathology; Macular Surgery ; Medicine ; R ; Ophthalmology ; RE1-994
    Subject code 610
    Publishing date 2015-01-01T00:00:00Z
    Publisher Ophthalmic Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Focal Choroidal Excavation in Best Vitelliform Macular Dystrophy

    Mohammad Riazi Esfahani / Hamid Riazi Esfahani / Alireza Mahmoudi / Mohammad Karim Johari / Karim Hemati

    Journal of Clinical and Diagnostic Research, Vol 9, Iss 5, Pp ND01-ND

    Case Report

    2015  Volume 02

    Abstract: Focal choroidal excavation (FCE) was first reported as a choroidal posteriorly excavated zone without any scleral change. Choroidal excavation also divided into conforming and nonconforming type. Numerous reports demonstrated association between FCE and ... ...

    Abstract Focal choroidal excavation (FCE) was first reported as a choroidal posteriorly excavated zone without any scleral change. Choroidal excavation also divided into conforming and nonconforming type. Numerous reports demonstrated association between FCE and other disease such as choroidal neovascularization and central serous choroidoretinopathy. Here, we report a rare case of FCE in a patient with Best disease. The patient was diagnosed by spectoral domain optical coherence tomography (SD-OCT). To the best of our knowledge, our patient is the second report of choroidal excavation in Best vitelliform macular dystrophy.
    Keywords best dystrophy ; fluorescein angiography ; oct ; Medicine ; R
    Language English
    Publishing date 2015-05-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Choroidal Mapping; a Novel Approach for Evaluating Choroidal Thickness and Volume

    Jila Noori / Mohammad Riazi Esfahani / Fedra Hajizadeh / Mohammad-Mehdi Zaferani

    Journal of Ophthalmic & Vision Research, Vol 7, Iss 2, Pp 180-

    2012  Volume 185

    Abstract: There are a limited number of non-invasive imaging techniques available for assessing the choroid, a structure that may be affected by a variety of retinal disorders or become primarily involved in conditions such as polypoidal choroidal vasculopathy and ...

    Abstract There are a limited number of non-invasive imaging techniques available for assessing the choroid, a structure that may be affected by a variety of retinal disorders or become primarily involved in conditions such as polypoidal choroidal vasculopathy and choroidal tumors. The introduction of enhanced depth imaging optical coherence tomography (EDI-OCT) has provided the advantage of in vivo cross-sectional imaging of the choroid, similar to the retina, with standard commercially available spectraldomain OCT machines. In this article, we review this imaging technique and introduce choroidal mapping as a novel approach for obtaining accurate topographic and volumetric information on the choroid in normal and diseased states.
    Keywords Enhanced Depth Imaging Optical Coherence Tomography; Choroidal Map ; Medicine ; R ; Ophthalmology ; RE1-994
    Publishing date 2012-01-01T00:00:00Z
    Publisher Ophthalmic Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Visual prostheses

    Mohammad Hossein Maghami / Amir Masoud Sodagar / Alireza Lashay / Hamid Riazi-Esfahani / Mohammad Riazi-Esfahani

    Journal of Ophthalmic & Vision Research, Vol 9, Iss 4, Pp 494-

    The enabling technology to give sight to the blind

    2014  Volume 505

    Abstract: Millions of patients are either slowly losing their vision or are already blind due to retinal degenerative diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) or because of accidents or injuries. Employment of ... ...

    Abstract Millions of patients are either slowly losing their vision or are already blind due to retinal degenerative diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) or because of accidents or injuries. Employment of artificial means to treat extreme vision impairment has come closer to reality during the past few decades. Currently, many research groups work towards effective solutions to restore a rudimentary sense of vision to the blind. Aside from the efforts being put on replacing damaged parts of the retina by engineered living tissues or microfabricated photoreceptor arrays, implantable electronic microsystems, referred to as visual prostheses, are also sought as promising solutions to restore vision. From a functional point of view, visual prostheses receive image information from the outside world and deliver them to the natural visual system, enabling the subject to receive a meaningful perception of the image. This paper provides an overview of technical design aspects and clinical test results of visual prostheses, highlights past and recent progress in realizing chronic high-resolution visual implants as well as some technical challenges confronted when trying to enhance the functional quality of such devices.
    Keywords Electrical Stimulation; Medical Implants; Neural Prostheses; Visual Prostheses ; Medicine ; R ; Ophthalmology ; RE1-994
    Subject code 700
    Publishing date 2014-01-01T00:00:00Z
    Publisher Ophthalmic Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Predictive value of pupillary response to mydriatic agents for diagnosis of retinopathy of prematurity

    Ramak Roohipoor / Mohammad Riazi-Esfahani / Nazanin Ebrahimiadib / Reza Karkhaneh / Mohammad Zarei / Sara Besharat / Fariba Ghassemi / Mohammad Reza Ostovaneh

    Journal of Ophthalmic & Vision Research, Vol 10, Iss 4, Pp 417-

    2015  Volume 423

    Abstract: Purpose: To evaluate the feasibility of screening for retinopathy of prematurity (ROP) by assessing the pupillary response to mydriatics. Methods: This observational case series included 134 eyes of 67 premature infants with birth weight less than 2,000 ... ...

    Abstract Purpose: To evaluate the feasibility of screening for retinopathy of prematurity (ROP) by assessing the pupillary response to mydriatics. Methods: This observational case series included 134 eyes of 67 premature infants with birth weight less than 2,000 grams and gestational age less than 33 weeks. A composite eye drop composed of phenylephrine 1%, tetracaine and tropicamide 0.5% was applied 3 times within 5-minute intervals and pupil diameters were measured. The eyes were examined by experienced ROP specialists using an indirect ophthalmoscope. Zone and stage of ROP, presence of plus disease and need for treatment were recorded. The relationship between the pupillary response to mydriatics, and presence and severity of ROP was evaluated. Logistic regression was used for statistical analysis. Results: According to receiver operating characteristic (ROC) curve analysis, final pupil diameter after mydriatic administration was found the most accurate factor among other factors to recognize ROP zone I from zones II and III (Area under ROC: 0.92 [95%CI: 0.85-0.98]). The best cutoff value for final pupil diameter was 5.6 mm, because it could differentiate involvement of zone I from zones II and III with sensitivity of 80% and specificity of 100%. Conclusion: Response of the pupil to mydriatic eye drops may be useful as a less invasive method for rough estimation of ROP in high risk babies who need emergent attention; however, it cannot be considered as a screening test due to its low sensitivity.
    Keywords Mydriatic Eye Drops; Predictive Value; Pupillary Response; Retinopathy of Prematurity; Screening ; Medicine ; R ; Ophthalmology ; RE1-994
    Subject code 610
    Publishing date 2015-01-01T00:00:00Z
    Publisher Ophthalmic Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Design and development of intraocular polymeric implant systems for long-term controlled-release of clindamycin phosphate for toxoplasmic retinochoroiditis

    Lana Tamaddon / S Abolfazl Mostafavi / Reza Karkhane / Mohammad Riazi-Esfahani / Farid Abedin Dorkoosh / Morteza Rafiee-Tehrani

    Advanced Biomedical Research, Vol 4, Iss 1, Pp 32-

    2015  Volume 32

    Abstract: Background: The release of the anti-toxoplasmosis drug, clindamycin phosphate, from intraocular implants of the biodegradable polymers poly (D, L-lactic acid) (PLA) and poly (D, L-lactide-co-glycolide) (PLGA) has been studied in vitro. Materials and ... ...

    Abstract Background: The release of the anti-toxoplasmosis drug, clindamycin phosphate, from intraocular implants of the biodegradable polymers poly (D, L-lactic acid) (PLA) and poly (D, L-lactide-co-glycolide) (PLGA) has been studied in vitro. Materials and Methods: The preparation of the implants was performed by a melt-extrusion method. The developed extrudates were characterized and compared in in-vitro release profiles for elucidating the drug release mechanism. The formulations containing up to 40% w/w of drug were prepared. Release data in phosphate buffer (pH 7.4) were analyzed by high performance liquid chromatography. The release kinetics were fitted to the zero-order, Higuchi′s square-root, first order and the Korsmeyer-Peppas empirical equations for the estimation of various parameters of the drug release curves. Degradation of implants was also investigated morphologically with time (Scanning Electron Microscopy). Results: It was observed that, the release profiles for the formulations exhibit a typical biphasic profile for bulk-eroding systems, characterized by a first phase of burst release (in first 24 hrs), followed by a phase of slower release. The duration of the secondary phase was found to be proportional to the molecular weight and monomer ratio of copolymers and also polymer-to-drug ratios. It was confirmed that Higuchi and first-order kinetics were the predominant release mechanisms than zero order kinetic. The Korsmeyer-Peppas exponent (n) ranged between 0.10 and 0.96. This value, confirmed fickian as the dominant mechanism for PLA formulations (n ≤ 0.45) and the anomalous mechanism, for PLGAs (0.45 < n < 0.90). Conclusion: The implant of PLA (I.V. 0.2) containing 20% w/w of clindamycin, was identified as the optimum formulation in providing continuous efficient in-vitro release of clindamycin for about 5 weeks.
    Keywords Clindamycin phosphate ; intraocular implant ; PLA ; PLGA ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 660
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Photodynamic therapy and intravitreal bevacizumab with versus without triamcinolone for neovascular age-related macular degeneration; a randomized clinical trial

    Niloofar Piri / Hamid Ahmadieh / Ramin Taei / Masoud Soheilian / Reza Karkhaneh / Alireza Lashay / Faegheh Golbafian / Mehdi Yaseri / Mohammad Riazi Esfahani

    Journal of Ophthalmic & Vision Research, Vol 9, Iss 4, Pp 469-

    2014  Volume 477

    Abstract: Purpose: To compare the outcomes of photodynamic therapy (PDT) combined with intravitreal bevacizumab (IVB) with versus without intravitreal triamcinolone (IVT) in neovascular age-related macular degeneration (AMD). Methods: Eighty-four eyes with active ... ...

    Abstract Purpose: To compare the outcomes of photodynamic therapy (PDT) combined with intravitreal bevacizumab (IVB) with versus without intravitreal triamcinolone (IVT) in neovascular age-related macular degeneration (AMD). Methods: Eighty-four eyes with active CNV secondary to AMD with no prior treatment were enrolled and followed for 1-year. Eligible eyes were randomly assigned to either PDT/IVB or PDT/IVB/IVT. The main outcome measure was change in best-corrected visual acuity (BCVA). Results: Mean patient age was 71 ΁ 9 years. BCVA changes from baseline were statistically significant in both study arms at all follow-up intervals, however no significant difference was observed between the two groups regarding BCVA changes at week 12 (95% CI:-0.11-0.12 LogMAR) and other time points (all P > 0.6). Mixed model analysis revealed a significant effect from age (P < 0.001), pigment epithelial detachment (P = 0.009) and baseline BCVA (P < 0.001) on visual improvement. Significant central macular thickness (CMT) reduction occurred at all-time points as compared to baseline in both groups which was comparable between the study arms. There was no significant difference between the study arms in terms of retreatment rate (P = 0.1) and survival to the first repeat IVB injection (P = 0.065). Conclusion: Additional low-dose IVT to a PDT/IVB regimen for neovascular AMD provided no beneficial effects in terms BCVA or CMT, yet demonstrated a trend toward extending the injection-free period.
    Keywords Age-Related Macular Degeneration; Bevacizumab; Choroidal Neovascular Membrane; Combination (Combined) Therapy ; Photodynamic Therapy; Triamcinolone ; Medicine ; R ; Ophthalmology ; RE1-994
    Subject code 616
    Publishing date 2014-01-01T00:00:00Z
    Publisher Ophthalmic Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Optical Coherence Tomographic Findings in Highly Myopic Eyes

    Hooshang Faghihi Faghihi / Fedra Hajizadeh Hajizadeh / Mohammad Riazi-Esfahani Riazi-Esfahani

    Journal of Ophthalmic & Vision Research, Vol 5, Iss 2, Pp 110-

    2010  Volume 121

    Abstract: Optical coherence tomography (OCT) has enhanced our understanding of changes in different ocular layers when axial myopia progresses and the globe is stretched. These findings consist of dehiscence of retinal layers known as retinoschisis, paravascular ... ...

    Abstract Optical coherence tomography (OCT) has enhanced our understanding of changes in different ocular layers when axial myopia progresses and the globe is stretched. These findings consist of dehiscence of retinal layers known as retinoschisis, paravascular inner retinal cleavage, cysts and lamellar holes, peripapillary intrachoroidal cavitation, tractional internal limiting membrane detachment, macular holes (lamellar and full thickness), posterior retinal detachment, and choroidal neovascular membranes. In this review, recent observations regarding retinal changes in highly myopic eyes explored by OCT are described to highlight structural findings that cannot be diagnosed by simple ophthalmoscopy.
    Keywords Optical Coherence Tomography ; OCT; High Myopia ; Medicine ; R ; Ophthalmology ; RE1-994
    Publishing date 2010-01-01T00:00:00Z
    Publisher Ophthalmic Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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