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  1. Article: Vitamin D Effect on Ultrasonography and Laboratory Indices and Biochemical Indicators in the Blood: an Interventional Study on 12 to 18-Year-Old Children with Fatty Liver.

    Namakin, Kokab / Hosseini, Mahya / Zardast, Mahmoud / Mohammadifard, Mahyar

    Pediatric gastroenterology, hepatology & nutrition

    2021  Volume 24, Issue 2, Page(s) 187–196

    Abstract: Purpose: The rising prevalence of childhood obesity in the past decades has caused non-alcoholic fatty liver disease (NAFLD) to become the most common cause of pediatric chronic liver disease worldwide. This study was aimed at determining the effect of ... ...

    Abstract Purpose: The rising prevalence of childhood obesity in the past decades has caused non-alcoholic fatty liver disease (NAFLD) to become the most common cause of pediatric chronic liver disease worldwide. This study was aimed at determining the effect of vitamin D (Vit D) on ultrasonography and laboratory indices of NAFLD and some blood biochemical indicators in children.
    Methods: In this interventional study liver ultrasonography was performed in 200 children with overweight and obesity. A 108 had fatty liver among which 101 were randomly divided into two groups of study (n=51) and control (n=50). The study group was treated with Vit D, 50000 U once a week whereas the control group received placebo with the same dose and package, both for 12 weeks. At the end of the intervention lab tests and ultrasound study was performed once again to evaluate the response to treatment.
    Results: It was found out that Vit D supplementation improved the fatty liver grade in the study group. The mean changes in hemoglobin (Hb), uric acid, highdensity lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), insulin, albumin and alanine aminotransferase (ALT) was significantly higher in the study group compared to controls (
    Conclusion: Vit D supplementation in addition to improving the fatty liver grade in ultrasonography and increasing the blood Vit D level, increases the HDL and Hb level besides decreasing uric acid, LDL, HOMA-IR, insulin and ALT levels.
    Language English
    Publishing date 2021-03-04
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3032413-0
    ISSN 2234-8840 ; 2234-8646
    ISSN (online) 2234-8840
    ISSN 2234-8646
    DOI 10.5223/pghn.2021.24.2.187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Breast cancer screening behavior and its associated factors in female employees in South Khorasan.

    Tahergorabi, Zoya / Mohammadifard, Mahyar / Salmani, Fatemeh / Moodi, Mitra

    Journal of education and health promotion

    2021  Volume 10, Page(s) 102

    Abstract: Background: Breast cancer is a preventable disease, using three secondary preventive methods of mammography, clinical breast examination (CBE), and breast self-examination (BSE) that can lead to early detection of breast cancer. This study was designed ... ...

    Abstract Background: Breast cancer is a preventable disease, using three secondary preventive methods of mammography, clinical breast examination (CBE), and breast self-examination (BSE) that can lead to early detection of breast cancer. This study was designed to assess breast cancer screening behavior and its associated factors in females employed in South Khorasan.
    Materials and methods: In this analytic-descriptive study, 2256 female personnel of governmental organizations were investigated in Birjand city in 2016-2017. The data collection tool was a three-part questionnaire: sociodemographic characteristics, knowledge about breast cancer screening methods plus women's performance, and stage of change regarding screening behaviors of mammography, CBE, and BSE. The data were analyzed by SPSS 16 and one-way analysis variance, Tukey's
    Results: The mean ± standard deviation score of knowledge of the women was 3.45 ± 1.5. There was a significant difference of the mean score of knowledge between the single and married (
    Conclusions: This study reveals insufficient knowledge of female workers about breast cancer and the negative influence of low knowledge on the practice of breast cancer screening behavior. Therefore, the establishment and maintenance of regular educational courses for female employees is essential.
    Language English
    Publishing date 2021-03-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_750_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A review of applying transarterial chemoembolization (TACE) method for management of hepatocellular carcinoma.

    Ghanaati, Hossein / Mohammadifard, Mahyar / Mohammadifard, Mahtab

    Journal of family medicine and primary care

    2021  Volume 10, Issue 10, Page(s) 3553–3560

    Abstract: Liver cancer is one of the most ordinary reasons for death among cancers. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. In spite of the fact that various remedial methods have been approved particularly the survival effects of ... ...

    Abstract Liver cancer is one of the most ordinary reasons for death among cancers. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. In spite of the fact that various remedial methods have been approved particularly the survival effects of the transcatheter arterial chemoembolization (TACE) method have been accomplished widely in the HCC treatment. By applying the TACE method correctly, good survival outcomes can be achieved without harmfully affecting the hepatic functions. Transarterial chemoembolization mixes the effect of avascular necrosis (AVN) with the effect of regional chemotherapy those are under the influence of arterial embolization. By knowing the fact that the metastases of liver cancer and also perfusion indices in hepatocellular carcinoma (HCC) are via hepatic arteries, doctors chose the TACE method for the treatment of liver cancer. On the other hand, in this method, the radiologists can easily convey antitumor remedies via the arteries. Anyway, medium-level HCC is a sensitive stage of the heterogeneous disease that many patients suffer from, so specialists must consider it as a hazardous syndrome. The TACE procedure could be applied just in cases that the liver function of patients is appropriate yet, the patient liver portal vein do not have any problems and the patients do not have ascites disorder. This review is aimed to figure out the evident advantages of TACE especially by a comprehensive view on the medium level HCC. Because of that this treatment method is suggested as a first-line remedy. At last, the future landscape of the initial factors of research in managing HCC disorders have been summarized.
    Language English
    Publishing date 2021-11-05
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_2347_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Relevance between Helicobacter

    Mohammadifard, Mahyar / Saremi, Zeinab / Rastgoo, Mahboobe / Akbari, Ehsan

    Journal of medicine and life

    2019  Volume 12, Issue 2, Page(s) 168–172

    Abstract: There is evidence that infection ... ...

    Abstract There is evidence that infection by
    MeSH term(s) Adult ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Helicobacter Infections/blood ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori/physiology ; Humans ; Iran/epidemiology ; Lipids/blood ; Liver/enzymology ; Liver/pathology ; Male ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Transaminases/metabolism
    Chemical Substances Lipids ; Transaminases (EC 2.6.1.-)
    Language English
    Publishing date 2019-07-16
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2559353-5
    ISSN 1844-3117 ; 1844-3109 ; 1844-122X
    ISSN (online) 1844-3117 ; 1844-3109
    ISSN 1844-122X
    DOI 10.25122/jml-2019-0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Focal Cerebral Arteriopathy in a Pediatric Patient with COVID-19.

    Mirzaee, Seyed Mohammad Mousavi / Gonçalves, Fabrício Guimarães / Mohammadifard, Mahyar / Tavakoli, Shirin Mojgan / Vossough, Arastoo

    Radiology

    2020  Volume 297, Issue 2, Page(s) E274–E275

    MeSH term(s) Betacoronavirus ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/etiology ; COVID-19 ; Cerebral Arterial Diseases/etiology ; Cerebral Arteries/diagnostic imaging ; Child ; Coronavirus Infections/complications ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Stroke/diagnostic imaging ; Stroke/etiology
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2020202197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The role of other imaging modalities in evaluating the tubal patency.

    Mohammadifard, Mahyar / Saburi, Amin

    Journal of human reproductive sciences

    2014  Volume 7, Issue 2, Page(s) 154–155

    Language English
    Publishing date 2014-06-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 2418984-4
    ISSN 1998-4766 ; 0974-1208
    ISSN (online) 1998-4766
    ISSN 0974-1208
    DOI 10.4103/0974-1208.138877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Comparison of mammography and ultrasonography findings with pathology results in patients with breast cancer in Birjand, Iran.

    Haghighi, Fatemeh / Naseh, Ghodratollah / Mohammadifard, Mahyar / Abdollahi, Naeeme

    Electronic physician

    2017  Volume 9, Issue 10, Page(s) 5494–5498

    Abstract: Background: Early diagnosis of breast cancer, the incidence of which among Iranian women is about a decade earlier than in developed countries, is important.: Objective: To compare mammography and ultrasonography findings with those of pathology in ... ...

    Abstract Background: Early diagnosis of breast cancer, the incidence of which among Iranian women is about a decade earlier than in developed countries, is important.
    Objective: To compare mammography and ultrasonography findings with those of pathology in patients with breast cancer.
    Methods: This descriptive cross-sectional study was performed using medical records of 79 patients with breast malignancies, who were referred to Imam Reza Hospital and private laboratories of Birjand, Iran, from December 2012 to December 2014. The patients' information was recorded using a checklist, which included name, code, age, ultrasonography, and mammography results and pathology reports. The results of ultrasonography and mammography were compared with pathology findings as the gold standard. SPSS Version 21 was used for data analysis.
    Results: The mean age of the patients was 46.94 ± 11.76 years. The results showed that 74.7%, 16.5%, and 7.6% of the patients had ductal carcinoma, lobular carcinoma, and mixed carcinoma, respectively. About 72.5%, 24.6%, and 2.9% of the patients had stage 2, 3, and 1 breast cancer, respectively. In addition, both breasts were involved in 1.3% of the patients. The ultrasound findings were positive and false negative in 97.5% and 2.5% of the cases. Moreover, the mammography results were positive and false negative in 98.7% and 1.3% of the patients.
    Conclusion: This study showed that mammography is the preferred modality in screening breast cancer patients; the use of complementary tests such as ultrasonography is recommended, especially in high-risk women.
    Language English
    Publishing date 2017-10-25
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2524187-4
    ISSN 2008-5842
    ISSN 2008-5842
    DOI 10.19082/5494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Marshall and Rotterdam Computed Tomography scores in predicting early deaths after brain trauma.

    Mohammadifard, Mahyar / Ghaemi, Kazem / Hanif, Hamed / Sharifzadeh, Gholamreza / Haghparast, Marzieh

    European journal of translational myology

    2018  Volume 28, Issue 3, Page(s) 7542

    Abstract: Trauma is one of the most important issues of most healthcare systems accompanying with head trauma in the most cases. We sought to determine the scoring system and initial Computed Tomography (CT) findings predicting the death at hospital discharge ( ... ...

    Abstract Trauma is one of the most important issues of most healthcare systems accompanying with head trauma in the most cases. We sought to determine the scoring system and initial Computed Tomography (CT) findings predicting the death at hospital discharge (early death) in patients with traumatic brain injury based on Marshall and Rotterdam CT scores. This is a cross sectional study on traumatic neurosurgical patients with mild-to-severe traumatic brain injury admitted to the emergency department of Emam Reza Hospital, Birjand University of Medical Sciences. Patients≥18 years old with TBI during last 24 hours with GCS≤13 were included and exclusion criteria were multiple trauma, penetrating injuries, previous history of anticoagulant therapy, pregnancy, not willingness for participation. Their initial CT and status at hospital discharge, one and three months (dead or alive) were reviewed, and both CT scores were calculated. We examined whether each score is related to death using SPSS11 by The Mann-Whitney U at the level of p≤0.05. Overall, 98 patients were included. Mean age was 43.52±21.29. Most patients were male (63.3%). Mean Marshall and Rotterdam CT scores were 3.2±1.3 and 2.5±1. The mortality at two weeks, one moth and three months were 19.4%, 20.4%, and 20.4%. Rotterdam CT score was significantly different based on type of hematoma. Median GCS score in alive and dead patients on 2 weeks were 10 and 4 (p=0.0001), at one month were 10 and 4 (p=0.0001), and at three months were 10 and 4 (p=0.0001). The median Marshall CT score on 2 weeks were 2 and 4 (p=0.0001), at one month were 2 and 4 (p=0.0001), and at three months were 2 and 4 (p=0.0001). The median Rotterdam CT score on 2 weeks were 2 and 4 (p=0.0001), at one month were 2 and 3 (p=0.001), and at three months were 2 and 3 (p=0.001). The Rotterdam CT score was significantly correlated with mortality at two weeks, one month and three months (p=0.004, p=0.001, and p=0.001, respectively). The Marshall CT score was not significantly correlated with mortality at any time. The Rotterdam CT score was more accurate for prediction of mortality on 2 weeks (ROC80.9), at one month (ROC80.7), and at three months were (ROC80.7) than The Rotterdam CT score (ROC 76, 74.1, and 74.1, respectively). This study concluded that The Marshall CT score was more accurate for prediction of mortality on 2 weeks, at one month, and at three months were than The Marshall CT score with higher ROC. The correlation of the Rotterdam CT score with mortality was significant.
    Language English
    Publishing date 2018-07-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2545577-1
    ISSN 2037-7460 ; 2037-7452
    ISSN (online) 2037-7460
    ISSN 2037-7452
    DOI 10.4081/ejtm.2018.7542
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  9. Article ; Online: Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer.

    Naseh, Ghodratolah / Mohammadifard, Mahyar / Mohammadifard, Mahtab

    IUBMB life

    2016  Volume 68, Issue 10, Page(s) 799–805

    Abstract: The aim of this study was to evaluate the protein and mRNA expressions of matrix metalloproteinase-14 (MMP14) and CDK7 in gastric cancer (GC) tissues. Upregulation of MMP14 mRNA level was observed in GC tissues when compared with the matched normal ... ...

    Abstract The aim of this study was to evaluate the protein and mRNA expressions of matrix metalloproteinase-14 (MMP14) and CDK7 in gastric cancer (GC) tissues. Upregulation of MMP14 mRNA level was observed in GC tissues when compared with the matched normal tissues (mean ± SD: 3.92 ± 1.15 vs. 1.35 ± 0.81, P < 0.001). This study indicated that mRNA levels of CDK7 were statistically overexpressed in GC when compared with matched normal tissues (4.12 ± 0.84 vs. 1.43 ± 0.71, P < 0.001). The protein levels of MMP14 were found to be increased in GC (60.41%; P < 0.001). The expression of CDK7 was higher in GC tissues than matched normal tissues (70.83; P < 0.001). We found that high MMP14 expression was related to advanced TNM stage (P = 0.004), tumor grade (P = 0.002), and lymph node metastasis (P = 0.015), but no association with other clinical variables (P > 0.05). In addition, high expression of CDK7 was significantly linked to advanced TNM stage (P = 0.001), pathological grade (P = 0.012), and presence of lymph node metastasis (P = 0.009), while no correlation between CDK7 expression and other clinical variables, such as age and gender, distance metastasis. The patients with high expression of MMP14 and CDK7 exhibited worse survival time than those with higher levels. Cox multivariate regression analysis clearly showed that high expression of MMP14 and CDK7 was independent prognostic factors for overall survival in patients with GC. Taken together, these results indicated the overexpression of above markers in the progression and the tumorigenesis of GC and overall patient survival. © 2016 IUBMB Life, 68(10):799-805, 2016.
    MeSH term(s) Aged ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Female ; Gene Expression ; Humans ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Matrix Metalloproteinase 14/genetics ; Matrix Metalloproteinase 14/metabolism ; Middle Aged ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Stomach Neoplasms/enzymology ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Up-Regulation
    Chemical Substances Cyclin-Dependent Kinases (EC 2.7.11.22) ; cyclin-dependent kinase-activating kinase (EC 2.7.11.22) ; MMP14 protein, human (EC 3.4.24.80) ; Matrix Metalloproteinase 14 (EC 3.4.24.80)
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.1543
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  10. Article: Comparison of the sonographic findings in laparoscopic cholecystostomy with and without hemostatic agent on 45-day follow-up of patients attending hospital.

    Mohammadifard, Mahyar / Naseh, Ghodratollah / Oskooi, Rozita Khatamian / Sharifzadeh, Gholamreza / Eshraghi, Samira

    Journal of family medicine and primary care

    2019  Volume 8, Issue 5, Page(s) 1678–1684

    Abstract: Introduction: Cholelithiasis is one of the most prevalent pathological conditions, and elective laparoscopic cholecystostomy with and without hemostatic agent (HA) is the therapeutic approach to its treatment. This research study aimed to compare the ... ...

    Abstract Introduction: Cholelithiasis is one of the most prevalent pathological conditions, and elective laparoscopic cholecystostomy with and without hemostatic agent (HA) is the therapeutic approach to its treatment. This research study aimed to compare the sonographic findings of patients who underwent cholecystostomy with and without HA use.
    Materials and methods: This cross-sectional, descriptive-analysis study was conducted by available nonprobability sampling technique, and according to Cochran Formula, 144 patients, who underwent laparoscopic cholecystostomy, were recruited and divided into two groups including a group of 85 patients with HA use and a group of 59 patients without HA use. Patients in each group had sonography on discharge date and 15, 30, and 45 days after the surgery. Data were collected and entered in SPSS-24 software; meanwhile, descriptive statistics was used to analyze Chi-square test, Fisher's exact test, and Friedman and Wilcoxon nonparametric test.
    Findings: The results of the study showed that the presence of echogenic mass with reverberation artifact (abscess mucosa) on 15- and 30-day follow-up sonography of patients, who underwent laparoscopic cholecystostomy, were significantly higher in patients with HA than in the group without HA (
    Conclusion: These findings might be the indication of HA agents' effect on surgical operations and their resemblance to abscess. Due to the possibility of temporary immune responses to HA, as an external object, it is necessary, in vital pathologies, to pay close attention to what differentiates the normal imaging appearance in follow-up sonography.
    Language English
    Publishing date 2019-06-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_92_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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