Article ; Online: Coronavirus disease 2019 vaccine in pediatric post-kidney transplantation.
2023 Volume 37, Issue 6, Page(s) e14983
Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and the resulting disease, coronavirus disease 2019 (COVID-19), have spread to millions of persons worldwide. Many vaccines have been developed; however, their efficacy ... ...
| Abstract | Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and the resulting disease, coronavirus disease 2019 (COVID-19), have spread to millions of persons worldwide. Many vaccines have been developed; however, their efficacy in pediatric solid organ transplant recipients is yet to be determined. Methods: This is a prospective observational, non-interventional single-center study on the safety and efficacy of a COVID-19 vaccine (BNT162b2) in pediatric kidney transplant recipients. The primary aim of this study was to evaluate immunogenicity according to SARS-CoV-2-specific neutralizing antibody titer after two vaccine doses. The secondary aims were to investigate the safety of the vaccines, solicited local and systemic adverse reactions, incidence of COVID-19 post-vaccination, and effects on transplant graft function. Baseline investigations were conducted on pediatric renal transplant recipients, and recruited participants were advised to have the Comirnaty® mRNA vaccine according to protocol. Results: A total of 48 patients (male, n = 31, 64.6%; female, n = 17, 35.4%), median age 14 [12-16] years were included, and all received two doses of the vaccine. The vaccine had a favorable safety and side-effect profile. The S-antibody titer of all patients ranged between .4 and 2,500 U/ml and was > 50 U/ml in 89% of the patients. No difference in the measured antibody immune response was noted between infected and uninfected children. No major side effects were reported. Conclusion: The vaccine had a favorable safety profile in 12- to 15-year-old kidney transplant recipients, producing a greater measured antibody response than that in older transplant recipients. |
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| MeSH term(s) | Adolescent ; Child ; Female ; Humans ; Male ; Antibodies, Viral ; BNT162 Vaccine/adverse effects ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Kidney Transplantation ; SARS-CoV-2 ; Transplant Recipients |
| Chemical Substances | Antibodies, Viral ; BNT162 Vaccine ; COVID-19 Vaccines |
| Language | English |
| Publishing date | 2023-04-07 |
| Publishing country | Denmark |
| Document type | Observational Study ; Journal Article |
| ZDB-ID | 639001-8 |
| ISSN | 1399-0012 ; 0902-0063 |
| ISSN (online) | 1399-0012 |
| ISSN | 0902-0063 |
| DOI | 10.1111/ctr.14983 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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