Article ; Online: Synthesis, characterization, and radiosynthesis of fluorine-18-AVT-011 as a Pgp chemoresistance imaging marker.
2022 Volume 12, Issue 1, Page(s) 18584
Abstract: P-glycoprotein (Pgp) is the most studied ATP-binding cassette (ABC) efflux transporter and contributes to chemoresistance. A few tracers have been developed to detect the in-vivo status of chemoresistance using positron emission tomography (PET) imaging. ...
Abstract | P-glycoprotein (Pgp) is the most studied ATP-binding cassette (ABC) efflux transporter and contributes to chemoresistance. A few tracers have been developed to detect the in-vivo status of chemoresistance using positron emission tomography (PET) imaging. In our study, we have synthesized labeled AVT-011 with fluorine-18 ( |
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MeSH term(s) | Animals ; Mice ; Positron Emission Tomography Computed Tomography ; Tissue Distribution ; Drug Resistance, Neoplasm ; Fluorine Radioisotopes/chemistry ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; ATP-Binding Cassette Transporters/metabolism |
Chemical Substances | Fluorine-18 (GZ5I74KB8G) ; Fluorine Radioisotopes ; Radiopharmaceuticals ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; ATP-Binding Cassette Transporters |
Language | English |
Publishing date | 2022-11-03 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2615211-3 |
ISSN | 2045-2322 ; 2045-2322 |
ISSN (online) | 2045-2322 |
ISSN | 2045-2322 |
DOI | 10.1038/s41598-022-22930-6 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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