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  1. Article ; Online: Heart Brake: An Unusual Cardiac Manifestation of COVID-19.

    Kir, Devika / Mohan, Chaitra / Sancassani, Rhea

    JACC. Case reports

    2020  Volume 2, Issue 9, Page(s) 1252–1255

    Abstract: A 49-year-old man presented with worsening high-grade fevers, dry cough, and shortness of breath. He tested positive for severe acute respiratory syndrome-coronavirus-2 and was noted to have bradycardia with intermittent high-degree atrioventricular ... ...

    Abstract A 49-year-old man presented with worsening high-grade fevers, dry cough, and shortness of breath. He tested positive for severe acute respiratory syndrome-coronavirus-2 and was noted to have bradycardia with intermittent high-degree atrioventricular block. However, cardiac biomarkers and echocardiographic findings were normal, thus making this an unusual and interesting manifestation of myocardial involvement of this novel coronavirus. (
    Keywords covid19
    Language English
    Publishing date 2020-05-03
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2020.04.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: HEART BRAKE-An unusual cardiac manifestation of Coronavirus disease 2019 (COVID-19)

    Kir, Devika / Mohan, Chaitra / Sancassani, Rhea

    Abstract: A 49-year-old male presented with worsening high-grade fevers, dry cough and shortness of breath, tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and was noted to have bradycardia with intermittent high-degree AV block. ... ...

    Abstract A 49-year-old male presented with worsening high-grade fevers, dry cough and shortness of breath, tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and was noted to have bradycardia with intermittent high-degree AV block. However, cardiac biomarkers and echocardiography were normal, making this an unusual and interesting manifestation showing myocardial involvement of this novel coronavirus.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #154905
    Database COVID19

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  3. Article ; Online: PCSK9 inhibition: A promise fulfilled?

    White, Khendi / Mohan, Chaitra / Rocco, Michael

    Cleveland Clinic journal of medicine

    2016  Volume 83, Issue 11 Suppl 2, Page(s) S36–S44

    Abstract: The association of reduced proprotein convertase subtilisin/kexin type 9 (PCSK9) activity with reduced cardiovascular disease (CVD) events--and the need for add-ons to statin therapy to achieve treatment goals--has led to the rapid development and US ... ...

    Abstract The association of reduced proprotein convertase subtilisin/kexin type 9 (PCSK9) activity with reduced cardiovascular disease (CVD) events--and the need for add-ons to statin therapy to achieve treatment goals--has led to the rapid development and US Food and Drug Administration (FDA) approval of monoclonal antibody therapies to inhibit PCSK9. Now that PCSK9 inhibitors are approved by the FDA for use in certain patients, data from ongoing long-term clinical trials addressing tolerability, safety, and proof of additional reduction in CVD events are eagerly awaited.
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.83.s2.05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A 14-year-old female with difficulty swallowing.

    Mohan, Chaitra / Riedel, Brian D / Nield, Linda S

    Pediatric annals

    2015  Volume 44, Issue 1, Page(s) 22–25

    MeSH term(s) Adolescent ; Barium ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Endoscopy, Digestive System ; Esophageal Achalasia/diagnosis ; Esophageal Achalasia/surgery ; Esophagus/pathology ; Esophagus/surgery ; Female ; Fundoplication ; Humans ; Manometry
    Chemical Substances Barium (24GP945V5T)
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/00904481-20151226-05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Predictors of permanent pacemaker requirement after cardiac surgery for infective endocarditis.

    Hill, Terence E / Kiehl, Erich L / Shrestha, Nabin K / Gordon, Steven M / Pettersson, Gosta B / Mohan, Chaitra / Hussein, Ayman / Hussain, Syed / Wazni, Oussama / Wilkoff, Bruce L / Menon, Venu / Tarakji, Khaldoun G

    European heart journal. Acute cardiovascular care

    2021  Volume 10, Issue 3, Page(s) 329–334

    Abstract: Background: Infectious endocarditis is often complicated by conduction abnormalities at the time of presentation. Cardiac surgery is the treatment of choice for many infectious endocarditis patients, but carries an additional risk of persistent ... ...

    Abstract Background: Infectious endocarditis is often complicated by conduction abnormalities at the time of presentation. Cardiac surgery is the treatment of choice for many infectious endocarditis patients, but carries an additional risk of persistent postoperative conduction abnormality. We sought to define the incidence and clinical predictors of significant postoperative conduction abnormalities necessitating permanent pacemaker implantation after cardiac surgery for infectious endocarditis.
    Methods: All consecutive patients with infectious endocarditis who were surgically treated at Cleveland Clinic from 2007 to 2013 were identified using the Cleveland Clinic Infective Endocarditis Registry and the Cardiovascular Information Registry. Patients with a pre-existing cardiac implantable electronic device were excluded. The primary outcome was the need for permanent pacemaker placement postoperatively for atrioventricular block. Regression analysis was performed to identify risk factors for permanent pacemaker requirement.
    Results: Among 444 infectious endocarditis patients who underwent cardiac surgery for infectious endocarditis, 57 (13%) required postoperative permanent pacemaker for atrioventricular block. Multivariable analysis identified that prolongation in preoperative PR and QRS intervals, Staphylococcus aureus as the infectious endocarditis organism, the presence of intracardiac abscess, tricuspid valve involvement, and prior valvular surgery independently predicted postoperative permanent pacemaker placement. The developed model exhibited excellent predictive ability (c-statistic 0.88) and calibration.
    Conclusion: Infectious endocarditis cardiac surgery patients often require a postoperative permanent pacemaker. Preoperative conduction abnormality, S. aureus infection, abscess, tricuspid valve involvement, and prior valvular surgery are strong predictors of postoperative permanent pacemaker placement.
    MeSH term(s) Cardiac Surgical Procedures/adverse effects ; Endocarditis/diagnosis ; Endocarditis/epidemiology ; Endocarditis/surgery ; Humans ; Pacemaker, Artificial ; Retrospective Studies ; Risk Factors ; Staphylococcus aureus ; Treatment Outcome
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1177/2048872619848661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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