LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 13

Search options

  1. Article: Machine Learning in the Detection of Oral Lesions With Clinical Intraoral Images.

    Y, Dinesh / Ramalingam, Karthikeyan / Ramani, Pratibha / Mohan Deepak, Ramya

    Cureus

    2023  Volume 15, Issue 8, Page(s) e44018

    Abstract: Introduction: Artificial intelligence in oncology has gained a lot of interest in recent years. Early detection of Oral squamous cell carcinoma (OSCC) is crucial for early management to attain a better prognosis and overall survival. Machine learning ( ... ...

    Abstract Introduction: Artificial intelligence in oncology has gained a lot of interest in recent years. Early detection of Oral squamous cell carcinoma (OSCC) is crucial for early management to attain a better prognosis and overall survival. Machine learning (ML) has also been used in oral cancer studies to explore the discrimination between clinically normal and oral cancer.
    Materials and methods: A dataset comprising 360 clinical intra-oral images of OSCC, Oral Potentially Malignant Disorders (OPMDs) and clinically healthy oral mucosa were used. Clinicians trained the machine learning model with the clinical images (n=300). Roboflow software (Roboflow Inc, USA) was used to classify and annotate images along with Multi-class annotation and object detection models trained by two expert oral pathologists. The test dataset (n=60) of new clinical images was again evaluated by two clinicians and Roboflow. The results were tabulated and Kappa statistics was performed using SPSS v23.0 (IBM Corp., Armonk, NY).  Results: Training dataset clinical images (n=300) were used to train the clinicians and Roboflow algorithm. The test dataset (n=60) of new clinical images was again evaluated by the clinicians and Roboflow. The observed outcomes revealed that the Mean Average Precision (mAP) was 25.4%, precision 29.8% and Recall 32.9%. Based on the kappa statistical analysis the 0.7 value shows a moderate agreement between the clinicians and the machine learning model. The test dataset showed the specificity and sensitivity of the Roboflow machine learning model to be 75% and 88.9% respectively.  Conclusion: In conclusion, machine learning showed promising results in the early detection of suspected lesions using clinical intraoral images and aids general dentists and patients in the detection of suspected lesions such as OPMDs and OSCC that require biopsy and immediate treatment.
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.44018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: It's the data, stupid: Inflection point for Artificial Intelligence in Indian healthcare.

    Ramaswamy, Anjali / R Gowda, Naveen / Vikas, H / Prabhu, Meghana / Sharma, D K / Gowda, Praveen R / Mohan, Deepak / Kumar, Atul

    Artificial intelligence in medicine

    2022  Volume 128, Page(s) 102300

    Abstract: Indian healthcare is fast growing and with significant chunk of it being in small, fragmented, informal sector; Artificial Intelligence (AI) is pegged as a magical tool for a better healthcare system. There is an inclination to merely mimic the US ... ...

    Abstract Indian healthcare is fast growing and with significant chunk of it being in small, fragmented, informal sector; Artificial Intelligence (AI) is pegged as a magical tool for a better healthcare system. There is an inclination to merely mimic the US approach in the on-going policy making and legislative exercises, which can have serious fallouts for Indian healthcare. India needs a different approach to suite her unique requirements. In this regard, each of the five stages in AI development lifecycle has been analyzed in the light of current on-ground realities. These boil down to three fold challenges of how to increase adoption of digital health, prevent data silos and create maximum value from data. Availability of quality data for value addition without barriers and restrictions is the common denominator for leveraging the full potential of AI. This requires liberal policies enabling secondary use of data in developing countries with rapidly growing healthcare sector akin to India. This has to be carefully balanced with data privacy and security. Restrictive healthcare data policies and laws can slow down adoption of digitization, perpetuate status-quo, be biased towards the incumbent players, cause Industry stagnation and thus will do more harm than good. It is therefore the data policies that will make or break AI in Indian healthcare.
    MeSH term(s) Artificial Intelligence ; Delivery of Health Care ; India
    Language English
    Publishing date 2022-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 645179-2
    ISSN 1873-2860 ; 0933-3657
    ISSN (online) 1873-2860
    ISSN 0933-3657
    DOI 10.1016/j.artmed.2022.102300
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Prosthetic management of posttraumatic external auditory canal atresia: A rare cause of conductive hearing loss.

    Adhershitha, A R / Anilkumar, S / Rajesh, C / Mohan, Deepak C

    Journal of Indian Prosthodontic Society

    2016  Volume 16, Issue 4, Page(s) 390–394

    Abstract: Acquired external auditory canal (EAC) atresia is an infrequent entity which can originate from a number of different causes including trauma, infection, neoplasia, inflammation, and radiotherapy. Posttraumatic atresias are exceptionally rare, only 10% ... ...

    Abstract Acquired external auditory canal (EAC) atresia is an infrequent entity which can originate from a number of different causes including trauma, infection, neoplasia, inflammation, and radiotherapy. Posttraumatic atresias are exceptionally rare, only 10% of atresias are attributed to trauma in most of the series. The management of stenosis of the EAC is challenging as it is associated with residual hearing loss and late recurrence. Traditional stents often occlude the EAC, resulting in a temporary conductive hearing loss. This case report describes the technique of fabrication of a wide-bored acrylic stent which attained additional retention from the folds of the auricle. The customized earmold stent effectively prevented restenosis, while the large bore provided ventilation and improved hearing subjectively during the stenting period.
    Language English
    Publishing date 2016-10-03
    Publishing country India
    Document type Case Reports
    ISSN 0972-4052
    ISSN 0972-4052
    DOI 10.4103/0972-4052.167949
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Metastatic well-differentiated neuroendocrine carcinoma of the pancreas: case report and review of literature.

    Martin, Mersadies R / Malik, Umer F / Mohan, Deepak / Mahmoud, Ahmed

    Cases journal

    2009  Volume 2, Page(s) 8973

    Language English
    Publishing date 2009-09-01
    Publishing country England
    Document type Case Reports
    ZDB-ID 2431132-7
    ISSN 1757-1626 ; 1757-1626
    ISSN (online) 1757-1626
    ISSN 1757-1626
    DOI 10.4076/1757-1626-2-8973
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Synchronous sentinel lymph node metastasis of lobular and ductal carcinoma.

    Mohan, Deepak / Mullin, Brian R / Dabbs, David J

    Archives of pathology & laboratory medicine

    2004  Volume 128, Issue 3, Page(s) 365

    MeSH term(s) Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/diagnosis ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/secondary ; Carcinoma, Lobular/diagnosis ; Carcinoma, Lobular/pathology ; Carcinoma, Lobular/secondary ; Female ; Humans ; Lymphatic Metastasis ; Middle Aged ; Sentinel Lymph Node Biopsy
    Language English
    Publishing date 2004-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/2004-128-365-SSLNMO
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Epidermoid metaplasia of the cervix.

    Ionescu, Diana N / Mohan, Deepak / Carter, Gloria / Dabbs, David J

    Archives of pathology & laboratory medicine

    2004  Volume 128, Issue 9, Page(s) 1052–1053

    MeSH term(s) Adult ; Cervix Uteri/embryology ; Cervix Uteri/pathology ; Epithelium/pathology ; Female ; Humans ; Metaplasia
    Language English
    Publishing date 2004-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/2004-128-1052-EMOTC
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases.

    Esposito, Nicole Nicosia / Mohan, Deepak / Brufsky, Adam / Lin, Yan / Kapali, Malathy / Dabbs, David J

    Archives of pathology & laboratory medicine

    2006  Volume 130, Issue 10, Page(s) 1516–1521

    Abstract: Context: Phyllodes tumors (PTs) of the breast are biphasic neoplasms composed of epithelium and a spindle-cell stroma. Currently, PTs are classified as benign, borderline, or malignant based on histopathologic features. However, histologic ... ...

    Abstract Context: Phyllodes tumors (PTs) of the breast are biphasic neoplasms composed of epithelium and a spindle-cell stroma. Currently, PTs are classified as benign, borderline, or malignant based on histopathologic features. However, histologic classification does not always predict outcome. Objective.-To determine the prognostic value of a variety of clinicopathologic features and immunoreactivities in PTs.
    Design: Sixteen benign, 8 borderline, and 6 malignant PTs with follow-up were examined for reactivity across a panel of immunohistochemical stains, including c-Kit, endothelin 1, p16, p21, p53, and Ki-67. Clinicopathologic features, including stromal cellularity, mitotic rate, and margin status, were also assessed. Tumor variables were compared among tumor subgroups and between tumors that did and did not recur.
    Results: Of the 30 PTs, 4 recurred (1 benign, 2 borderline, 1 malignant). One patient with a malignant tumor died of metastatic disease 34 months after initial diagnosis. The overall positive rate of c-Kit immunoreactivity was 13% in benign, 63% in borderline, and 67% in malignant PTs. Endothelin 1 epithelial cytoplasmic staining was seen in 100% of benign, 50% of borderline, and 17% of malignant PTs. Additionally, p16, p21, p53, and Ki-67 were differentially expressed among benign, borderline, and malignant tumors. Positive surgical resection margins was the only variable that significantly predicted recurrent disease (P = .02).
    Conclusions: Stromal c-Kit positivity and epithelial endothelin 1 negativity are more often associated with malignant PTs; however, only positive margin status is significantly associated with tumor behavior.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Disease Progression ; Endothelin-1/metabolism ; Epithelium/metabolism ; Female ; Humans ; Immunohistochemistry/methods ; Ki-67 Antigen/metabolism ; Mastectomy ; Mastectomy, Segmental ; Middle Aged ; Neoplasm Recurrence, Local ; Phyllodes Tumor/metabolism ; Phyllodes Tumor/pathology ; Phyllodes Tumor/surgery ; Prognosis ; Proto-Oncogene Proteins c-kit/metabolism ; Staining and Labeling ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances Biomarkers, Tumor ; Endothelin-1 ; Ki-67 Antigen ; Tumor Suppressor Protein p53 ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2006-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/2006-130-1516-PTACAI
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Serum phosphate and lactate vary with FSH in an early postmenopausal population.

    Virji, Mohamed A / Mohan, Deepak / Borysenko, Christopher W / Trucco, Giuliana / Blair, Harry C

    Clinical biochemistry

    2006  Volume 39, Issue 12, Page(s) 1164–1167

    Abstract: Objective: We examined serum in recent postmenopausal women to determine the relationship of menopausal status, as FSH level, to serum acid-base balance.: Design, setting, and patients: Serum electrolytes of 58 women, aged 53-58, were measured ... ...

    Abstract Objective: We examined serum in recent postmenopausal women to determine the relationship of menopausal status, as FSH level, to serum acid-base balance.
    Design, setting, and patients: Serum electrolytes of 58 women, aged 53-58, were measured relative to serum FSH. The subjects were over one year since the last menstrual period and were from an academic practice setting.
    Results: In women with FSH <35 IU/L (n=20, mean 16.6 IU/L, SD 6.8), phosphate and lactate were reduced relative to women with FSH >35 IU/L (n=38, mean 84.8 IU/L, SD 34.5). No other major anions showed significant differences. Both groups were analyzed by mass spectroscopy for fatty acids and anionic metabolic intermediates. Lactate was the predominant anion in the organic group but accounted for only about 10% of the FSH-responsive anion change. This change was mainly due to a 0.1-mM increase in phosphate in the high FSH group.
    Conclusions: There is a direct correlation of early postmenopausal FSH to increasing serum phosphate. Changes in phosphorus may reflect differences in the rate of bone loss.
    MeSH term(s) Calcium/blood ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Lactic Acid/blood ; Middle Aged ; Phosphates/blood ; Postmenopause/blood
    Chemical Substances Phosphates ; Lactic Acid (33X04XA5AT) ; Follicle Stimulating Hormone (9002-68-0) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2006-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 390372-2
    ISSN 0009-9120
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2006.08.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Microdissection-based genotyping assists discrimination of reactive gliosis from glioma.

    Finkelstein, Sydney D / Mohan, Deepak / Hamilton, Ronald L / Sasatomi, Eizaburo / Swalsky, Patricia A / Lieberman, Frank S

    American journal of clinical pathology

    2004  Volume 121, Issue 5, Page(s) 671–678

    Abstract: We used molecular anatomic pathology to determine the mutational status (loss of heterozygosity [LOH]) to make the distinction between reactive gliosis and glial neoplasia. LOH has been shown to be absent in reactive states and present in neoplastic ... ...

    Abstract We used molecular anatomic pathology to determine the mutational status (loss of heterozygosity [LOH]) to make the distinction between reactive gliosis and glial neoplasia. LOH has been shown to be absent in reactive states and present in neoplastic cellular proliferations. Three groups of patient specimens were analyzed: group 1, reactive gliosis (n = 15); group 2, gliomas of varying histologic type and grade (n = 54); group 3, diagnostically challenging reactive gliosis vs glioma (n = 16). No group 1 cases (0/15 [0%]) showed allelic loss, whereas all high-grade glial neoplasms, a subset of group 2 (35/35 [100%]) manifested at least 1 allelic loss alteration, with most cases (33/35 [94%]) displaying 2 or more such changes. During a look forward at the group 3 patients, clinical history clarified the problematic diagnosis in a subset of 11 patients: 8 (73%) of 11 clinical outcomes were predicted correctly by our analysis. The molecular anatomic pathology approach outlined herein is designed for minute, formalin-fixed, paraffin-embedded specimens, which are encountered in everyday surgical pathology practice. Molecular anatomic pathology opens the possibilities of molecular analysis to everyday pathology practice.
    MeSH term(s) Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; DNA Mutational Analysis ; DNA, Neoplasm/analysis ; Diagnosis, Differential ; Genotype ; Glioma/genetics ; Glioma/pathology ; Gliosis/genetics ; Gliosis/pathology ; Humans ; Loss of Heterozygosity ; Microdissection ; Microsatellite Repeats/genetics ; Polymerase Chain Reaction ; Retrospective Studies
    Chemical Substances DNA, Neoplasm
    Language English
    Publishing date 2004-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1309/WF2H-L03T-7YP7-13NK
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Microdissection genotyping of mixed glial and primitive neuroectodermal central nervous system neoplasm.

    Mohan, Deepak / Rao, Gutti R / Swalsky, Patricia A / Bakker, Anke / Martinez, A Julio / Finkelstein, Sydney D

    Archives of pathology & laboratory medicine

    2004  Volume 128, Issue 10, Page(s) 1161–1164

    Abstract: A 22-year-old man with previous radiation treatment for childhood astrocytoma underwent resection of a right parietooccipital lesion. Histopathology revealed a malignant neoplasm with areas of astrocytic and primitive neuroectodermal components. To ... ...

    Abstract A 22-year-old man with previous radiation treatment for childhood astrocytoma underwent resection of a right parietooccipital lesion. Histopathology revealed a malignant neoplasm with areas of astrocytic and primitive neuroectodermal components. To resolve the relationship and cellular origin, representative tissue was microdissected from several targets, obtaining a balanced mixture of each element. Nonneoplastic brain parenchyma was separately microdissected to determine polymorphic marker informativeness and to serve as an internal negative control. Despite the relatively small quantity of tissue removed for each microdissection target, sufficient material was available for reliable, balanced, polymerase chain reaction-format genotyping encompassing a panel of tumor suppressor genes and genetic loci associated with these forms of neoplasia. The findings revealed distinct discordant genotypic profiles for each of the neoplastic components. The efficacy of the approach used for molecular analysis of this complex neoplasm and the implication of the genotypic findings are discussed.
    MeSH term(s) Adult ; Astrocytes/pathology ; Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Brain Neoplasms/surgery ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/genetics ; Central Nervous System Neoplasms/surgery ; Diagnosis, Differential ; Genotype ; Glioma/diagnosis ; Glioma/genetics ; Glioma/surgery ; Humans ; Male ; Microdissection/methods ; Mixed Tumor, Malignant/diagnosis ; Mixed Tumor, Malignant/genetics ; Mixed Tumor, Malignant/surgery ; Neuroectodermal Tumors, Primitive/diagnosis ; Neuroectodermal Tumors, Primitive/genetics ; Neuroectodermal Tumors, Primitive/surgery
    Language English
    Publishing date 2004-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/2004-128-1161-MGOMGA
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top