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Article: Opioid: Plenitude versus pittance.

Mohanti, Bidhu Kalyan

2023 Volume 35, Issue 5, Page(s) 303–307

Abstract: The opioid crisis in the USA and in other developed countries can potentially affect low- and middle-income countries (LMICs). The licit medical use of opioids has two sides. The USA and high-income countries maintain abundant supply for medical ... ...

Abstract	The opioid crisis in the USA and in other developed countries can potentially affect low- and middle-income countries (LMICs). The licit medical use of opioids has two sides. The USA and high-income countries maintain abundant supply for medical prescription. Between 1990 and 2010, the use of opioids for cancer pain relief was overtaken by a dramatic rise in the opioid prescriptions for non-cancer acute or chronic pain. The surge led to the opioid epidemic, recognized as social catastrophe in the USA, Canada and in some countries in Europe. From 2016, the medical community, health policy regulators and law-makers have taken actions to tackle this opioid crisis. On the other side, formulary deficiency and low opioid availability exists for three-fourths of the global population living in LMICs. Physicians and nurses in Asia and Africa engaged in cancer pain relief and palliative care face a constant paucity of opioids. Millions of patients in LMICs, suffering from life-modifying cancer pain, do not have access to morphine and other essential opioids, due to restrictive opioid policies. Attention will be needed to improve opioid availability in large parts of the world, even though the opioid crisis has led to control the licit medical use in the USA.
MeSH term(s)	Humans ; Analgesics, Opioid/adverse effects ; Pain/epidemiology ; Cancer Pain ; Palliative Care ; Pain Management
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2023-05-11
Publishing country	India
Document type	Journal Article
ZDB-ID	645116-0
ISSN	0970-258X
ISSN	0970-258X
DOI	10.25259/NMJI_539_20
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Article ; Online: Lessons from narrative medicine: Cancer care will improve with narrative oncologyLessons from narrative medicine: Cancer care will improve with narrative oncology.

Mohanti, Bidhu Kalyan

Indian journal of cancer

2021 Volume 58, Issue 4, Page(s) 615–618

Abstract: Narrative medicine (NM) is a new discipline in healthcare that helps the patients and physicians to tell and listen to the accounts of disease, illness, and suffering. In the last 20 years, NM has moved into the realms of biomedical education, research, ... ...

Abstract	Narrative medicine (NM) is a new discipline in healthcare that helps the patients and physicians to tell and listen to the accounts of disease, illness, and suffering. In the last 20 years, NM has moved into the realms of biomedical education, research, and training. The complexity of cancer management can gain from the medical humanism of NM. A new model of cancer care called narrative oncology (NO) with NM-based skill sets of attention, representation, and affiliation can build narrative competence, therapeutic relationship, and clinical trust. The oncologists, patients, and their family caregivers, and the cancer care health system will create an inclusive and empathetic eco-system. This paper outlines the broad framework of NM, which becomes narrative oncology for cancer medicine. The clinicians, nurses, health workers, and scientists should learn and implement this new discipline alongside their biomedical activities.
MeSH term(s)	Humans ; Medical Oncology/methods ; Narrative Medicine/methods ; Neoplasms/therapy
Language	English
Publishing date	2021-12-16
Publishing country	India
Document type	Journal Article
ZDB-ID	410194-7
ISSN	1998-4774 ; 0019-509X
ISSN (online)	1998-4774
ISSN	0019-509X
DOI	10.4103/ijc.IJC_809_20
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Article: Efficient and Reliable Data Extraction in Radiation Oncology using Python Programming Language: A Pilot Study.

Chauhan, Rohit Singh / Pradhan, Anirudh / Munshi, Anusheel / Mohanti, Bidhu Kalyan

Journal of medical physics

2023 Volume 48, Issue 1, Page(s) 13–18

Abstract: Background and purpose: In recent years, data science approaches have entered health-care systems such as radiology, pathology, and radiation oncology. In our pilot study, we developed an automated data mining approach to extract data from a treatment ... ...

Abstract	Background and purpose: In recent years, data science approaches have entered health-care systems such as radiology, pathology, and radiation oncology. In our pilot study, we developed an automated data mining approach to extract data from a treatment planning system (TPS) with high speed, maximum accuracy, and little human interaction. We compared the amount of time required for manual data extraction versus the automated data mining technique. Materials and methods: A Python programming script was created to extract specified parameters and features pertaining to patients and treatment (a total of 25 features) from TPS. We successfully implemented automation in data mining, utilizing the application programming interface environment provided by the external beam radiation therapy equipment provider for the whole group of patients who were accepted for treatment. Results: This in-house Python-based script extracted selected features for 427 patients in 0.28 ± 0.03 min with 100% accuracy at an astonishing rate of 0.04 s/plan. Comparatively, manual extraction of 25 parameters took an average of 4.5 ± 0.33 min/plan, along with associated transcriptional and transpositional errors and missing data information. This new approach turned out to be 6850 times faster than the conventional approach. Manual feature extraction time increased by a factor of nearly 2.5 if we doubled the number of features extracted, whereas for the Python script, it increased by a factor of just 1.15. Conclusion: We conclude that our in-house developed Python script can extract plan data from TPS at a far higher speed (>6000 times) and with the best possible accuracy compared to manual data extraction.
Language	English
Publishing date	2023-04-18
Publishing country	India
Document type	Journal Article
ZDB-ID	1193902-3
ISSN	1998-3913 ; 0971-6203
ISSN (online)	1998-3913
ISSN	0971-6203
DOI	10.4103/jmp.jmp_12_23
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Article ; Online: Peer reviewers from low- and middle-income countries(LMIC) for open access journals in oncology can improve the equity in cancer research and clinical trials.

Mohanti, Bidhu Kalyan / Munshi, Anusheel / Sarkar, Biplab / Sharma, Atul / Deo, Surya Vs

Journal of cancer policy

2023 Volume 36, Page(s) 100419

Abstract: Open access journals (OAJ) in biomedicine are promoted to improve the reach and distribution of global health research (GHR). However, in the last 20 years, article publishing charge (APC) is attracting and publishing the vast majority of papers from ... ...

Abstract	Open access journals (OAJ) in biomedicine are promoted to improve the reach and distribution of global health research (GHR). However, in the last 20 years, article publishing charge (APC) is attracting and publishing the vast majority of papers from high-income countries (HIC) in "oncology" journals under OAJ. This paper outlines the impediments for cancer research and publication from low-and middle-income countries (LMIC): (a) existing disparities in cancer care facilities and survival outcomes between HIC and LMIC, (b) more than 70 % of OAJ in 'oncology' subject levy APC, becoming unaffordable for scientists and clinicians from LMIC, (c) impactful OAJ in oncology engage less than 10 % of members from LMIC in editorial board or as peer reviewer, whereas two-third of cancer diagnosis and management occur in these countries. Peer review serves the editors by recommending the relevant papers. Thus, peer reviewers from developing countries working for the OAJs in "oncology" can increase the diversity in publication, improving the GHR in cancer management. The cancer research and clinical trials which can bring to notice the challenges and hurdles faced by researchers, clinicians and cancer patients in LMIC will be served to some measure by engaging peer reviewers from those countries who understand the ecosystem.
MeSH term(s)	Humans ; Developing Countries ; Access to Information ; Ecosystem ; Periodicals as Topic ; Peer Review ; Neoplasms/diagnosis
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ISSN	2213-5383
ISSN (online)	2213-5383
DOI	10.1016/j.jcpo.2023.100419
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Article ; Online: Ida Belle Scudder and Ketayun Ardeshir Dinshaw: The two iconic women who shaped the face of radiation oncology in India.

Bansal, Manishi / Jindal, Ankush / Mohanti, Bidhu Kalyan

Journal of medical biography

2020 Volume 30, Issue 2, Page(s) 102–106

Abstract: The early twentieth century India saw profound paucity in health care delivery and education, and the beliefs of people were ruled mainly by ignorance, superstitions and myths. Diseases like cancer and its treatment were totally unknown during that time ... ...

Abstract	The early twentieth century India saw profound paucity in health care delivery and education, and the beliefs of people were ruled mainly by ignorance, superstitions and myths. Diseases like cancer and its treatment were totally unknown during that time in India. Dr Ida Belle Scudder, American woman, came to India to break all norms and sacrificed her entire life to work in a missionary hospital. Gradually she trained herself to treat cancer patients and established a fully equipped radiotherapy centre to treat such patients. Later, the field of radiation oncology was transformed and modernised by another influential woman, Dr Ketayun Ardeshir Dinshaw, who with her leadership attributes left no stone unturned to firmly establish the role of radiation in the management of cancer and bringing its benefits to the people of India.
MeSH term(s)	Female ; Humans ; India ; Leadership ; Missionaries ; Radiation Oncology/history ; United States
Language	English
Publishing date	2020-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1159267-9
ISSN	1758-1087 ; 0967-7720
ISSN (online)	1758-1087
ISSN	0967-7720
DOI	10.1177/0967772020944698
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Article ; Online: Integrating psycho-oncology services in cancer care in India.

Mathew, Bincy / Mohanti, Bidhu Kalyan / Tewari, Saipriya / Munshi, Anusheel

Indian journal of cancer

2021 Volume 58, Issue 2, Page(s) 290–293

Abstract: Psychological distress is often an under-diagnosed problem in cancer care. Addressing psychosocial issues would enhance treatment compliance, physician-patient relationship, treatment efficacy and quality of life. This article emphasizes the importance ... ...

Abstract	Psychological distress is often an under-diagnosed problem in cancer care. Addressing psychosocial issues would enhance treatment compliance, physician-patient relationship, treatment efficacy and quality of life. This article emphasizes the importance of integrating psycho-oncology services in cancer care and attempts to define the various roles that a psycho-oncologist can play across the entire trajectory. It also highlights the indispensable role played by the oncologists' referrals in maximizing the benefits of psycho-oncology services received by patients and their caregivers.
MeSH term(s)	Delivery of Health Care, Integrated/standards ; Humans ; India/epidemiology ; Neoplasms/epidemiology ; Neoplasms/psychology ; Neoplasms/therapy ; Patient Care Team/standards ; Psycho-Oncology/methods ; Psychotherapy/methods ; Quality of Life
Language	English
Publishing date	2021-01-06
Publishing country	India
Document type	Journal Article
ZDB-ID	410194-7
ISSN	1998-4774 ; 0019-509X
ISSN (online)	1998-4774
ISSN	0019-509X
DOI	10.4103/ijc.IJC_217_20
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Article ; Online: Calculation of set-up margin in frameless stereotactic radiotherapy accounting for translational and rotational patient positing error.

Manikandan, Arjunan / Sarkar, Biplab / Munshi, Anusheel / Krishnankutty, Saneg / Ganesh, Tharmarnadar / Mohanti, Bidhu Kalyan / Manikandan, Sujatha / Anirudh, Pradhan / Chandrasekharan, Surekha

Journal of cancer research and therapeutics

2023 Volume 19, Issue 2, Page(s) 169–176

Abstract: Context: Rotation corrected set-up margins in stereotactic radiotherapy (SRT).: Aims: This study aimed to calculate the rotational positional error corrected set-up margin in frameless SRT.: Settings and design: 6D setup errors for the ... ...

Abstract	Context: Rotation corrected set-up margins in stereotactic radiotherapy (SRT). Aims: This study aimed to calculate the rotational positional error corrected set-up margin in frameless SRT. Settings and design: 6D setup errors for the steriotactic radiotherapy patients were converted to 3D translational only error mathematically. Setup margins were calculated with and without considering the rotational error and compared. Materials and methods: A total of 79 patients of SRT each received >1 fraction (3-6 fractions) incorporated in this study. Two cone-beam computed tomography (CBCT) scans were acquired for each session of treatment, before and after the robotic couch-aided patient position correction using a CBCT. The postpositional correction set-up margin was calculated using the van Herk formula. Further, a planning target volume_R (PTV_R) (with rotational correction) and PTV_NR (without rotational correction) were calculated by applying the rotation corrected and uncorrected set-up margins on the gross tumor volumes (GTVs). Statistical Analysis Used: General. Results: A total of 380 sessions of pre- (190) and post (190) table positional correction CBCT was analyzed. Posttable position correction mean positional error for lateral, longitudinal, and vertical translational and rotational shifts was (x)-0.01 ± 0.05 cm, (y)-0.02 ± 0.05 cm, (z) 0.00 ± 0.05 cm, and (θ) 0.04° ± 0.3°, (Φ) 0.1° ± 0.4°, (Ψ) 0.0° ± 0.4°, respectively. The GTV volumes show a range of 0.13 cc-39.56 cc, with a mean volume of 6.35 ± 8.65 cc. Rotational correction incorporated postpositional correction set-up margin the in lateral (x), longitudinal (y) and vertical (z) directions were 0.05 cm, 0.12 cm, and 0.1 cm, respectively. PTV_R ranges from 0.27 cc to 44.7 cc, with a mean volume of 7.7 ± 9.8 cc. PTV_NR ranges from 0.32 cc to 46.0 cc, with a mean volume of 8.1 ± 10.1 cc. Conclusions: The postcorrection linear set-up margin matches well with the conventional set-up margin of 1 mm. Beyond a GTV radius of 2 cm, the difference between PTV_NR and PTV_R is ≤2.5%, hence not significant.
MeSH term(s)	Humans ; Radiation Oncology ; Radiosurgery ; Cone-Beam Computed Tomography ; Posture
Language	English
Publishing date	2023-06-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_359_21
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Article ; Online: Comparative effectiveness of verbal instruction versus video-based education (VIVid) among family caregivers for improving the quality of life in advanced head and neck cancer patients receiving palliative care in Eastern India: a randomized controlled trial.

Narayanan, Sri Priya / Mohanty, Sumita / Mohanti, Bidhu Kalyan / Rath, Hemamalini / Atreya, Shrikant / Rout, Archana / Mahapatra, Shilpa

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

2023 Volume 32, Issue 12, Page(s) 3495–3506

Abstract: Purpose: To determine if video-based educational intervention compared to the standard verbal guidelines, provided to caregivers on home-based palliative care could enhance the quality of life (QoL) in advanced head and neck cancer (HNC) patients.: ... ...

Abstract	Purpose: To determine if video-based educational intervention compared to the standard verbal guidelines, provided to caregivers on home-based palliative care could enhance the quality of life (QoL) in advanced head and neck cancer (HNC) patients. Methods: The study employed a prospective, two-arm parallel-group, randomized controlled trial design. Investigators prepared a real-world demonstrational video of ten minutes duration regarding home-based care for family caregivers, with voice-over in Odia language (Eastern India). The contents of the video addressed the management of common problems in palliative care among HNC patients. This study included 180 participants, 90 patient & caregiver dyads randomized to interventional (video-based education) or control (verbal instruction) groups. Patients' QoL was measured at baseline and 3 weeks follow-up using EORTC QLQ C30. Data were analyzed descriptively, and the Chi-square, Mann-Whitney U, T-test, spearman correlation, and multiple hierarchical regression analyses were employed for statistical analysis, with a significance level of p < 0.05. Results: Seventy participant dyads completed the planned two assessments: baseline and at the end of 3rd week (Intervention = 37; Control = 33). The intervention group showed a significant improvement in the patient's health-related QoL, physical, emotional, and social functioning. Symptom burden reduction was observed for pain, nausea, and fatigue. A significant increase in the change in QoL with the video-based education group (VBE) compared to the verbal instruction (VI) group after adjusting for age, gender, physical functioning, and pain symptomology (adjusted R Conclusion: VBE intervention using smart-phone may offer caregivers a viable means of enhancing self-management while improving patients' QoL within the socio-cultural challenges for home-based palliative care in India. Further research on training caregivers using digital interventions and home-based visits is recommended. Trial registration number: CTRI/2021/06/034473 [Registered on: 30/06/2021].
MeSH term(s)	Humans ; Palliative Care ; Quality of Life/psychology ; Caregivers/psychology ; Prospective Studies ; Head and Neck Neoplasms/therapy ; Pain
Language	English
Publishing date	2023-08-02
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1161148-0
ISSN	1573-2649 ; 0962-9343
ISSN (online)	1573-2649
ISSN	0962-9343
DOI	10.1007/s11136-023-03484-0
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Article: Adjuvant radiation therapy for malignant tumours of the eyelid: Experience from a tertiary cancer centre in India.

Pathy, Sushmita / Venkatesulu, Bhanu Prasad / Mallick, Supriya / Deo, Suryanarayana S V / Mohanti, Bidhu Kalyan

The National medical journal of India

2021 Volume 33, Issue 5, Page(s) 271–275

Abstract: Background: . Tumours of the eyelid are a rare subgroup of neoplasms with varied histology and inherent differences in clinical behaviour. Surgery is the standard of care, and adjuvant radiation therapy (RT) is given in the presence of features ... ...

Abstract	Background: . Tumours of the eyelid are a rare subgroup of neoplasms with varied histology and inherent differences in clinical behaviour. Surgery is the standard of care, and adjuvant radiation therapy (RT) is given in the presence of features suggesting a high risk of local recurrence. The treatment of lymph nodes in the neck is debatable. We reviewed the utility of RT for lymph nodes in the neck in patients with malignant tumours of the eyelid. Methods: . We reviewed medical records of all patients with tumours of the eyelid treated at our centre from July 2006 to December 2014 for their demographic, clinical profile, treatment details and outcome. Results: . The records of 37 patients were included for analysis, of these 34 underwent surgery and 21 received adjuvant RT. Their median age was 60 (range 30-85) years. Sebaceous cell carcinoma was the most common (50.4%). The median disease-free survival (DFS) was 35 months (95% CI 17.9-52.0). The 1- and 3-year DFS were 82.7% and 45%, respectively. Univariate analysis showed a superior outcome with early stage (T1) tumours (p=0.01), RT dose of ≥60 Gy and those underwent lymph node dissection (p=0.03). The presence of high-risk factors including close or positive margin had an inferior outcome with a trend towards statistical significance (p=0.06). Conclusion: . We found a favourable outcome with early T stage, RT dose of ≥60 Gy and lymph node dissection. High-risk histopathological features including close margins and positive lymph nodes merit adjuvant RT including regional lymph nodes.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Eyelid Neoplasms/epidemiology ; Eyelid Neoplasms/radiotherapy ; Eyelid Neoplasms/surgery ; Humans ; Lymph Node Excision ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/radiotherapy ; Radiotherapy, Adjuvant ; Retrospective Studies
Language	English
Publishing date	2021-07-02
Publishing country	India
Document type	Journal Article
ZDB-ID	645116-0
ISSN	0970-258X
ISSN	0970-258X
DOI	10.4103/0970-258X.317464
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Article ; Online: An audit of Grade III or more skin reactions in consecutively assessed patients at a modern radiation oncology center.

Pandey, Vikas Kumar / Munshi, Anusheel / Mohanti, Bidhu Kalyan / Bansal, Kanika / Rastogi, Khushboo / Ganesh, Tharmarnadar / Chauhan, Rohit Singh / Chaudhari, Bhavini / Pandey, Pramod

Journal of cancer research and therapeutics

2022 Volume 18, Issue 1, Page(s) 84–88

Abstract: Purpose: Radiation dermatitis is most common and debilitating side effects of radiotherapy leading to treatment interruption, thereby compromising the local control, and effecting quality of life. With the invent of modern imaging and recent advances in ...

Abstract	Purpose: Radiation dermatitis is most common and debilitating side effects of radiotherapy leading to treatment interruption, thereby compromising the local control, and effecting quality of life. With the invent of modern imaging and recent advances in megavoltage radiotherapy, radiation-related side effects have reduced. In this audit, we report the risk factors associated with Grade III dermatitis in modern centers. Materials and methods: We analyzed 172 patients treated with volume modulated arc therapy (VMAT) and static field intensity-modulated radiotherapy (SFIMRT) at our center. All head and neck, breast, gynecological, GU malignancies, and sarcoma patients treated with a dose of >45 Gy from April 2018 to December 2019 were included in the study. On couch, treatment verification was done with cone-beam computer tomography (CBCT). Slice-by-slice verification of planning target volume (PTV) with CBCT was done in the first three fractions and weekly thereafter. Skin evaluation was done using CTCAE v. 5. Statistical analysis was done using SPSS v. 22. Results: Of the 172 patients treated with VMAT and SFIMRT, 15 patients (8.7%) had Grade III dermatitis. Grade III dermatitis was mostly seen in breast cancer followed by head-and-neck patients. More reactions were observed in patients with advanced stage disease. Treatment verification is important at the later course of treatment, especially in head-and-neck cases where the treatment volume is large and PTV may extend outside skin. Contributing factors of radiation dermatitis at modern radiotherapy center are gene mutation, use of concurrent chemoradiotherapy, and bolus. Conclusion: We hereby conclude that PTV mismatch in weekly treatment verification, genetic mutations, concurrent chemo-radiotherapy, use of thermoplastic mask, and bolus are the contributing factors for Grade III dermatitis in modern radiotherapy centers.
MeSH term(s)	Humans ; Quality of Life ; Radiation Oncology ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods
Language	English
Publishing date	2022-04-05
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.JCRT_611_20
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