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  1. Book: Blutdruck

    Mohaupt, Markus G.

    (Therapeutische Umschau ; 69,5)

    2012  

    Author's details Gasthrsg. Markus G. Mohaupt
    Series title Therapeutische Umschau ; 69,5
    Collection
    Keywords Hypertonie
    Subject Arterielle Hypertonie ; Arterieller Hochdruck ; Bluthochdruck ; Hochdruck ; Hypertension ; Hypertonus
    Language German
    Size S. 269 - 330 : Ill., graph. Darst.
    Publisher Huber
    Publishing place Bern u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT017222877
    ISBN 978-3-456-85059-7 ; 3-456-85059-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ue I Zs 180 -69- verfügbar in Königswinter Königswinter

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  2. Book: Kalzium

    Mohaupt, Markus G.

    Kind, Frau, Menopause, Schwangerschaft, Nierensteinleiden, Bluthochdruck, Substitution, Hyperkalzämie

    (Therapeutische Umschau ; 64,5)

    2007  

    Author's details Gasthrsg. M. Mohaupt
    Series title Therapeutische Umschau ; 64,5
    Collection
    Keywords Calcium ; Pathophysiologie ; Calciumstoffwechselstörung
    Subject Calcium ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Calzium ; Kalzium
    Language German
    Size S. 233 - 292 : Ill.
    Publisher Huber
    Publishing place Bern u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015093153
    ISBN 978-3-456-84432-9 ; 3-456-84432-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ue I Zs 180 -64- verfügbar in Königswinter Königswinter

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  3. Book: Praxisratgeber Niereninsuffizienz

    Mohaupt, Markus G. / Simonetti, Giacomo D.

    (UNI-MED science)

    2008  

    Author's details [Markus G. Mohaupt ; Giacomo D. Simonetti]
    Series title UNI-MED science
    Keywords Niereninsuffizienz
    Subject Renale Insuffizienz ; Niere
    Language German
    Size 61 S. : graph. Darst.
    Publisher UNI-MED
    Publishing place Bremen u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT015777667
    ISBN 978-3-8374-1066-2 ; 3-8374-1066-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 6808 order for loan Magazin

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  4. Article: Salz- und Wasser-Zufuhr bei Dialysepatienten

    Mohaupt, Markus

    Dialyse aktuell

    2019  Volume 23, Issue 09, Page(s) 411–415

    Abstract: Die Regulation von Na und Aldosteron ist komplex und eng mit dem Renin-Angiotensin-II-Aldosteron-System (RAAS) verknüpft. Die Aldosteron-Renin-Relation wird in physiologischen und pathophysiologischen Situationen, z. B. durch eine Hämodialysebehandlung, ... ...

    Abstract Die Regulation von Na und Aldosteron ist komplex und eng mit dem Renin-Angiotensin-II-Aldosteron-System (RAAS) verknüpft. Die Aldosteron-Renin-Relation wird in physiologischen und pathophysiologischen Situationen, z. B. durch eine Hämodialysebehandlung, entkoppelt. Zudem ist die Angiotensin-I-Aktivierung durch das Angiontensin I Converting Enzyme (ACE) gesteigert. Komplizierend ist Na mit unterschiedlichen Wirkungen kompartimentalisiert: extrazellulär volumenwirksam, ossär zum langsamen Austausch gespeichert und wasserfrei im Gewebe tonizitätsassoziiert metabolisch aktiv. Eine spezifisch Na -arme Diät ist nicht sinnvoll, da sie mit einer höheren Mortalität assoziiert ist. Jedoch scheint bei sonst gutem Ernährungszustand eine Kochsalz-Zufuhr von unter 6–7 g/d und eine geringe interdialytische Gewichtszunahme vorteilhaft für das Überleben zu sein. Studien zum Dialysat-Na sind von mäßiger Qualität und zeigen, dass ein tieferes Dialysat-Na zu einer geringeren interdialytischen Gewichtszunahme, zu einem niedrigeren prädialytischen Blutdruck und zu einem reduzierten Einsatz von Antihypertensiva führt. Krämpfe und intradialytische Blutdruckabfälle nehmen zu. Einige potenzielle Forschungsfragestellungen werden beschrieben.
    Language German
    Publishing date 2019-11-01
    Publisher © Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2146225-2
    ISSN 1860-3300 ; 1434-0704
    ISSN (online) 1860-3300
    ISSN 1434-0704
    DOI 10.1055/a-0982-8647
    Database Thieme publisher's database

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    Zs.A 6979: Show issues Location:
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  5. Article ; Online: Lipid lowering: PCSK9 inhibitors - new kids on the block target their breakthrough.

    Mohaupt, Markus

    Swiss medical weekly

    2016  Volume 146, Page(s) w14345

    MeSH term(s) Anticholesteremic Agents/pharmacology ; Apolipoproteins B/metabolism ; Cholesterol, LDL/metabolism ; Dyslipidemias/drug therapy ; Dyslipidemias/genetics ; Humans ; Hyperlipoproteinemia Type II/drug therapy ; Hyperlipoproteinemia Type II/genetics ; Proprotein Convertase 9/antagonists & inhibitors
    Chemical Substances Anticholesteremic Agents ; Apolipoproteins B ; Cholesterol, LDL ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2016.14345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Metformin-Treatment Option for Social Impairment? An Open Clinical Trial to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior.

    Gasser, Benedikt / Kurz, Johann / Buerki, Samuel / Mohaupt, Markus

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 7

    Abstract: Background: Social behavior is mediated by steroid hormones, whereby various lines of evidence indicate that metformin might improve the symptoms of social withdrawal. This directly yields to the aim of the study to correlate the impact of metformin ... ...

    Abstract Background: Social behavior is mediated by steroid hormones, whereby various lines of evidence indicate that metformin might improve the symptoms of social withdrawal. This directly yields to the aim of the study to correlate the impact of metformin treatment on the potential alterations in steroid hormone homeostasis, which is ultimately impacting social behavior. Therefore, urinary samples of patients before and after treatment with metformin will be correlated to social behavior to elucidate potential changes in steroid hormone profiles and social behavior.
    Material and methods: An observational study in healthy adults with a new indication for metformin. Steroid hormone analysis, including the most prominent androgen, estrogen, progesterone, aldosterone, corticosterone, cortisone and cortisol metabolites analyzed with gas chromatography-mass spectrometry and a questionnaire on social behavior (Autism Spectrum Questionnaire (AQ)) will be administered prior to and after around a 12-week phase of metformin treatment.
    Discussion: It is likely that due to different pathophysiological mechanisms such as an effect on the respiratory chain in mitochondria or via AMP-activated protein kinase, a general alteration of steroid hormone levels can be detected prior to post treatment. The encompassing measurement of steroid hormones shall give hints concerning the involvement of specific cascades yielding potential pharmacological targets for future research.
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12070998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [No title information]

    Mohaupt, Markus G

    Therapeutische Umschau. Revue therapeutique

    2016  Volume 73, Issue 7, Page(s) 431–435

    Title translation Window of opportunity.
    MeSH term(s) Evidence-Based Medicine ; Female ; Health Promotion/methods ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/diagnosis ; Infant, Newborn, Diseases/prevention & control ; Pregnancy ; Pregnancy Complications, Cardiovascular/diagnosis ; Pregnancy Complications, Cardiovascular/prevention & control ; Risk Reduction Behavior ; Treatment Outcome
    Language German
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a000814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Testosterone/Epitestosterone Ratios-Further Hints to Explain Hyperandrogenemia in Children with Autism.

    Gasser, Benedikt / Kurz, Johann / Mohaupt, Markus

    Diseases (Basel, Switzerland)

    2021  Volume 9, Issue 1

    Abstract: Background: Epitestosterone [E] has for a long time been considered as a biologically inactive androgen. However, recently a distinct antiandrogenic activity of this naturally occurring endogenous epimer of Testosterone has been demonstrated. Especially ...

    Abstract Background: Epitestosterone [E] has for a long time been considered as a biologically inactive androgen. However, recently a distinct antiandrogenic activity of this naturally occurring endogenous epimer of Testosterone has been demonstrated. Especially the ratios of testosterone/epitestosterone (T/E) seem to be key as inhibition of epitestosterone on androgen activity was postulated. As in autism, a higher androgen activity was implied. We, therefore, suggested higher levels of T/E ratios of children with autism versus children with typical development.
    Methods: Urine probes of 22 girls with autism (BMI 18.7 ± 4.3; average age 12.3 ± 3.8 years) and a sample of 51 controls (BMI 17.0 ± 2.6; average age 11.9 ± 4 years), as well as 61 boys with autism (BMI 17.04 ± 2. average age 11.9 ± 2.5 years) and 61 control boys (BMI 17.0 ± 2.6; average age 11.1 ± 3.0 years), were analyzed with gas chromatography mass spectrometry.
    Results: The average T/E ratio of all boys with autism was 2.5 ± 1.8 versus 2.4 ± 1.3 in boys with typical development, respectively. No significant difference between boys with autism versus boys with typical development could be detected (
    Discussion: As encompassing steroid hormone analysis are expensive and work-intensive, we hoped to find an easily applicable biomarker to support diagnostics in autism. However, as a relatively small sample of only 22 girls with autism were analyzed and menstrual cycle and pubertal status were only partly controllable through the matching of BMI and age, the question arises if it was an incidental finding. Nevertheless, one suggestion might be that epitestosterone has the effect of a competitive inhibition on the androgen receptor, which would probably help to explain the higher prevalence of autism in boys as compared to girls. Presumably, as no significant difference was detected in boys, this effect might not be as relevant from a steroid hormone perspective, and other effects such as altered 17/20-hydroxylase activity as previously shown in boys and girls with autism seem to have more relevance. Analysis of larger samples, including plenty of metabolites and enzymatic cascades, as well as the role of backdoor pathway activity of androgen synthesis of girls with autism, are demanded in order to validate current findings of altered steroid hormones in autism.
    Language English
    Publishing date 2021-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases9010013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: How Is CYP17A1 Activity Altered in Autism? A Pilot Study to Identify Potential Pharmacological Targets.

    Gasser, Benedikt Andreas / Kurz, Johann / Dick, Bernhard / Mohaupt, Markus Georg

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12060867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: C-reactive protein and its role in preeclampsia.

    Mohaupt, Markus G

    Hypertension (Dallas, Tex. : 1979)

    2015  Volume 65, Issue 2, Page(s) 285–286

    MeSH term(s) Animals ; C-Reactive Protein/physiology ; Choline-Phosphate Cytidylyltransferase/physiology ; Female ; Humans ; Neurokinin B/metabolism ; Pre-Eclampsia/etiology ; Pregnancy ; Receptors, Neurokinin-3/physiology
    Chemical Substances Receptors, Neurokinin-3 ; Neurokinin B (86933-75-7) ; C-Reactive Protein (9007-41-4) ; Choline-Phosphate Cytidylyltransferase (EC 2.7.7.15) ; PCYT1B protein, human (EC 2.7.7.15)
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.114.04531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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