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  1. Article ; Online: Adsorptive Removal of Naproxen from Water Using Polyhedral Oligomeric Silesquioxane (POSS) Covalent Organic Frameworks (COFs)

    Suleiman Bala / Che Azurahanim Che Abdullah / Mohamed Ibrahim Mohamed Tahir / Mohd Basyaruddin Abdul Rahman

    Nanomaterials, Vol 12, Iss 14, p

    2022  Volume 2491

    Abstract: Covalent organic frameworks are porous crystalline compounds made up of organic material bonded together by strong reversible covalent bonds (these are novel types of materials which have the processability of extended or repeated structures with high ... ...

    Abstract Covalent organic frameworks are porous crystalline compounds made up of organic material bonded together by strong reversible covalent bonds (these are novel types of materials which have the processability of extended or repeated structures with high performance, like those of thermosets and thermoplastics that produce high surface coverage). These have a long-term effect on an arrangement’s geometry and permeability. These compounds are entirely made up of light elements like H, B, C, N, O and Si. Pharmaceuticals and personal care products (PPCPs) have emerged as a new threatened species. A hazardous substance known as an “emerging toxin,” such as naproxen, is one that has been established or is generated in sufficient amounts in an environment, creating permanent damage to organisms. COF-S7, OAPS and 2-methylanthraquionone(2-MeAQ), and COF-S12, OAPS and terephthalaldehyde (TPA) were effectively synthesized by condensation (solvothermal) via a Schiff base reaction (R 1 R 2 C=NR′), with a molar ratio of 1:8 for OAPS to linker (L1 and L2), at a temperature of 125 °C and 100 °C for COF-S7 and COF-S12, respectively. The compounds obtained were assessed using several spectroscopy techniques, which revealed azomethine C=N bonds, aromatic carbon environments via solid 13 C and 29 Si NMR, the morphological structure and porosity, and the thermostability of these materials. The remedied effluent was investigated, and a substantial execution was noted in the removal ability of the naproxen over synthesized materials, such as 70% and 86% at a contact time of 210 min and 270 min, respectively, at a constant dose of 0.05 g and pH 7. The maximum adsorption abilities of the substances were found to be 35 mg/g and 42 mg/g. The pH result implies that there is stable exclusion with a rise in pH to 9. At pH 9, the drop significance was attained for COF-S7 with the exception of COF-S12, which was detected at pH 11, due to the negative Foster charge, consequent to the repulsion among the synthesized COFs and naproxen solution. ...
    Keywords covalent organic frameworks ; naproxen ; octa(phenyl)silesquioxane ; anti-inflammatory drugs ; adsorption ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Exploring the Potential of a Highly Scalable Metal-Organic Framework CALF-20 for Selective Gas Adsorption at Low Pressure

    Mostafa Yousefzadeh Borzehandani / Majid Namayandeh Jorabchi / Emilia Abdulmalek / Mohd Basyaruddin Abdul Rahman / Muhammad Alif Mohammad Latif

    Polymers, Vol 15, Iss 760, p

    2023  Volume 760

    Abstract: In this study, the ability of the highly scalable metal-organic framework (MOF) CALF-20 to adsorb polar and non-polar gases at low pressure was investigated using grand canonical Monte Carlo (GCMC) and molecular dynamics (MD) simulations. The results ... ...

    Abstract In this study, the ability of the highly scalable metal-organic framework (MOF) CALF-20 to adsorb polar and non-polar gases at low pressure was investigated using grand canonical Monte Carlo (GCMC) and molecular dynamics (MD) simulations. The results from the simulated adsorption isotherms revealed that the highest loading was achieved for SO 2 and Cl 2 , while the lowest loading was found for F 2 molecules. The analysis of interaction energies indicated that SO 2 molecules were able to form the strongest adsorbent-adsorbate interactions and had a tight molecular packing due to their polarity and angular structure. Additionally, Cl 2 gas was found to be highly adsorbed due to its large van der Waals surface and strong chemical affinity in CALF-20 pores. MD simulations showed that SO 2 and Cl 2 had the lowest mobility inside CALF-20 pores. The values of the Henry coefficient and isosteric heat of adsorption confirmed that CALF-20 could selectively adsorb SO 2 and Cl 2 . Based on the results, it was concluded that CALF-20 is a suitable adsorbent for SO 2 and Cl 2 but not for F 2 . This research emphasizes the importance of molecular size, geometry, and polarity in determining the suitability of a porous material as an adsorbent for specific adsorbates.
    Keywords metal-organic framework ; CALF-20 ; selective adsorption ; grand canonical monte carlo ; molecular dynamics ; Organic chemistry ; QD241-441
    Subject code 541
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Antifreeze Proteins

    Bimo Ario Tejo / Azren Aida Asmawi / Mohd Basyaruddin Abdul Rahman

    Makara Journal of Science, Vol 24, Iss 1, Pp 58-

    Char oteins: Characteristics and P acteristics and Potential Applications otential Applications

    2020  Volume 64

    Abstract: The freezing of water is usually fatal to most organisms because it causes extensive damage to cell membranes due to the formation of ice crystals. However, several structurally different classes of antifreeze proteins (AFPs) found in fish, insects, ... ...

    Abstract The freezing of water is usually fatal to most organisms because it causes extensive damage to cell membranes due to the formation of ice crystals. However, several structurally different classes of antifreeze proteins (AFPs) found in fish, insects, plants, and microorganisms, including bacteria, yeast, and fungi, have been found to be capable of modifying the growth of ice crystals by thermal hysteresis and ice recrystallization inhibition. This unique property could potentially be applied to medicine and the industry as it is useful when low-temperature storage is required and ice crystallization must be avoided. However, the application of AFPs today is not economically viable due to the complexity of the large proteins, the laborious procedures required, and the low yields obtained. A wide range of peptides mimicking their parent proteins were recently successfully designed and chemically synthesized. The developed approaches present new opportunities to understand the structure–function relationship of small-structured peptides with antifreeze properties. This mini-review highlights the diversity, classification, and properties of AFPs. The emerging applications of short mimetic peptides of AFPs and their potential application are also described.
    Keywords antifreeze peptide ; antifreeze protein ; ice recrystallization inhibition ; thermal hysteresis ; Science (General) ; Q1-390
    Subject code 540
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Universitas Indonesia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Elucidating the Aromatic Properties of Covalent Organic Frameworks Surface for Enhanced Polar Solvent Adsorption

    Mostafa Yousefzadeh Borzehandani / Emilia Abdulmalek / Mohd Basyaruddin Abdul Rahman / Muhammad Alif Mohammad Latif

    Polymers, Vol 13, Iss 1861, p

    2021  Volume 1861

    Abstract: Covalent organic frameworks (COFs) have a distinguished surface as they are mostly made by boron, carbon, nitrogen and oxygen. Many applications of COFs rely on polarity, size, charge, stability and hydrophobicity/hydrophilicity of their surface. In this ...

    Abstract Covalent organic frameworks (COFs) have a distinguished surface as they are mostly made by boron, carbon, nitrogen and oxygen. Many applications of COFs rely on polarity, size, charge, stability and hydrophobicity/hydrophilicity of their surface. In this study, two frequently used COFs sheets, COF-1 and covalent triazine-based frameworks (CTF-1), are studied. In addition, a theoretical porous graphene (TPG) was included for comparison purposes. The three solid sheets were investigated for aromaticity and stability using quantum mechanics calculations and their ability for water and ethanol adsorption using molecular dynamics simulations. COF-1 demonstrated the poorest aromatic character due to the highest energy delocalization interaction between B–O bonding orbital of sigma type and unfilled valence-shell nonbonding of boron. CTF-1 was identified as the least kinetically stable and the most chemically reactive. Both COF-1 and CTF-1 showed good surface properties for selective adsorption of water via hydrogen bonding and electrostatic interactions. Among the three sheets, TPG’s surface was mostly affected by aromatic currents and localized π electrons on the phenyl rings which in turn made it the best platform for selective adsorption of ethanol via van der Waals interactions. These results can serve as guidelines for future studies on solvent adsorption for COFs materials.
    Keywords covalent organic frameworks ; COF-1 ; CTF-1 ; aromaticity ; stability ; water ; Organic chemistry ; QD241-441
    Subject code 540 ; 541
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: ZIF-90 nanoparticles modified with a homing peptide for targeted delivery of cisplatin

    Adamu Abubakar / Emilia Abdulmalek / Wan Norhamidah Wan Ibrahim / Kyle E. Cordova / Mohd Basyaruddin Abdul Rahman

    Frontiers in Chemistry, Vol

    2022  Volume 10

    Abstract: To improve the selective delivery of cisplatin (Cis) to cancer cells, we report and establish the significance of active, targeting drug delivery nanosystems for efficient treatment of lung cancer. Specifically, pH-responsive nano-sized zeolitic ... ...

    Abstract To improve the selective delivery of cisplatin (Cis) to cancer cells, we report and establish the significance of active, targeting drug delivery nanosystems for efficient treatment of lung cancer. Specifically, pH-responsive nano-sized zeolitic imidazolate framework (nZIF-90) was synthesized, post-synthetically modified with an Arg-Gly-Asp peptide motif (RGD@nZIF-90), a known cancer cell homing peptide, and loaded with a large amount of Cis (RGD@Cis⊂nZIF-90). RGD@Cis⊂nZIF-90 was shown to be highly stable under physiological conditions (pH = 7.4) with framework dissociation occurring under slightly acidic conditions (pH = 5.0)–conditions relevant to tumor cells–from which 90% of the encapsulated Cis was released in a sustained manner. In vitro assays demonstrated that RGD@Cis⊂nZIF-90 achieved significantly better cytotoxicity (65% at 6.25 μg ml−1) and selectivity (selectivity index = 4.18 after 48 h of treatment) against adenocarcinoma alveolar epithelial cancer cells (A549) when compared with the unmodified Cis⊂nZIF-90 (22%). Cellular uptake using A549 cells indicated that RGD@Cis⊂nZIF-90 was rapidly internalized leading to significant cell death. After successfully realizing this nanocarrier system, we demonstrated its efficacy in transporting and delivering Cis to cancer cells.
    Keywords nanocarrier (nanoparticle) ; zeolitic imidalozate framework ; post-synthetic modification (PSM) ; RGD ; peptide ; targeted delivery ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

    Azren Aida Asmawi / Norazlinaliza Salim / Emilia Abdulmalek / Mohd Basyaruddin Abdul Rahman

    International Journal of Molecular Sciences, Vol 21, Iss 4357, p

    2020  Volume 4357

    Abstract: The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor ... ...

    Abstract The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor solubility has limited their clinical success. Given this, an aerosolized nanoemulsion system for pulmonary delivery is recommended to mitigate these drawbacks. In this study, DTX- and CCM-loaded nanoemulsions were optimized using the D-optimal mixture experimental design (MED). The effect of nanoemulsion compositions towards two response variables, namely, particle size and aerosol size, was studied. The optimized formulations for both DTX- and CCM-loaded nanoemulsions were determined, and their physicochemical and aerodynamic properties were evaluated as well. The MED models achieved the optimum formulation for DTX- and CCM-loaded nanoemulsions containing a 6.0 wt% mixture of palm kernel oil ester (PKOE) and safflower seed oils (1:1), 2.5 wt% of lecithin, 2.0 wt% mixture of Tween 85 and Span 85 (9:1), and 2.5 wt% of glycerol in the aqueous phase. The actual values of the optimized formulations were in line with the predicted values obtained from the MED, and they exhibited desirable attributes of physicochemical and aerodynamic properties for inhalation therapy. Thus, the optimized formulations have potential use as a drug delivery system for a pulmonary application.
    Keywords D-optimal ; mixture experimental design ; aerosol ; curcumin ; docetaxel ; nanoemulsion ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 660
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Ultrasound-assisted extraction conditions optimisation using response surface methodology from Mitragyna speciosa (Korth.) Havil leaves

    Fazila Zakaria / Jen-Kit Tan / Siti Munirah Mohd Faudzi / Mohd Basyaruddin Abdul Rahman / Siti Efliza Ashari

    Ultrasonics Sonochemistry, Vol 81, Iss , Pp 105851- (2021)

    2021  

    Abstract: The optimisation of the Ultrasound-Assisted Extraction (UAE) method was investigated by employing the Central Composite Rotatable Design (CCRD) of Response Surface Methodology (RSM). The UAE method was based on a simple ultrasound treatment using ... ...

    Abstract The optimisation of the Ultrasound-Assisted Extraction (UAE) method was investigated by employing the Central Composite Rotatable Design (CCRD) of Response Surface Methodology (RSM). The UAE method was based on a simple ultrasound treatment using methanol as the extraction medium to facilitate the cell disruption of Mitragyna speciosa leaves for optimum extraction yield and Total Phenolic Content (TPC). Three different parameters comprising extraction temperature (X1: 25–50 °C), sonication time (X2: 15–50 min), and solvent to solid ratio (X3: 10–30 mL/g), and were selected as the independent variables, while two response variables were selected, namely extraction yield (Y1) and TPC (Y2). Based on the results, the developed quadratic polynomial model correlated with the experimental data is based on the coefficient of determination (R2) of extraction yield (0.9972, p < 0.0001) and TPC (0.9553, p < 0.0001). At 25 °C, 15 min sonication time, and 10 mL/g of solvent to solid ratio, the optimal conditions recorded an extraction yield and TPC of 22.69% and 143.51 mg gallic acid equivalent (GAE)/g, respectively. Furthermore, the actual response and the predicted values of the developed models correlated with each other as the Residual Standard Error (RSE) values were <5%. Meanwhile, the Liquid Chromatography- tandem Mass Spectrometry (LC-MS/MS) was employed to characterise the optimised M. speciosa extract and revealed the presence of major phytochemicals, including catechin, rutin, kaempferol, coumarin, gallic acid, chlorogenic acid, and caffeic acid. These compounds could exhibit certain therapeutic effects, such as anti-inflammatory, antibacterial, and antioxidant. Therefore, the findings in this study supported the suggestion that the various available bioactive compounds besides alkaloids contributed to the bioactive properties in M. speciosa, making it an effective traditional herbal medicine to treat various illnesses.
    Keywords Mitragyna Speciosa ; Response surface methodology ; Ultrasound-assisted extraction ; Extraction yield ; Total phenolic content ; Phytochemical compound ; Chemistry ; QD1-999 ; Acoustics. Sound ; QC221-246
    Subject code 660
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Development of nano-colloidal system for fullerene by ultrasonic-assisted emulsification techniques based on artificial neural network

    Cheng Loong Ngan / Hamid Reza Fard Masoumi / Mahiran Basri / Mohd Basyaruddin Abdul Rahman

    Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 4162-

    2019  Volume 4170

    Abstract: Propagation of high intensity ultrasonic waves and shearing effect in formulating nanoemulsion loaded fullerene for drug delivery was investigated. Artificial neural network (ANN) was applied to optimize the emulsification process by varying the ... ...

    Abstract Propagation of high intensity ultrasonic waves and shearing effect in formulating nanoemulsion loaded fullerene for drug delivery was investigated. Artificial neural network (ANN) was applied to optimize the emulsification process by varying the ultrasonic and homogenization parameters. Control of operating conditions, such as sonication amplitude (30–70%) and duration (60–120 s), as well as homogenization rate (4000–5000 rpm), was tested to determine the physical attributes of nanoemulsion. Ultrasonic cavitation showed far greater effects as compared to high shear homogenization in controlling the droplet size (sonication time) and viscosity (sonication amplitude) of the nanoemulsion system. Levenberg–Marquardt algorithm produced the optimum topology with network architecture of three inputs, four hidden nodes, and two outputs. Validation further confirmed the aptness of the proposed model with low root mean square error. In this study, ANN has superior predictive ability by yielding low percentage of residual standard error. An ultrasonic approach in formulating fullerene nanoemulsion system is a powerful technique in minimization of droplet size and acquisition of desirable viscosity. This serves as a platform to advance fullerene in nanomedicine field despite its hydrophobicity. Keywords: Nanoemulsion, Fullerene, Artificial neural network, Ultrasonic cavitation, High shear homogenization
    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Pretreatment of oil palm trunk in deep eutectic solvent and optimization of enzymatic hydrolysis of pretreated oil palm trunk

    Zulkefli, Syarilaida / Emilia Abdulmalek / Mohd. Basyaruddin Abdul Rahman

    Renewable energy. 2017 July, v. 107

    2017  

    Abstract: Deep eutectic solvents (DES) were utilised as pretreatment media on oil palm trunk (OPT) fibre in order to change the morphology of the highly crystalline cellulose prior to enzymatic hydrolysis. Among all the DESs tested, ethylammonium chloride: ... ...

    Abstract Deep eutectic solvents (DES) were utilised as pretreatment media on oil palm trunk (OPT) fibre in order to change the morphology of the highly crystalline cellulose prior to enzymatic hydrolysis. Among all the DESs tested, ethylammonium chloride: ethylene glycol (EAC:EG) was found to be the most efficient solvent for the pretreatment of OPT fibre. The pretreatment of OPT by EAC:EG had removed 42% lignin and 83% hemicellulose with the ability to dissolve the OPT biomass (58%) after heating at 100 °C for 48 h. FTIR analysis was used in determining the chemical characteristic changes where OPT treated in EAC:EG had more disruption of hydroxyl bond and indication of delignification compared to OPT treated with other DESs. Enzymatic hydrolysis was carried out on OPT treated in EAC:EG and the highest glucose production (74%) was achieved at 50 °C after 24 h with 15 mg/mL substrate concentration, 50 FPU/g of Celluclast 1.5 L and 100 CBU/ml of Novozyme 188.
    Keywords biomass ; cellulose ; delignification ; Elaeis guineensis ; enzymatic hydrolysis ; ethylene glycol ; Fourier transform infrared spectroscopy ; glucose ; heat ; hemicellulose ; lignin ; renewable energy sources ; solvents
    Language English
    Dates of publication 2017-07
    Size p. 36-41.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2001449-1
    ISSN 0960-1481
    ISSN 0960-1481
    DOI 10.1016/j.renene.2017.01.037
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Synthesis and in vitro biological evaluations of novel tetrapeptide as therapeutic agent for wound treatment

    Nur Izzah Md Fadilah / Haslina Ahmad / Mohd Basyaruddin Abdul Rahman / Suet Lin Chia / Shiow-Fern Ng / Sze Wei Leong

    Journal of Saudi Chemical Society, Vol 24, Iss 8, Pp 606-

    2020  Volume 619

    Abstract: We report a new small peptide containing four amino acid residues (glycine-aspartic acid-proline-histidine) conjugated with palmitic acid (Palmitoyl-GDPH) that was synthesized, characterized and evaluated for its biological activities. The Palmitoyl-GDPH ...

    Abstract We report a new small peptide containing four amino acid residues (glycine-aspartic acid-proline-histidine) conjugated with palmitic acid (Palmitoyl-GDPH) that was synthesized, characterized and evaluated for its biological activities. The Palmitoyl-GDPH was prepared by solid phase peptide synthesis (SPPS) with high percentage purity of 98.6%. The results of circular dichroism (CD) demonstrated the feasibility and stability of Palmitoyl-GDPH secondary structure at many temperatures up to 60 °C. Palmitoyl-GDPH showed its greatest collagenase inhibition activity and nitric oxide (NO) scavenging effect of 80.00 ± 2.22% at 1.0 mg/ml and 83.40 ± 8.08% at 2.5 mg/ml, respectively. In addition, in-vitro cell based study revealed that Palmitoyl-GDPH was not toxic and possessed strong proliferative activity towards normal human dermal fibroblast (NHDF) cell line. Wound scratch assay method showed that Palmitoyl-GDPH significantly promoted the cell migration which progressed faster compared to tetracycline-treated group (positive control) by about 98.39 ± 2.79% and 95.79 ± 3.83%, respectively. Collectively, these results suggested that newly synthesized Palmitoyl-GDPH possessed a strong candidate for use as therapeutic agent and can be a novel approach in the treatment of cutaneous wounds.
    Keywords Tetrapeptide ; Therapeutic agent ; Cytotoxicity ; Cell proliferation ; Cell migration ; Wound healing ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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