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  1. AU="Mohd Fadzly Amar Jamil"
  2. AU="Serda Sozkes"
  3. AU="Bomsdorf, Eckart"
  4. AU=Popescu L M
  5. AU="Patti Herring, R"
  6. AU="Sancar, Serpil"
  7. AU=Llorente Cristina
  8. AU=Martin Seth S
  9. AU="Mau, Yi-Chien"
  10. AU="Lucas, Dominique N"
  11. AU="Aaliya Minhaz"
  12. AU=Jahn Katharina
  13. AU="Krach, Sören"
  14. AU="Bower, Hilary"
  15. AU="Kansakar, Prerana"
  16. AU="McCullagh, Elizabeth A"
  17. AU="Pereira, Ivanio Alves"
  18. AU="Singh, Rupinder"
  19. AU="Leung, Cheuk Lun"
  20. AU=Berman Claudia G
  21. AU=Chang Wen Xiu
  22. AU=Chen Jianchun
  23. AU="Zhou, Long" AU="Zhou, Long"
  24. AU=Bauer Michael AU=Bauer Michael
  25. AU=Clapp Benjamin
  26. AU="Makarenko, V"
  27. AU="Stahl, Anna"
  28. AU="Wa, Qingbo"
  29. AU="Annette T. Byrne"
  30. AU="Godwin Oligbu"

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  1. Artikel ; Online: Influence of Population Density for COVID-19 Spread in Malaysia

    Kurubaran Ganasegeran / Mohd Fadzly Amar Jamil / Alan Swee Hock Ch’ng / Irene Looi / Kalaiarasu M. Peariasamy

    International Journal of Environmental Research and Public Health, Vol 18, Iss 9866, p

    An Ecological Study

    2021  Band 9866

    Abstract: The rapid transmission of highly contagious infectious diseases within communities can yield potential hotspots or clusters across geographies. For COVID-19, the impact of population density on transmission models demonstrates mixed findings. This study ... ...

    Abstract The rapid transmission of highly contagious infectious diseases within communities can yield potential hotspots or clusters across geographies. For COVID-19, the impact of population density on transmission models demonstrates mixed findings. This study aims to determine the correlations between population density, clusters, and COVID-19 incidence across districts and regions in Malaysia. This countrywide ecological study was conducted between 22 January 2021 and 4 February 2021 involving 51,476 active COVID-19 cases during Malaysia’s third wave of the pandemic, prior to the reimplementation of lockdowns. Population data from multiple sources was aggregated and spatial analytics were performed to visualize distributional choropleths of COVID-19 cases in relation to population density. Hierarchical cluster analysis was used to synthesize dendrograms to demarcate potential clusters against population density. Region-wise correlations and simple linear regression models were deduced to observe the strength of the correlations and the propagation effects of COVID-19 infections relative to population density. Distributional heats in choropleths and cluster analysis showed that districts with a high number of inhabitants and a high population density had a greater number of cases in proportion to the population in that area. The Central region had the strongest correlation between COVID-19 cases and population density ( r = 0.912; 95% CI 0.911, 0.913; p < 0.001). The propagation effect and the spread of disease was greater in urbanized districts or cities. Population density is an important factor for the spread of COVID-19 in Malaysia.
    Schlagwörter population density ; clusters ; urbanization ; COVID-19 ; Malaysia ; Medicine ; R
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Clinicians’ Perceived Understanding of Biostatistical Results in the Medical Literature

    Kurubaran Ganasegeran / Alan Swee Hock Ch’ng / Mohd Fadzly Amar Jamil / Irene Looi

    Medicina, Vol 55, Iss 6, p

    A Cross-Sectional Study

    2019  Band 227

    Abstract: Background and objectives: The continuum of evidence-based medicine (EBM) depends solely on clinicians’ commitment to keep current with the latest clinical information. Exploration on clinicians’ understanding of biostatistical results in the medical ... ...

    Abstract Background and objectives: The continuum of evidence-based medicine (EBM) depends solely on clinicians’ commitment to keep current with the latest clinical information. Exploration on clinicians’ understanding of biostatistical results in the medical literature is sparse to date. This study aimed to evaluate clinicians’ perceived understanding of biostatistical results in the medical literature and the factors influencing them. Materials and Methods: A cross-sectional study was conducted among 201 clinicians at the Seberang Jaya Hospital, a cluster-lead research hospital in Northern Malaysia. A self-administered questionnaire that consisted of items on sociodemographics, validated items on clinicians’ confidence level in interpreting statistical concepts, perceived understanding of biostatistics, and familiarity with different statistical methods were used. Descriptive, univariate, and multivariate analyses were conducted. Results: Perceived understanding of biostatistical results among clinicians in our sample was nearly 75%. In the final regression model, perceived understanding was significantly higher among clinicians who were able to interpret p -values with complete confidence (AOR = 3.0, 95% CI 1.1−8.1), clinicians who regularly encounter measures of central tendencies (AOR = 2.3, 95% CI 1.1−5.2), and clinicians who regularly encounter inferential statistics (AOR = 2.2, 95% CI 1.1−4.5) while appraising the medical literature. Conclusions: High perceived understanding was significantly associated with clinicians’ confidence in interpreting statistical concepts and familiarity with different statistical methods. Our findings form a platform to understand clinicians’ ability to appraise rigorous biostatistical results in the medical literature for the retrieval of evidence-based data to be used in routine clinical practice.
    Schlagwörter biostatistics ; medical literature ; appraisal ; clinicians ; evidence-based medicine ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 310
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Mapping the Scientific Landscape of Diabetes Research in Malaysia (2000–2018)

    Kurubaran Ganasegeran / Chee Peng Hor / Mohd Fadzly Amar Jamil / Purnima Devi Suppiah / Juliana Mohd Noor / Norshahida Abdul Hamid / Deik Roy Chuan / Mohd Rizal Abdul Manaf / Alan Swee Hock Ch’ng / Irene Looi

    International Journal of Environmental Research and Public Health, Vol 18, Iss 318, p

    A Systematic Scientometrics Study

    2021  Band 318

    Abstract: The escalated burden of diabetes on the population’s health has catalyzed rigorous scientific research to produce appropriate evidence for treatment and control. Malaysia suffers from the leading diabetes epidemic within the Western Pacific region. It is ...

    Abstract The escalated burden of diabetes on the population’s health has catalyzed rigorous scientific research to produce appropriate evidence for treatment and control. Malaysia suffers from the leading diabetes epidemic within the Western Pacific region. It is crucial to map the scientific landscape of diabetes research for the country to identify trends in productivity and determine whether research efforts are directed toward the needs-gaps priority for evidence synthesis that could be used for the drafting of policies and guidelines. This systematic scientometrics study was conducted to map the scientific research output (trends and distribution, citation frequency, keywords link visualization, and thematic cluster conceptualization) related to diabetes between 2000–2018 in Malaysia. Using three international databases (PubMed, EMBASE, Scopus) and one local database (MyCite), scientific publication records related to diabetes in Malaysia between 2000 and 2018 were retrieved and analyzed using quantitative and qualitative methodologies. Microsoft Excel 2016, EndNote X9.2, BibExcel 2016, GraphPad Prism 8.0.1, VOS viewer software 1.6.13, and R software version 1.3.959 were used to analyze the trend and contents of diabetes publications. A total of 2094 publication records that accounted for 35,497 citations were analyzed. Kuala Lumpur was the most scientifically productive state in Malaysia, contributing 754 papers. Medical Journal of Malaysia had the highest number of publications. The inflection point of the Malaysian diabetes research output was in 2013, with most publications being non-collaborative research works. Most publications originated from academia, especially from local public universities. The overall publication productivity of diabetes research in Malaysia was conceptualized into eleven thematic clusters, with clinical and animal studies being the most prevalent themes. The diabetes literature in Malaysia has grown steadily over the past 19 years. However, the cumulative evidence remains inadequate ...
    Schlagwörter scientometrics ; diabetes mellitus ; scientific landscape ; science mapping ; Malaysia ; Medicine ; R
    Thema/Rubrik (Code) 001
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: A Systematic Review of the Economic Burden of Type 2 Diabetes in Malaysia

    Kurubaran Ganasegeran / Chee Peng Hor / Mohd Fadzly Amar Jamil / Hong Chuan Loh / Juliana Mohd Noor / Norshahida Abdul Hamid / Purnima Devi Suppiah / Mohd Rizal Abdul Manaf / Alan Swee Hock Ch’ng / Irene Looi

    International Journal of Environmental Research and Public Health, Vol 17, Iss 5723, p

    2020  Band 5723

    Abstract: Diabetes causes significant disabilities, reduced quality of life and mortality that imposes huge economic burden on societies and governments worldwide. Malaysia suffers a high diabetes burden in Asia, but the magnitude of healthcare expenditures ... ...

    Abstract Diabetes causes significant disabilities, reduced quality of life and mortality that imposes huge economic burden on societies and governments worldwide. Malaysia suffers a high diabetes burden in Asia, but the magnitude of healthcare expenditures documented to aid national health policy decision-making is limited. This systematic review aimed to document the economic burden of diabetes in Malaysia, and identify the factors associated with cost burden and the methods used to evaluate costs. Studies conducted between 2000 and 2019 were retrieved using three international databases (PubMed, Scopus, EMBASE) and one local database (MyCite), as well as manual searches. Peer reviewed research articles in English and Malay on economic evaluations of adult type 2 diabetes conducted in Malaysia were included. The review was registered with PROSPERO (CRD42020151857), reported according to PRISMA and used a quality checklist adapted for cost of illness studies. Data were extracted using a data extraction sheet that included study characteristics, total costs, different costing methods and a scoring system to assess the quality of studies reviewed. The review identified twelve eligible studies that conducted cost evaluations of type 2 diabetes in Malaysia. Variation exists in the costs and methods used in these studies. For direct costs, four studies evaluated costs related to complications and drugs, and two studies were related to outpatient and inpatient costs each. Indirect and intangible costs were estimated in one study. Four studies estimated capital and recurrent costs. The estimated total annual cost of diabetes in Malaysia was approximately USD 600 million. Age, type of hospitals or health provider, length of inpatient stay and frequency of outpatient visits were significantly associated with costs. The most frequent epidemiological approach employed was prevalence-based ( n = 10), while cost analysis was the most common costing approach used. The current review offers the first documented evidence on cost ...
    Schlagwörter diabetes ; economic burden ; cost of illness ; healthcare costs ; Malaysia ; Medicine ; R
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.

    Beng-Siang Khor / Mohd Fadzly Amar Jamil / Mohamad Ilham Adenan / Alexander Chong Shu-Chien

    PLoS ONE, Vol 6, Iss 12, p e

    2011  Band 28340

    Abstract: A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to ... ...

    Abstract A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to mitigate the harshness of drug withdrawal. A series of experiments was conducted to investigate the effect of mitragynine on anxiety behavior, cortisol level and expression of stress pathway related genes in zebrafish undergoing morphine withdrawal phase. Adult zebrafish were subjected to two weeks chronic morphine exposure at 1.5 mg/L, followed by withdrawal for 24 hours prior to tests. Using the novel tank diving tests, we first showed that morphine-withdrawn zebrafish display anxiety-related swimming behaviors such as decreased exploratory behavior and increased erratic movement. Morphine withdrawal also elevated whole-body cortisol levels, which confirms the phenotypic stress-like behaviors. Exposing morphine-withdrawn fish to mitragynine however attenuates majority of the stress-related swimming behaviors and concomitantly lower whole-body cortisol level. Using real-time PCR gene expression analysis, we also showed that mitragynine reduces the mRNA expression of corticotropin releasing factor receptors and prodynorphin in zebrafish brain during morphine withdrawal phase, revealing for the first time a possible link between mitragynine's ability to attenuate anxiety during opiate withdrawal with the stress-related corticotropin pathway.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2011-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes.

    Jun Lu / Heming Wei / Jianjun Wu / Mohd Fadzly Amar Jamil / Mei Lan Tan / Mohd Ilham Adenan / Philip Wong / Winston Shim

    PLoS ONE, Vol 9, Iss 12, p e

    2014  Band 115648

    Abstract: INTRODUCTION:Mitragynine is a major bioactive compound of Kratom, which is derived from the leave extracts of Mitragyna speciosa Korth or Mitragyna speciosa (M. speciosa), a medicinal plant from South East Asia used legally in many countries as stimulant ...

    Abstract INTRODUCTION:Mitragynine is a major bioactive compound of Kratom, which is derived from the leave extracts of Mitragyna speciosa Korth or Mitragyna speciosa (M. speciosa), a medicinal plant from South East Asia used legally in many countries as stimulant with opioid-like effects for the treatment of chronic pain and opioid-withdrawal symptoms. Fatal incidents with Mitragynine have been associated with cardiac arrest. In this study, we determined the cardiotoxicity of Mitragynine and other chemical constituents isolated using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). METHODS AND RESULTS:The rapid delayed rectifier potassium current (IKr), L-type Ca2+ current (ICa,L) and action potential duration (APD) were measured by whole cell patch-clamp. The expression of KCNH2 and cytotoxicity was determined by real-time PCR and Caspase activity measurements. After significant IKr suppression by Mitragynine (10 µM) was confirmed in hERG-HEK cells, we systematically examined the effects of Mitragynine and other chemical constituents in hiPSC-CMs. Mitragynine, Paynantheine, Speciogynine and Speciociliatine, dosage-dependently (0.1∼100 µM) suppressed IKr in hiPSC-CMs by 67%∼84% with IC50 ranged from 0.91 to 2.47 µM. Moreover, Mitragynine (10 µM) significantly prolonged APD at 50 and 90% repolarization (APD50 and APD90) (439.0±11.6 vs. 585.2±45.5 ms and 536.0±22.6 vs. 705.9±46.1 ms, respectively) and induced arrhythmia, without altering the L-type Ca2+ current. Neither the expression, and intracellular distribution of KCNH2/Kv11.1, nor the Caspase 3 activity were significantly affected by Mitragynine. CONCLUSIONS:Our study indicates that Mitragynine and its analogues may potentiate Torsade de Pointes through inhibition of IKr in human cardiomyocytes.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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