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  1. Article ; Online: Interplay of mitochondria-associated membrane proteins and autophagy: Implications in neurodegeneration.

    Kulkarni, Prakash G / Mohire, Vaibhavi M / Waghmare, Pranjal P / Banerjee, Tanushree

    Mitochondrion

    2024  Volume 76, Page(s) 101874

    Abstract: Since the discovery of membrane contact sites between ER and mitochondria called mitochondria-associated membranes (MAMs), several pieces of evidence identified their role in the regulation of different cellular processes such as ... ...

    Abstract Since the discovery of membrane contact sites between ER and mitochondria called mitochondria-associated membranes (MAMs), several pieces of evidence identified their role in the regulation of different cellular processes such as Ca
    Language English
    Publishing date 2024-03-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2056923-3
    ISSN 1872-8278 ; 1567-7249
    ISSN (online) 1872-8278
    ISSN 1567-7249
    DOI 10.1016/j.mito.2024.101874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mitofusin-2: Functional switch between mitochondrial function and neurodegeneration.

    Kulkarni, Prakash G / Mohire, Vaibhavi M / Bhaisa, Pooja K / Joshi, Mrudula M / Puranik, Chitranshi M / Waghmare, Pranjal P / Banerjee, Tanushree

    Mitochondrion

    2023  Volume 69, Page(s) 116–129

    Abstract: Mitochondria are highly dynamic organelles known to play role in the regulation of several cellular biological processes. However, their dynamics such as number, shape, and biological functions are regulated by mitochondrial fusion and fission process. ... ...

    Abstract Mitochondria are highly dynamic organelles known to play role in the regulation of several cellular biological processes. However, their dynamics such as number, shape, and biological functions are regulated by mitochondrial fusion and fission process. The balance between the fusion and fission process is most important for the maintenance of mitochondrial structure as well as cellular functions. The alterations within mitochondrial dynamic processes were found to be associated with the progression of neurodegenerative diseases. In recent years, mitofusin-2 (Mfn2), a GTPase has emerged as a multifunctional protein which not only is found to regulate the mitochondrial fusion-fission process but also known to regulate several cellular functions such as mitochondrial metabolism, cellular biogenesis, signalling, and apoptosis via maintaining the ER-mitochondria contact sites. In this review, we summarize the current knowledge of the structural and functional properties of the Mfn2, its transcriptional regulation and their roles in several cellular functions with a focus on current advances in the pathogenesis of neurodegenerative diseases.
    MeSH term(s) Humans ; Apoptosis ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism ; Mitochondria/metabolism ; Mitochondrial Dynamics/physiology ; Mitochondrial Proteins/metabolism ; Neurodegenerative Diseases/metabolism
    Chemical Substances GTP Phosphohydrolases (EC 3.6.1.-) ; Mitochondrial Proteins ; MFN2 protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2023-02-09
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056923-3
    ISSN 1872-8278 ; 1567-7249
    ISSN (online) 1872-8278
    ISSN 1567-7249
    DOI 10.1016/j.mito.2023.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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