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  1. Article ; Online: An uncoordinated effort: A new mechanism of exercise intolerance in fibrotic interstitial lung disease.

    Mohning, Michael P

    Respirology (Carlton, Vic.)

    2021  Volume 26, Issue 7, Page(s) 634–635

    MeSH term(s) Fibrosis ; Humans ; Idiopathic Pulmonary Fibrosis ; Lung Diseases, Interstitial
    Language English
    Publishing date 2021-05-17
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14087
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  2. Article ; Online: Cardiopulmonary Exercise Testing.

    de Boer, Esther / Petrache, Irina / Mohning, Michael P

    JAMA

    2022  Volume 327, Issue 13, Page(s) 1284–1285

    MeSH term(s) Exercise Test ; Oxygen Consumption
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.2037
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  3. Article ; Online: Idiopathic pulmonary fibrosis: the radiologist's role in making the diagnosis.

    Mohning, Michael P / Richards, John Caleb / Huie, Tristan J

    The British journal of radiology

    2019  Volume 92, Issue 1099, Page(s) 20181003

    Abstract: Radiologists have a critical role in the evaluation and diagnosis of suspected idiopathic pulmonary fibrosis (IPF). Accurate pattern identification on imaging is key in the multidisciplinary diagnostic process and frequently obviates the need for a ... ...

    Abstract Radiologists have a critical role in the evaluation and diagnosis of suspected idiopathic pulmonary fibrosis (IPF). Accurate pattern identification on imaging is key in the multidisciplinary diagnostic process and frequently obviates the need for a surgical lung biopsy. In this review, we describe the clinical and imaging features of IPF in the context of recently revised international guidelines; contrast findings in other diseases that may inform differential diagnosis of fibrotic lung disease; and highlight common complications associated with pulmonary fibrosis.
    MeSH term(s) Diagnosis, Differential ; Humans ; Idiopathic Pulmonary Fibrosis/diagnostic imaging ; Lung/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Radiologists ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2019-05-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20181003
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  4. Article ; Online: Pirfenidone in fibrotic hypersensitivity pneumonitis: a double-blind, randomised clinical trial of efficacy and safety.

    Fernández Pérez, Evans R / Crooks, James L / Lynch, David A / Humphries, Stephen M / Koelsch, Tilman L / Swigris, Jeffrey J / Solomon, Joshua J / Mohning, Michael P / Groshong, Steve D / Fier, Kaitlin

    Thorax

    2023  Volume 78, Issue 11, Page(s) 1097–1104

    Abstract: Background: Fibrotic hypersensitivity pneumonitis (FHP) is an irreversible lung disease with high morbidity and mortality. We sought to evaluate the safety and effect of pirfenidone on disease progression in such patients.: Methods: We conducted a ... ...

    Abstract Background: Fibrotic hypersensitivity pneumonitis (FHP) is an irreversible lung disease with high morbidity and mortality. We sought to evaluate the safety and effect of pirfenidone on disease progression in such patients.
    Methods: We conducted a single-centre, randomised, double-blinded, placebo-controlled trial in adults with FHP and disease progression. Patients were assigned in a 2:1 ratio to receive either oral pirfenidone (2403 mg/day) or placebo for 52 weeks. The primary end point was the mean absolute change in the per cent predicted forced vital capacity (FVC%). Secondary end points included progression-free survival (PFS, time to a relative decline ≥10% in FVC and/or diffusing capacity of the lung for carbon monoxide (DLCO), acute respiratory exacerbation, a decrease of ≥50 m in the 6 min walk distance, increase or introduction of immunosuppressive drugs or death), change in FVC slope and mean DLCO%, hospitalisations, radiological progression of lung fibrosis and safety.
    Results: After randomising 40 patients, enrolment was interrupted by the COVID-19 pandemic. There was no significant between-group difference in FVC% at week 52 (mean difference -0.76%, 95% CI -6.34 to 4.82). Pirfenidone resulted in a lower rate of decline in the adjusted FVC% at week 26 and improved PFS (HR 0.26, 95% CI 0.12 to 0.60). Results for other secondary end points showed no significant difference between groups. No deaths occurred in the pirfenidone group and one death (respiratory) occurred in the placebo group. There were no treatment-emergent serious adverse events.
    Conclusions: The trial was underpowered to detect a difference in the primary end point. Pirfenidone was found to be safe and improved PFS in patients with FHP.
    Trial registration mumber: NCT02958917.
    MeSH term(s) Adult ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Treatment Outcome ; Pandemics ; COVID-19 ; Vital Capacity ; Pyridones/adverse effects ; Double-Blind Method ; Disease Progression ; Alveolitis, Extrinsic Allergic/drug therapy
    Chemical Substances pirfenidone (D7NLD2JX7U) ; Pyridones
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2022-219795
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  5. Article: Signatures of Mitochondrial Dysfunction and Impaired Fatty Acid Metabolism in Plasma of Patients with Post-Acute Sequelae of COVID-19 (PASC).

    Guntur, Vamsi P / Nemkov, Travis / de Boer, Esther / Mohning, Michael P / Baraghoshi, David / Cendali, Francesca I / San-Millán, Inigo / Petrache, Irina / D'Alessandro, Angelo

    Metabolites

    2022  Volume 12, Issue 11

    Abstract: Exercise intolerance is a major manifestation of post-acute sequelae of severe acute respiratory syndrome coronavirus infection (PASC, or "long-COVID"). Exercise intolerance in PASC is associated with higher arterial blood lactate accumulation and lower ... ...

    Abstract Exercise intolerance is a major manifestation of post-acute sequelae of severe acute respiratory syndrome coronavirus infection (PASC, or "long-COVID"). Exercise intolerance in PASC is associated with higher arterial blood lactate accumulation and lower fatty acid oxidation rates during graded exercise tests to volitional exertion, suggesting altered metabolism and mitochondrial dysfunction. It remains unclear whether the profound disturbances in metabolism that have been identified in plasma from patients suffering from acute coronavirus disease 2019 (COVID-19) are also present in PASC. To bridge this gap, individuals with a history of previous acute COVID-19 infection that did not require hospitalization were enrolled at National Jewish Health (Denver, CO, USA) and were grouped into those that developed PASC (n = 29) and those that fully recovered (n = 16). Plasma samples from the two groups were analyzed via mass spectrometry-based untargeted metabolomics and compared against plasma metabolic profiles of healthy control individuals (n = 30). Observational demographic and clinical data were retrospectively abstracted from the medical record. Compared to plasma of healthy controls or individuals who recovered from COVID-19, PASC plasma exhibited significantly higher free- and carnitine-conjugated mono-, poly-, and highly unsaturated fatty acids, accompanied by markedly lower levels of mono-, di- and tricarboxylates (pyruvate, lactate, citrate, succinate, and malate), polyamines (spermine) and taurine. Plasma from individuals who fully recovered from COVID-19 exhibited an intermediary metabolic phenotype, with milder disturbances in fatty acid metabolism and higher levels of spermine and taurine. Of note, depletion of tryptophan-a hallmark of disease severity in COVID-19-is not normalized in PASC patients, despite normalization of kynurenine levels-a tryptophan metabolite that predicts mortality in hospitalized COVID-19 patients. In conclusion, PASC plasma metabolites are indicative of altered fatty acid metabolism and dysfunctional mitochondria-dependent lipid catabolism. These metabolic profiles obtained at rest are consistent with previously reported mitochondrial dysfunction during exercise, and may pave the way for therapeutic intervention focused on restoring mitochondrial fat-burning capacity.
    Language English
    Publishing date 2022-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12111026
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  6. Article: Duration of rheumatoid arthritis and the risk of developing interstitial lung disease.

    Mohning, Michael P / Amigues, Isabelle / Demoruelle, M Kristen / Fernández Pérez, Evans R / Huie, Tristan J / Keith, Rebecca K / Olson, Amy L / Yunt, Zulma X / Chung, Jonathan H / Hobbs, Stephen / Swigris, Jeffrey J / Solomon, Joshua J

    ERJ open research

    2021  Volume 7, Issue 1

    Abstract: Age of ILD onset is similar in patients with RA-UIP and RA-NSIP but duration of RA before ILD onset ... ...

    Abstract Age of ILD onset is similar in patients with RA-UIP and RA-NSIP but duration of RA before ILD onset differs
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00633-2020
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  7. Article: Design and rationale of a randomised, double-blind trial of the efficacy and safety of pirfenidone in patients with fibrotic hypersensitivity pneumonitis.

    Fernández Pérez, Evans R / Crooks, James L / Swigris, Jeffrey J / Solomon, Joshua J / Mohning, Michael P / Huie, Tristan J / Koslow, Matthew / Lynch, David A / Groshong, Steve D / Fier, Kaitlin

    ERJ open research

    2021  Volume 7, Issue 2

    Abstract: Hypersensitivity pneumonitis (HP) is an immunologically mediated form of lung disease resulting from inhalational exposure to any of a large variety of antigens. A subgroup of patients with HP develops pulmonary fibrosis (fibrotic HP; FHP), a significant ...

    Abstract Hypersensitivity pneumonitis (HP) is an immunologically mediated form of lung disease resulting from inhalational exposure to any of a large variety of antigens. A subgroup of patients with HP develops pulmonary fibrosis (fibrotic HP; FHP), a significant cause of morbidity and mortality. This study will evaluate the safety and efficacy of the antifibrotic pirfenidone in treating FHP. This single-centre, randomised, double-blind, placebo-controlled trial is enrolling adults with FHP (ClinicalTrials.gov: NCT02958917). Study participants must have fibrotic abnormalities involving ≥5% of the lung parenchyma on high-resolution computed tomography scan, forced vital capacity (FVC) ≥40% and diffusing capacity of the lung for carbon monoxide ≥30% of predicted values. Study participants will be randomised in a 2:1 ratio to receive pirfenidone 2403 mg·day
    Language English
    Publishing date 2021-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00054-2021
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  8. Article ; Online: Anchored to asthma.

    Mohning, Michael P / Janssen, William J / Groshong, Steve D / Canham, E Michael

    Annals of the American Thoracic Society

    2015  Volume 12, Issue 3, Page(s) 448–450

    MeSH term(s) Asthma/complications ; Asthma/diagnosis ; Asthma/drug therapy ; Auscultation ; Cough/diagnosis ; Cough/drug therapy ; Cough/etiology ; Diagnosis, Differential ; Dyspnea/diagnosis ; Dyspnea/drug therapy ; Dyspnea/etiology ; Female ; Humans ; Middle Aged ; Radiography, Thoracic ; Severity of Illness Index
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201410-456CC
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    Zs.A 5828: Show issues Location:
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  9. Article ; Online: Decreased Fatty Acid Oxidation and Altered Lactate Production during Exercise in Patients with Post-acute COVID-19 Syndrome.

    de Boer, Esther / Petrache, Irina / Goldstein, Nir M / Olin, J Tod / Keith, Rebecca C / Modena, Brian / Mohning, Michael P / Yunt, Zulma X / San-Millán, Inigo / Swigris, Jeffrey J

    American journal of respiratory and critical care medicine

    2021  Volume 205, Issue 1, Page(s) 126–129

    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/metabolism ; Chronic Disease ; Exercise ; Fatty Acids/metabolism ; Female ; Humans ; Lactic Acid/blood ; Lipid Metabolism ; Male ; Middle Aged ; Oxidation-Reduction ; Oxygen Consumption ; Retrospective Studies ; Post-Acute COVID-19 Syndrome
    Chemical Substances Fatty Acids ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2021-10-12
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202108-1903LE
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  10. Article ; Online: Placental transmogrification of the lung: a rare cause of unilateral bullous disease.

    Mohning, Michael P / Schwarz, Marvin I / McKinley, Sarah J

    American journal of respiratory and critical care medicine

    2014  Volume 190, Issue 1, Page(s) e1

    MeSH term(s) Cough/etiology ; Dyspnea/etiology ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Lung/physiopathology ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/pathology ; Male ; Middle Aged ; Tomography, X-Ray Computed
    Language English
    Publishing date 2014-07-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201307-1361IM
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