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Book ; Thesis: Effects of the dietary supplement cinnamon on metabolic markers of type 2 diabetes mellitus patients

Mohr, Thomas Adrian / Schöndorf, Thomas / Herzig, Stefan

analysis of a multicenter, double blinded, placebo controlled, randomized parallel two arm trial

2010

Institution	Institut für Pharmakologie
Author's details	vorgelegt von Thomas Mohr ; 1. Berichterstatter/Berichterstatterin: Privatdozent Dr. rer. nat. Dr. rer. medic. Th. Schöndorf, 2. Berichterstatter/Berichterstatterin: Universitätsprofessor Dr. med. S. Herzig ; aus dem Institut für Pharmakologie der Universität zu Köln
Language	English
Size	115 S. : graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Köln, Univ., Diss., 2010
HBZ-ID	HT016475592
Database	Catalogue ZB MED Medicine, Health

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Book ; Online ; Thesis: Effects of the dietary supplement cinnamon on metabolic markers of type 2 diabetes mellitus patients

Mohr, Thomas Adrian / Schöndorf, Thomas / Herzig, Stefan

analysis of a multicenter, double blinded, placebo controlled, randomized parallel two arm trial

2010

Institution	Institut für Pharmakologie
Author's details	vorgelegt von Thomas Mohr ; 1. Berichterstatter/Berichterstatterin: Privatdozent Dr. rer. nat. Dr. rer. medic. Th. Schöndorf, 2. Berichterstatter/Berichterstatterin: Universitätsprofessor Dr. med. S. Herzig ; aus dem Institut für Pharmakologie der Universität zu Köln
Subject code	610
Language	English
Size	115 S. : graph. Darst.
Publishing country	Germany
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Köln, Univ., Diss., 2010
Note	Open Access
HBZ-ID	HT016466647
DOI	10.4126/38m-000000269
Database	Repository for Life Sciences

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Article ; Online: Red Blood Cell Stiffness and Adhesion Are Species-Specific Properties Strongly Affected by Temperature and Medium Changes in Single Cell Force Spectroscopy.

Baier, Dina / Müller, Torsten / Mohr, Thomas / Windberger, Ursula

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 9

Abstract: Besides human red blood cells (RBC), a standard model used in AFM-single cell force spectroscopy (SCFS), little is known about apparent Young's modulus (Ea) or adhesion of animal RBCs displaying distinct cellular features. To close this knowledge gap, we ...

Abstract	Besides human red blood cells (RBC), a standard model used in AFM-single cell force spectroscopy (SCFS), little is known about apparent Young's modulus (Ea) or adhesion of animal RBCs displaying distinct cellular features. To close this knowledge gap, we probed chicken, horse, camel, and human fetal RBCs and compared data with human adults serving as a repository for future studies. Additionally, we assessed how measurements are affected under physiological conditions (species-specific temperature in autologous plasma vs. 25 °C in aqueous NaCl solution). In all RBC types, Ea decreased with increasing temperature irrespective of the suspension medium. In mammalian RBCs, adhesion increased with elevated temperatures and scaled with reported membrane sialic acid concentrations. In chicken only adhesion decreased with higher temperature, which we attribute to the lower AE-1 concentration allowing more membrane undulations. Ea decreased further in plasma at every test temperature, and adhesion was completely abolished, pointing to functional cell enlargement by adsorption of plasma components. This halo elevated RBC size by several hundreds of nanometers, blunted the thermal input, and will affect the coupling of RBCs with the flowing plasma. The study evidences the presence of a RBC surface layer and discusses the tremendous effects when RBCs are probed at physiological conditions.
MeSH term(s)	Adult ; Animals ; Camelus/blood ; Cell Adhesion/physiology ; Cell Membrane/metabolism ; Chickens/blood ; Erythrocytes/cytology ; Horses/blood ; Humans ; Microscopy, Atomic Force/methods ; Single-Cell Analysis/methods ; Temperature
Language	English
Publishing date	2021-05-08
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26092771
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mesenchymal Stem Cell Conditioned Medium Modulates Inflammation in Tenocytes: Complete Conditioned Medium Has Superior Therapeutic Efficacy than Its Extracellular Vesicle Fraction.

Soukup, Robert / Gerner, Iris / Mohr, Thomas / Gueltekin, Sinan / Grillari, Johannes / Jenner, Florien

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Tendinopathy, a prevalent overuse injury, lacks effective treatment options, leading to a significant impact on quality of life and socioeconomic burden. Mesenchymal stem/stromal cells (MSCs) and their secretome, including conditioned medium (CM) and ... ...

Abstract	Tendinopathy, a prevalent overuse injury, lacks effective treatment options, leading to a significant impact on quality of life and socioeconomic burden. Mesenchymal stem/stromal cells (MSCs) and their secretome, including conditioned medium (CM) and extracellular vesicles (EVs), have shown promise in tissue regeneration and immunomodulation. However, it remains unclear which components of the secretome contribute to their therapeutic effects. This study aimed to compare the efficacy of CM, EVs, and the soluble protein fraction (PF) in treating inflamed tenocytes. CM exhibited the highest protein and particle concentrations, followed by PF and EVs. Inflammation significantly altered gene expression in tenocytes, with CM showing the most distinct separation from the inflamed control group. Treatment with CM resulted in the most significant differential gene expression, with both upregulated and downregulated genes related to inflammation and tissue regeneration. EV treatment also demonstrated a therapeutic effect, albeit to a lesser extent. These findings suggest that CM holds superior therapeutic efficacy compared with its EV fraction alone, emphasizing the importance of the complete secretome in tendon injury treatment.
MeSH term(s)	Humans ; Culture Media, Conditioned/pharmacology ; Culture Media, Conditioned/metabolism ; Tenocytes/metabolism ; Quality of Life ; Extracellular Vesicles/metabolism ; Inflammation/metabolism ; Proteins/metabolism ; Mesenchymal Stem Cells/metabolism
Chemical Substances	Culture Media, Conditioned ; Proteins
Language	English
Publishing date	2023-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241310857
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hybrid Approaches for Selective Laser Sintering by Building on Dissimilar Materials.

Goetzendorfer, Babette / Mohr, Thomas / Hellmann, Ralf

Materials (Basel, Switzerland)

2020 Volume 13, Issue 22

Abstract: We introduced a new approach in selective laser sintering for hybrid multicomponent systems by fabricating the sintered polyamide 12 (PA12) part directly onto a similar (PA12) or dissimilar (polyamide 6 (PA6) and tool steel 1.2709) joining partner. Thus, ...

Abstract	We introduced a new approach in selective laser sintering for hybrid multicomponent systems by fabricating the sintered polyamide 12 (PA12) part directly onto a similar (PA12) or dissimilar (polyamide 6 (PA6) and tool steel 1.2709) joining partner. Thus, the need for adhesive substances or joining pressure was completely circumvented, leading to the possibility of pure hybrid lightweight bi-polymer or metal-polymer systems. By taking advantage of the heating capabilities of the sinter laser regarding the substrate surface, different exposure strategies circumvented the lack of overlapping melting temperatures of dissimilar polymers. Therefore, even sintering on non-PA12 polymers was made possible. Finally, the transfer on metallic substrates-made up by selective laser melting (SLM)-was successfully performed, closing the gap between two powder-based additive processes, selective laser sintering (SLS) and SLM.
Language	English
Publishing date	2020-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13225285
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Systematic Analysis of the Transcriptome Profiles and Co-Expression Networks of Tumour Endothelial Cells Identifies Several Tumour-Associated Modules and Potential Therapeutic Targets in Hepatocellular Carcinoma.

Mohr, Thomas / Katz, Sonja / Paulitschke, Verena / Aizarani, Nadim / Tolios, Alexander

Cancers

2021 Volume 13, Issue 8

Abstract: Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most common cause of cancer-related death, with tumour associated liver endothelial cells being thought to be major drivers in HCC progression. This study aims to compare the ... ...

Abstract	Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most common cause of cancer-related death, with tumour associated liver endothelial cells being thought to be major drivers in HCC progression. This study aims to compare the gene expression profiles of tumour endothelial cells from the liver with endothelial cells from non-tumour liver tissue, to identify perturbed biologic functions, co-expression modules, and potentially drugable hub genes that could give rise to novel therapeutic targets and strategies. Gene Set Variation Analysis (GSVA) showed that cell growth-related pathways were upregulated, whereas apoptosis induction, immune and inflammatory-related pathways were downregulated in tumour endothelial cells. Weighted Gene Co-expression Network Analysis (WGCNA) identified several modules strongly associated to tumour endothelial cells or angiogenic activated endothelial cells with high endoglin (
Language	English
Publishing date	2021-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13081768
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Article ; Online: A Transformative Leadership Journey: Experiences of Graduates of the American Physical Therapy Association Fellowship in Education Leadership.

Jette, Diane U / Nordstrom, Terrence M / Gresham, Barbara / Peel, Claire / Majsak, Michael J / Mohr, Thomas

Journal, physical therapy education

2022 Volume 37, Issue 1, Page(s) 60–69

Abstract: Introduction: Physical therapy education has an acute need for effective leaders due to multiple factors, including increasing numbers of programs and retirement of experienced leaders. Recognizing the need for formal leadership education, the American ... ...

Abstract	Introduction: Physical therapy education has an acute need for effective leaders due to multiple factors, including increasing numbers of programs and retirement of experienced leaders. Recognizing the need for formal leadership education, the American Physical Therapy Association (APTA) developed a fellowship in physical therapy educational leadership in 2011. This study aimed to understand participants' perceptions of their leadership experience and the role of the APTA fellowship. Literature review: A commonly reported approach to evaluating leadership education programs was designed by Kirkpatrick. Participants: Twenty-five fellowship graduates from 2012 to 2019 participated. Methods: We used a qualitative methodological approach incorporating a heuristic technique to gain an understanding of fellowship graduates' long-term perspectives. Semi-structured interviews were conducted via Zoom. Data were analyzed using thematic analysis. Results: Three themes were constructed using a journey metaphor: embarking on the journey, engaging in the journey, and realizing the effects of the journey. 1) Embarking on the journey included 2 subthemes: a) participants' personal aspirations as career planners, reluctant leaders, or explorers; and b) institutions' goals for a change in leadership or intentional succession planning. 2) Engaging in the journey included 3 subthemes: a) the fellowship learning environment builds a sense of community; b) consideration of leadership frames influences participants' thinking about leadership; and c) participants' institutional environment influences their learning. 3) Effects of the journey included 3 subthemes: a) personal growth as a leader including personal awareness and confidence; b) institutions' benefits from participants' leadership projects and increased engagement in institutional leadership; and c) physical therapy professions' gains from participants' seeking leadership positions in professional organizations. Discussion/conclusions: The APTA Fellowship in Educational Leadership results in transformative change of participants as leaders. Findings offer guidance to individuals considering embarking on a leadership journey and institutions considering how to prepare and support emerging leaders in physical therapy education.
MeSH term(s)	Humans ; United States ; Leadership ; Fellowships and Scholarships ; Learning
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Journal Article
ISSN	1938-3533
ISSN (online)	1938-3533
DOI	10.1097/JTE.0000000000000255
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Proteome of Extracellular Vesicles Released from Pulmonary Microvascular Endothelium Reveals Impact of Oxygen Conditions on Biotrauma.

Schaubmayr, Wolfgang / Hochreiter, Beatrix / Hunyadi-Gulyas, Eva / Riegler, Louise / Schmidt, Katy / Tiboldi, Akos / Moser, Bernhard / Klein, Klaus U / Krenn, Katharina / Scharbert, Gisela / Mohr, Thomas / Schmid, Johannes A / Spittler, Andreas / Tretter, Verena

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: The lung can experience different oxygen concentrations, low as in hypoxia, high as under supplemental oxygen therapy, or oscillating during intermittent hypoxia as in obstructive sleep apnea or intermittent hypoxia/hyperoxia due to cyclic atelectasis in ...

Abstract	The lung can experience different oxygen concentrations, low as in hypoxia, high as under supplemental oxygen therapy, or oscillating during intermittent hypoxia as in obstructive sleep apnea or intermittent hypoxia/hyperoxia due to cyclic atelectasis in the ventilated patient. This study aimed to characterize the oxygen-condition-specific protein composition of extracellular vesicles (EVs) released from human pulmonary microvascular endothelial cells in vitro to decipher their potential role in biotrauma using quantitative proteomics with bioinformatic evaluation, transmission electron microscopy, flow cytometry, and non-activated thromboelastometry (NATEM). The release of vesicles enriched in markers CD9/CD63/CD81 was enhanced under intermittent hypoxia, strong hyperoxia and intermittent hypoxia/hyperoxia. Particles with exposed phosphatidylserine were increased under intermittent hypoxia. A small portion of vesicles were tissue factor-positive, which was enhanced under intermittent hypoxia and intermittent hypoxia/hyperoxia. EVs from treatment with intermittent hypoxia induced a significant reduction of Clotting Time in NATEM analysis compared to EVs isolated after normoxic exposure, while after intermittent hypoxia/hyperoxia, tissue factor in EVs seems to be inactive. Gene set enrichment analysis of differentially expressed genes revealed that EVs from individual oxygen conditions potentially induce different biological processes such as an inflammatory response under strong hyperoxia and intermittent hypoxia/hyperoxia and enhancement of tumor invasiveness under intermittent hypoxia.
MeSH term(s)	Humans ; Oxygen/pharmacology ; Oxygen/metabolism ; Hyperoxia/metabolism ; Proteome/metabolism ; Endothelial Cells/pathology ; Thromboplastin/metabolism ; Lung/pathology ; Hypoxia/metabolism ; Extracellular Vesicles/metabolism ; Endothelium/pathology
Chemical Substances	Oxygen (S88TT14065) ; Proteome ; Thromboplastin (9035-58-9)
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042415
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of prehospital high-dose glucocorticoid on hemodynamics in patients resuscitated from out-of-hospital cardiac arrest: a sub-study of the STEROHCA trial.

Obling, Laust E R / Beske, Rasmus P / Meyer, Martin A S / Grand, Johannes / Wiberg, Sebastian / Mohr, Thomas / Damm-Hejmdal, Anders / Forman, Julie L / Frikke-Schmidt, Ruth / Folke, Fredrik / Møller, Jacob E / Kjaergaard, Jesper / Hassager, Christian

Critical care (London, England)

2024 Volume 28, Issue 1, Page(s) 28

Abstract: Background: Following resuscitated out-of-hospital cardiac arrest (OHCA), inflammatory markers are significantly elevated and associated with hemodynamic instability and organ dysfunction. Vasopressor support is recommended to maintain a mean arterial ... ...

Abstract	Background: Following resuscitated out-of-hospital cardiac arrest (OHCA), inflammatory markers are significantly elevated and associated with hemodynamic instability and organ dysfunction. Vasopressor support is recommended to maintain a mean arterial pressure (MAP) above 65 mmHg. Glucocorticoids have anti-inflammatory effects and may lower the need for vasopressors. This study aimed to assess the hemodynamic effects of prehospital high-dose glucocorticoid treatment in resuscitated comatose OHCA patients. Methods: The STEROHCA trial was a randomized, placebo-controlled, phase 2 trial comparing one prehospital injection of methylprednisolone 250 mg with placebo immediately after resuscitated OHCA. In this sub-study, we included patients who remained comatose at admission and survived until intensive care unit (ICU) admission. The primary outcome was cumulated norepinephrine use from ICU admission until 48 h reported as mcg/kg/min. Secondary outcomes included hemodynamic status characterized by MAP, heart rate, vasoactive-inotropic score (VIS), and the VIS/MAP-ratio as well as cardiac function assessed by pulmonary artery catheter measurements. Linear mixed-model analyses were performed to evaluate mean differences between treatment groups at all follow-up times. Results: A total of 114 comatose OHCA patients were included (glucocorticoid: n = 56, placebo: n = 58) in the sub-study. There were no differences in outcomes at ICU admission. From the time of ICU admission up to 48 h post-admission, patients in the glucocorticoid group cumulated a lower norepinephrine use (mean difference - 0.04 mcg/kg/min, 95% CI - 0.07 to - 0.01, p = 0.02). Moreover, after 12-24 h post-admission, the glucocorticoid group demonstrated a higher MAP with mean differences ranging from 6 to 7 mmHg (95% CIs from 1 to 12), a lower VIS (mean differences from - 4.2 to - 3.8, 95% CIs from - 8.1 to 0.3), and a lower VIS/MAP ratio (mean differences from - 0.10 to - 0.07, 95% CIs from - 0.16 to - 0.01), while there were no major differences in heart rate (mean differences from - 4 to - 3, 95% CIs from - 11 to 3). These treatment differences between groups were also present 30-48 h post-admission but to a smaller extent and with increased statistical uncertainty. No differences were found in pulmonary artery catheter measurements between groups. Conclusions: Prehospital treatment with high-dose glucocorticoid was associated with reduced norepinephrine use in resuscitated OHCA patients. Trial registration: EudraCT number: 2020-000855-11; submitted March 30, 2020. URL: https://www. Clinicaltrials: gov Unique Identifier: NCT04624776.
MeSH term(s)	Humans ; Glucocorticoids/pharmacology ; Glucocorticoids/therapeutic use ; Coma/drug therapy ; Out-of-Hospital Cardiac Arrest/complications ; Out-of-Hospital Cardiac Arrest/drug therapy ; Hemodynamics ; Norepinephrine/therapeutic use ; Emergency Medical Services
Chemical Substances	Glucocorticoids ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-024-04808-3
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Article ; Online: Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets.

Hagn, Gerhard / Meier-Menches, Samuel M / Plessl-Walder, Günter / Mitra, Gaurav / Mohr, Thomas / Preindl, Karin / Schlatter, Andreas / Schmidl, Doreen / Gerner, Christopher / Garhöfer, Gerhard / Bileck, Andrea

Journal of proteome research

2024

Abstract: Metabolomics is an emerging and powerful bioanalytical method supporting clinical investigations. Serum and plasma are commonly used without rational prioritization. Serum is collected after blood coagulation, a complex biochemical process involving ... ...

Abstract	Metabolomics is an emerging and powerful bioanalytical method supporting clinical investigations. Serum and plasma are commonly used without rational prioritization. Serum is collected after blood coagulation, a complex biochemical process involving active platelet metabolism. This may affect the metabolome and increase the variance, as platelet counts and function may vary substantially in individuals. A multiomics approach systematically investigating the suitability of serum and plasma for clinical studies demonstrated that metabolites correlated well (
Language	English
Publishing date	2024-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.3c00761
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