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Article ; Online: “Review” a core pillar of urgent care provision in primary care

Moien A B Khan

Journal of Family Medicine and Primary Care, Vol 9, Iss 9, Pp 5072-

2020 Volume 5073

Keywords	Medicine ; R
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Insulin Signal Transduction Perturbations in Insulin Resistance

Mariyam Khalid / Juma Alkaabi / Moien A. B. Khan / Abdu Adem

International Journal of Molecular Sciences, Vol 22, Iss 8590, p

2021 Volume 8590

Abstract: Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance in insulin-responsive tissues precedes the onset of pancreatic β-cell ... ...

Abstract	Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance in insulin-responsive tissues precedes the onset of pancreatic β-cell dysfunction. Multiple molecular and pathophysiological mechanisms are involved in insulin resistance. Insulin resistance is a consequence of a complex combination of metabolic disorders, lipotoxicity, glucotoxicity, and inflammation. There is ample evidence linking different mechanistic approaches as the cause of insulin resistance, but no central mechanism is yet described as an underlying reason behind this condition. This review combines and interlinks the defects in the insulin signal transduction pathway of the insulin resistance state with special emphasis on the AGE-RAGE-NF-κB axis. Here, we describe important factors that play a crucial role in the pathogenesis of insulin resistance to provide directionality for the events. The interplay of inflammation and oxidative stress that leads to β-cell decline through the IAPP-RAGE induced β-cell toxicity is also addressed. Overall, by generating a comprehensive overview of the plethora of mechanisms involved in insulin resistance, we focus on the establishment of unifying mechanisms to provide new insights for the future interventions of type 2 diabetes mellitus.
Keywords	insulin resistance ; hyperglycemia ; type 2 diabetes mellitus ; insulin signaling ; pancreatic beta cells ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Complementary feeding practices and the associated risk of childhood obesity among ethnic minority groups living in high-income countries

Linda Östlundh / Omar Omar / Moien A B Khan / Teresa Arora / Maido Tsenoli

BMJ Open, Vol 12, Iss

protocol for a systematic review and meta-analysis

2022 Volume 3

Keywords	Medicine ; R
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Relationship between Cellphone Usage on the Physical and Mental Wellbeing of University Students

Muhammad Daniyal / Syed Fahad Javaid / Ali Hassan / Moien A. B. Khan

International Journal of Environmental Research and Public Health, Vol 19, Iss 9352, p

A Cross-Sectional Study

2022 Volume 9352

Abstract: 1) Background: The study aims to examine the use of cell phones on physical and mental health status and their impact on personality among university students. (2) Methods: A cross-sectional study was conducted using a semi-structured questionnaire. The ...

Abstract	(1) Background: The study aims to examine the use of cell phones on physical and mental health status and their impact on personality among university students. (2) Methods: A cross-sectional study was conducted using a semi-structured questionnaire. The association of physical and mental health variables with the demographic variables was examined using Pearson’s correlation and χ 2 -test. The binary logistic regression model was further used to predict the probabilities of negative impact on personality due to excessive use of cell phones. (3) Results: A total of 400 participants participated with a mean age of 24.45 ± 3.45 years. The average eye strain was more in High cell phone users HCPU than in LCPU and that difference was significant p = 0.000. The average neck pain was more in (HCPU) than Low cell phone users (LCPU) and there was a significant difference between the two groups with p = 0.006. The average weight gain was more in HCPU than LCPU and that difference was significant p = 0.000. Considering back pain, back pain was found more in HCPU as compared to LCPU with a statistical difference at p = 0.027. Cell phone usage significantly correlated with eye strain (r = 0.577, p = 0.000), neck pain (r = 0.543, p = 0.000), back pain (r = 0.611, p = 0.000), weight gain (r = 0.423, p = 0.000), depression (r = 0.430, p = 0.000), loneliness (r = −0.276, p = 0.002), and mood disorder (r = 0.608, p = 0.000). Eye strain, neck pain, and back pain was observed more in HCPU than in LCPU. HCPU felt they gained more weight when compared to the respondents in the LCPU group. HCPU felt more changes in mood and feeling low when compared to the LCPU, while LCPU group felt more lonelier when compared to the HCPU group. (4) Conclusions: The study highlights a significant association between excess use of cell phones and negative effects on physical and mental health wellbeing. Based on the results, it is recommended that more physical activities and alternative to minimize cell phone usage should be planned for the ...
Keywords	physical health ; mental health ; cell phone addiction ; youths ; Pakistan ; Medicine ; R
Subject code	796
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Elevated troponin level and nonspecific ST‐segment and T‐wave changes in a suspected acute pancreatitis patient, post‐SARS‐Cov‐2 infection

Mohammad Pourfridoni / Moien A. B. Khan / Alam Khalil‐Khan / Afshin Mohammad Bagheri Rafsanjani / Hedyeh Askarpour

Clinical Case Reports, Vol 10, Iss 11, Pp n/a-n/a (2022)

A case report

2022

Abstract: Abstract The case report describes a post‐COVID‐19 patient with severe right upper quadrant (RUQ) pain, moderate epigastric pain, high troponin levels, and nonspecific ST‐segment and T‐wave changes on electrocardiogram (ECG). ...

Abstract	Abstract The case report describes a post‐COVID‐19 patient with severe right upper quadrant (RUQ) pain, moderate epigastric pain, high troponin levels, and nonspecific ST‐segment and T‐wave changes on electrocardiogram (ECG).
Keywords	abdominal pain ; acute pancreatitis ; case report ; COVID‐19 ; electrocardiography ; SARS‐Cov‐2 ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinicopathological characteristics of 8697 patients with COVID-19 in China

Moien A B Khan / Elpidoforos Soteriades / Reem Juma Al Falasi / Adeel Saleem

Family Medicine and Community Health, Vol 8, Iss

meta-analysis

2020 Volume 2

Keywords	Medicine (General) ; R5-920 ; covid19
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tailoring time series models for forecasting coronavirus spread

Leila Ismail / Huned Materwala / Taieb Znati / Sherzod Turaev / Moien A.B. Khan

Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2972-

Case studies of 187 countries

2020 Volume 3206

Abstract: When will the coronavirus end? Are the current precautionary measures effective? To answer these questions it is important to forecast regularly and accurately the spread of COVID-19 infections. Different time series forecasting models have been applied ... ...

Abstract	When will the coronavirus end? Are the current precautionary measures effective? To answer these questions it is important to forecast regularly and accurately the spread of COVID-19 infections. Different time series forecasting models have been applied in the literature to tackle the pandemic situation. The current research efforts developed few of these models and validates its accuracy for selected countries. It becomes difficult to draw an objective comparison between the performance of these models at a global scale. This is because, the time series trend for the infection differs between the countries depending on the strategies adopted by the healthcare organizations to decrease the spread. Consequently, it is important to develop a tailored model for a country that allows healthcare organizations to better judge the effect of the undertaken precautionary measures, and provision more efficiently the needed resources to face this disease. This paper addresses this void. We develop and compare the performance of the time series models in the literature in terms of root mean squared error and mean absolute percentage error.
Keywords	Coronavirus ; COVID-19 ; Epidemic transmission ; Forecasting models ; Machine learning models ; Pandemic ; Biotechnology ; TP248.13-248.65 ; covid19
Subject code	330
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Camel Milk on Glucose Homeostasis in Patients with Diabetes

Refat AlKurd / Nivine Hanash / Narmin Khalid / Dana N. Abdelrahim / Moien A. B. Khan / Lana Mahrous / Hadia Radwan / Farah Naja / Mohamed Madkour / Khaled Obaideen / Katia Abu Shihab / MoezAlIslam Faris

Nutrients, Vol 14, Iss 1245, p

A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2022 Volume 1245

Abstract: The effects of camel milk (CM) intake on glycemic control in patients with diabetes are controversial. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of CM intake on glucose ... ...

Abstract	The effects of camel milk (CM) intake on glycemic control in patients with diabetes are controversial. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of CM intake on glucose homeostasis parameters in patients with both types of diabetes mellitus; T1DM and T2DM. We searched Google Scholar, PubMed/MEDLINE, EBSCO host, CINAHL, ScienceDirect, Cochrane, ProQuest Medical, Web of Science, and Scopus databases from inception until the end of November 2021. Relevant RCTs were identified, and the effect size was reported as mean difference (MD) and standard deviation (SD). Parameters of glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), postprandial blood glucose (PBG), fasting serum insulin (FI), insulin resistance (expressed in terms of HOMA-IR), insulin dose (ID) received, serum insulin antibody (IA), and C-peptide (CP) were tested. Out of 4054 collected articles, 14 RCTs (total 663 subjects) were eligible for inclusion. The pooled results obtained using a random-effects model showed a statistically significant decrease in HbA1c levels (MD, −1.24, 95% confidence interval (CI): −2.00, −0.48, p < 0.001 heterogeneity ( I 2 ) = 94%) and ID received (MD, −16.72, 95% CI: −22.09, −11.35 p < 0.00001, I 2 = 90%), with a clear tendency was shown, but non-significant, to decrease FBG (MD, −23.32, 95% CI: −47.33, 0.70, p = 0.06, I 2 = 98%) in patients with diabetes who consumed CM in comparison to those on usual care. Conversely, the consumption of CM did not show significant reductions in the rest of the glucose homeostasis parameters. Subgroup analysis revealed that patients with T2DM were more beneficially affected by CM intake than those with T1DM in lowering FBG, while patients with T1DM were more beneficially affected by CM intake than those with T2DM in lowering HbA1c. Both fresh and treated (pasteurized/fermented) CM gave similar beneficial effects in lowering HbA1c. Lastly, a relatively superior effect for longer duration on shorter ...
Keywords	Arabian camel ; Camelus dromedaries ; complementary and alternative medicine (CAM) ; glucometabolic parameters ; glycemic control ; insulin resistance ; Nutrition. Foods and food supply ; TX341-641
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Global Incidence and Mortality Patterns of Pedestrian Road Traffic Injuries by Sociodemographic Index, with Forecasting

Moien A. B. Khan / Michal Grivna / Javaid Nauman / Elpidoforos S. Soteriades / Arif Alper Cevik / Muhammad Jawad Hashim / Romona Govender / Salma Rashid Al Azeezi

International Journal of Environmental Research and Public Health, Vol 17, Iss 6, p

Findings from the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study

2020 Volume 2135

Abstract: 1) Background: Pedestrian injuries (PIs) represent a significant proportion of road traffic injuries. Our aim was to investigate the incidence and mortality of PIs in different age groups and sociodemographic index (SDI) categories between 1990 and 2017. ...

Abstract	(1) Background: Pedestrian injuries (PIs) represent a significant proportion of road traffic injuries. Our aim was to investigate the incidence and mortality of PIs in different age groups and sociodemographic index (SDI) categories between 1990 and 2017. (2) Method: Estimates of age-standardized incidence and mortality along with trends of PIs by SDI levels were obtained from the Global Burden of Disease from 1990 to 2017. We also forecasted the trends across all the SDI categories until 2040 using the Statistical Package for the Social Sciences (SPSS Statistics for Windows, version 23.0, Chicago, IL, USA) time series expert modeler. (3) Results: Globally, the incidence of PIs increased by 3.31% (−9.94 to 16.56) in 2017 compared to 1990. Men have higher incidence of PIs than women. Forecasted incidence was 132.02 (127.37 to 136.66) per 100,000 population in 2020, 101.52 (65.99 to 137.05) in 2030, and reduced further to 71.02 (10.62 to 152.65) by 2040. Globally across all SDI categories, there was a decreasing trend in mortality due to PIs with the global estimated percentage reduction of 37.12% (−45.19 to −29.04). (4) Conclusions: The results show that PIs are still a burden for all SDI categories despite some variation. Although incidence and mortality are expected to decrease globally, some SDI categories and specific vulnerable age groups may require particular attention. Further studies addressing incidence and mortality patterns in vulnerable SDI categories are needed.
Keywords	road traffic injuries ; pedestrians ; public safety ; global burden ; economic loss ; health policy ; healthcare system ; health indicators ; Medicine ; R
Subject code	380
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990–2019

Giulio Castelpietra / Ann Kristin Skrindo Knudsen / Emilie E. Agardh / Benedetta Armocida / Massimiliano Beghi / Kim Moesgaard Iburg / Giancarlo Logroscino / Rui Ma / Fabrizio Starace / Nicholas Steel / Giovanni Addolorato / Catalina Liliana Andrei / Tudorel Andrei / Jose L Ayuso-Mateos / Maciej Banach / Till Winfried Bärnighausen / Francesco Barone-Adesi / Akshaya Srikanth Bhagavathula / Felix Carvalho /

Márcia Carvalho / Joht Singh Chandan / Vijay Kumar Chattu / Rosa A.S. Couto / Natália Cruz-Martins / Paul I. Dargan / Keshab Deuba / Diana Dias da Silva / Adeniyi Francis Fagbamigbe / Eduarda Fernandes / Pietro Ferrara / Florian Fischer / Peter Andras Gaal / Alessandro Gialluisi / Juanita A. Haagsma / Josep Maria Haro / M. Tasdik Hasan / Syed Shahzad Hasan / Sorin Hostiuc / Licia Iacoviello / Ivo Iavicoli / Elham Jamshidi / Jost B. Jonas / Tamas Joo / Jacek Jerzy Jozwiak / Srinivasa Vittal Katikireddi / Joonas H. Kauppila / Moien A.B. Khan / Adnan Kisa / Sezer Kisa / Mika Kivimäki

The Lancet Regional Health. Europe, Vol 16, Iss , Pp 100341- (2022)

Findings from the Global Burden of Disease Study 2019

2022

Abstract: Summary: Background: Mental health is a public health issue for European young people, with great heterogeneity in resource allocation. Representative population-based studies are needed. The Global Burden of Disease (GBD) Study 2019 provides ... ...

Abstract	Summary: Background: Mental health is a public health issue for European young people, with great heterogeneity in resource allocation. Representative population-based studies are needed. The Global Burden of Disease (GBD) Study 2019 provides internationally comparable information on trends in the health status of populations and changes in the leading causes of disease burden over time. Methods: Prevalence, incidence, Years Lived with Disability (YLDs) and Years of Life Lost (YLLs) from mental disorders (MDs), substance use disorders (SUDs) and self-harm were estimated for young people aged 10-24 years in 31 European countries. Rates per 100,000 population, percentage changes in 1990-2019, 95% Uncertainty Intervals (UIs), and correlations with Sociodemographic Index (SDI), were estimated. Findings: In 2019, rates per 100,000 population were 16,983 (95% UI 12,823 – 21,630) for MDs, 3,891 (3,020 - 4,905) for SUDs, and 89·1 (63·8 - 123·1) for self-harm. In terms of disability, anxiety contributed to 647·3 (432–912·3) YLDs, while in terms of premature death, self-harm contributed to 319·6 (248·9–412·8) YLLs, per 100,000 population. Over the 30 years studied, YLDs increased in eating disorders (14·9%;9·4-20·1) and drug use disorders (16·9%;8·9-26·3), and decreased in idiopathic developmental intellectual disability (–29·1%;23·8-38·5). YLLs decreased in self-harm (–27·9%;38·3-18·7). Variations were found by sex, age-group and country. The burden of SUDs and self-harm was higher in countries with lower SDI, MDs were associated with SUDs. Interpretation: Mental health conditions represent an important burden among young people living in Europe. National policies should strengthen mental health, with a specific focus on young people. Funding: The Bill and Melinda Gates Foundation
Keywords	Young people ; Mental health ; Mental disorders ; Self-harm ; Substance use ; Europe ; Public aspects of medicine ; RA1-1270
Subject code	306
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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