Article ; Online: Cross-sectional analysis of depressive symptom profiles and serum C-reactive protein levels: data from the Northern Finland 1966 birth cohort.
2024 Volume 78, Issue 2, Page(s) 95–102
Abstract: Purpose: Individuals with depression exhibit significantly higher levels of systemic inflammation than those without depression, particularly among those with atypical depression. However, this association has been less convincing at the population ... ...
| Abstract | Purpose: Individuals with depression exhibit significantly higher levels of systemic inflammation than those without depression, particularly among those with atypical depression. However, this association has been less convincing at the population level among individuals without a formal depression diagnosis but with suggestive symptoms. Our aim was to clarify this association. Materials and methods: In a large birth cohort sample of the Finnish general population, we examined the cross-sectional association between high-sensitivity C-reactive protein (hsCRP) levels in venous blood samples and atypical/non-atypical depressive symptoms using the Beck Depression Inventory-II to screen 5443 middle-aged participants. Results: As expected, depressive symptoms associated to elevated hsCRP-levels compared to non-depressed. Participants with the atypical subtype of depressive symptoms ( Conclusions: These results provide additional support for previous research linking depression and inflammation and add to the field with a unique and sizeable study population. Furthermore, the current results support the notion that different types of depressive symptoms may be associated with inflammatory markers in slightly different ways. |
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| MeSH term(s) | Humans ; Middle Aged ; Biomarkers ; Birth Cohort ; C-Reactive Protein/analysis ; Cross-Sectional Studies ; Depression/diagnosis ; Depression/epidemiology ; Finland/epidemiology ; Inflammation/epidemiology | |||||
| Chemical Substances | Biomarkers ; C-Reactive Protein (9007-41-4) ; CRP protein, human | |||||
| Language | English | |||||
| Publishing date | 2024-01-31 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1104974-1 | |||||
| ISSN | 1502-4725 ; 0803-9488 ; 0029-1455 | |||||
| ISSN (online) | 1502-4725 | |||||
| ISSN | 0803-9488 ; 0029-1455 | |||||
| DOI | 10.1080/08039488.2023.2274341 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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