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  1. Article ; Online: Emerging Invasive Group A Streptococcus M1

    Zhi, Xiangyun / Li, Ho Kwong / Li, Hanqi / Loboda, Zuzanna / Charles, Samson / Vieira, Ana / Huse, Kristin / Jauneikaite, Elita / Reeves, Lucy / Mok, Kai Yi / Coelho, Juliana / Lamagni, Theresa / Sriskandan, Shiranee

    Emerging infectious diseases

    2023  Volume 29, Issue 5, Page(s) 1007–1010

    Abstract: Increasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage ... ...

    Abstract Increasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage M1
    MeSH term(s) Humans ; Streptococcus pyogenes/genetics ; Scarlet Fever/epidemiology ; Alleles ; England/epidemiology ; Streptococcal Infections/diagnosis ; Streptococcal Infections/epidemiology ; Polymerase Chain Reaction ; Antigens, Bacterial/genetics ; Bacterial Outer Membrane Proteins/genetics
    Chemical Substances Antigens, Bacterial ; Bacterial Outer Membrane Proteins
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2905.221887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential.

    Tan, Cedric C S / Trew, Jahcub / Peacock, Thomas P / Mok, Kai Yi / Hart, Charlie / Lau, Kelvin / Ni, Dongchun / Orme, C David L / Ransome, Emma / Pearse, William D / Coleman, Christopher M / Bailey, Dalan / Thakur, Nazia / Quantrill, Jessica L / Sukhova, Ksenia / Richard, Damien / Kahane, Laura / Woodward, Guy / Bell, Thomas /
    Worledge, Lisa / Nunez-Mino, Joe / Barclay, Wendy / van Dorp, Lucy / Balloux, Francois / Savolainen, Vincent

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3322

    Abstract: There has been limited characterisation of bat-borne coronaviruses in Europe. Here, we screened for coronaviruses in 48 faecal samples from 16 of the 17 bat species breeding in the UK, collected through a bat rehabilitation and conservationist network. ... ...

    Abstract There has been limited characterisation of bat-borne coronaviruses in Europe. Here, we screened for coronaviruses in 48 faecal samples from 16 of the 17 bat species breeding in the UK, collected through a bat rehabilitation and conservationist network. We recovered nine complete genomes, including two novel coronavirus species, across six bat species: four alphacoronaviruses, a MERS-related betacoronavirus, and four closely related sarbecoviruses. We demonstrate that at least one of these sarbecoviruses can bind and use the human ACE2 receptor for infecting human cells, albeit suboptimally. Additionally, the spike proteins of these sarbecoviruses possess an R-A-K-Q motif, which lies only one nucleotide mutation away from a furin cleavage site (FCS) that enhances infectivity in other coronaviruses, including SARS-CoV-2. However, mutating this motif to an FCS does not enable spike cleavage. Overall, while UK sarbecoviruses would require further molecular adaptations to infect humans, their zoonotic risk warrants closer surveillance.
    MeSH term(s) Animals ; Humans ; Chiroptera ; COVID-19/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Genomics ; United Kingdom ; Phylogeny ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38717-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rapid expansion and international spread of M1

    Vieira, Ana / Wan, Yu / Ryan, Yan / Li, Ho Kwong / Guy, Rebecca L / Papangeli, Maria / Huse, Kristin K / Reeves, Lucy C / Soo, Valerie W C / Daniel, Roger / Harley, Alessandra / Broughton, Karen / Dhami, Chenchal / Ganner, Mark / Ganner, Marjorie A / Mumin, Zaynab / Razaei, Maryam / Rundberg, Emma / Mammadov, Rufat /
    Mills, Ewurabena A / Sgro, Vincenzo / Mok, Kai Yi / Didelot, Xavier / Croucher, Nicholas J / Jauneikaite, Elita / Lamagni, Theresa / Brown, Colin S / Coelho, Juliana / Sriskandan, Shiranee

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3916

    Abstract: The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage ... ...

    Abstract The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage M1
    MeSH term(s) Streptococcus pyogenes/genetics ; Streptococcus pyogenes/pathogenicity ; Streptococcus pyogenes/isolation & purification ; United Kingdom/epidemiology ; Humans ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Phylogeny ; COVID-19/epidemiology ; Pandemics ; Scarlet Fever/epidemiology ; Scarlet Fever/microbiology ; Mutation ; Repressor Proteins/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Genome, Bacterial ; Europe/epidemiology ; Bacterial Proteins
    Chemical Substances CsrR protein, Streptococcus pyogenes ; Repressor Proteins ; Bacterial Proteins
    Language English
    Publishing date 2024-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47929-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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